Dermatomyositis

Common Name(s)

Dermatomyositis

Dermatomyositis is one of a group of acquired muscle diseases called inflammatory myopathies (disorder of muscle tissue or muscles), which are characterized by chronic muscle inflammation accompanied by muscle weakness. The cardinal symptom is a skin rash that precedes or accompanies progressive muscle weakness.  Dermatomyositis may occur at any age, but is most common in adults in their late 40s to early 60s, or children between 5 and 15 years of age. There is no cure for dermatomyositis, but the symptoms can be treated. Options include medication, physical therapy, exercise, heat therapy (including microwave and ultrasound), orthotics and assistive devices, and rest. The cause of dermatomyositis is unknown.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dermatomyositis" for support, advocacy or research.

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 15 Jul 2015

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The Myositis Association

The mission of the Myositis Association is to: - Provide support to myositis patients and their families - Provide connections between the Medical Advisory Board and the general medical and patient communities - Increase funding to support myositis research

Last Updated: 14 Jan 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dermatomyositis" for support, advocacy or research.

Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 15 Jul 2015

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The Myositis Association

The mission of the Myositis Association is to: - Provide support to myositis patients and their families - Provide connections between the Medical Advisory Board and the general medical and patient communities - Increase funding to support myositis research

http://www.myositis.org

Last Updated: 14 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dermatomyositis" returned 675 free, full-text research articles on human participants. First 3 results:

MiR-146a Regulates Inflammatory Infiltration by Macrophages in Polymyositis/Dermatomyositis by Targeting TRAF6 and Affecting IL-17/ICAM-1 Pathway.
 

Author(s): Yuanqin Yin, Fei Li, Jing Shi, Songlin Li, Jingjing Cai, Youhong Jiang

Journal: Cell. Physiol. Biochem.. 2016 ;40(3-4):486-498.

 

The primary objective of this study was to investigate the role of miR-146a in inducing the inflammatory infiltration of macrophages in polymyositis/dermatomyositis (PM/DM) through targeting TNF receptor associated factor 6 (TRAF6), which may further down-regulate the Interleukin-17 ...

Last Updated: 27 Nov 2016

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Gene Expression Profile of Inflammatory Myopathy with Malignancy is Similar to that of Dermatomyositis rather than Polymyositis.
 

Author(s): Tomoko Noda, Masahiro Iijima, Seiya Noda, Shinya Maeshima, Hirotaka Nakanishi, Seigo Kimura, Haruki Koike, Shinsuke Ishigaki, Yohei Iguchi, Masahisa Katsuno, Gen Sobue

Journal: Intern. Med.. ;55(18):2571-80.

 

Objective An association has been reported between inflammatory myopathies (IMs), which include polymyositis (PM) and dermatomyositis (DM), and malignancy, and the concept of cancer-associated myositis (CAM) was recently proposed. We herein attempted to determine the features and ...

Last Updated: 16 Sep 2016

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[Dermatomyositis and Panniculitis: the function of immunoglobulins].
 

Author(s): Nadia Ben Abdelhafidh, Sana Toujeni, Asma Kefi, Najeh Bousetta, Sameh Sayhi, Imen Gharsallah, Salah Othmani

Journal:

 

Panniculitis is an inflammatory disease of subcutaneous adipose tissue which is rarely associated with dermatomyositis. It can occur before, after or simultaneously with muscle damage. In most cases, the evolution of panniculitis and of other dermatomyositis affections is favorable ...

Last Updated: 12 Aug 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dermatomyositis" returned 55 free, full-text review articles on human participants. First 3 results:

Clinically Amyopathic Dermatomyositis Complicated by Pleural Effusion Case Report, Literature Review, and Proposed Mechanism.
 

Author(s): Ying Wu, Sheetal Chhaya, Bert Hurowitz, Thomas Ardiles, Richard Carlson

Journal: Bull Hosp Jt Dis (2013). 2015 Jul;73(3):217-20.

 

Polymyositis-dermatomyositis (PM-DM) is a chronic inflammatory disorder that mainly involves muscles and skin. Clinically amyopathic dermatomyositis (CADM) is a unique subset of PM-DM with typical skin manifestations but little or no evidence of musculoskeletal involvement. Many cases ...

Last Updated: 5 Nov 2015

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Polymyositis and dermatomyositis: novel insights into the pathogenesis and potential therapeutic targets.
 

Author(s): Arash H Lahouti, Lisa Christopher-Stine

Journal: Discov Med. 2015 Jun;19(107):463-70.

 

Polymyositis (PM) and dermatomyositis (DM) are the two major forms of inflammatory muscle diseases. They are characterized clinically primarily by proximal muscle weakness. The disease mechanisms that cause muscle damage and dysfunction are not fully understood. However, because of ...

Last Updated: 16 Jul 2015

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Dermatomyositis as the first manifestation of gallbladder adenocarcinoma: case report and literature overview.
 

Author(s): Petra Jurcic

Journal:

 

Dermatomyositis (DM) is characterized by pathognomic cutaneous manifestations (heliotrope rash, periorbital edema, Gottron's papules) and proximal muscle weakness. In this paper, I will present the case of a 48-year-old female patient whose dermatomyositis was initially diagnosed ...

Last Updated: 19 Apr 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Tofacitinib in Refractory Dermatomyositis
 

Status: Recruiting

Condition Summary: Dermatomyositis

 

Last Updated: 25 Jan 2017

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Trial of IMO-8400 in Adult Patients With Dermatomyositis
 

Status: Recruiting

Condition Summary: Dermatomyositis

 

Last Updated: 7 Feb 2017

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Abatacept in Juvenile Dermatomyositis
 

Status: Recruiting

Condition Summary: Dermatomyositis

 

Last Updated: 16 Nov 2015

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