Adenoid Cystic Carcinoma

Common Name(s)

Adenoid Cystic Carcinoma

Adenoid cystic carcinoma is a rare form of adenocarcinoma (a cancer that arises from gladular tissue). Adenoid cystic carcinoma is found mainly in the head and neck, but can occasionally occur in a womanÕs uterus or other sites in the body. It most commonly occurs in the salivary glands, in locations such as the palate (the roof of the mouth), nasopharynx (air passageway at the upper part of the throat and behind the nose), inner lining of the mouth, larynx, or trachea. Symptoms may include difficulty swallowing, hoarseness, dull pain, numbness or palpable lumps. Regardless of its location, adenoid cystic carcinoma tends to spread along nerves or through the bloodstream. A small percentage of cases spread to the lymph nodes. The most common location for metatasis is the lung. Adenoid cystic carcinoma is often unpredictable, with long periods of no activity followed by rapid growth. The cause of adenoid cystic carcinoma is not known and no specific risk factors have been identified. Treatment depends on the size and location of the tumor, whether the cancer has spread, and the patient's overall health, but may include surgery, radiation or chemotherapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid Cystic Carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

Last Updated: 5 May 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid Cystic Carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

http://www.accrf.org

Last Updated: 5 May 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adenoid Cystic Carcinoma" returned 218 free, full-text research articles on human participants. First 3 results:

High expression of SOX2 is associated with poor prognosis in patients with salivary gland adenoid cystic carcinoma.
 

Author(s): Wei Dai, Xuexin Tan, Changfu Sun, Qing Zhou

Journal:

 

Sex determining region Y-BOX2 (SOX2), one of the key members of the SOX family, is a transcription factor that is involved in the maintenance of embryonic stem cell pluripotency and in multiple developmental processes. Recent studies have shown that SOX2 is aberrantly expressed in ...

Last Updated: 15 May 2014

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Expressions of ABCG2, CD133, and podoplanin in salivary adenoid cystic carcinoma.
 

Author(s): Wuwei Li, Ryo Tamamura, Bo Wang, Qigui Liu, Han Liu, Tingjiao Liu, Naoki Katase, Jing Xiao, Hitoshi Nagatsuka

Journal: Biomed Res Int. 2014 ;2014():132349.

 

Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors with a high risk of recurrence and metastasis. Current studies on cancer stem cells (CSCs) have verified that CSCs are the driving force behind tumor initiation and progression, suggesting that ...

Last Updated: 7 May 2014

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Late-developing tongue adenoid cystic carcinoma after pulmonary metastasectomy: a case report.
 

Author(s): Young Jo Sa, Sung Bo Sim, Tae-Jung Kim, Seok Whan Moon, Chan Beom Park

Journal:

 

Adenoid cystic carcinoma (ACC) is a relatively rare epithelial tumor of the salivary glands that accounts for approximately 5 to 10% of all salivary gland neoplasms. The typical clinical and pathological findings of this tumor include slow indolent growth, common local recurrence, ...

Last Updated: 24 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adenoid Cystic Carcinoma" returned 19 free, full-text review articles on human participants. First 3 results:

Glottic-Subglottic adenoid cystic carcinoma. A case report and review of the literature.
 

Author(s): Domenico Testa, Germano Guerra, Giovanni Conzo, Michele Nunziata, Gioacchino D'Errico, Maria Siano, Gennaro Ilardi, Mario Vitale, Francesco Riccitiello, Gaetano Motta

Journal: BMC Surg. 2013 ;13 Suppl 2():S48.

 

Malignant tumours of minor salivary glands are uncommon, representing only 2-4% of all head and neck cancers. In the larynx, minor salivary gland tumours rarely occur and constitute less than 1% of laryngeal neoplasm. Most of the minor salivary gland tumours arise in the subglottis; ...

Last Updated: 14 Jan 2014

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Adenoid cystic carcinoma of the paranasal sinuses: retrospective series and review of the literature.
 

Author(s): G Michel, M Joubert, A S Delemazure, F Espitalier, N Durand, O Malard

Journal: Eur Ann Otorhinolaryngol Head Neck Dis. 2013 Nov;130(5):257-62.

 

Adenoid cystic carcinomas (ACC) are rare malignant tumours arising in the major and minor salivary glands. Involvement of the nasal cavity and paranasal sinuses is rare and poorly described. The purpose of this study was to define the clinical and prognostic criteria of ACC of the ...

Last Updated: 28 Oct 2013

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Adenoid cystic carcinoma: clinical and molecular features.
 

Author(s): Christopher A Moskaluk

Journal: Head Neck Pathol. 2013 Mar;7(1):17-22.

 

The clinical features and common molecular alterations of adenoid cystic carcinoma (ACC) are reviewed in this paper. ACC is an uncommon neoplasm that most frequently arises in salivary glands and related tissue in the head and neck region. ACC has distinct histologic features, with ...

Last Updated: 15 Mar 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Adenoid Cystic Carcinoma, Erbitux, and Particle Therapy
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 23 Apr 2013

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Study of RAD001 in Adenoid Cystic Carcinoma
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 28 Jun 2010

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Regorafenib in Patients With Progressive, Recurrent/Metastatic Adenoid Cystic Carcinoma
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 3 Dec 2014

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