Diabetes Insipidus

Common Name(s)

Diabetes Insipidus

Diabetes insipidus is a condition where the kidneys do not function properly, causing individuals to have to urinate frequently and often become dehydrated. Normally, the kidneys, which are small organs located in the abdomen (belly), filter a person’s blood multiple times a day and create urine. However, when a person has diabetes insipidus, they filter out too much water and create too much urine. This causes the individual to have to urinate more frequently, often every hour of the day and night. There are different types of diabetes insipidus depending on the actual chemical cause of the disorder. Onset of diabetes insipidus can occur at any age beyond infancy. Most symptoms of diabetes insipidus can be controlled with medication, and depending on the cause, it may sometimes resolve after a period of time. During this time, however, it is important to have a physician manage the condition to prevent dehydration or other potential consequences of diabetes insipidus. The frequency of diabetes insipidus is 3 in every 100,000 people.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes Insipidus" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes Insipidus" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diabetes Insipidus" returned 439 free, full-text research articles on human participants. First 3 results:

[Systemic necrotizing vasculitis presenting as gangrene combined with diabetes insipidus: a case report].
 

Author(s): Qing Huang, Yu-lan Liu

Journal: Beijing Da Xue Xue Bao. 2015 Dec;47(6):1028-30.

 

The male patient reported here presented as gangrene and central diabetes insipidus (CDI), who had characteristics of vasculitis. The patient complained about polydipsia and polyuria half a year ago, and then developed tingling, pain and blackish discoloration of some fingers and ...

Last Updated: 18 Dec 2015

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Evolutionary Influenced Interaction Pattern as Indicator for the Investigation of Natural Variants Causing Nephrogenic Diabetes Insipidus.
 

Author(s): Steffen Grunert, Dirk Labudde

Journal: Comput Math Methods Med. 2015 ;2015():641393.

 

The importance of short membrane sequence motifs has been shown in many works and emphasizes the related sequence motif analysis. Together with specific transmembrane helix-helix interactions, the analysis of interacting sequence parts is helpful for understanding the process during ...

Last Updated: 16 Jul 2015

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Hypothalamic type of hypopituitarism and central diabetes insipidus probably linked to Rathke's cleft cyst.
 

Author(s): Tomoko Asano, Hodaka Yamada, Masashi Yoshida, Atsushi Aoki, Aki Ikoma, Ikuyo Kusaka, Hideo Toyoshima, Masafumi Kakei, San-E Ishikawa

Journal: Intern. Med.. 2015 ;54(8):935-40.

 

A 73-year-old woman was admitted due to weight loss and generalized malaise. The basal levels of all the anterior pituitary hormones, except for prolactin, were reduced. However, they were all elevated in response to exogenous hypothalamic hormones. After starting hydrocortisone replacement, ...

Last Updated: 16 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diabetes Insipidus" returned 32 free, full-text review articles on human participants. First 3 results:

Congenital nephrogenic diabetes insipidus with end-stage renal disease.
 

Author(s): Hyun Ho Ryu, Jong Hoon Chung, Byung Chul Shin, Hyun Lee Kim

Journal: Korean J. Intern. Med.. 2015 Mar;30(2):259-61.

 

Last Updated: 9 Mar 2015

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A novel therapeutic effect of statins on nephrogenic diabetes insipidus.
 

Author(s): Leonilde Bonfrate, Giuseppe Procino, David Q-H Wang, Maria Svelto, Piero Portincasa

Journal: J. Cell. Mol. Med.. 2015 Feb;19(2):265-82.

 

Statins competitively inhibit hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase, resulting in reduced plasma total and low-density lipoprotein cholesterol levels. Recently, it has been shown that statins exert additional 'pleiotropic' effects by increasing expression levels ...

Last Updated: 29 Jan 2015

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Ifosfamide-induced Fanconi syndrome with diabetes insipidus.
 

Author(s): Ah Young Leem, Han Sang Kim, Byung Woo Yoo, Beo Deul Kang, Min Hwan Kim, Sun Young Rha, Hyo Song Kim

Journal: Korean J. Intern. Med.. 2014 Mar;29(2):246-9.

 

Ifosfamide-induced Fanconi syndrome is a rare complication that typically occurs in young patients due to a cumulative dose of ifosfamide > 40-60 g/m(2), a reduction in kidney mass, or concurrent cisplatin treatment. It is usually characterized by severe and fatal progression accompanied ...

Last Updated: 20 Mar 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Metformin and Congenital Nephrogenic Diabetes Insipidus
 

Status: Recruiting

Condition Summary: Diabetes Insipidus

 

Last Updated: 20 Apr 2016

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Use of Copeptin in Diabetes Insipidus
 

Status: Recruiting

Condition Summary: Diabetes Insipidus (Central and Nephrogen); Primary Polydipsia

 

Last Updated: 4 Jan 2016

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Tracking Neurodegeneration in Early Wolfram Syndrome
 

Status: Recruiting

Condition Summary: Type 1 Diabetes; Diabetes Insipidus; Diabetes Mellitus; Wolfram Syndrome

 

Last Updated: 13 Jan 2016

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