Desmoid Tumor

Common Name(s)

Desmoid Tumor

A desmoid tumor is the abnormal growth of cells in connective tissues, which are tissues that help to maintain the structure of the body and include the tissues covering muscle (fascia), cartilage and fat.  Though these tumors have a tendency to invade surrounding tissues and organs (be aggressive), they rarely spread to more distant parts of the body (metastasize).  Desmoid tumors occur in 2-5 people per million and are most often found in the muscles of the shoulder or abdominal wall, though they can occur in other parts of the body as well.   The first signs that a desmoid tumor is growing include a growing mass or lump; if the mass presses on other parts of the body, it could cause moderate pain, numbness, tingling, or limit the movement of limbs.   A desmoid tumor is usually diagnosed by magnetic resonance imaging (MRI) followed by a biopsy.  Treatment consists of surgery to remove as much of the tumor as possible; radiation therapy, chemotherapy, or hormone therapy may also be used to reduce the chance that the tumor might regrow following surgery.   The cause of desmoid tumors is not completely clear;  however, approximately 5% of these tumors are associated with an inherited colon cancer syndrome known as familial adenomatous polyposis (FAP).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Desmoid Tumor" for support, advocacy or research.

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The Desmoid Tumor Research Foundation

Dedicated to funding research to find a cure for desmoid tumors

Last Updated: 19 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Desmoid Tumor" for support, advocacy or research.

Logo
The Desmoid Tumor Research Foundation

Dedicated to funding research to find a cure for desmoid tumors

http://www.dtrf.org

Last Updated: 19 Feb 2013

View Details

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Desmoid Tumor" returned 45 free, full-text research articles on human participants. First 3 results:

Desmoid tumor-associated pain is dependent on mast cell expression of cyclooxygenase-2.
 

Author(s): Makoto Emori, Mitsunori Kaya, Tomoko Mitsuhashi, Hiroko Asanuma, Toshihiko Yamashita

Journal:

 

This study aimed to investigate the expression profile of cyclooxygenase-2 (COX-2) in desmoid tumor specimens and to evaluate the correlation of intratumoral COX-2 expression with pain status.

Last Updated: 20 Feb 2014

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Huge desmoid tumor of the anterior abdominal wall mimicking an intraabdominal mass in a postpartum woman: a case report.
 

Author(s): Khaled Trigui, Mahdi Bouassida, Houda Kilani, Mohamed Mongi Mighri, Selim Sassi, Fathi Chebbi, Hassen Touinsi, Sadok Sassi

Journal:

 

Desmoid tumors are benign neoplasms that most often arise from muscle aponeurosis and have been associated with both trauma and pregnancy. The etiology of desmoids has not been determined. We report the case of anterior abdominal wall desmoid tumor in a female patient with previous ...

Last Updated: 17 Apr 2013

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Desmoid tumor of posterior cruciate ligament of the knee: a case report.
 

Author(s): Wang Ling, Song Kedong, Wang Hong, Zhang Weiguo, Lv Decheng

Journal:

 

Desmoid tumor is a rare type of cancer that develops in the tissues that form tendons and ligaments. These tumors, also called aggressive fibromatosis, are considered benign with no metastatic potential. They may invade nearby tissues and organs, however, and can be difficult to control. ...

Last Updated: 1 Mar 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Desmoid Tumor" returned 5 free, full-text review articles on human participants. First 3 results:

Pancreatic solid cystic desmoid tumor: case report and literature review.
 

Author(s): Bin Xu, Ling-Hua Zhu, Jia-Guo Wu, Xian-Fa Wang, Erik Matro, Jun-Jun Ni

Journal: World J. Gastroenterol.. 2013 Dec;19(46):8793-8.

 

Desmoid tumors (DTs) are nonmetastatic, locally aggressive neoplasms with a high rate of postoperative recurrence. Pancreatic DTs are especially rare; only a few cases have been reported to date. This paper describes a case of a sporadic cystic DT of the pancreas managed successfully ...

Last Updated: 31 Dec 2013

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Isolated desmoid tumor of pancreatic tail with cyst formation diagnosed by beta-catenin immunostaining: a rare case report with review of literature.
 

Author(s): Ram Nawal Rao, Preeti Agarwal, Praveer Rai, Basant Kumar

Journal:

 

Isolated pancreatic desmoid tumors with cyst formation are uncommon benign mesenchymal soft tissue tumors, characterized by the dense fibroblastic proliferations with abundant extra-cellular collagen matrix. Intra-abdominal desmoid tumor usually involve the mesentery and retroperitoneum ...

Last Updated: 14 May 2013

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Postoperative retroperitoneal desmoid tumor mimics recurrent gastrointestinal stromal tumor: a case report.
 

Author(s): Liang-Yu Shih, Chang-Kuo Wei, Chih-Wen Lin, Chih-En Tseng

Journal: World J. Gastroenterol.. 2012 Nov;18(42):6172-6.

 

Desmoid tumor is a locally invasive, myofibroblastic, nonmetastatic tumor. Its pathogenesis remains unclear and it may involve genetic abnormalities, sex hormones and traumatic injury, including surgery. Postoperative intra-abdominal desmoid tumor is rare, especially in the retroperitoneum. ...

Last Updated: 16 Nov 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

PAZOPANIB Efficacy and Tolerance in Desmoids Tumors
 

Status: Recruiting

Condition Summary: Progressive Desmoids Tumors

 

Last Updated: 10 Jun 2013

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Last Updated: 13 Feb 2014

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Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis
 

Status: Recruiting

Condition Summary: Desmoid Tumor

 

Last Updated: 9 Sep 2014

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