Adenoid Cystic Carcinoma

Common Name(s)

Adenoid Cystic Carcinoma

Adenoid cystic carcinoma (ACC) is a rare form of adenocarcinoma, which is cancer that begins in gladular tissues. ACC most commonly arises in the head and neck, in various parts of the major and minor salivary glands including the palate, nasopharynx, lining of the mouth, voice box (larynx) or windpipe (trachea). It can also occur in the breast, uterus, or other locations in the body. Early symptoms depend on the tumor's location and may include lumps under the lining of the mouth or facial skin; numbness in the mouth or face; difficulty swallowing; hoarseness; pain; or paralysis of a facial nerve. ACC often has long periods with no growth followed by growth spurts; however, it can be aggressive in some people. ACC spreads along nerves or through the bloodstream, and only spreads to the lymph nodes in about 5-10% of cases. The cause of ACC is currently unknown. Treatment depends on many factors and may include surgery, radiation, and/or chemotherapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid Cystic Carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

Last Updated: 5 May 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid Cystic Carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

http://www.accrf.org

Last Updated: 5 May 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adenoid Cystic Carcinoma" returned 223 free, full-text research articles on human participants. First 3 results:

Influence of ribosomal protein L39-L in the drug resistance mechanisms of lacrimal gland adenoid cystic carcinoma cells.
 

Author(s): Qing Ye, Shao-Feng Ding, Zhi-An Wang, Jie Feng, Wen-Bin Tan

Journal: Asian Pac. J. Cancer Prev.. 2014 ;15(12):4995-5000.

 

Cancer constitutes a key pressure on public health regardless of the economy state in different countries. As a kind of highly malignant epithelial tumor, lacrimal gland adenoid cystic carcinoma can occur in any part of the body, such as salivary gland, submandibular gland, trachea, ...

Last Updated: 7 Jul 2014

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Fibrotic airway stenosis following radiotherapy in patients with adenoid cystic carcinoma.
 

Author(s): Jung Seop Eom, BoKyong Kim, Hojoong Kim, Kyeongman Jeon, Sang-Won Um, Won-Jung Koh, Gee Young Suh, Man Pyo Chung, O Jung Kwon

Journal: Respirology. 2014 Aug;19(6):914-20.

 

Radiotherapy is usually administered to the central airway in patients with unresectable adenoid cystic carcinoma (ACC). The purpose of this study was to describe the outcomes of endobronchial intervention in patients with airway stenosis following radiotherapy for ACC. Moreover, ...

Last Updated: 21 Jul 2014

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High expression of SOX2 is associated with poor prognosis in patients with salivary gland adenoid cystic carcinoma.
 

Author(s): Wei Dai, Xuexin Tan, Changfu Sun, Qing Zhou

Journal:

 

Sex determining region Y-BOX2 (SOX2), one of the key members of the SOX family, is a transcription factor that is involved in the maintenance of embryonic stem cell pluripotency and in multiple developmental processes. Recent studies have shown that SOX2 is aberrantly expressed in ...

Last Updated: 15 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adenoid Cystic Carcinoma" returned 20 free, full-text review articles on human participants. First 3 results:

Malignant adenomyoepithelioma combined with adenoid cystic carcinoma of the breast: a case report and literature review.
 

Author(s): Ying Yang, Yanmei Wang, Jinsong He, Guoqing Pan, Xiaoyu Tuo, Aimei Jiang, Li Bian

Journal:

 

Malignant adenomyoepithelioma and adenoid cystic carcinoma are both rare malignant epithelial-myoepithelial tumors of the breast. We report a very rare case with a malignant adenomyoepithelioma combining with adenoid cystic carcinoma in a single mass.

Last Updated: 8 Aug 2014

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Glottic-Subglottic adenoid cystic carcinoma. A case report and review of the literature.
 

Author(s): Domenico Testa, Germano Guerra, Giovanni Conzo, Michele Nunziata, Gioacchino D'Errico, Maria Siano, Gennaro Ilardi, Mario Vitale, Francesco Riccitiello, Gaetano Motta

Journal: BMC Surg. 2013 ;13 Suppl 2():S48.

 

Malignant tumours of minor salivary glands are uncommon, representing only 2-4% of all head and neck cancers. In the larynx, minor salivary gland tumours rarely occur and constitute less than 1% of laryngeal neoplasm. Most of the minor salivary gland tumours arise in the subglottis; ...

Last Updated: 14 Jan 2014

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Adenoid cystic carcinoma of the paranasal sinuses: retrospective series and review of the literature.
 

Author(s): G Michel, M Joubert, A S Delemazure, F Espitalier, N Durand, O Malard

Journal: Eur Ann Otorhinolaryngol Head Neck Dis. 2013 Nov;130(5):257-62.

 

Adenoid cystic carcinomas (ACC) are rare malignant tumours arising in the major and minor salivary glands. Involvement of the nasal cavity and paranasal sinuses is rare and poorly described. The purpose of this study was to define the clinical and prognostic criteria of ACC of the ...

Last Updated: 28 Oct 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Adenoid Cystic Carcinoma, Erbitux, and Particle Therapy
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 23 Apr 2013

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Study of RAD001 in Adenoid Cystic Carcinoma
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 28 Jun 2010

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Regorafenib in Patients With Progressive, Recurrent/Metastatic Adenoid Cystic Carcinoma
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 18 Mar 2015

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