Depression

Common Name(s)

Depression

Depression is a condition in which a person feels discouraged, sad, hopeless, unmotivated, or disinterested in life in general. When these feelings last for a short period of time, it may be a case of "the blues." But when such feelings last for more than two weeks and interfere with daily activities such as taking care of family, spending time with friends, or going to work or school, it is a major depressive episode. Other symptoms may include changes in appetite and sleeping pattern, feelings of worthlessness or guilt, inability to concentrate, inability to find pleasure in former interests, social withdrawal, irritability, anger, anxiety, indecisiveness and unexplained aches and pains. Individuals with recurrent thoughts of suicide and death should seek immediate help either by contacting a suicide help line or going to a medical emergency center.

Depression is a medical illness involving an imbalance of brain chemicals. It is not a sign of personal weakness or character flaw. The exact cause of depression is unknown at this time. However, it is believed that depression may be caused by a combination of genetics and a stressful environment or life situation. Treatment of depression may include becoming involved with support groups, medications, and attending counseling sessions. Talk to your doctor to decide on the best treatment options if you or a family member has depression. Support groups are also a good source of up to date information and can help connect you with others affected by depression. Please also see: major depression, dysthymia, bipolar disorder, and postpartum depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Depression" for support, advocacy or research.

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Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

Last Updated: 24 Jun 2015

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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

Last Updated: 15 Apr 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 6 Apr 2015

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Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

Last Updated: 15 Apr 2013

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The Balanced Mind Foundation

The Balanced Mind Foundation guides families raising children with mood disorders to the answers, support and stability they seek.

Last Updated: 18 Oct 2012

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Depression" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

http://www.adaa.org

Last Updated: 24 Jun 2015

View Details
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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

http://www.ndmda.org

Last Updated: 15 Apr 2014

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 6 Apr 2015

View Details
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Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

http://www.oklahomafamilynetwork.org

Last Updated: 15 Apr 2013

View Details
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The Balanced Mind Foundation

The Balanced Mind Foundation guides families raising children with mood disorders to the answers, support and stability they seek.

http://www.thebalancedmind.org

Last Updated: 18 Oct 2012

View Details

 

General Support Organizations

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General Resources

Depression

A brochure for individuals and families discussing symptoms, causes, treatment and recovery supports.

Updated 29 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Depression" returned 8430 free, full-text research articles on human participants. First 3 results:

Depression and circadian typology.
 

Author(s): Jelena Bielen, Anja Melada, Ivona Markelić

Journal: Psychiatr Danub. 2015 Jun;27(2):190-2.

 

The relationship between circadian disruptions and depressive disorders is a topic of great interest in contemporary psychiatry. Circadian rhythms include all physiological processes displaying a period around 24 hours. Sleep/wake cycles, body temperature, hormone secretion and other ...

Last Updated: 10 Jun 2015

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Effects of Twenty-four Move Shadow Boxing Combined with psychosomatic relaxation on Depression and Anxiety in Patients with Type-2 Diabetes.
 

Author(s): Yingying Zheng, Yiyi Zhou, Qiujia Lai

Journal: Psychiatr Danub. 2015 Jun;27(2):174-9.

 

The aim of the current study was to observe the effects of Twenty-four Move Shadow Boxing combined with psychosomatic relaxation on depression and anxiety in patients with Type-2 Diabetes.

Last Updated: 10 Jun 2015

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Depression and serum interleukin-6 levels in patients on dialysis.
 

Author(s): Boran Uglešić, Dragan Ljutić, Davor Lasić, Ivo Jeličić, Vitomir Višić, Trpimir Glavina, Željko Šundov, Željko Puljiz, Marija Žuljan Cvitanović, Ana Meter

Journal: Psychiatr Danub. 2015 Jun;27(2):168-73.

 

Depression is a common psychiatric problem in patients undergoing dialysis. Several studies have been performed to validate the association between depression and inflammation in haemodialysis patients. The levels of proinflammatory cytokines are increased in chronic renal failure ...

Last Updated: 10 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Depression" returned 1125 free, full-text review articles on human participants. First 3 results:

Intranasal drug delivery in neuropsychiatry: focus on intranasal ketamine for refractory depression.
 

Author(s): Chittaranjan Andrade

Journal: J Clin Psychiatry. 2015 May;76(5):628-31.

 

Intranasal drug delivery (INDD) systems offer a route to the brain that bypasses problems related to gastrointestinal absorption, first-pass metabolism, and the blood-brain barrier; onset of therapeutic action is rapid, and the inconvenience and discomfort of parenteral administration ...

Last Updated: 3 Jun 2015

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Depression sum-scores don't add up: why analyzing specific depression symptoms is essential.
 

Author(s): Eiko I Fried, Randolph M Nesse

Journal:

 

Most measures of depression severity are based on the number of reported symptoms, and threshold scores are often used to classify individuals as healthy or depressed. This method--and research results based on it--are valid if depression is a single condition, and all symptoms are ...

Last Updated: 17 Apr 2015

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Improving outcomes in patients with bipolar depression: a comprehensive review.
 

Author(s): Andrew A Nierenberg, Roger S McIntyre, Gary S Sachs

Journal: J Clin Psychiatry. 2015 Mar;76(3):e10.

 

Only 3 medications are currently approved in the US for acute bipolar depression: 2 atypical antipsychotics and a combination atypical antipsychotic-selective serotonin reuptake inhibitor. Metabolic, neurologic, and hormonal adverse events are associated with all of the atypical antipsychotics ...

Last Updated: 2 Apr 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Triple Chronotherapy for Perinatal Depression
 

Status: Recruiting

Condition Summary: Depression; Major Depressive Disorder; Postpartum Depression

 

Last Updated: 16 Dec 2014

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Evaluating the Efficacy of Adjunctive Minocycline for the Treatment of Bipolar Depression
 

Status: Recruiting

Condition Summary: Bipolar Disorder; Bipolar Depression; Bipolar I Depression; Bipolar II Depression

 

Last Updated: 25 Jul 2011

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Low Field Magnetic Stimulation (LFMS) in Subjects With Treatment-Resistant Depression (TRD)
 

Status: Recruiting

Condition Summary: Depression; Depressive Disorder; Depressive Disorder, Treatment-resistant; Depressive Disorder, Major

 

Last Updated: 1 Sep 2015

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