Diagnosis Unknown

Common Name(s)

Diagnosis Unknown, No Diagnosis, Not Yet Diagnosed, Undiagnosed Condition

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diagnosis Unknown" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2013

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In Need Of Diagnosis, Inc.

INOD's mission is to provide help and support for individuals distressed with disorders that have eluded medical diagnosis and to identify and encourage the implementation of protocols that will facilitate quicker and more accurate diagnosis. Provide collective identity. Provide education and voice within healthcare industry. Maintain database of signs, symptoms, demographics, historical enviormental impacts, and effective treatments. Provide Physician referrals.

Last Updated: 24 Jul 2014

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Syndromes Without A Name USA

We are an organization that advocates for children and young adults who have syndromes without a name. We offer support, advice and information on the challenges that families face when there is no diagnosis. We also advocate for changes in the medical community that will benefit undiagnosed individuals.

Last Updated: 3 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diagnosis Unknown" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2013

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In Need Of Diagnosis, Inc.

INOD's mission is to provide help and support for individuals distressed with disorders that have eluded medical diagnosis and to identify and encourage the implementation of protocols that will facilitate quicker and more accurate diagnosis. Provide collective identity. Provide education and voice within healthcare industry. Maintain database of signs, symptoms, demographics, historical enviormental impacts, and effective treatments. Provide Physician referrals.

http://www.inod.org

Last Updated: 24 Jul 2014

View Details
Syndromes Without A Name USA

We are an organization that advocates for children and young adults who have syndromes without a name. We offer support, advice and information on the challenges that families face when there is no diagnosis. We also advocate for changes in the medical community that will benefit undiagnosed individuals.

http://www.undiagnosed-usa.org

Last Updated: 3 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diagnosis Unknown" returned 31 free, full-text research articles on human participants. First 3 results:

Melanoma patients with unknown primary site or nodal recurrence after initial diagnosis have a favourable survival compared to those with synchronous lymph node metastasis and primary tumour.
 

Author(s): Benjamin Weide, Christine Faller, Margrit Elsässer, Petra Büttner, Annette Pflugfelder, Ulrike Leiter, Thomas Kurt Eigentler, Jürgen Bauer, Friedegund Meier, Claus Garbe

Journal:

 

A direct comparison of prognosis between patients with regional lymph node metastases (LNM) detected synchronously with the primary melanoma (primary LNM), patients who developed their first LNM subsequently (secondary LNM) and those with initial LNM in melanoma with unknown primary ...

Last Updated: 4 Jul 2013

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Novel microRNA-based assay demonstrates 92% agreement with diagnosis based on clinicopathologic and management data in a cohort of patients with carcinoma of unknown primary.
 

Author(s): George Pentheroudakis, Nicholas Pavlidis, George Fountzilas, Dimitrios Krikelis, Anna Goussia, Aikaterini Stoyianni, Mats Sanden, Brianna St Cyr, Noga Yerushalmi, Hila Benjamin, Eti Meiri, Ayelet Chajut, Shai Rosenwald, Ranit Aharonov, Yael Spector

Journal:

 

Cancer of unknown or uncertain primary is a major diagnostic and clinical challenge, since identifying the tissue-of-origin of metastases is crucial for selecting optimal treatment. MicroRNAs are a family of non-coding, regulatory RNA molecules that are tissue-specific, with a great ...

Last Updated: 28 Jun 2013

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Molecular profiling diagnosis in unknown primary cancer: accuracy and ability to complement standard pathology.
 

Author(s): F Anthony Greco, Wayne J Lennington, David R Spigel, John D Hainsworth

Journal: J. Natl. Cancer Inst.. 2013 Jun;105(11):782-90.

 

Molecular tumor profiling (MTP) is a potentially powerful diagnostic tool for identifying the tissue of origin in patients with cancer of unknown primary (CUP). However, validation of the accuracy and clinical value of MTP has been difficult because the anatomic primary site in most ...

Last Updated: 5 Jun 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diagnosis Unknown" returned 5 free, full-text review articles on human participants. First 3 results:

Cancer of unknown primary: progress in the search for improved and rapid diagnosis leading toward superior patient outcomes.
 

Author(s): F A Greco, K Oien, M Erlander, R Osborne, G Varadhachary, J Bridgewater, D Cohen, H Wasan

Journal: Ann. Oncol.. 2012 Feb;23(2):298-304.

 

This paper explores the enigma of cancer of unknown primary (CUP) in relation to rapidly improving molecular diagnostic approaches. It is based on the first global collaboration meeting on improving research and clinical outcomes in CUP organized by the CUP Foundation. We review the ...

Last Updated: 25 Jan 2012

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Cancers of unknown primary site: ESMO clinical recommendations for diagnosis, treatment and follow-up.
 

Author(s): E Briasoulis, N Pavlidis, E Felip,

Journal: Ann. Oncol.. 2009 May;20 Suppl 4():154-5.

 

Last Updated: 20 May 2009

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Diagnostic and therapeutic management of carcinoma of unknown primary: histopathological and molecular diagnosis.
 

Author(s): G Viale, M G Mastropasqua

Journal: Ann. Oncol.. 2006 Sep;17 Suppl 10():x163-7.

 

Last Updated: 4 Oct 2006

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 4 May 2014

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Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies
 

Status: Recruiting

Condition Summary: Acinar Cell Adenocarcinoma of the Pancreas; Adenocarcinoma of the Gallbladder; Adenocarcinoma of Unknown Primary; Adult Primary Cholangiocellular Carcinoma; Advanced Adult Primary Liver Cancer; Cholangiocarcinoma of the Extrahepatic Bile Duct; Cholangiocarcinoma of the Gallbladder; Diffuse Adenocarcinoma of the Stomach; Duct Cell Adenocarcinoma of the Pancreas; Intestinal Adenocarcinoma of the Stomach; Localized Unresectable Adult Primary Liver Cancer; Metastatic Carcinoma of Unknown Primary; Metastatic Extrahepatic Bile Duct Cancer; Mixed Adenocarcinoma of the Stomach; Mucinous Adenocarcinoma of the Colon; Mucinous Adenocarcinoma of the Rectum; Newly Diagnosed Carcinoma of Unknown Primary; Signet Ring Adenocarcinoma of the Colon; Signet Ring Adenocarcinoma of the Rectum; Stage III Pancreatic Cancer; Stage IIIA Colon Cancer; Stage IIIA Gallbladder Cancer; Stage IIIA Gastric Cancer; Stage IIIA Rectal Cancer; Stage IIIB Colon Cancer; Stage IIIB Gallbladder Cancer; Stage IIIB Gastric Cancer; Stage IIIB Rectal Cancer; Stage IIIC Colon Cancer; Stage IIIC Gastric Cancer; Stage IIIC Rectal Cancer; Stage IV Gastric Cancer; Stage IV Pancreatic Cancer; Stage IVA Colon Cancer; Stage IVA Gallbladder Cancer; Stage IVA Rectal Cancer; Stage IVB Colon Cancer; Stage IVB Gallbladder Cancer; Stage IVB Rectal Cancer; Unresectable Extrahepatic Bile Duct Cancer

 

Last Updated: 20 Mar 2014

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Cisplatin and Etoposide With or Without Veliparib in Treating Patients With Extensive Stage Small Cell Lung Cancer or Metastatic Large Cell Neuroendocrine Non-Small Cell Lung Cancer
 

Status: Recruiting

Condition Summary: Extensive Stage Small Cell Lung Cancer; Large Cell Lung Cancer; Metastatic Carcinoma of Unknown Primary; Neuroendocrine Carcinoma; Newly Diagnosed Carcinoma of Unknown Primary; Stage IV Non-small Cell Lung Cancer

 

Last Updated: 19 Sep 2014

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