Diphtheria

Common Name(s)

Diphtheria

Diphtheria is a rare and serious bacterial infection that affects the function of mucous membranes in the nose and throat. The bacteria get passed from person to person through contaminated personal or household items and airborne infected droplets. Young children and elderly people are at higher risk of getting diphtheria. Symptoms of diphtheria include gray/black mucus covering the throat and tonsils, sore throat, swollen glands, difficulty breathing, fever and chills, nasal discharge, and an overall feeling of discomfort (malaise). An antitoxin, which counteracts the toxin of the bacteria, as well as antibiotics, can be used to treat diphtheria. Some people with diphtheria may need hospitalization or surgery to remove the lining in the throat. There is a vaccination for diphtheria that effectively prevents the bacterial infection for many individuals and is part of the routine childhood vaccinations in most parts of the world.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diphtheria" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diphtheria" returned 687 free, full-text research articles on human participants. First 3 results:

Barriers to Receipt of Prenatal Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine Among Mothers of Infants Aged <4 Months with Pertussis - California, 2016.
 

Author(s): Sarah New, Kathleen Winter, Rebeca Boyte, Kathleen Harriman, Anya Gutman, Amber Christiansen, Sarah Royce

Journal:

 

Vaccination with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine is recommended for all pregnant women to protect infants who are too young for vaccination from severe pertussis-related outcomes (1-3). However, Tdap vaccine coverage among pregnant ...

Last Updated: 31 Dec 1969

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Immunogenicity and safety of the quadrivalent meningococcal vaccine MenACWY-TT co-administered with a combined diphtheria-tetanus-acellular pertussis vaccine versus their separate administration in adolescents and young adults: A phase III, randomized study.
 

Author(s): Luis Rivera, Tino F Schwarz, Kyung-Hyo Kim, Yun-Kyung Kim, Ulrich Behre, Sung-Ho Cha, Dae Sun Jo, Jacob Lee, Jin-Soo Lee, Brigitte Cheuvart, Archana Jastorff, Marie Van der Wielen

Journal: Vaccine. 2018 07;36(31):4750-4758.

 

This study evaluated the immunogenicity and safety of quadrivalent meningococcal conjugate vaccine using tetanus (T) toxoid as carrier protein (MenACWY-TT) co-administered with combined diphtheria-tetanus-acellular pertussis vaccine (Tdap) versus their separate administration in adolescents ...

Last Updated: 31 Dec 1969

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Carrier study and treatment of close contacts: A must for diphtheria eradication.
 

Author(s): Usha Udgaonkar

Journal: Indian J Med Microbiol. ;36(1):148.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diphtheria" returned 16 free, full-text review articles on human participants. First 3 results:

Immunization of preterm infants with GSK's hexavalent combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b conjugate vaccine: A review of safety and immunogenicity.
 

Author(s): Felix Omeñaca, Liliana Vázquez, Pilar Garcia-Corbeira, Narcisa Mesaros, Linda Hanssens, Jan Dolhain, Ivonne Puente Gómez, Johannes Liese, Markus Knuf

Journal: Vaccine. 2018 02;36(7):986-996.

 

Infants with history of prematurity (<37 weeks gestation) and low birth weight (LBW, <2500 g) are at high risk of infection due to functional immaturity of normal physical and immunological defense mechanisms. Despite current recommendations that infants with history of prematurity/LBW ...

Last Updated: 31 Dec 1969

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Adult vaccination against tetanus and diphtheria: the European perspective.
 

Author(s): B Weinberger

Journal: Clin. Exp. Immunol.. 2017 Jan;187(1):93-99.

 

Besides immunizations against influenza, Streptococcus pneumoniae and herpes zoster, which are recommended specifically for elderly people, regular booster vaccinations against tetanus, diphtheria and in some cases pertussis and polio are recommended in many European countries for ...

Last Updated: 31 Dec 1969

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Corynebacterium ulcerans cutaneous diphtheria.
 

Author(s): Luke S P Moore, Asuka Leslie, Margie Meltzer, Ann Sandison, Androulla Efstratiou, Shiranee Sriskandan

Journal: Lancet Infect Dis. 2015 Sep;15(9):1100-1107.

 

We describe the case of a patient with cutaneous diphtheria caused by toxigenic Corynebacterium ulcerans who developed a right hand flexor sheath infection and symptoms of sepsis such as fever, tachycardia, and elevated C-reactive protein, after contact with domestic cats and dogs, ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Heterologous Effect of Diptheria, Tetanus, Acellular Pertussis Vaccination on Influenza Challenge in the Elderly
 

Status: Recruiting

Condition Summary: Heterologous Effects of Vaccines

 

Last Updated: 25 Jul 2017

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Study on the Safety and Immunogenicity of Boostrix Vaccine in Pregnant Malian Women and Their Infants
 

Status: Not yet recruiting

Condition Summary: Clostridium Difficile Immunisation; Diphtheria; Diphtheria Immunisation; Pertussis; Tetanus; Tetanus Immunisation

 

Last Updated: 15 Nov 2018

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