Diabetes Insipidus

Common Name(s)

Diabetes Insipidus

Diabetes insipidus is a condition where the kidneys do not function properly, causing individuals to have to urinate frequently and often become dehydrated. Normally, the kidneys, which are small organs located in the abdomen (belly), filter a person’s blood multiple times a day and create urine. However, when a person has diabetes insipidus, they filter out too much water and create too much urine. This causes the individual to have to urinate more frequently, often every hour of the day and night. There are different types of diabetes insipidus depending on the actual chemical cause of the disorder. Onset of diabetes insipidus can occur at any age beyond infancy. Most symptoms of diabetes insipidus can be controlled with medication, and depending on the cause, it may sometimes resolve after a period of time. During this time, however, it is important to have a physician manage the condition to prevent dehydration or other potential consequences of diabetes insipidus. The frequency of diabetes insipidus is 3 in every 100,000 people.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes Insipidus" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes Insipidus" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diabetes Insipidus" returned 373 free, full-text research articles on human participants. First 3 results:

The McGill Geriatric Lithium-Induced Diabetes Insipidus Clinical Study (McGLIDICS).
 

Author(s): Soham Rej, Marilyn Segal, Nancy C P Low, Istvan Mucsi, Christina Holcroft, Kenneth Shulman, Karl Looper

Journal: Can J Psychiatry. 2014 Jun;59(6):327-34.

 

Despite being a common and potentially serious condition, nephrogenic diabetes insipidus (NDI) remains poorly understood in older lithium users. Our main objective was to compare the prevalence of NDI symptoms and decreased urine osmolality ([UOsm] < 300 milli-Osmoles [mOsm/kg]) among ...

Last Updated: 10 Jul 2014

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X-ray structure of human aquaporin 2 and its implications for nephrogenic diabetes insipidus and trafficking.
 

Author(s): Anna Frick, Urszula Kosinska Eriksson, Fabrizio de Mattia, Fredrik Oberg, Kristina Hedfalk, Richard Neutze, Willem J de Grip, Peter M T Deen, Susanna Törnroth-Horsefield

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Apr;111(17):6305-10.

 

Human aquaporin 2 (AQP2) is a water channel found in the kidney collecting duct, where it plays a key role in concentrating urine. Water reabsorption is regulated by AQP2 trafficking between intracellular storage vesicles and the apical membrane. This process is tightly controlled ...

Last Updated: 30 Apr 2014

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Congenital toxoplasmosis presenting as central diabetes insipidus in an infant: a case report.
 

Author(s): Sarar Mohamed, Abdaldafae Osman, Nasir A Al Jurayyan, Abdulrahman Al Nemri, Mustafa A M Salih

Journal:

 

Congenital toxoplasmosis has a wide range of presentation at birth varying from severe neurological features such as hydrocephalus and chorioretinitis to a well appearing baby, who may develop complications late in infancy. While neuroendocrine abnormalities associated with congenital ...

Last Updated: 2 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diabetes Insipidus" returned 26 free, full-text review articles on human participants. First 3 results:

Inherited secondary nephrogenic diabetes insipidus: concentrating on humans.
 

Author(s): D Bockenhauer, D G Bichet

Journal: Am. J. Physiol. Renal Physiol.. 2013 Apr;304(8):F1037-42.

 

The study of human physiology is paramount to understanding disease and developing rational and targeted treatments. Conversely, the study of human disease can teach us a lot about physiology. Investigations into primary inherited nephrogenic diabetes insipidus (NDI) have contributed ...

Last Updated: 16 Apr 2013

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Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment.
 

Author(s): Hanne B Moeller, Søren Rittig, Robert A Fenton

Journal: Endocr. Rev.. 2013 Apr;34(2):278-301.

 

The water channel aquaporin-2 (AQP2), expressed in the kidney collecting ducts, plays a pivotal role in maintaining body water balance. The channel is regulated by the peptide hormone arginine vasopressin (AVP), which exerts its effects through the type 2 vasopressin receptor (AVPR2). ...

Last Updated: 8 Apr 2013

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Two new large deletions of the AVPR2 gene causing nephrogenic diabetes insipidus and a review of previously published deletions.
 

Author(s): Laura Anesi, Paola de Gemmis, Daniela Galla, Uros Hladnik

Journal: Nephrol. Dial. Transplant.. 2012 Oct;27(10):3705-12.

 

In this paper, we report two new original deletions and present an extended review of the previously characterized AVPR2 gene deletions to better understand the underlying deletion mechanisms.

Last Updated: 1 Nov 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Use of Copeptin in Diabetes Insipidus
 

Status: Recruiting

Condition Summary: Diabetes Insipidus (Central and Nephrogen); Primary Polydipsia

 

Last Updated: 12 Sep 2013

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A PK Study of 3 Dosages of Tolvaptan in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
 

Status: Recruiting

Condition Summary: Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

 

Last Updated: 29 Nov 2014

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Implementation Study of the Peer-to-Peer Program for Patients With Diabetes
 

Status: Not yet recruiting

Condition Summary: Diabetes Insipidus

 

Last Updated: 3 Oct 2014

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