Diphtheria

Common Name(s)

Diphtheria

Diphtheria is a rare and serious bacterial infection that affects the function of mucous membranes in the nose and throat. The bacteria get passed from person to person through contaminated personal or household items and airborne infected droplets. Young children and elderly people are at higher risk of getting diphtheria. Symptoms of diphtheria include gray/black mucus covering the throat and tonsils, sore throat, swollen glands, difficulty breathing, fever and chills, nasal discharge, and an overall feeling of discomfort (malaise). An antitoxin, which counteracts the toxin of the bacteria, as well as antibiotics, can be used to treat diphtheria. Some people with diphtheria may need hospitalization or surgery to remove the lining in the throat. There is a vaccination for diphtheria that effectively prevents the bacterial infection for many individuals and is part of the routine childhood vaccinations in most parts of the world.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diphtheria" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diphtheria" returned 645 free, full-text research articles on human participants. First 3 results:

Last Updated: 4 Aug 2017

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Assessment of safety and efficacy against Bordetella pertussis of a new tetanus-reduced dose diphtheria-acellular pertussis vaccine in a murine model.
 

Author(s): Hyo Jin Kwon, Seung Beom Han, Bo Ram Kim, Kyu Ri Kang, Dong Ho Huh, Gi Sub Choi, Dong Ho Ahn, Jin Han Kang

Journal:

 

Tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccination during adolescence was introduced in response to the resurgence of pertussis in various countries. A new Tdap vaccine was manufactured in Korea as a countermeasure against a predicted Tdap vaccine shortage. This ...

Last Updated: 5 Apr 2017

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The Introduction of Diphtheria-Tetanus-Pertussis and Oral Polio Vaccine Among Young Infants in an Urban African Community: A Natural Experiment.
 

Author(s): Søren Wengel Mogensen, Andreas Andersen, Amabelia Rodrigues, Christine S Benn, Peter Aaby

Journal: EBioMedicine. 2017 Mar;17():192-198.

 

We examined the introduction of diphtheria-tetanus-pertussis (DTP) and oral polio vaccine (OPV) in an urban community in Guinea-Bissau in the early 1980s.

Last Updated: 11 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diphtheria" returned 13 free, full-text review articles on human participants. First 3 results:

Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type B vaccine; Infanrix™ hexa: twelve years of experience in Italy.
 

Author(s): Vincenzo Baldo, Paolo Bonanni, Marcela Castro, Giovanni Gabutti, Elisabetta Franco, Federico Marchetti, Rosa Prato, Francesco Vitale

Journal: Hum Vaccin Immunother. 2014 ;10(1):129-37.

 

Infant vaccination using 2-dose priming at 3 and 5 mo of age with a booster at 11-12 mo of age was pioneered in Italy. The 3-5-11 schedule is now used in a growing number of European countries. Infanrix™ hexa (DTPa-HBV-IPV/Hib, GlaxoSmithKline Vaccines) was first licensed for use ...

Last Updated: 16 May 2014

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pH-triggered conformational switching along the membrane insertion pathway of the diphtheria toxin T-domain.
 

Author(s): Alexey S Ladokhin

Journal:

 

The translocation (T)-domain plays a key role in the action of diphtheria toxin and is responsible for transferring the catalytic domain across the endosomal membrane into the cytosol in response to acidification. Deciphering the molecular mechanism of pH-dependent refolding and membrane ...

Last Updated: 8 Aug 2013

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Heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor in normal and neoplastic hematopoiesis.
 

Author(s): Fabrizio Vinante, Antonella Rigo

Journal: Toxins (Basel). 2013 Jun;5(6):1180-1201.

 

Heparin-binding EGF-like growth factor (HB-EGF) belongs to the EGF family of growth factors. It is biologically active either as a molecule anchored to the membrane or as a soluble form released by proteolytic cleavage of the extracellular domain. HB-EGF is involved in relevant physiological ...

Last Updated: 26 Jul 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Vaccine -diphthEria -tetaNus -Acellular pertUssis-inactivated polioviruS
 

Status: Recruiting

Condition Summary: Diphtheria; Tetanus; Pertussis; Poliomyelitis

 

Last Updated: 3 Feb 2017

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Heterologous Effect of Diptheria, Tetanus, Acellular Pertussis Vaccination on Influenza Challenge in the Elderly
 

Status: Recruiting

Condition Summary: Heterologous Effects of Vaccines

 

Last Updated: 25 Jul 2017

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Evaluation of Immunogenicity, Safety and Reactogenicity of GSK Biologicals' Boostrix Vaccine Administered as a Booster Dose in Healthy Russian Subjects
 

Status: Not yet recruiting

Condition Summary: Diphtheria-Tetanus-acellular Pertussis Vaccines

 

Last Updated: 11 Oct 2017

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