Diphtheria

Common Name(s)

Diphtheria

Diphtheria is a rare and serious bacterial infection that affects the function of mucous membranes in the nose and throat. The bacteria get passed from person to person through contaminated personal or household items and airborne infected droplets. Young children and elderly people are at higher risk of getting diphtheria. Symptoms of diphtheria include gray/black mucus covering the throat and tonsils, sore throat, swollen glands, difficulty breathing, fever and chills, nasal discharge, and an overall feeling of discomfort (malaise). An antitoxin, which counteracts the toxin of the bacteria, as well as antibiotics, can be used to treat diphtheria. Some people with diphtheria may need hospitalization or surgery to remove the lining in the throat. There is a vaccination for diphtheria that effectively prevents the bacterial infection for many individuals and is part of the routine childhood vaccinations in most parts of the world.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diphtheria" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diphtheria" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diphtheria" returned 548 free, full-text research articles on human participants. First 3 results:

Vaccination with tetanus, diphtheria, and acellular pertussis vaccine of pregnant women enrolled in Medicaid--Michigan, 2011-2013.
 

Author(s): Michelle Housey, Fan Zhang, Corinne Miller, Sarah Lyon-Callo, Jevon McFadden, Erika Garcia, Rachel Potter,

Journal: MMWR Morb. Mortal. Wkly. Rep.. 2014 Sep;63(38):839-42.

 

In October 2011, the Advisory Committee on Immunization Practices (ACIP) first recommended the routine administration of a tetanus, diphtheria, and acellular pertussis vaccine (Tdap) during pregnancy as a strategy to protect infants from pertussis (also known as whooping cough). This ...

Last Updated: 26 Sep 2014

Go To URL
Letter to the editor: cutaneous diphtheria in a migrant from an endemic country in east Africa, Austria May 2014.
 

Author(s): S Huhulescu, S Hirk, V Zeinzinger, P Hasenberger, H Skvara, R Mullegger, F Allerberger, A Indra

Journal:

 

Last Updated: 11 Jul 2014

Go To URL
Access to diphtheria antitoxin for therapy and diagnostics.
 

Author(s): L Both, J White, S Mandal, A Efstratiou

Journal:

 

The most effective treatment for diphtheria is swift administration of diphtheria antitoxin (DAT) with conjunct antibiotic therapy. DAT is an equine immunoglobulin preparation and listed among the World Health Organization Essential Medicines. Essential Medicines should be available ...

Last Updated: 27 Jun 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diphtheria" returned 23 free, full-text review articles on human participants. First 3 results:

pH-triggered conformational switching along the membrane insertion pathway of the diphtheria toxin T-domain.
 

Author(s): Alexey S Ladokhin

Journal:

 

The translocation (T)-domain plays a key role in the action of diphtheria toxin and is responsible for transferring the catalytic domain across the endosomal membrane into the cytosol in response to acidification. Deciphering the molecular mechanism of pH-dependent refolding and membrane ...

Last Updated: 8 Aug 2013

Go To URL
Heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor in normal and neoplastic hematopoiesis.
 

Author(s): Fabrizio Vinante, Antonella Rigo

Journal: Toxins (Basel). 2013 Jun;5(6):1180-1201.

 

Heparin-binding EGF-like growth factor (HB-EGF) belongs to the EGF family of growth factors. It is biologically active either as a molecule anchored to the membrane or as a soluble form released by proteolytic cleavage of the extracellular domain. HB-EGF is involved in relevant physiological ...

Last Updated: 26 Jul 2013

Go To URL
Corynebacterium ulcerans diphtheria: an emerging zoonosis in Brazil and worldwide.
 

Author(s): Alexandre Alves de Souza de Oliveira Dias, Louisy Sanchez Santos, Priscila Soares Sabbadini, Cíntia Silva Santos, Feliciano Correa Silva Junior, Fátima Napoleão, Prescilla Emy Nagao, Maria Helena Simões Villas-Bôas, Raphael Hirata Junior, Ana Luíza Mattos Guaraldi

Journal: Rev Saude Publica. 2011 Dec;45(6):1176-91.

 

The article is a literature review on the emergence of human infections caused by Corynebacterium ulcerans in many countries including Brazil. Articles in Medline/PubMed and SciELO databases published between 1926 and 2011 were reviewed, as well as articles and reports of the Brazilian ...

Last Updated: 29 Nov 2011

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Post Marketing Surveillance for ADACEL™ in South Korea
 

Status: Recruiting

Condition Summary: Diphtheria; Tetanus; Pertussis

 

Last Updated: 23 Jul 2014

Go to URL
Regulatory Post-Marketing Surveillance Study for TETRAXIM™
 

Status: Recruiting

Condition Summary: Diphtheria; Tetanus; Pertussis; Poliomyelitis

 

Last Updated: 20 Aug 2014

Go to URL
Post-marketing Surveillance to Assess the Safety of Infanrix-IPV Vaccine Among Infants and Children in Korea
 

Status: Recruiting

Condition Summary: Acellular Pertussis; Diphtheria; Tetanus; Poliomyelitis

 

Last Updated: 6 Nov 2014

Go to URL