Adenoid cystic carcinoma

Common Name(s)

Adenoid cystic carcinoma

Adenoid cystic carcinoma is a rare type of cancer that usually develops in the salivary glands, which are the areas of the body where saliva is produced. Although less common, adenoid cystic carcinoma can also grow inside the breasts, eyes, lungs, brain, throat, and paranasal sinuses. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow. This process is known as metastasis.

Adenoid cystic carcinoma most commonly occurs in adults between the ages of 40 and 60, although it can appear in all age groups. The most common symptom of adenoid cystic carcinoma is painless swelling on the face, neck, or mouth area. This cancer may also cause facial pain and nerve paralysis, which results in difficulty displaying facial expressions. Depending on the size of the cancer, affected individuals may also experience difficulty with vision or breathing. Diagnosis is usually made with a combination of a physical exam, imaging studies, blood tests, and other laboratory studies. Diagnosis may require a doctor to take a biopsy, or sample, of the tissue to look at under a microscope in order to determine if the cells are growing in an abnormal way.

Treatment for adenoid cystic carcinoma depends on many factors such as how large the cancer is and if it has spread to other areas of the body. If you or a family member has been diagnosed with adenoid cystic carcinoma, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid cystic carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

Last Updated: 5 May 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Adenoid cystic carcinoma" for support, advocacy or research.

Adenoid Cystic Carcinoma Research Foundation

The Adenoid Cystic Carcinoma Research Foundation (ACCRF) supports research into adenoid cystic carcinoma that will accelerate the development of improved therapies and a cure for the disease.

http://www.accrf.org

Last Updated: 5 May 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Adenoid cystic carcinoma" returned 366 free, full-text research articles on human participants. First 3 results:

[Analysis of BNIP3 expression and clinical research in salivary adenoid cystic carcinoma].
 

Author(s): Chen Zhanwei, Sun Dubin, Huang Shengyun, Wu Haiwei, Zhang Dongsheng

Journal: Hua Xi Kou Qiang Yi Xue Za Zhi. 2016 Aug;34(4):404-407.

 

This study investigated the expression of BNIP3 in salivary adenoid cystic carcinoma (SACC) and its correlations to the clinicopathological features and prognosis of patients with SACC. The role of BNIP3 in the progress of hypoxia-induced autophagy was elucidated.

Last Updated: 20 Mar 2017

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Biochemical changes of salivary gland adenoid cystic carcinoma cells induced by SGI-1776.
 

Author(s): Xiuxiu Hou, Yunfang Yu, Jianguo Feng, Jiafeng Wang, Chuanming Zheng, Zhiqiang Ling, Minghua Ge, Xin Zhu

Journal: Exp. Cell Res.. 2017 Mar;352(2):403-411.

 

Provirus integration site for Moloney murine leukemia virus 1 (Pim-1) has proved to be an oncogene and it is known that to depress Pim-1 activity may be a novel oncological treatment strategy. SGI-1776, a small molecule, is the first clinically tested inhibitor of the Pim kinase family. ...

Last Updated: 23 Feb 2017

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Risk factors and prognosis for salivary gland adenoid cystic carcinoma in southern china: A 25-year retrospective study.
 

Author(s): Dai-Qiao Ouyang, Li-Zhong Liang, Guang-Sen Zheng, Zun-Fu Ke, De-Sheng Weng, Wei-Fa Yang, Yu-Xiong Su, Gui-Qing Liao

Journal: Medicine (Baltimore). 2017 Feb;96(5):e5964.

 

Adenoid cystic carcinoma (ACC) is characterized by slow growth, frequent local recurrences, and high incidence of distant metastasis (DM). The aim of this study was to evaluate predictive factors for local-regional (LR) recurrence, DM, and survival in ACC.A retrospective review of ...

Last Updated: 2 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Adenoid cystic carcinoma" returned 45 free, full-text review articles on human participants. First 3 results:

Adenoid cystic carcinoma of the palate: case report and review of literature.
 

Author(s): Uday Shankar Yaga, Nishanth Gollamudi, Ashwini Kumar Mengji, Radhika Besta, Prashanth Panta, Bhanu Prakash, Edunuri Rajashekar

Journal:

 

Adenoid Cystic Carcinoma (ACC) is a rare tumor constitutes for less than 1% of head and neck malignancies and 10% of all salivary gland tumors. Palate is the most common site to be involved in the oral cavity followed by parotid gland and submandibular gland. They are usually asymptomatic, ...

Last Updated: 19 Sep 2016

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Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review.
 

Author(s): Henrik Hellquist, Alena Skálová, Leon Barnes, Antonio Cardesa, Lester D R Thompson, Asterios Triantafyllou, Michelle D Williams, Kenneth O Devaney, Douglas R Gnepp, Justin A Bishop, Bruce M Wenig, Carlos Suárez, Juan P Rodrigo, Andrés Coca-Pelaz, Primož Strojan, Jatin P Shah, Marc Hamoir, Patrick J Bradley, Carl E Silver, Pieter J Slootweg, Vincent Vander Poorten, Afshin Teymoortash, Jesus E Medina, K Thomas Robbins, Karen T Pitman, Luiz P Kowalski, Remco de Bree, William M Mendenhall, Jean Anderson Eloy, Robert P Takes, Alessandra Rinaldo, Alfio Ferlito

Journal: Adv Ther. 2016 Mar;33(3):357-68.

 

Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon ...

Last Updated: 16 Apr 2016

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Adenoid cystic carcinoma of the trachea.
 

Author(s): Heena M Desai, Rohit Thakare, Gayathri P Amonkar, Vinaya Karkhanis, Jyotsna M Joshi

Journal: Indian J Pathol Microbiol. ;58(4):516-8.

 

Primary salivary gland-type tumors of the lung and airways being unusual, they pose a diagnostic challenge on small biopsies and are usually consigned as non-small cell lung carcinomas. Since the clinical behavior of these tumors is different from the conventional lung tumors, it ...

Last Updated: 9 Nov 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 19 Jun 2017

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A Study of Apatinib in Metastatic Adenoid Cystic Carcinoma of the Head and Neck
 

Status: Recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 30 Sep 2016

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Trail Evaluating Particle Therapy With or Without Apatinib for H&N Adenoid Cystic Carcinoma
 

Status: Not yet recruiting

Condition Summary: Adenoid Cystic Carcinoma

 

Last Updated: 20 Oct 2016

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