Diabetes Insipidus

Common Name(s)

Diabetes Insipidus

Diabetes insipidus is a condition where the kidneys do not function properly, causing individuals to have to urinate frequently and often become dehydrated. Normally, the kidneys, which are small organs located in the abdomen (belly), filter a person’s blood multiple times a day and create urine. However, when a person has diabetes insipidus, they filter out too much water and create too much urine. This causes the individual to have to urinate more frequently, often every hour of the day and night. There are different types of diabetes insipidus depending on the actual chemical cause of the disorder. Onset of diabetes insipidus can occur at any age beyond infancy. Most symptoms of diabetes insipidus can be controlled with medication, and depending on the cause, it may sometimes resolve after a period of time. During this time, however, it is important to have a physician manage the condition to prevent dehydration or other potential consequences of diabetes insipidus. The frequency of diabetes insipidus is 3 in every 100,000 people.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes Insipidus" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes Insipidus" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diabetes Insipidus" returned 372 free, full-text research articles on human participants. First 3 results:

Granulomatosis with polyangiitis preceded by central diabetes insipidus.
 

Author(s): So Sampei, Ryu Watanabe, Tomonori Ishii, Hideo Harigae

Journal: Intern. Med.. 2014 ;53(15):1725-6.

 

Last Updated: 4 Aug 2014

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The McGill Geriatric Lithium-Induced Diabetes Insipidus Clinical Study (McGLIDICS).
 

Author(s): Soham Rej, Marilyn Segal, Nancy C P Low, Istvan Mucsi, Christina Holcroft, Kenneth Shulman, Karl Looper

Journal: Can J Psychiatry. 2014 Jun;59(6):327-34.

 

Despite being a common and potentially serious condition, nephrogenic diabetes insipidus (NDI) remains poorly understood in older lithium users. Our main objective was to compare the prevalence of NDI symptoms and decreased urine osmolality ([UOsm] < 300 milli-Osmoles [mOsm/kg]) among ...

Last Updated: 10 Jul 2014

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Desmopressin orally disintegrating tablet in Japanese patients with central diabetes insipidus: a retrospective study of switching from intranasal desmopressin.
 

Author(s): Takaaki Murakami, Tomonobu Hatoko, Takuo Nambu, Yuki Matsuda, Koji Matsuo, Shin Yonemitsu, Seiji Muro, Shogo Oki

Journal: Endocr. J.. 2014 ;61(8):773-9.

 

Central diabetes insipidus (CDI) is a rare disease characterized by polyuria and polydipsia. Patients with CDI have been successfully treated with desmopressin administered either by intranasal instillation or oral tablets. Recently, a desmopressin orally disintegrating tablet (ODT) ...

Last Updated: 1 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diabetes Insipidus" returned 28 free, full-text review articles on human participants. First 3 results:

Ifosfamide-induced Fanconi syndrome with diabetes insipidus.
 

Author(s): Ah Young Leem, Han Sang Kim, Byung Woo Yoo, Beo Deul Kang, Min Hwan Kim, Sun Young Rha, Hyo Song Kim

Journal: Korean J. Intern. Med.. 2014 Mar;29(2):246-9.

 

Ifosfamide-induced Fanconi syndrome is a rare complication that typically occurs in young patients due to a cumulative dose of ifosfamide > 40-60 g/m(2), a reduction in kidney mass, or concurrent cisplatin treatment. It is usually characterized by severe and fatal progression accompanied ...

Last Updated: 20 Mar 2014

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The prevalence of IgG4-related hypophysitis in 170 consecutive patients with hypopituitarism and/or central diabetes insipidus and review of the literature.
 

Author(s): Hironori Bando, Genzo Iguchi, Hidenori Fukuoka, Masaaki Taniguchi, Masaaki Yamamoto, Ryusaku Matsumoto, Kentaro Suda, Hitoshi Nishizawa, Michiko Takahashi, Eiji Kohmura, Yutaka Takahashi

Journal:

 

The prevalence and clinical characteristics of IgG4-related hypophysitis remain unclear due to the limited number of case reports. Therefore, in this study, we screened consecutive outpatients with hypopituitarism and/or diabetes insipidus (DI) to estimate its prevalence.

Last Updated: 23 Dec 2013

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Inherited secondary nephrogenic diabetes insipidus: concentrating on humans.
 

Author(s): D Bockenhauer, D G Bichet

Journal: Am. J. Physiol. Renal Physiol.. 2013 Apr;304(8):F1037-42.

 

The study of human physiology is paramount to understanding disease and developing rational and targeted treatments. Conversely, the study of human disease can teach us a lot about physiology. Investigations into primary inherited nephrogenic diabetes insipidus (NDI) have contributed ...

Last Updated: 16 Apr 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Metformin and Congenital Nephrogenic Diabetes Insipidus
 

Status: Not yet recruiting

Condition Summary: Diabetes Insipidus

 

Last Updated: 29 May 2015

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Use of Copeptin in Diabetes Insipidus
 

Status: Recruiting

Condition Summary: Diabetes Insipidus (Central and Nephrogen); Primary Polydipsia

 

Last Updated: 20 Apr 2015

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Tracking Neurodegeneration in Early Wolfram Syndrome
 

Status: Recruiting

Condition Summary: Type 1 Diabetes; Diabetes Insipidus; Diabetes Mellitus; Wolfram Syndrome

 

Last Updated: 22 May 2015

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