Dilated Cardiomyopathy

Common Name(s)

Dilated Cardiomyopathy

Dilated cardiomyopathy is a disease of the heart muscle which primarily affects the heart's main pumping chamber, the left ventricle. It is the most common type of cardiomyopathy and typically affects those aged 20 to 60. The left ventricle of affected individuals becomes enlarged (dilated) and cannot pump blood to the body with as much force as a healthy heart can. The heart muscle also has difficulty contracting normally, which can lead to irregular heartbeats (arrhythmia), blood clots, or sudden death. Over time, the heart becomes weaker and heart failure can occur. While the cause of dilated cardiomyopathy is often unknown (idiopathic), some cases are acquired or inherited.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dilated Cardiomyopathy" for support, advocacy or research.

Barth Syndrome Foundation

Our mission is saving lives through education, advances in treatment, and finding a cure for Barth syndrome.

Last Updated: 11 Apr 2016

View Details
Children's Cardiomyopathy Foundation

Our mission is to accelerate the search for a cure by stimulating and supporting promising research on pediatric cardiomyopathy, by educating and assisting physicians and patients on the complexities of the disease, and by increasing awareness and advocacy on behalf of affected children and their families.

Last Updated: 20 Jul 2015

View Details
Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dilated Cardiomyopathy" for support, advocacy or research.

Barth Syndrome Foundation

Our mission is saving lives through education, advances in treatment, and finding a cure for Barth syndrome.

https://www.barthsyndrome.org

Last Updated: 11 Apr 2016

View Details
Children's Cardiomyopathy Foundation

Our mission is to accelerate the search for a cure by stimulating and supporting promising research on pediatric cardiomyopathy, by educating and assisting physicians and patients on the complexities of the disease, and by increasing awareness and advocacy on behalf of affected children and their families.

http://www.childrenscardiomyopathy.org

Last Updated: 20 Jul 2015

View Details
Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

Barth Syndrome Professional Healthcare Brochure

Important information regarding diagnosis and treatment of Barth syndrome.

Updated 12 Apr 2014

Open Doc
2014 Conference Program

2014 Conference Program

Updated 14 Jan 2015

Open Doc
How to Diagnose

How to diagnose Barth syndrome

Updated 14 Jan 2015

Go To URL
Overview of Barth syndrome

Overview of Barth syndrome

Updated 14 Jan 2015

Go To URL
Barath Syndrome Journal

Newsletter published twice a year.

Updated 15 Mar 2016

Open Doc
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dilated Cardiomyopathy" returned 1454 free, full-text research articles on human participants. First 3 results:

The effect of BMI, serum leptin, and adiponectin levels on prognosis in patients with non-ischaemic dilated cardiomyopathy.
 

Author(s): Celina Wojciechowska, Wojciech Jacheć, Ewa Romuk, Ewa Nowalany-Kozielska, Andrzej Tomasik, Lucyna Siemińska

Journal: Endokrynol Pol. 2017 ;68(1):26-34.

 

The recent studies demonstrated that obese heart failure patients have better prognosis - "obesity paradox". The aim of the study was to evaluate the relationship between body mass index (BMI), leptin and adiponectin concentrations and prognosis in patients with heart failure due ...

Last Updated: 3 Mar 2017

Go To URL
A Randomized Comparative Study on the Efficacy of Intracoronary Infusion of Autologous Bone Marrow Mononuclear Cells and Mesenchymal Stem Cells in Patients With Dilated Cardiomyopathy.
 

Author(s): Wentao Xiao, Suping Guo, Chuanyu Gao, Guoyou Dai, Yongjv Gao, Muwei Li, Xianpei Wang, Dayi Hu

Journal: Int Heart J. 2017 Apr;58(2):238-244.

 

Stem cell therapy has shown therapeutic benefit in dilated cardiomyopathy (DCM), but doubt remains about the most appropriate stem cell subpopulation. The current study compared the efficacy of intracoronary administration of bone marrow mononuclear cells (BMMC) or mesenchymal stem ...

Last Updated: 13 Feb 2017

Go To URL
Three-Dimensional Left Ventricular Torsion in Patients With Dilated Cardiomyopathy - A Marker of Disease Severity.
 

Author(s): Krunoslav Michael Sveric, Stefan Ulbrich, Mohamed Rady, Tobias Ruf, Heda Kvakan, Ruth H Strasser, Stefanie Jellinghaus

Journal: Circ. J.. 2017 Mar;81(4):529-536.

 

LV twist has a key role in maintaining left ventricular (LV) contractility during exercise. The purpose of this study was to investigate LV torsion instead of twist as a surrogate marker of peak oxygen uptake (peak V̇O2) assessed by cardiopulmonary exercise testing (CPET) in patients ...

Last Updated: 26 Jan 2017

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dilated Cardiomyopathy" returned 78 free, full-text review articles on human participants. First 3 results:

Genetic Variations Leading to Familial Dilated Cardiomyopathy.
 

Author(s): Kae Won Cho, Jongsung Lee, Youngjo Kim

Journal: Mol. Cells. 2016 Oct;39(10):722-727.

 

Cardiomyopathy is a major cause of death worldwide. Based on pathohistological abnormalities and clinical manifestation, cardiomyopathies are categorized into several groups: hypertrophic, dilated, restricted, arrhythmogenic right ventricular, and unclassified. Dilated cardiomyopathy, ...

Last Updated: 1 Nov 2016

Go To URL
HLA-DR3 antigen in the resistance to idiopathic dilated cardiomyopathy.
 

Author(s): B Jin, B W Wu, Z C Wen, H M Shi, J Zhu

Journal: Braz. J. Med. Biol. Res.. 2016 ;49(4):e5131.

 

Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR3 antigen and IDC risk are inconclusive. ...

Last Updated: 24 Mar 2016

Go To URL
Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin.
 

Author(s): James A Spudich, Tural Aksel, Sadie R Bartholomew, Suman Nag, Masataka Kawana, Elizabeth Choe Yu, Saswata S Sarkar, Jongmin Sung, Ruth F Sommese, Shirley Sutton, Carol Cho, Arjun S Adhikari, Rebecca Taylor, Chao Liu, Darshan Trivedi, Kathleen M Ruppel

Journal: J. Exp. Biol.. 2016 Jan;219(Pt 2):161-7.

 

Hypertrophic cardiomyopathy is the most frequently occurring inherited cardiovascular disease, with a prevalence of more than one in 500 individuals worldwide. Genetically acquired dilated cardiomyopathy is a related disease that is less prevalent. Both are caused by mutations in ...

Last Updated: 21 Jan 2016

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

A Clinical Study of Immunoadsorption Therapy for Dilated Cardiomyopathy
 

Status: Recruiting

Condition Summary: Dilated Cardiomyopathy

 

Last Updated: 8 Oct 2016

Go to URL
Multicenter Study of Immunoadsorption in Dilated Cardiomyopathy
 

Status: Recruiting

Condition Summary: Dilated Cardiomyopathy

 

Last Updated: 11 May 2017

Go to URL
Transcoronary Infusion of Cardiac Progenitor Cells in Pediatric Dilated Cardiomyopathy
 

Status: Recruiting

Condition Summary: Dilated Cardiomyopathy

 

Last Updated: 23 Apr 2017

Go to URL