Diabetes Insipidus

Common Name(s)

Diabetes Insipidus

Diabetes insipidus is a condition where the kidneys do not function properly, causing individuals to have to urinate frequently and often become dehydrated. Normally, the kidneys, which are small organs located in the abdomen (belly), filter a person’s blood multiple times a day and create urine. However, when a person has diabetes insipidus, they filter out too much water and create too much urine. This causes the individual to have to urinate more frequently, often every hour of the day and night. There are different types of diabetes insipidus depending on the actual chemical cause of the disorder. Onset of diabetes insipidus can occur at any age beyond infancy. Most symptoms of diabetes insipidus can be controlled with medication, and depending on the cause, it may sometimes resolve after a period of time. During this time, however, it is important to have a physician manage the condition to prevent dehydration or other potential consequences of diabetes insipidus. The frequency of diabetes insipidus is 3 in every 100,000 people.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes Insipidus" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes Insipidus" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diabetes Insipidus" returned 445 free, full-text research articles on human participants. First 3 results:

Partial nephrogenic diabetes insipidus caused by a novel AQP2 variation impairing trafficking of the aquaporin-2 water channel.
 

Author(s): Pia Dollerup, Troels Møller Thomsen, Lene N Nejsum, Mia Færch, Martin Österbrand, Niels Gregersen, Søren Rittig, Jane H Christensen, Thomas J Corydon

Journal:

 

Autosomal dominant inheritance of congenital nephrogenic diabetes insipidus (CNDI) is rare and usually caused by variations in the AQP2 gene. We have investigated the genetic and molecular background underlying symptoms of diabetes insipidus (DI) in a Swedish family with autosomal ...

Last Updated: 30 Dec 2015

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[Systemic necrotizing vasculitis presenting as gangrene combined with diabetes insipidus: a case report].
 

Author(s): Qing Huang, Yu-lan Liu

Journal: Beijing Da Xue Xue Bao. 2015 Dec;47(6):1028-30.

 

The male patient reported here presented as gangrene and central diabetes insipidus (CDI), who had characteristics of vasculitis. The patient complained about polydipsia and polyuria half a year ago, and then developed tingling, pain and blackish discoloration of some fingers and ...

Last Updated: 18 Dec 2015

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Case report of severe Cushing's syndrome in medullary thyroid cancer complicated by functional diabetes insipidus, aortic dissection, jejunal intussusception, and paraneoplastic dysautonomia: remission with sorafenib without reduction in cortisol concentration.
 

Author(s): Muhammad M Hammami, Najla Duaiji, Ghazi Mutairi, Sabah Aklabi, Nasser Qattan, Mohei El-Din M Abouzied, Mohamed W Sous

Journal:

 

Normalization of cortisol concentration by multikinase inhibitors have been reported in three patients with medullary thyroid cancer-related Cushing's syndrome. Aortic dissection has been reported in three patients with Cushing's syndrome. Diabetes insipidus without intrasellar metastasis, ...

Last Updated: 10 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diabetes Insipidus" returned 33 free, full-text review articles on human participants. First 3 results:

Identification of an AVP-NPII mutation within the AVP moiety in a family with neurohypophyseal diabetes insipidus: review of the literature.
 

Author(s): Costas Koufaris, Angelos Alexandrou, Carolina Sismani, Nicos Skordis

Journal: Hormones (Athens). ;14(3):442-6.

 

Familial neurohypophyseal diabetes insipidus (FNDI) is a disorder characterized by excess excretion of diluted urine (polyuria) and increased uptake of fluids (polydipsia). The disorder is caused by mutations affecting the AVP-NPII gene, resulting in absent or deficient secretion ...

Last Updated: 3 Aug 2015

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Congenital nephrogenic diabetes insipidus with end-stage renal disease.
 

Author(s): Hyun Ho Ryu, Jong Hoon Chung, Byung Chul Shin, Hyun Lee Kim

Journal: Korean J. Intern. Med.. 2015 Mar;30(2):259-61.

 

Last Updated: 9 Mar 2015

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A novel therapeutic effect of statins on nephrogenic diabetes insipidus.
 

Author(s): Leonilde Bonfrate, Giuseppe Procino, David Q-H Wang, Maria Svelto, Piero Portincasa

Journal: J. Cell. Mol. Med.. 2015 Feb;19(2):265-82.

 

Statins competitively inhibit hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase, resulting in reduced plasma total and low-density lipoprotein cholesterol levels. Recently, it has been shown that statins exert additional 'pleiotropic' effects by increasing expression levels ...

Last Updated: 29 Jan 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Metformin and Congenital Nephrogenic Diabetes Insipidus
 

Status: Recruiting

Condition Summary: Diabetes Insipidus

 

Last Updated: 20 Apr 2016

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Use of Copeptin in Diabetes Insipidus
 

Status: Recruiting

Condition Summary: Diabetes Insipidus (Central and Nephrogen); Primary Polydipsia

 

Last Updated: 4 Jan 2016

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Tracking Neurodegeneration in Early Wolfram Syndrome
 

Status: Recruiting

Condition Summary: Type 1 Diabetes; Diabetes Insipidus; Diabetes Mellitus; Wolfram Syndrome

 

Last Updated: 13 Jan 2016

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