Diphtheria

Common Name(s)

Diphtheria

Diphtheria is a rare and serious bacterial infection that affects the function of mucous membranes in the nose and throat. The bacteria get passed from person to person through contaminated personal or household items and airborne infected droplets. Young children and elderly people are at higher risk of getting diphtheria. Symptoms of diphtheria include gray/black mucus covering the throat and tonsils, sore throat, swollen glands, difficulty breathing, fever and chills, nasal discharge, and an overall feeling of discomfort (malaise). An antitoxin, which counteracts the toxin of the bacteria, as well as antibiotics, can be used to treat diphtheria. Some people with diphtheria may need hospitalization or surgery to remove the lining in the throat. There is a vaccination for diphtheria that effectively prevents the bacterial infection for many individuals and is part of the routine childhood vaccinations in most parts of the world.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diphtheria" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diphtheria" returned 653 free, full-text research articles on human participants. First 3 results:

Last Updated: 31 Dec 1969

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Diphtheria Revisited.
 

Author(s): Surendra B Mathur, Sharmila B Mukherjee

Journal: Indian Pediatr. 2017 May;54(5):411-412.

 

Last Updated: 31 Dec 1969

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Waning protection following 5 doses of a 3-component diphtheria, tetanus, and acellular pertussis vaccine.
 

Author(s): Nicola P Klein, Joan Bartlett, Bruce Fireman, Laurie Aukes, Philip O Buck, Girishanthy Krishnarajah, Roger Baxter

Journal: Vaccine. 2017 06;35(26):3395-3400.

 

The effectiveness of diphtheria, tetanus, and acellular pertussis (DTaP) vaccines wanes substantially after the 5th dose given at ages 4-6years, but has not been described following 5 doses of the same type of DTaP vaccine. We investigated waning effectiveness against pertussis in ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diphtheria" returned 14 free, full-text review articles on human participants. First 3 results:

Adult vaccination against tetanus and diphtheria: the European perspective.
 

Author(s): B Weinberger

Journal: Clin. Exp. Immunol.. 2017 Jan;187(1):93-99.

 

Besides immunizations against influenza, Streptococcus pneumoniae and herpes zoster, which are recommended specifically for elderly people, regular booster vaccinations against tetanus, diphtheria and in some cases pertussis and polio are recommended in many European countries for ...

Last Updated: 31 Dec 1969

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Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type B vaccine; Infanrix™ hexa: twelve years of experience in Italy.
 

Author(s): Vincenzo Baldo, Paolo Bonanni, Marcela Castro, Giovanni Gabutti, Elisabetta Franco, Federico Marchetti, Rosa Prato, Francesco Vitale

Journal: Hum Vaccin Immunother. 2014 ;10(1):129-37.

 

Infant vaccination using 2-dose priming at 3 and 5 mo of age with a booster at 11-12 mo of age was pioneered in Italy. The 3-5-11 schedule is now used in a growing number of European countries. Infanrix™ hexa (DTPa-HBV-IPV/Hib, GlaxoSmithKline Vaccines) was first licensed for use ...

Last Updated: 31 Dec 1969

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pH-triggered conformational switching along the membrane insertion pathway of the diphtheria toxin T-domain.
 

Author(s): Alexey S Ladokhin

Journal:

 

The translocation (T)-domain plays a key role in the action of diphtheria toxin and is responsible for transferring the catalytic domain across the endosomal membrane into the cytosol in response to acidification. Deciphering the molecular mechanism of pH-dependent refolding and membrane ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Vaccine -diphthEria -tetaNus -Acellular pertUssis-inactivated polioviruS
 

Status: Recruiting

Condition Summary: Diphtheria; Tetanus; Pertussis; Poliomyelitis

 

Last Updated: 3 Feb 2017

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Heterologous Effect of Diptheria, Tetanus, Acellular Pertussis Vaccination on Influenza Challenge in the Elderly
 

Status: Recruiting

Condition Summary: Heterologous Effects of Vaccines

 

Last Updated: 25 Jul 2017

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Evaluation of Immunogenicity, Safety and Reactogenicity of GSK Biologicals' Boostrix Vaccine Administered as a Booster Dose in Healthy Russian Subjects
 

Status: Not yet recruiting

Condition Summary: Diphtheria-Tetanus-acellular Pertussis Vaccines

 

Last Updated: 5 Dec 2017

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