Dyspepsia

Common Name(s)

Dyspepsia, Indigestion

Dyspepsia is discomfort or pain from the upper digestive tract, also known as indigestion. This discomfort may be originating from the stomach, throat, or upper intestine. Common symptoms of dyspepsia include bloating, nausea, loss of appetite, a burning sensation, regurgitation, and burping. Dyspepsia without the presence of another gastrointestinal (GI) condition is known as functional dyspepsia. Dyspepsia is very common and affects 15% of the Western population.

Dyspepsia may be caused by another GI condition or may be caused by specific food sensitivities or stressors. Potential causes include disorders in the movement of food through the upper GI tract, the presence of ulcers, and acid reflux disease. Certain foods, such as lactose in those who are lactose intolerant, caffeine, alcohol, or oral medications may also cause dyspepsia. Stomach or duodenal ulcers may cause dyspepsia. Depression, anxiety, and increased stress may also cause dyspepsia.

Treatment is often dependent upon the specific cause of the dyspepsia. Dietary changes such as avoidance of the foods that cause symptoms is often suggested. Behavioral changes such as eating frequent, smaller meals rather than three large meals, and not lying down after eating may also alleviate symptoms. Refraining from smoking or wearing tight fitting clothes may be beneficial, as well as maintaining a healthy body weight. Medications to decrease stomach acid or pain may also be used. Certain anti-inflammatory medications, such as ibuprofen, may cause damage to the lining of the stomach and should be minimized or avoided in individuals with dyspepsia. If you are suffering from dyspepsia, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dyspepsia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dyspepsia" returned 652 free, full-text research articles on human participants. First 3 results:

[Effect of Amitriptyline in Patients with Functional Dyspepsia].
 

Author(s): Yunju Jo

Journal: Korean J Gastroenterol. 2015 Oct;66(4):245-7.

 

Last Updated: 20 Jan 2016

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Zhiqiaochuanxiong decoction for major depressive disorder complicated by functional dyspepsia: a case report with fast-acting efficacy.
 

Author(s): Min Luo, Xi Huang, Yang Wang, Ping Ren

Journal: J Tradit Chin Med. 2015 Dec;35(6):697-702.

 

To introduce a clinical case from Professor Huang Xi from Xiangya Hospital in traditional Chinese medical (TCM) treatment for a major depressive disorder (MDD) complicated by functional dyspepsia (FD).

Last Updated: 8 Jan 2016

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Melatonin may have a role in the pathogenesis of functional dyspepsia in males.
 

Author(s): F Ermis, A Uyanikoglu, F Akyuz, O Yonal, F Keskin, S Ciftci, Z Mungan

Journal: Eur Rev Med Pharmacol Sci. 2015 Dec;19(23):4675-8.

 

Pathogenesis of functional dyspepsia (FD) is complex. Melatonin is synthesized in enterochromaffin cells (EC) of the digestive system. It may influence gut function. The aim of this study is to evaluate the serum melatonin levels in FD patients.

Last Updated: 24 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dyspepsia" returned 104 free, full-text review articles on human participants. First 3 results:

Gene polymorphisms associated with functional dyspepsia.
 

Author(s): Anastasia Kourikou, George P Karamanolis, George D Dimitriadis, Konstantinos Triantafyllou

Journal: World J. Gastroenterol.. 2015 Jul;21(25):7672-82.

 

Functional dyspepsia (FD) is a constellation of functional upper abdominal complaints with poorly elucidated pathophysiology. However, there is increasing evidence that susceptibility to FD is influenced by hereditary factors. Genetic association studies in FD have examined genotypes ...

Last Updated: 13 Jul 2015

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Systematic review with meta-analysis: prompt endoscopy as the initial management strategy for uninvestigated dyspepsia in Asia.
 

Author(s): S L Chen, K A Gwee, J S Lee, H Miwa, H Suzuki, P Guo, Y T Hao, M H Chen

Journal: Aliment. Pharmacol. Ther.. 2015 Feb;41(3):239-52.

 

Prompt endoscopy should be considered as an initial strategy for uninvestigated dyspepsia in the background of high prevalence of Helicobacter pylori infection and malignancy. However, with changes of disease patterns and dyspepsia definition, the prevalence of organic lesions at ...

Last Updated: 7 May 2015

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Systematic review with meta-analysis: post-infectious functional dyspepsia.
 

Author(s): S Futagami, T Itoh, C Sakamoto

Journal: Aliment. Pharmacol. Ther.. 2015 Jan;41(2):177-88.

 

The prevalence of functional dyspepsia (FD) following infectious gastroenteritis has not been systematically reviewed.

Last Updated: 16 Dec 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Functional Dyspepsia (FD) - Clinical Response to Montelukast in Children
 

Status: Recruiting

Condition Summary: Eosinophilia; Dyspepsia

 

Last Updated: 5 Feb 2015

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BRAVO Study for Functional Dyspepsia
 

Status: Recruiting

Condition Summary: Dyspepsia; Gastroesophageal Reflux

 

Last Updated: 11 Aug 2015

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SSRI Study for Functional Dyspepsia (SS)
 

Status: Recruiting

Condition Summary: Dyspepsia; Anxiety; Depression

 

Last Updated: 11 Aug 2015

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