Depression

Common Name(s)

Depression

Depression is a condition in which a person feels discouraged, sad, hopeless, unmotivated, or disinterested in life in general. When these feelings last for a short period of time, it may be a case of "the blues." But when such feelings last for more than two weeks and interfere with daily activities such as taking care of family, spending time with friends, or going to work or school, it is a major depressive episode. Other symptoms may include changes in appetite and sleeping pattern, feelings of worthlessness or guilt, inability to concentrate, inability to find pleasure in former interests, social withdrawal, irritability, anger, anxiety, indecisiveness and unexplained aches and pains. Individuals with recurrent thoughts of suicide and death should seek immediate help either by contacting a suicide help line or going to a medical emergency center.

Depression is a medical illness involving an imbalance of brain chemicals. It is not a sign of personal weakness or character flaw. The exact cause of depression is unknown. It sometimes runs in families. Depression is believed to be a combination of genetics and a stressful environment or life situation. Depression is treatable. Treatment of depression may include support groups, medication, talk therapy, or other strategies. Talk to your doctor to decide on the best treatment options if you or a family member has depression. Support groups are also a good source of up to date information and can help connect you with others affected by depression. Please also see: major depression, dysthymia, bipolar disorder, and postpartum depression. Depression often occurs with anxiety disorders as well.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Depression" for support, advocacy or research.

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Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

Last Updated: 15 Feb 2013

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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

Last Updated: 15 Apr 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 29 Jan 2013

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Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

Last Updated: 15 Apr 2013

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The Balanced Mind Foundation

The Balanced Mind Foundation guides families raising children with mood disorders to the answers, support and stability they seek.

Last Updated: 18 Oct 2012

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Depression" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

http://www.adaa.org

Last Updated: 15 Feb 2013

View Details
Logo
Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

http://www.ndmda.org

Last Updated: 15 Apr 2014

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

View Details
National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 29 Jan 2013

View Details
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Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

http://www.oklahomafamilynetwork.org

Last Updated: 15 Apr 2013

View Details
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The Balanced Mind Foundation

The Balanced Mind Foundation guides families raising children with mood disorders to the answers, support and stability they seek.

http://www.thebalancedmind.org

Last Updated: 18 Oct 2012

View Details

 

General Support Organizations

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General Resources

Depression

A brochure for individuals and families discussing symptoms, causes, treatment and recovery supports.

Updated 29 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Depression" returned 7817 free, full-text research articles on human participants. First 3 results:

Depression and multimorbidity in psychiatry and primary care.
 

Author(s): Tom O'Dowd

Journal: J Clin Psychiatry. 2014 Nov;75(11):e1319-20.

 

Last Updated: 4 Dec 2014

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The effect of electroconvulsive therapy on neurocognitive function in treatment-resistant bipolar disorder depression.
 

Author(s): Ute Kessler, Helle K Schoeyen, Ole A Andreassen, Geir E Eide, Ulrik F Malt, Ketil J Oedegaard, Gunnar Morken, Kjetil Sundet, Arne E Vaaler

Journal: J Clin Psychiatry. 2014 Nov;75(11):e1306-13.

 

To compare the effects of right unilateral (RUL) electroconvulsive therapy (ECT) and algorithm-based pharmacologic treatment (APT) on neurocognitive function in treatment-resistant bipolar disorder depression.

Last Updated: 4 Dec 2014

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Therapist-assisted Internet-delivered cognitive behavior therapy for depression and anxiety: translating evidence into clinical practice.
 

Author(s): H D Hadjistavropoulos, N E Pugh, M M Nugent, H Hesser, G Andersson, M Ivanov, C G Butz, G Marchildon, G J G Asmundson, B Klein, D W Austin

Journal: J Anxiety Disord. 2014 Dec;28(8):884-93.

 

This dissemination study examined the effectiveness of therapist-assisted Internet-delivered Cognitive Behavior Therapy (ICBT) when offered in clinical practice. A centralized unit screened and coordinated ICBT delivered by newly trained therapists working in six geographically dispersed ...

Last Updated: 3 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Depression" returned 1032 free, full-text review articles on human participants. First 3 results:

Overview of the prevalence, impact, and management of depression and anxiety in chronic obstructive pulmonary disease.
 

Author(s): Maria Panagioti, Charlotte Scott, Amy Blakemore, Peter A Coventry

Journal:

 

More than one third of individuals with chronic obstructive pulmonary disease (COPD) experience comorbid symptoms of depression and anxiety. This review aims to provide an overview of the burden of depression and anxiety in those with COPD and to outline the contemporary advances ...

Last Updated: 24 Nov 2014

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[Brain activation as endophenotype for investigating genetics of depression].
 

Author(s): E Opmeer, R Kortekaas, A Aleman

Journal: Tijdschr Psychiatr. 2014 ;56(11):717-25.

 

Many factors are involved in the pathogenesis of depression. This article provides an overview of the results given in the thesis entitled 'Linking Depression', in which some putative underlying neurobiological and genetic mechanisms of depression are examined.

Last Updated: 18 Nov 2014

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[Post-stroke depression].
 

Author(s): Mónika Schulte-Altedorneburg, Dániel Bereczki

Journal: Orv Hetil. 2014 Aug;155(34):1335-43.

 

Cerebrovascular diseases are associated with a high incidence of psychiatric disorders. Depressive illness after stroke has been extensively investigated during the last three decades. Post-stroke depression is estimated to occur in 30-35% of the patients during the first year after ...

Last Updated: 18 Aug 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Triple Chronotherapy for Perinatal Depression
 

Status: Recruiting

Condition Summary: Depression; Major Depressive Disorder; Postpartum Depression

 

Last Updated: 16 Dec 2014

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Evaluating the Efficacy of Adjunctive Minocycline for the Treatment of Bipolar Depression
 

Status: Recruiting

Condition Summary: Bipolar Disorder; Bipolar Depression; Bipolar I Depression; Bipolar II Depression

 

Last Updated: 25 Jul 2011

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Deep Brain Stimulation (DBS) for Treatment-Resistant Depression (TRD)
 

Status: Recruiting

Condition Summary: Treatment Resistant Depression; Depressive Disorder, Treatment-Resistant; Depression, Bipolar

 

Last Updated: 6 Dec 2014

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