Diphtheria

Common Name(s)

Diphtheria

Diphtheria is a rare and serious bacterial infection that affects the function of mucous membranes in the nose and throat. The bacteria get passed from person to person through contaminated personal or household items and airborne infected droplets. Young children and elderly people are at higher risk of getting diphtheria. Symptoms of diphtheria include gray/black mucus covering the throat and tonsils, sore throat, swollen glands, difficulty breathing, fever and chills, nasal discharge, and an overall feeling of discomfort (malaise). An antitoxin, which counteracts the toxin of the bacteria, as well as antibiotics, can be used to treat diphtheria. Some people with diphtheria may need hospitalization or surgery to remove the lining in the throat. There is a vaccination for diphtheria that effectively prevents the bacterial infection for many individuals and is part of the routine childhood vaccinations in most parts of the world.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diphtheria" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diphtheria" returned 701 free, full-text research articles on human participants. First 3 results:

Long-Term Protection against Diphtheria in the Netherlands after 50 Years of Vaccination: Results from a Seroepidemiological Study.
 

Author(s): E M Swart, P G M van Gageldonk, H E de Melker, F R van der Klis, G A M Berbers, L Mollema

Journal:

 

To evaluate the National Immunisation Programme (NIP) a population-based cross-sectional seroepidemiological study was performed in the Netherlands. We assessed diphtheria antitoxin levels in the general Dutch population and in low vaccination coverage (LVC) areas where a relatively ...

Last Updated: 11 Feb 2016

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Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development.
 

Author(s): Joerg U Schmohl, Deborah Todhunter, Seung Oh, Daniel A Vallera

Journal:

 

Targeted toxins require multiple treatments and therefore must be deimmunized. We report a method of protein deimmunization based on the point mutation of highly hydrophilic R, K, D, E, and Q amino acids on the molecular surface of truncated diphtheria-toxin (DT390).

Last Updated: 17 Oct 2015

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Licensure of a Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine and Guidance for Use as a Booster Dose.
 

Author(s): Jennifer Liang, Greg Wallace, Gina Mootrey

Journal:

 

On March 24, 2015, the Food and Drug Administration licensed an additional combined diphtheria and tetanus toxoids and acellular pertussis adsorbed (DTaP) and inactivated poliovirus (IPV) vaccine (DTaP-IPV) (Quadracel, Sanofi Pasteur Inc.). Quadracel is the second DTaP-IPV vaccine ...

Last Updated: 4 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diphtheria" returned 25 free, full-text review articles on human participants. First 3 results:

Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type B vaccine; Infanrix™ hexa: twelve years of experience in Italy.
 

Author(s): Vincenzo Baldo, Paolo Bonanni, Marcela Castro, Giovanni Gabutti, Elisabetta Franco, Federico Marchetti, Rosa Prato, Francesco Vitale

Journal: Hum Vaccin Immunother. 2014 ;10(1):129-37.

 

Infant vaccination using 2-dose priming at 3 and 5 mo of age with a booster at 11-12 mo of age was pioneered in Italy. The 3-5-11 schedule is now used in a growing number of European countries. Infanrix™ hexa (DTPa-HBV-IPV/Hib, GlaxoSmithKline Vaccines) was first licensed for use ...

Last Updated: 16 May 2014

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pH-triggered conformational switching along the membrane insertion pathway of the diphtheria toxin T-domain.
 

Author(s): Alexey S Ladokhin

Journal:

 

The translocation (T)-domain plays a key role in the action of diphtheria toxin and is responsible for transferring the catalytic domain across the endosomal membrane into the cytosol in response to acidification. Deciphering the molecular mechanism of pH-dependent refolding and membrane ...

Last Updated: 8 Aug 2013

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Heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor in normal and neoplastic hematopoiesis.
 

Author(s): Fabrizio Vinante, Antonella Rigo

Journal: Toxins (Basel). 2013 Jun;5(6):1180-1201.

 

Heparin-binding EGF-like growth factor (HB-EGF) belongs to the EGF family of growth factors. It is biologically active either as a molecule anchored to the membrane or as a soluble form released by proteolytic cleavage of the extracellular domain. HB-EGF is involved in relevant physiological ...

Last Updated: 26 Jul 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Adsorbed in Healthy Subjects
 

Status: Recruiting

Condition Summary: Tetanus; Diphtheria; Pertussis; Whooping Cough

 

Last Updated: 6 Jun 2016

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Vaccine -diphthEria -tetaNus -Acellular pertUssis-inactivated polioviruS
 

Status: Recruiting

Condition Summary: Diphtheria; Tetanus; Pertussis; Poliomyelitis

 

Last Updated: 14 Jun 2016

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Safety and Immunogenicity Study of Tetanus, Diphtheria and Acellular Pertussis (Tdap) Vaccine
 

Status: Not yet recruiting

Condition Summary: Tetanus; Diphtheria; Whooping Cough

 

Last Updated: 22 Jun 2016

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