Adenoid cystic carcinoma

Common Name(s)

Adenoid cystic carcinoma

Adenoid cystic carcinoma is a rare type of cancer that usually develops in the salivary glands, which are the areas of the body where saliva is produced. Although less common, adenoid cystic carcinoma can also grow inside the breasts, eyes, lungs, brain, throat, and paranasal sinuses. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow. This process is known as metastasis.

Adenoid cystic carcinoma most commonly occurs in adults between the ages of 40 and 60, although it can appear in all age groups. The most common symptom of adenoid cystic carcinoma is painless swelling on the face, neck, or mouth area. This cancer may also cause facial pain and nerve paralysis, which results in difficulty displaying facial expressions. Depending on the size of the cancer, affected individuals may also experience difficulty with vision or breathing. Diagnosis is usually made with a combination of a physical exam, imaging studies, blood tests, and other laboratory studies. Diagnosis may require a doctor to take a biopsy, or sample, of the tissue to look at under a microscope in order to determine if the cells are growing in an abnormal way.

Treatment for adenoid cystic carcinoma depends on many factors such as how large the cancer is and if it has spread to other areas of the body. If you or a family member has been diagnosed with adenoid cystic carcinoma, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid cystic carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

Last Updated: 5 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid cystic carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

http://www.accrf.org

Last Updated: 5 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adenoid cystic carcinoma" returned 351 free, full-text research articles on human participants. First 3 results:

Carcinoma-Associated Fibroblasts Lead the Invasion of Salivary Gland Adenoid Cystic Carcinoma Cells by Creating an Invasive Track.
 

Author(s): Jiao Li, Zhuqiang Jia, Jing Kong, Fuyin Zhang, Shimeng Fang, Xiaojie Li, Wuwei Li, Xuesong Yang, Yong Luo, Bingcheng Lin, Tingjiao Liu

Journal:

 

Carcinoma-associated fibroblasts (CAFs) are critical in determining tumor invasion and metastasis. However the role of CAFs in the invasion of salivary gland adenoid cystic carcinoma (ACC) is poorly understood. In this study, we isolated primary CAFs from two ACC patients. ACC-derived ...

Last Updated: 9 Mar 2016

Go To URL
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma.
 

Author(s): Yotam Drier, Matthew J Cotton, Kaylyn E Williamson, Shawn M Gillespie, Russell J H Ryan, Michael J Kluk, Christopher D Carey, Scott J Rodig, Lynette M Sholl, Amir H Afrogheh, William C Faquin, Lurdes Queimado, Jun Qi, Michael J Wick, Adel K El-Naggar, James E Bradner, Christopher A Moskaluk, Jon C Aster, Birgit Knoechel, Bradley E Bernstein

Journal: Nat. Genet.. 2016 Mar;48(3):265-72.

 

Translocation events are frequent in cancer and may create chimeric fusions or 'regulatory rearrangements' that drive oncogene overexpression. Here we identify super-enhancer translocations that drive overexpression of the oncogenic transcription factor MYB as a recurrent theme in ...

Last Updated: 24 Feb 2016

Go To URL
Axillary lymph node metastases in adenoid cystic carcinoma of the breast. A rare finding.
 

Author(s): D Spiliopoulos, G Mitsopoulos, S Kaptanis, C Halkias

Journal: G Chir. ;36(5):209-13.

 

Adenoid cystic carcinoma (ACC) of the breast is a rare malignant salivary-type neoplasm that has a good prognosis and represents less than 1% of all breast cancers. It is a triple negative carcinoma that presents as a painful mass. The mean age at the time of diagnosis is 50-60 years ...

Last Updated: 29 Dec 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adenoid cystic carcinoma" returned 42 free, full-text review articles on human participants. First 3 results:

Primary cutaneous adenoid cystic carcinoma of the eyelid and literature review.
 

Author(s): Deniz Turgut Coban, Muhammet Kazim Erol, Dinc Suren, Birsel Tutus

Journal: Arq Bras Oftalmol. ;78(5):323-5.

 

Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare malignant epithelial tumor most commonly observed in the scalp and skin of the chest and originating from the palpebral portion of the lacrimal gland in the orbit. Here we describe the diagnosis and treatment of a rare case ...

Last Updated: 15 Oct 2015

Go To URL
Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling.
 

Author(s): Young Kwang Chae, Su Yun Chung, Andrew A Davis, Benedito A Carneiro, Sunandana Chandra, Jason Kaplan, Aparna Kalyan, Francis J Giles

Journal: Oncotarget. 2015 Nov;6(35):37117-34.

 

Adenoid cystic carcinoma (ACC) is a rare cancer with high potential for recurrence and metastasis. Efficacy of current treatment options, particularly for advanced disease, is very limited. Recent whole genome and exome sequencing has dramatically improved our understanding of ACC ...

Last Updated: 26 Nov 2015

Go To URL
Adenoid cystic carcinoma of cervix: two cases report and review of the literature.
 

Author(s): Khadija Benhayoune, Hinde El Fatemi, Abdelaziz Bannani, Abdelilah Melhouf, Toufik Harmouch

Journal:

 

Adenoid cystic carcinoma of the cervix is a rare and aggressive tumor with fatal outcome. In this paper we report two cases of primary adenoid cystic carcinoma and a review of literature. A 80 years old woman, admitted to our hospital with postmenopausal bleeding and hydrorrhea. Gynealogical ...

Last Updated: 19 Jun 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Adenoid Cystic Carcinoma, Erbitux, and Particle Therapy
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 23 Apr 2013

Go to URL
Testing Lenvatinib in Patients With Adenoid Cystic Carcinoma
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 15 Sep 2016

Go to URL
A Study of Apatinib in Metastatic Adenoid Cystic Carcinoma of the Head and Neck
 

Status: Not yet recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 14 May 2016

Go to URL