Dyspepsia

Common Name(s)

Dyspepsia, Indigestion

Dyspepsia is discomfort or pain from the upper digestive tract, also known as indigestion. This discomfort may be originating from the stomach, throat, or upper intestine. Common symptoms of dyspepsia include bloating, nausea, loss of appetite, a burning sensation, regurgitation, and burping. Dyspepsia without the presence of another gastrointestinal (GI) condition is known as functional dyspepsia. Dyspepsia is very common and affects 15% of the Western population.

Dyspepsia may be caused by another GI condition or may be caused by specific food sensitivities or stressors. Potential causes include disorders in the movement of food through the upper GI tract, the presence of ulcers, and acid reflux disease. Certain foods, such as lactose in those who are lactose intolerant, caffeine, alcohol, or oral medications may also cause dyspepsia. Stomach or duodenal ulcers may cause dyspepsia. Depression, anxiety, and increased stress may also cause dyspepsia.

Treatment is often dependent upon the specific cause of the dyspepsia. Dietary changes such as avoidance of the foods that cause symptoms is often suggested. Behavioral changes such as eating frequent, smaller meals rather than three large meals, and not lying down after eating may also alleviate symptoms. Refraining from smoking or wearing tight fitting clothes may be beneficial, as well as maintaining a healthy body weight. Medications to decrease stomach acid or pain may also be used. Certain anti-inflammatory medications, such as ibuprofen, may cause damage to the lining of the stomach and should be minimized or avoided in individuals with dyspepsia. If you are suffering from dyspepsia, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dyspepsia" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dyspepsia" returned 585 free, full-text research articles on human participants. First 3 results:

Zhiqiaochuanxiong decoction for major depressive disorder complicated by functional dyspepsia: a case report with fast-acting efficacy.
 

Author(s): Min Luo, Xi Huang, Yang Wang, Ping Ren

Journal: J Tradit Chin Med. 2015 Dec;35(6):697-702.

 

To introduce a clinical case from Professor Huang Xi from Xiangya Hospital in traditional Chinese medical (TCM) treatment for a major depressive disorder (MDD) complicated by functional dyspepsia (FD).

Last Updated: 8 Jan 2016

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[Construction of a online database for functional dyspepsia].
 

Author(s): Zaiwei Huang, Liping Chen, Bing Xiao

Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2015 Jun;35(6):907-11.

 

To establish a clinical database of functional dyspepsia for epidemiological researches and standardizing clinical diagnosis and treatment.

Last Updated: 26 Jun 2015

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The relationship between irritable bowel syndrome, functional dyspepsia, chronic fatigue and overactive bladder syndrome: a controlled study 6 years after acute gastrointestinal infection.
 

Author(s): Robert Persson, Knut-Arne Wensaas, Kurt Hanevik, Geir Egil Eide, Nina Langeland, Guri Rortveit

Journal:

 

To investigate in a cohort with previous gastrointestinal infection and a control group the prevalence of overactive bladder syndrome (OAB), and how it was associated with three other functional disorders; irritable bowel syndrome (IBS), functional dyspepsia (FD) and chronic fatigue (CF).

Last Updated: 10 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dyspepsia" returned 93 free, full-text review articles on human participants. First 3 results:

Efficacy and safety of acotiamide for the treatment of functional dyspepsia: systematic review and meta-analysis.
 

Author(s): Guoguang Xiao, Xiaoping Xie, Juan Fan, Jianjun Deng, Shan Tan, Yu Zhu, Qin Guo, Chaomin Wan

Journal: ScientificWorldJournal. 2014 ;2014():541950.

 

There are no treatments with established efficacy for this disorder so far.

Last Updated: 8 Sep 2014

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Helicobacter pylori and functional dyspepsia: an unsolved issue?
 

Author(s): Angelo Zullo, Cesare Hassan, Vincenzo De Francesco, Alessandro Repici, Raffaele Manta, Silverio Tomao, Bruno Annibale, Dino Vaira

Journal: World J. Gastroenterol.. 2014 Jul;20(27):8957-63.

 

Patients with Helicobacter pylori (H. pylori) infection may complain of dyspeptic symptoms without presence of macroscopic lesions on gastroduodenal mucosa. Such a condition is usually recognized as functional dyspepsia, and different pathogenetic mechanisms are involved. The role ...

Last Updated: 1 Aug 2014

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Effect of banxiaxiexin tang on treatment of functional dyspepsia: a meta-analysis of randomized controlled trials.
 

Author(s): Yongkang Gan, Huayi Liu, Liu Yang, Kuo Yang

Journal: J Tradit Chin Med. 2014 Apr;34(2):140-4.

 

To evaluate the efficacy of Banxiaxiexin Tang compared with Western Medicine in the treatment of functional dyspepsia (FD) through Meta-analysis.

Last Updated: 2 May 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Functional Dyspepsia (FD) - Clinical Response to Montelukast in Children
 

Status: Recruiting

Condition Summary: Eosinophilia; Dyspepsia

 

Last Updated: 5 Feb 2015

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BRAVO Study for Functional Dyspepsia
 

Status: Recruiting

Condition Summary: Dyspepsia; Gastroesophageal Reflux

 

Last Updated: 11 Aug 2015

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SSRI Study for Functional Dyspepsia (SS)
 

Status: Recruiting

Condition Summary: Dyspepsia; Anxiety; Depression

 

Last Updated: 11 Aug 2015

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