Diabetes Insipidus

Common Name(s)

Diabetes Insipidus

Diabetes insipidus is a condition where the kidneys do not function properly, causing individuals to have to urinate frequently and often become dehydrated. Normally, the kidneys, which are small organs located in the abdomen (belly), filter a person’s blood multiple times a day and create urine. However, when a person has diabetes insipidus, they filter out too much water and create too much urine. This causes the individual to have to urinate more frequently, often every hour of the day and night. There are different types of diabetes insipidus depending on the actual chemical cause of the disorder. Onset of diabetes insipidus can occur at any age beyond infancy. Most symptoms of diabetes insipidus can be controlled with medication, and depending on the cause, it may sometimes resolve after a period of time. During this time, however, it is important to have a physician manage the condition to prevent dehydration or other potential consequences of diabetes insipidus. The frequency of diabetes insipidus is 3 in every 100,000 people.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes Insipidus" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetes Insipidus" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diabetes Insipidus" returned 435 free, full-text research articles on human participants. First 3 results:

Induced pluripotent stem cells derived from a patient with autosomal dominant familial neurohypophyseal diabetes insipidus caused by a variant in the AVP gene.
 

Author(s): Lise Bols Toustrup, Yan Zhou, Helene Kvistgaard, Niels Gregersen, Søren Rittig, Lars Aagaard, Thomas Juhl Corydon, Yonglun Luo, Jane H Christensen

Journal: Stem Cell Res. 2017 Mar;19():37-42.

 

Autosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI) is caused by variants in the arginine vasopressin (AVP) gene. Here we report the generation of induced pluripotent stem cells (iPSCs) from a 42-year-old man carrying an adFNDI causing variant in exon 1 of the ...

Last Updated: 17 Apr 2017

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Acetazolamide in Lithium-Induced Nephrogenic Diabetes Insipidus.
 

Author(s): Craig E Gordon, Swapna Vantzelfde, Jean M Francis

Journal: N. Engl. J. Med.. 2016 11;375(20):2008-2009.

 

Last Updated: 13 Dec 2016

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[Etiological diagnosis of central diabetes insipidus: about 41 cases].
 

Author(s): Fatma Chaker, Melika Chihaoui, Meriem Yazidi, Hedia Slimane

Journal:

 

The occurrence of polyuria-polydipsia syndrome with hypotonic urine requires careful diagnostic strategy. This study aims to evaluate diagnostic modalities for central diabetes insipidus. We conducted a retrospective study of 41 cases with central diabetes insipidus (CDI). Data were ...

Last Updated: 19 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diabetes Insipidus" returned 28 free, full-text review articles on human participants. First 3 results:

Overlap of Post-obstructive Diuresis and Unmasked Diabetes Insipidus in a Case of IgG4-related Retroperitoneal Fibrosis and Tuberoinfundibular Hypophysitis: A Case Report and Review of the Literature.
 

Author(s): Midori Sasaki Yatabe, Kimio Watanabe, Yoshimitsu Hayashi, Junichi Yatabe, Satoshi Morimoto, Atsuhiro Ichihara, Masaaki Nakayama, Tsuyoshi Watanabe

Journal: Intern. Med.. ;56(1):47-53.

 

The clinical picture of IgG4-related disease (IgG4-RD) is diverse because various organs can be affected. We describe the case of a 56-year-old man with acute renal failure and tuberoinfundibular hypophysitis due to IgG4-RD. Steroid therapy lowered the serum IgG4 level and ameliorated ...

Last Updated: 4 Jan 2017

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Identification of an AVP-NPII mutation within the AVP moiety in a family with neurohypophyseal diabetes insipidus: review of the literature.
 

Author(s): Costas Koufaris, Angelos Alexandrou, Carolina Sismani, Nicos Skordis

Journal: Hormones (Athens). ;14(3):442-6.

 

Familial neurohypophyseal diabetes insipidus (FNDI) is a disorder characterized by excess excretion of diluted urine (polyuria) and increased uptake of fluids (polydipsia). The disorder is caused by mutations affecting the AVP-NPII gene, resulting in absent or deficient secretion ...

Last Updated: 3 Aug 2015

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Targeting renal purinergic signalling for the treatment of lithium-induced nephrogenic diabetes insipidus.
 

Author(s): B K Kishore, N G Carlson, C M Ecelbarger, D E Kohan, C E Müller, R D Nelson, J Peti-Peterdi, Y Zhang

Journal: Acta Physiol (Oxf). 2015 Jun;214(2):176-88.

 

Lithium still retains its critical position in the treatment of bipolar disorder by virtue of its ability to prevent suicidal tendencies. However, chronic use of lithium is often limited by the development of nephrogenic diabetes insipidus (NDI), a debilitating condition. Lithium-induced ...

Last Updated: 12 May 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Atorvastatin for the Treatment of Lithium-Induced Nephrogenic Diabetes Insipidus
 

Status: Not yet recruiting

Condition Summary: Lithium Use, Nephrogenic Diabetes Insipidus

 

Last Updated: 1 Jun 2017

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Use of Copeptin in Diabetes Insipidus
 

Status: Recruiting

Condition Summary: Diabetes Insipidus (Central and Nephrogen); Primary Polydipsia

 

Last Updated: 9 Jan 2017

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Shared Health Appointments and Reciprocal Enhanced Support
 

Status: Recruiting

Condition Summary: Diabetes Insipidus

 

Last Updated: 3 Mar 2017

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