Diverticular Disease

Common Name(s)

Diverticular Disease

Diverticular disease is characterized by the formation of diverticula, or small out-pouchings and pockets, in the walls of the colon (the last segment of the gastrointestinal tract which digests and carries food through the body). There are three types of diverticular diseases: diverticulosis, diverticular bleeding, and diverticulitis. The specific causes of diverticular diseases are unknown, but they are more common in people with a low fiber diet, which leads to increased pressure in the colon resulting in pocket formation. In diverticulosis (uncomplicated diverticular disease) the pockets form but do not become infected or inflamed, and therefore no symptoms occur. Infection or inflammation of the pockets (diverticulitis) can cause abdominal (belly) pain, fever, as well as other complications that may require surgery. Diverticular bleeding results in blood in the stool and bleeding from the rectum and anus, and may also require immediate medical attention. Diverticular diseases are managed by maintaining a high fiber diet (e.g. grains, vegetables), although episodes of diverticulitis and diverticular bleeding may require antibiotics, hospitalization, and potentially surgery.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diverticular Disease" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diverticular Disease" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diverticular Disease" returned 177 free, full-text research articles on human participants. First 3 results:

Intermittent versus every-day mesalazine therapy in preventing complications of diverticular disease: a long-term follow-up study.
 

Author(s): A Tursi, F Di Mario, G Brandimarte, W Elisei, M Picchio, S Loperfido, N Dal Bo', F Ferrara, R Marcello, H Heras Salvat, C Scarpignato

Journal: Eur Rev Med Pharmacol Sci. 2013 Dec;17(23):3244-8.

 

Mesalazine seems to be effective in preventing recurrence of acute uncomplicated diverticulitis (AUD), but the optimal mesalazine scheme to achieve these results is still debated.

Last Updated: 16 Dec 2013

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Presentation, distribution pattern, and management of diverticular disease in a Nigerian tertiary hospital.
 

Author(s): O I Alatise, A O Arigbabu, O O Lawal, V A Adetiloye, E A Agbakwuru, D A Ndububa

Journal: Niger J Clin Pract. ;16(2):226-31.

 

Colonic diverticular disease is one of the most common and costly gastrointestinal disorders among industrialized societies, which have recently been described among Africans. Presentations and distribution pattern of the disease among Africans appeared to be different from that described ...

Last Updated: 8 Apr 2013

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Altered expression pattern of molecular factors involved in colonic smooth muscle functions: an immunohistochemical study in patients with diverticular disease.
 

Author(s): Letizia Mattii, Chiara Ippolito, Cristina Segnani, Barbara Battolla, Rocchina Colucci, Amelio Dolfi, Gabrio Bassotti, Corrado Blandizzi, Nunzia Bernardini

Journal: PLoS ONE. 2013 ;8(2):e57023.

 

The pathogenesis of diverticular disease (DD) is thought to result from complex interactions among dietary habits, genetic factors and coexistence of other bowel abnormalities. These conditions lead to alterations in colonic pressure and motility, facilitating the formation of diverticula. ...

Last Updated: 25 Feb 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diverticular Disease" returned 23 free, full-text review articles on human participants. First 3 results:

Medical influences, surgical outcomes: role of common medications on the risk of perforation from untreated diverticular disease.
 

Author(s): Gianpiero Gravante, Shuker Yahia

Journal: World J. Gastroenterol.. 2013 Sep;19(36):5947-52.

 

Numerous drugs, largely used in the wards or at home, have a significant influence on patients with untreated diverticular disease. The consequences can be disastrous, may require an emergency operation, postoperative intensive care, and overall influence the patient's length of stay ...

Last Updated: 9 Oct 2013

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Updates in diverticular disease.
 

Author(s): Adam W Templeton, Lisa L Strate

Journal: Curr Gastroenterol Rep. 2013 Aug;15(8):339.

 

Diverticulosis and its major complications, diverticulitis and diverticular bleeding, are increasingly common indications for hospitalization and outpatient visits. Recent publications in the field of diverticular disease have challenged long-standing disease concepts and management ...

Last Updated: 6 Sep 2013

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Complicated diverticular disease: the changing paradigm for treatment.
 

Author(s): Abe Fingerhut, Nicolas Veyrie

Journal: Rev Col Bras Cir. ;39(4):322-7.

 

The term "complicated" diverticulitis is reserved for inflamed diverticular disease complicated by bleeding, abscess, peritonitis, fistula or bowel obstruction. Hemorrhage is best treated by angioembolization (interventional radiology). Treatment of infected diverticulitis has evolved ...

Last Updated: 31 Aug 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Gut Microbiome in Diverticulitis and Diverticulosis
 

Status: Not yet recruiting

Condition Summary: Diverticulitis; Diverticulosis; Diverticular Disease

 

Last Updated: 19 Aug 2014

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Prophylactic Elective Clipping of Colonic Diverticula
 

Status: Not yet recruiting

Condition Summary: Diverticular Disease

 

Last Updated: 20 Mar 2014

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Evaluation of the Metabolome in Diverticular Disease
 

Status: Recruiting

Condition Summary: Simple Diverticular Disease

 

Last Updated: 9 Apr 2013

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