Adenoid Cystic Carcinoma

Common Name(s)

Adenoid Cystic Carcinoma

Adenoid cystic carcinoma is a rare form of adenocarcinoma (a cancer that arises from gladular tissue). Adenoid cystic carcinoma is found mainly in the head and neck, but can occasionally occur in a womanÕs uterus or other sites in the body. It most commonly occurs in the salivary glands, in locations such as the palate (the roof of the mouth), nasopharynx (air passageway at the upper part of the throat and behind the nose), inner lining of the mouth, larynx, or trachea. Symptoms may include difficulty swallowing, hoarseness, dull pain, numbness or palpable lumps. Regardless of its location, adenoid cystic carcinoma tends to spread along nerves or through the bloodstream. A small percentage of cases spread to the lymph nodes. The most common location for metatasis is the lung. Adenoid cystic carcinoma is often unpredictable, with long periods of no activity followed by rapid growth. The cause of adenoid cystic carcinoma is not known and no specific risk factors have been identified. Treatment depends on the size and location of the tumor, whether the cancer has spread, and the patient's overall health, but may include surgery, radiation or chemotherapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid Cystic Carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

Last Updated: 5 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid Cystic Carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

http://www.accrf.org

Last Updated: 5 May 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adenoid Cystic Carcinoma" returned 213 free, full-text research articles on human participants. First 3 results:

Late-developing tongue adenoid cystic carcinoma after pulmonary metastasectomy: a case report.
 

Author(s): Young Jo Sa, Sung Bo Sim, Tae-Jung Kim, Seok Whan Moon, Chan Beom Park

Journal:

 

Adenoid cystic carcinoma (ACC) is a relatively rare epithelial tumor of the salivary glands that accounts for approximately 5 to 10% of all salivary gland neoplasms. The typical clinical and pathological findings of this tumor include slow indolent growth, common local recurrence, ...

Last Updated: 24 Apr 2014

Go To URL
Intracranial extension of adenoid cystic carcinoma: potential involvement of EphA2 expression and epithelial-mesenchymal transition in tumor metastasis: a case report.
 

Author(s): Junya Fukai, Koji Fujita, Toshikazu Yamoto, Takahiro Sasaki, Yuji Uematsu, Naoyuki Nakao

Journal:

 

Adenoid cystic carcinoma is a malignant epithelial tumor derived from salivary glands and tends to invade the surrounding structures including nervous system. We present a case of adenoid cystic carcinoma with intracranial extension and propose a novel molecular mechanism of adenoid ...

Last Updated: 14 Mar 2014

Go To URL
Ubiquitin-specific peptidase 22, a histone deubiquitinating enzyme, is a novel poor prognostic factor for salivary adenoid cystic carcinoma.
 

Author(s): Wei Dai, Yuan Yao, Qing Zhou, Chang-fu Sun

Journal:

 

Salivary Adenoid Cystic Carcinoma (SACC) is characterized by a high rate of local recurrence and infiltration, strong invasion to peripheral nerves or late distant metastasis. Our aim was to investigate the expression of Ubiquitin-specific protease 22 (USP22) in SACC patients and ...

Last Updated: 27 Jan 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adenoid Cystic Carcinoma" returned 19 free, full-text review articles on human participants. First 3 results:

Glottic-Subglottic adenoid cystic carcinoma. A case report and review of the literature.
 

Author(s): Domenico Testa, Germano Guerra, Giovanni Conzo, Michele Nunziata, Gioacchino D'Errico, Maria Siano, Gennaro Ilardi, Mario Vitale, Francesco Riccitiello, Gaetano Motta

Journal: BMC Surg. 2013 ;13 Suppl 2():S48.

 

Malignant tumours of minor salivary glands are uncommon, representing only 2-4% of all head and neck cancers. In the larynx, minor salivary gland tumours rarely occur and constitute less than 1% of laryngeal neoplasm. Most of the minor salivary gland tumours arise in the subglottis; ...

Last Updated: 14 Jan 2014

Go To URL
Adenoid cystic carcinoma: clinical and molecular features.
 

Author(s): Christopher A Moskaluk

Journal: Head Neck Pathol. 2013 Mar;7(1):17-22.

 

The clinical features and common molecular alterations of adenoid cystic carcinoma (ACC) are reviewed in this paper. ACC is an uncommon neoplasm that most frequently arises in salivary glands and related tissue in the head and neck region. ACC has distinct histologic features, with ...

Last Updated: 15 Mar 2013

Go To URL
Adenoid cystic carcinoma of the esophagus: report of two cases and review of the Chinese literature.
 

Author(s): Xu-feng Guo, Ten Mao, Zhi-tao Gu, Wen-tao Fang, Wen-hu Chen, Jin-chen Shao

Journal:

 

Squamous cell carcinoma is the major pathology type of esophageal cancer in China, where adenocarcinoma is rare and adenoid cystic carcinoma (ACC) is more rare comparing to the western countries. We report the surgical and pathologic findings of two cases of primary ACC of the esophagus, ...

Last Updated: 9 Jan 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Adenoid Cystic Carcinoma, Erbitux, and Particle Therapy
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 23 Apr 2013

Go to URL
Study of RAD001 in Adenoid Cystic Carcinoma
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 28 Jun 2010

Go to URL
Dovitinib in Adenoid Cystic Carcinoma
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 16 Apr 2013

Go to URL