Dyspepsia

Common Name(s)

Dyspepsia, Indigestion

Dyspepsia is discomfort or pain from the upper digestive tract, also known as indigestion. This discomfort may be originating from the stomach, throat, or upper intestine. Common symptoms of dyspepsia include bloating, nausea, loss of appetite, a burning sensation, regurgitation, and burping. Dyspepsia without the presence of another gastrointestinal (GI) condition is known as functional dyspepsia. Dyspepsia is very common and affects 15% of the Western population.

Dyspepsia may be caused by another GI condition or may be caused by specific food sensitivities or stressors. Potential causes include disorders in the movement of food through the upper GI tract, the presence of ulcers, and acid reflux disease. Certain foods, such as lactose in those who are lactose intolerant, caffeine, alcohol, or oral medications may also cause dyspepsia. Stomach or duodenal ulcers may cause dyspepsia. Depression, anxiety, and increased stress may also cause dyspepsia.

Treatment is often dependent upon the specific cause of the dyspepsia. Dietary changes such as avoidance of the foods that cause symptoms is often suggested. Behavioral changes such as eating frequent, smaller meals rather than three large meals, and not lying down after eating may also alleviate symptoms. Refraining from smoking or wearing tight fitting clothes may be beneficial, as well as maintaining a healthy body weight. Medications to decrease stomach acid or pain may also be used. Certain anti-inflammatory medications, such as ibuprofen, may cause damage to the lining of the stomach and should be minimized or avoided in individuals with dyspepsia. If you are suffering from dyspepsia, talk to your doctor about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dyspepsia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dyspepsia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dyspepsia" returned 619 free, full-text research articles on human participants. First 3 results:

Epigastric symptoms of gallbladder dyskinesia mistaken for functional dyspepsia: Retrospective observational study.
 

Author(s): Sung Won Jung, Min Sun Joo, Hyun Chang Choi, Sung Ill Jang, Young Sik Woo, Jin Bae Kim, Sang Hoon Park, Myung Seok Lee

Journal: Medicine (Baltimore). 2017 Apr;96(16):e6702.

 

Functional dyspepsia (FD) is a constellation of epigastric symptoms originating in the gastroduodenal region without organic and metabolic cause. However, similar confounding symptoms can also appear in patients with gallbladder (GB) dyskinesia. Therefore, symptoms of GB dyskinesia ...

Last Updated: 19 Apr 2017

Go To URL
Plasma ghrelin level and plasma ghrelin/obestatin ratio are related to intestinal metaplasia in elderly patients with functional dyspepsia.
 

Author(s): Su Hwan Kim, Ji Won Kim, Junsu Byun, Ji Bong Jeong, Byeong Gwan Kim, Kook Lae Lee

Journal:

 

Whether plasma ghrelin/obestatin levels are associated with Helicobacter pylori (H. pylori) infection, subtypes of functional dyspepsia (FD), and gastric mucosal histology has not yet been established in elderly patients.

Last Updated: 18 Apr 2017

Go To URL
Quality of life in dyspepsia and its subgroups using EQ-5D (EuroQol) questionnaire.
 

Author(s): Anurag J Shetty, Girisha Balaraju, Shiran Shetty, Cannanore G Pai

Journal: Saudi J Gastroenterol. ;23(2):112-116.

 

Dyspepsia has a significant impact on the quality of life. Health-related quality of life (HRQoL) can be assessed by disease-specific and generic HRQoL instruments. The present study evaluated HRQoL and compared it among dyspepsia subgroups by using EQ (Euro QoL)-5D questionnaire.

Last Updated: 31 Mar 2017

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dyspepsia" returned 101 free, full-text review articles on human participants. First 3 results:

[Current Status of Translational Research on Functional Dyspepsia].
 

Author(s): Jae Ho Park, Jong Wook Kim, Jong Kyu Park, Cheol Min Shin, Kee Wook Jung

Journal: Korean J Gastroenterol. 2016 Sep;68(3):132-7.

 

Functional dyspepsia (FD) has a diverse pathophysiology and treatment is difficult. Translational research to understand its pathophysiology is underway. Hormonal factors, including ghrelin, seem promising, offering an understanding of appetite and eating. Functional MRI brain study ...

Last Updated: 20 Sep 2016

Go To URL
Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis.
 

Author(s): Yaoyao Lu, Meng Chen, Zhiyin Huang, Chengwei Tang

Journal:

 

Antidepressants have been empirically used in the treatment of functional dyspepsia (FD). However, results from recent clinical trials investigating their efficacy are conflicting. The aim of this study is to evaluate the efficacy of antidepressants in the management of FD in adults.

Last Updated: 17 Jun 2016

Go To URL
Functional dyspepsia: new insights into pathogenesis and therapy.
 

Author(s): Nicholas J Talley

Journal: Korean J. Intern. Med.. 2016 May;31(3):444-56.

 

One in 10 people suffer from functional dyspepsia (FD), a clinical syndrome comprising chronic bothersome early satiety, or postprandial fullness, or epigastric pain or burning. Postprandial distress syndrome (PDS, comprising early satiety and/or postprandial fullness) and epigastric ...

Last Updated: 4 May 2016

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Motilitone to Treat Functional Dyspepsia
 

Status: Recruiting

Condition Summary: Dyspepsia

 

Last Updated: 15 Aug 2016

Go to URL
Efficacy of Bromopride and Simethicone Versus Bromopride in Functional Dyspepsia
 

Status: Recruiting

Condition Summary: Dyspepsia

 

Last Updated: 24 Jul 2017

Go to URL
Effectiveness of tDCS for the Treatment of Functional Dyspepsia
 

Status: Recruiting

Condition Summary: Dyspepsia

 

Last Updated: 17 May 2016

Go to URL