Dilated Cardiomyopathy

Common Name(s)

Dilated Cardiomyopathy

Dilated cardiomyopathy is a disease of the heart muscle which primarily affects the heart's main pumping chamber, the left ventricle. It is the most common type of cardiomyopathy and typically affects those aged 20 to 60. The left ventricle of affected individuals becomes enlarged (dilated) and cannot pump blood to the body with as much force as a healthy heart can. The heart muscle also has difficulty contracting normally, which can lead to irregular heartbeats (arrhythmia), blood clots, or sudden death. Over time, the heart becomes weaker and heart failure can occur. While the cause of dilated cardiomyopathy is often unknown (idiopathic), some cases are acquired or inherited.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dilated Cardiomyopathy" for support, advocacy or research.

Barth Syndrome Foundation

Our mission is saving lives through education, advances in treatment, and finding a cure for Barth syndrome.

Last Updated: 11 Apr 2016

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Children's Cardiomyopathy Foundation

Our mission is to accelerate the search for a cure by stimulating and supporting promising research on pediatric cardiomyopathy, by educating and assisting physicians and patients on the complexities of the disease, and by increasing awareness and advocacy on behalf of affected children and their families.

Last Updated: 20 Jul 2015

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Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dilated Cardiomyopathy" for support, advocacy or research.

Barth Syndrome Foundation

Our mission is saving lives through education, advances in treatment, and finding a cure for Barth syndrome.

https://www.barthsyndrome.org

Last Updated: 11 Apr 2016

View Details
Children's Cardiomyopathy Foundation

Our mission is to accelerate the search for a cure by stimulating and supporting promising research on pediatric cardiomyopathy, by educating and assisting physicians and patients on the complexities of the disease, and by increasing awareness and advocacy on behalf of affected children and their families.

http://www.childrenscardiomyopathy.org

Last Updated: 20 Jul 2015

View Details
Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

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General Support Organizations

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General Resources

Barth Syndrome Professional Healthcare Brochure

Important information regarding diagnosis and treatment of Barth syndrome.

Updated 12 Apr 2014

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2014 Conference Program

2014 Conference Program

Updated 14 Jan 2015

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How to Diagnose

How to diagnose Barth syndrome

Updated 14 Jan 2015

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Overview of Barth syndrome

Overview of Barth syndrome

Updated 14 Jan 2015

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Barath Syndrome Journal

Newsletter published twice a year.

Updated 15 Mar 2016

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dilated Cardiomyopathy" returned 1442 free, full-text research articles on human participants. First 3 results:

Apoptosis in Endomyocardial Biopsies from Patients with Dilated Cardiomyopathy.
 

Author(s): S Glumac, S Pejić, S Kostadinovic, Z Stojšić, J Vasiljevic

Journal: Folia Biol. (Praha). 2016 ;62(5):207-211.

 

Apoptosis is an active energy-consuming mechanism of cell death, which may contribute to heart failure in patients with dilated cardiomyopathy. Dilated cardiomyopathy is a common clinical outcome of many prolonged cardiac insults, and therefore is considered as the most prevalent ...

Last Updated: 15 Dec 2016

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Associations Between TIM1 Polymorphisms and Dilated Cardiomyopathy in a Han Chinese Population.
 

Author(s): Xiaochuan Xie, Chunmei Li, Bin Zhou, Xiaohui Dai, Li Rao

Journal: Int Heart J. 2016 Dec;57(6):742-746.

 

Immune dysfunction is implicated in dilated cardiomyopathy (DCM). Previous studies found that TIM1 polymorphisms were associated with immune dysfunction. However, the associations between TIM1 polymorphisms and DCM have not been investigated. Therefore, we conducted the present study ...

Last Updated: 7 Nov 2016

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Vidarabine, an Anti-Herpes Virus Agent, Protects Against the Development of Heart Failure With Relatively Mild Side-Effects on Cardiac Function in a Canine Model of Pacing-Induced Dilated Cardiomyopathy.
 

Author(s): Takashi Nakamura, Takayuki Fujita, Megumi Kishimura, Kenji Suita, Yuko Hidaka, Wenqian Cai, Masanari Umemura, Utako Yokoyama, Masami Uechi, Yoshihiro Ishikawa

Journal: Circ. J.. 2016 Nov;80(12):2496-2505.

 

In heart failure patients, chronic hyperactivation of sympathetic signaling is known to exacerbate cardiac dysfunction. In this study, the cardioprotective effect of vidarabine, an anti-herpes virus agent, which we identified as a cardiac adenylyl cyclase inhibitor, in dogs with pacing-induced ...

Last Updated: 7 Nov 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dilated Cardiomyopathy" returned 78 free, full-text review articles on human participants. First 3 results:

HLA-DR3 antigen in the resistance to idiopathic dilated cardiomyopathy.
 

Author(s): B Jin, B W Wu, Z C Wen, H M Shi, J Zhu

Journal: Braz. J. Med. Biol. Res.. 2016 ;49(4):e5131.

 

Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR3 antigen and IDC risk are inconclusive. ...

Last Updated: 24 Mar 2016

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Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin.
 

Author(s): James A Spudich, Tural Aksel, Sadie R Bartholomew, Suman Nag, Masataka Kawana, Elizabeth Choe Yu, Saswata S Sarkar, Jongmin Sung, Ruth F Sommese, Shirley Sutton, Carol Cho, Arjun S Adhikari, Rebecca Taylor, Chao Liu, Darshan Trivedi, Kathleen M Ruppel

Journal: J. Exp. Biol.. 2016 Jan;219(Pt 2):161-7.

 

Hypertrophic cardiomyopathy is the most frequently occurring inherited cardiovascular disease, with a prevalence of more than one in 500 individuals worldwide. Genetically acquired dilated cardiomyopathy is a related disease that is less prevalent. Both are caused by mutations in ...

Last Updated: 21 Jan 2016

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Dilated Cardiomyopathy Revealing Cushing Disease: A Case Report and Literature Review.
 

Author(s): Lucien Marchand, Bérénice Segrestin, Marion Lapoirie, Véronique Favrel, Julie Dementhon, Emmanuel Jouanneau, Gérald Raverot

Journal: Medicine (Baltimore). 2015 Nov;94(46):e2011.

 

Cardiovascular impairments are frequent in Cushing's syndrome and the hypercortisolism can result in cardiac structural and functional changes that lead in rare cases to dilated cardiomyopathy (DCM). Such cardiac impairment may be reversible in response to a eucortisolaemic state.A ...

Last Updated: 20 Nov 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Clinical Study of Immunoadsorption Therapy for Dilated Cardiomyopathy
 

Status: Recruiting

Condition Summary: Dilated Cardiomyopathy

 

Last Updated: 8 Oct 2016

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Multicenter Study of Immunoadsorption in Dilated Cardiomyopathy
 

Status: Recruiting

Condition Summary: Dilated Cardiomyopathy

 

Last Updated: 22 Nov 2016

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