Diabetes Insipidus

Common Name(s)

Diabetes Insipidus

Diabetes insipidus is a condition where the kidneys do not function properly, causing individuals to have to urinate frequently and often become dehydrated. Normally, the kidneys, which are small organs located in the abdomen (belly), filter a person’s blood multiple times a day and create urine. However, when a person has diabetes insipidus, they filter out too much water and create too much urine. This causes the individual to have to urinate more frequently, often every hour of the day and night. There are different types of diabetes insipidus depending on the actual chemical cause of the disorder. Onset of diabetes insipidus can occur at any age beyond infancy. Most symptoms of diabetes insipidus can be controlled with medication, and depending on the cause, it may sometimes resolve after a period of time. During this time, however, it is important to have a physician manage the condition to prevent dehydration or other potential consequences of diabetes insipidus. The frequency of diabetes insipidus is 3 in every 100,000 people.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes Insipidus" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes Insipidus" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diabetes Insipidus" returned 456 free, full-text research articles on human participants. First 3 results:

A novel mutation affecting the arginine-137 residue of AVPR2 in dizygous twins leads to nephrogenic diabetes insipidus and attenuated urine exosome aquaporin-2.
 

Author(s): Gitte R Hinrichs, Louise H Hansen, Maria R Nielsen, Christina Fagerberg, Hans Dieperink, Søren Rittig, Boye L Jensen

Journal: Physiol Rep. 2016 Apr;4(8):.

 

Mutations in the vasopressin V2 receptor gene AVPR2 may cause X-linked nephrogenic diabetes insipidus by defective apical insertion of aquaporin-2 in the renal collecting duct principal cell. Substitution mutations with exchange of arginine at codon 137 can cause nephrogenic syndrome ...

Last Updated: 27 Apr 2016

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Cholesteatoma in the Sellar Region Presenting as Hypopituitarism and Diabetes Insipidus.
 

Author(s): Xiangyi Kong, Huanwen Wu, Wenbin Ma, Yongning Li, Bing Xing, Yanguo Kong, Renzhi Wang

Journal: Medicine (Baltimore). 2016 Mar;95(10):e2938.

 

Clinically significant sellar cysts unrelated to pituitary adenomas are uncommon. Intracranial cholesteatomas are also rare and are most common in the middle ear and mastoid region. We report an even rarer case of cholesteatoma in the sellar region-a challenging diagnosis guided by ...

Last Updated: 11 Mar 2016

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History of Diabetes Insipidus.
 

Author(s): Giovanna Valenti, Grazia Tamma

Journal: G Ital Nefrol. 2016 Feb;33 Suppl 66():33.S66.1.

 

Under physiological conditions, fluid and electrolyte homoeostasis is maintained by the kidney adjusting urine volume and composition according to body needs. Diabetes Insipidus is a complex and heterogeneous clinical syndrome affecting water balance and characterized by constant ...

Last Updated: 26 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diabetes Insipidus" returned 34 free, full-text review articles on human participants. First 3 results:

Identification of an AVP-NPII mutation within the AVP moiety in a family with neurohypophyseal diabetes insipidus: review of the literature.
 

Author(s): Costas Koufaris, Angelos Alexandrou, Carolina Sismani, Nicos Skordis

Journal: Hormones (Athens). ;14(3):442-6.

 

Familial neurohypophyseal diabetes insipidus (FNDI) is a disorder characterized by excess excretion of diluted urine (polyuria) and increased uptake of fluids (polydipsia). The disorder is caused by mutations affecting the AVP-NPII gene, resulting in absent or deficient secretion ...

Last Updated: 3 Aug 2015

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Targeting renal purinergic signalling for the treatment of lithium-induced nephrogenic diabetes insipidus.
 

Author(s): B K Kishore, N G Carlson, C M Ecelbarger, D E Kohan, C E Müller, R D Nelson, J Peti-Peterdi, Y Zhang

Journal: Acta Physiol (Oxf). 2015 Jun;214(2):176-88.

 

Lithium still retains its critical position in the treatment of bipolar disorder by virtue of its ability to prevent suicidal tendencies. However, chronic use of lithium is often limited by the development of nephrogenic diabetes insipidus (NDI), a debilitating condition. Lithium-induced ...

Last Updated: 12 May 2015

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Congenital nephrogenic diabetes insipidus with end-stage renal disease.
 

Author(s): Hyun Ho Ryu, Jong Hoon Chung, Byung Chul Shin, Hyun Lee Kim

Journal: Korean J. Intern. Med.. 2015 Mar;30(2):259-61.

 

Last Updated: 9 Mar 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Metformin and Congenital Nephrogenic Diabetes Insipidus
 

Status: Recruiting

Condition Summary: Diabetes Insipidus

 

Last Updated: 31 Oct 2016

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Use of Copeptin in Diabetes Insipidus
 

Status: Recruiting

Condition Summary: Diabetes Insipidus (Central and Nephrogen); Primary Polydipsia

 

Last Updated: 6 Jul 2016

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Shared Health Appointments and Reciprocal Enhanced Support
 

Status: Recruiting

Condition Summary: Diabetes Insipidus

 

Last Updated: 22 Sep 2016

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