Adenoid cystic carcinoma

Common Name(s)

Adenoid cystic carcinoma

Adenoid cystic carcinoma is a rare type of cancer that usually develops in the salivary glands, which are the areas of the body where saliva is produced. Although less common, adenoid cystic carcinoma can also grow inside the breasts, eyes, lungs, brain, throat, and paranasal sinuses. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow. This process is known as metastasis.

Adenoid cystic carcinoma most commonly occurs in adults between the ages of 40 and 60, although it can appear in all age groups. The most common symptom of adenoid cystic carcinoma is painless swelling on the face, neck, or mouth area. This cancer may also cause facial pain and nerve paralysis, which results in difficulty displaying facial expressions. Depending on the size of the cancer, affected individuals may also experience difficulty with vision or breathing. Diagnosis is usually made with a combination of a physical exam, imaging studies, blood tests, and other laboratory studies. Diagnosis may require a doctor to take a biopsy, or sample, of the tissue to look at under a microscope in order to determine if the cells are growing in an abnormal way.

Treatment for adenoid cystic carcinoma depends on many factors such as how large the cancer is and if it has spread to other areas of the body. If you or a family member has been diagnosed with adenoid cystic carcinoma, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid cystic carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

Last Updated: 5 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid cystic carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

http://www.accrf.org

Last Updated: 5 May 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adenoid cystic carcinoma" returned 372 free, full-text research articles on human participants. First 3 results:

Whole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma.
 

Author(s): David W Sant, Wensi Tao, Matthew G Field, Daniel Pelaez, Ke Jin, Anthony Capobianco, Sander R Dubovy, David T Tse, Gaofeng Wang

Journal: Invest. Ophthalmol. Vis. Sci.. 2017 May;58(6):BIO240-BIO246.

 

To identify genomic mutations in lacrimal gland adenoid cystic carcinoma (LGACC) samples from patients.

Last Updated: 18 Aug 2017

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[Inhibitory effect and underlying mechanism of total saponins from Paris polyphylla var. yunnanensis on the proliferation of salivary adenoid cystic carcinoma ACC-83 cells].
 

Author(s): He Qiumin, Xu Biao, Wang Weihong, Bao Chongyun, Hu Shaowei

Journal: Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Jun;35(3):317-321.

 

To investigate the inhibitory effect and underlying mechanism of total saponins from Paris polyphylla var. yunnanensis on the proliferation of salivary adenoid cystic carcinoma ACC-83 cells.

Last Updated: 4 Jul 2017

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Long-term local control rates of patients with adenoid cystic carcinoma of the head and neck managed by surgery and postoperative radiation.
 

Author(s): Safina Ali, Frank L Palmer, Nora Katabi, Nancy Lee, Jatin P Shah, Snehal G Patel, Ian Ganly

Journal: Laryngoscope. 2017 Oct;127(10):2265-2269.

 

To report long-term local control in patients with adenoid cystic cancer (ACC) of the head and neck managed by surgery and identify factors predictive for local failure.

Last Updated: 21 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adenoid cystic carcinoma" returned 48 free, full-text review articles on human participants. First 3 results:

Cervical lymph node metastasis in adenoid cystic carcinoma of the sinonasal tract, nasopharynx, lacrimal glands and external auditory canal: a collective international review.
 

Author(s):

Journal: J Laryngol Otol. 2016 Dec;130(12):1093-1097.

 

To review reports of adenoid cystic carcinomas arising in the head and neck area outside of the major salivary glands, in order to enhance the care of patients with these unusual neoplasms.

Last Updated: 14 Nov 2016

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Adenoid cystic carcinoma of the palate: case report and review of literature.
 

Author(s): Uday Shankar Yaga, Nishanth Gollamudi, Ashwini Kumar Mengji, Radhika Besta, Prashanth Panta, Bhanu Prakash, Edunuri Rajashekar

Journal:

 

Adenoid Cystic Carcinoma (ACC) is a rare tumor constitutes for less than 1% of head and neck malignancies and 10% of all salivary gland tumors. Palate is the most common site to be involved in the oral cavity followed by parotid gland and submandibular gland. They are usually asymptomatic, ...

Last Updated: 19 Sep 2016

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Cervical Lymph Node Metastasis in Adenoid Cystic Carcinoma of the Larynx: A Collective International Review.
 

Author(s): Andrés Coca-Pelaz, Leon Barnes, Alessandra Rinaldo, Antonio Cardesa, Jatin P Shah, Juan P Rodrigo, Carlos Suárez, Jean Anderson Eloy, Justin A Bishop, Kenneth O Devaney, Lester D R Thompson, Bruce M Wenig, Primož Strojan, Marc Hamoir, Patrick J Bradley, Douglas R Gnepp, Carl E Silver, Pieter J Slootweg, Asterios Triantafyllou, Vincent Vander Poorten, Michelle D Williams, Alena Skálová, Henrik Hellquist, Afshin Teymoortash, Jesus E Medina, K Thomas Robbins, Karen T Pitman, Luiz P Kowalski, Remco de Bree, William M Mendenhall, Robert P Takes, Alfio Ferlito

Journal: Adv Ther. 2016 Apr;33(4):553-79.

 

Adenoid cystic carcinoma (AdCC) of the head and neck is a well-recognized pathologic entity that rarely occurs in the larynx. Although the 5-year locoregional control rates are high, distant metastasis has a tendency to appear more than 5 years post treatment. Because AdCC of the ...

Last Updated: 27 Apr 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 18 Aug 2017

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A Study of Apatinib in Recurrent/Metastatic Adenoid Cystic Carcinoma of the Head and Neck
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 27 Aug 2017

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Trail Evaluating Particle Therapy With or Without Apatinib for H&N Adenoid Cystic Carcinoma
 

Status: Not yet recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 20 Oct 2016

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