Adenoid cystic carcinoma

Common Name(s)

Adenoid cystic carcinoma

Adenoid cystic carcinoma is a rare type of cancer that usually develops in the salivary glands, which are the areas of the body where saliva is produced. Although less common, adenoid cystic carcinoma can also grow inside the breasts, eyes, lungs, brain, throat, and paranasal sinuses. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow. This process is known as metastasis.

Adenoid cystic carcinoma most commonly occurs in adults between the ages of 40 and 60, although it can appear in all age groups. The most common symptom of adenoid cystic carcinoma is painless swelling on the face, neck, or mouth area. This cancer may also cause facial pain and nerve paralysis, which results in difficulty displaying facial expressions. Depending on the size of the cancer, affected individuals may also experience difficulty with vision or breathing. Diagnosis is usually made with a combination of a physical exam, imaging studies, blood tests, and other laboratory studies. Diagnosis may require a doctor to take a biopsy, or sample, of the tissue to look at under a microscope in order to determine if the cells are growing in an abnormal way.

Treatment for adenoid cystic carcinoma depends on many factors such as how large the cancer is and if it has spread to other areas of the body. If you or a family member has been diagnosed with adenoid cystic carcinoma, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid cystic carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

Last Updated: 5 May 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid cystic carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

http://www.accrf.org

Last Updated: 5 May 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adenoid cystic carcinoma" returned 362 free, full-text research articles on human participants. First 3 results:

[Expression of midkine and microvessel density in salivary adenoid cystic carcinoma].
 

Author(s): Jun Chen, Jimei Li, Weil Li, Hongmei Hu

Journal: Hua Xi Kou Qiang Yi Xue Za Zhi. 2016 Apr;34(2):189-93.

 

This study aimed to investigate the expression of midkine (MK) and microvessel density (MVD) in patients with salivary adenoid cystic carcinoma (SACC) and its clinical significance, as well as detect the correlation between the expression of MK and MVD in SACC.

Last Updated: 24 Jun 2016

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Adding concurrent chemotherapy to postoperative radiotherapy improves locoregional control but Not overall survival in patients with salivary gland adenoid cystic carcinoma-a propensity score matched study.
 

Author(s): Cheng-En Hsieh, Chien-Yu Lin, Li-Yu Lee, Lan-Yan Yang, Chun-Chieh Wang, Hung-Ming Wang, Joseph Tung-Chieh Chang, Kang-Hsing Fan, Chun-Ta Liao, Tzu-Chen Yen, Ku-Hao Fang, Yan-Ming Tsang

Journal:

 

To compare the long-term outcomes in patients with salivary gland adenoid cystic carcinoma (SGACC) treated with post-operative chemoradiotherapy (POCRT) versus post-operative radiotherapy (PORT).

Last Updated: 22 Mar 2016

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Carcinoma-Associated Fibroblasts Lead the Invasion of Salivary Gland Adenoid Cystic Carcinoma Cells by Creating an Invasive Track.
 

Author(s): Jiao Li, Zhuqiang Jia, Jing Kong, Fuyin Zhang, Shimeng Fang, Xiaojie Li, Wuwei Li, Xuesong Yang, Yong Luo, Bingcheng Lin, Tingjiao Liu

Journal:

 

Carcinoma-associated fibroblasts (CAFs) are critical in determining tumor invasion and metastasis. However the role of CAFs in the invasion of salivary gland adenoid cystic carcinoma (ACC) is poorly understood. In this study, we isolated primary CAFs from two ACC patients. ACC-derived ...

Last Updated: 9 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adenoid cystic carcinoma" returned 45 free, full-text review articles on human participants. First 3 results:

Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review.
 

Author(s): Henrik Hellquist, Alena Skálová, Leon Barnes, Antonio Cardesa, Lester D R Thompson, Asterios Triantafyllou, Michelle D Williams, Kenneth O Devaney, Douglas R Gnepp, Justin A Bishop, Bruce M Wenig, Carlos Suárez, Juan P Rodrigo, Andrés Coca-Pelaz, Primož Strojan, Jatin P Shah, Marc Hamoir, Patrick J Bradley, Carl E Silver, Pieter J Slootweg, Vincent Vander Poorten, Afshin Teymoortash, Jesus E Medina, K Thomas Robbins, Karen T Pitman, Luiz P Kowalski, Remco de Bree, William M Mendenhall, Jean Anderson Eloy, Robert P Takes, Alessandra Rinaldo, Alfio Ferlito

Journal: Adv Ther. 2016 Mar;33(3):357-68.

 

Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon ...

Last Updated: 16 Apr 2016

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Primary cutaneous adenoid cystic carcinoma of the eyelid and literature review.
 

Author(s): Deniz Turgut Coban, Muhammet Kazim Erol, Dinc Suren, Birsel Tutus

Journal: Arq Bras Oftalmol. ;78(5):323-5.

 

Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare malignant epithelial tumor most commonly observed in the scalp and skin of the chest and originating from the palpebral portion of the lacrimal gland in the orbit. Here we describe the diagnosis and treatment of a rare case ...

Last Updated: 15 Oct 2015

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Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling.
 

Author(s): Young Kwang Chae, Su Yun Chung, Andrew A Davis, Benedito A Carneiro, Sunandana Chandra, Jason Kaplan, Aparna Kalyan, Francis J Giles

Journal: Oncotarget. 2015 Nov;6(35):37117-34.

 

Adenoid cystic carcinoma (ACC) is a rare cancer with high potential for recurrence and metastasis. Efficacy of current treatment options, particularly for advanced disease, is very limited. Recent whole genome and exome sequencing has dramatically improved our understanding of ACC ...

Last Updated: 26 Nov 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Adenoid Cystic Carcinoma, Erbitux, and Particle Therapy
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 23 Apr 2013

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Testing Lenvatinib in Patients With Adenoid Cystic Carcinoma
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 13 Dec 2016

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A Study of Apatinib in Metastatic Adenoid Cystic Carcinoma of the Head and Neck
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 30 Sep 2016

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