Diverticular Disease

Common Name(s)

Diverticular Disease

Diverticular disease is characterized by the formation of diverticula, or small out-pouchings and pockets, in the walls of the colon (the last segment of the gastrointestinal tract which digests and carries food through the body). There are three types of diverticular diseases: diverticulosis, diverticular bleeding, and diverticulitis. The specific causes of diverticular diseases are unknown, but they are more common in people with a low fiber diet, which leads to increased pressure in the colon resulting in pocket formation. In diverticulosis (uncomplicated diverticular disease) the pockets form but do not become infected or inflamed, and therefore no symptoms occur. Infection or inflammation of the pockets (diverticulitis) can cause abdominal (belly) pain, fever, as well as other complications that may require surgery. Diverticular bleeding results in blood in the stool and bleeding from the rectum and anus, and may also require immediate medical attention. Diverticular diseases are managed by maintaining a high fiber diet (e.g. grains, vegetables), although episodes of diverticulitis and diverticular bleeding may require antibiotics, hospitalization, and potentially surgery.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diverticular Disease" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diverticular Disease" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diverticular Disease" returned 187 free, full-text research articles on human participants. First 3 results:

Association between the location of diverticular disease and the irritable bowel syndrome: a multicenter study in Japan.
 

Author(s): Eiji Yamada, Masahiko Inamori, Eri Uchida, Emiko Tanida, Motoyoshi Izumi, Kimiya Takeshita, Tetsuro Fujii, Kazuto Komatsu, Jun Hamanaka, Shin Maeda, Akira Kanesaki, Nobuyuki Matsuhashi, Atsushi Nakajima

Journal: Am. J. Gastroenterol.. 2014 Dec;109(12):1900-5.

 

No previous reports have shown an association between location of diverticular disease (DD) and the irritable bowel syndrome (IBS).

Last Updated: 4 Dec 2014

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Uncomplicated diverticular disease: innate and adaptive immunity in human gut mucosa before and after rifaximin.
 

Author(s): Rossella Cianci, Simona Frosali, Danilo Pagliari, Paola Cesaro, Lucio Petruzziello, Fabio Casciano, Raffaele Landolfi, Guido Costamagna, Franco Pandolfi

Journal: J Immunol Res. 2014 ;2014():696812.

 

Uncomplicated diverticular disease (UDD) is a frequent condition in adults. The pathogenesis of symptoms remains unknown. Bacteria are able to interact with Toll-like receptors (TLRs) and to induce inflammation through both innate immunity and T-cell recruitment. We investigated the ...

Last Updated: 18 Aug 2014

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Surgical management of colonic diverticular disease: discrepancy between right- and left-sided diseases.
 

Author(s): Heung-Kwon Oh, Eon Chul Han, Heon-Kyun Ha, Eun Kyung Choe, Sang Hui Moon, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park

Journal: World J. Gastroenterol.. 2014 Aug;20(29):10115-20.

 

To compare the outcome of the surgical management of left-sided and right-sided diverticular disease.

Last Updated: 11 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diverticular Disease" returned 24 free, full-text review articles on human participants. First 3 results:

Epidemiology of diverticular disease -- systematic review of the literature.
 

Author(s): I Tănase, S Păun, B Stoica, I Negoi, B Gaspar, M Beuran

Journal: Chirurgia (Bucur). ;110(1):9-14.

 

Associated with the Western diet and life style,diverticular disease is affecting more and more developing countries worldwide. Recent studies show an increase in incidence of the disease at young age, that raises the risk of complications, along with major consequences for the patient ...

Last Updated: 24 Mar 2015

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Medical influences, surgical outcomes: role of common medications on the risk of perforation from untreated diverticular disease.
 

Author(s): Gianpiero Gravante, Shuker Yahia

Journal: World J. Gastroenterol.. 2013 Sep;19(36):5947-52.

 

Numerous drugs, largely used in the wards or at home, have a significant influence on patients with untreated diverticular disease. The consequences can be disastrous, may require an emergency operation, postoperative intensive care, and overall influence the patient's length of stay ...

Last Updated: 9 Oct 2013

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Updates in diverticular disease.
 

Author(s): Adam W Templeton, Lisa L Strate

Journal: Curr Gastroenterol Rep. 2013 Aug;15(8):339.

 

Diverticulosis and its major complications, diverticulitis and diverticular bleeding, are increasingly common indications for hospitalization and outpatient visits. Recent publications in the field of diverticular disease have challenged long-standing disease concepts and management ...

Last Updated: 6 Sep 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Gut Microbiome in Diverticulitis and Diverticulosis
 

Status: Not yet recruiting

Condition Summary: Diverticulitis; Diverticulosis; Diverticular Disease

 

Last Updated: 22 Sep 2014

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Prophylactic Elective Clipping of Colonic Diverticula
 

Status: Not yet recruiting

Condition Summary: Diverticular Disease

 

Last Updated: 20 Mar 2014

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Evaluation of the Metabolome in Diverticular Disease
 

Status: Recruiting

Condition Summary: Simple Diverticular Disease

 

Last Updated: 16 Oct 2014

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