Depression

Common Name(s)

Depression

Depression is a condition in which a person feels discouraged, sad, hopeless, unmotivated, or disinterested in life in general. When these feelings last for a short period of time, it may be a case of "the blues." But when such feelings last for more than two weeks and interfere with daily activities such as taking care of family, spending time with friends, or going to work or school, it is a major depressive episode. Other symptoms may include changes in appetite and sleeping pattern, feelings of worthlessness or guilt, inability to concentrate, inability to find pleasure in former interests, social withdrawal, irritability, anger, anxiety, indecisiveness and unexplained aches and pains. Individuals with recurrent thoughts of suicide and death should seek immediate help either by contacting a suicide help line or going to a medical emergency center.

Depression is a medical illness involving an imbalance of brain chemicals. It is not a sign of personal weakness or character flaw. The exact cause of depression is unknown at this time. However, it is believed that depression may be caused by a combination of genetics and a stressful environment or life situation. Treatment of depression may include becoming involved with support groups, medications, and attending counseling sessions. Talk to your doctor to decide on the best treatment options if you or a family member has depression. Support groups are also a good source of up to date information and can help connect you with others affected by depression. Please also see: major depression, dysthymia, bipolar disorder, and postpartum depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Depression" for support, advocacy or research.

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Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

Last Updated: 15 Feb 2013

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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

Last Updated: 15 Apr 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 27 Apr 2015

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National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 6 Apr 2015

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Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

Last Updated: 15 Apr 2013

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The Balanced Mind Foundation

The Balanced Mind Foundation guides families raising children with mood disorders to the answers, support and stability they seek.

Last Updated: 18 Oct 2012

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Depression" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

http://www.adaa.org

Last Updated: 15 Feb 2013

View Details
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Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

http://www.ndmda.org

Last Updated: 15 Apr 2014

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 27 Apr 2015

View Details
National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 6 Apr 2015

View Details
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Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

http://www.oklahomafamilynetwork.org

Last Updated: 15 Apr 2013

View Details
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The Balanced Mind Foundation

The Balanced Mind Foundation guides families raising children with mood disorders to the answers, support and stability they seek.

http://www.thebalancedmind.org

Last Updated: 18 Oct 2012

View Details

 

General Support Organizations

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General Resources

Depression

A brochure for individuals and families discussing symptoms, causes, treatment and recovery supports.

Updated 29 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Depression" returned 7993 free, full-text research articles on human participants. First 3 results:

[Homocysteine and cognitive functions in bipolar depression].
 

Author(s): Agnieszka Permoda-Osip, Jacek Kisielewski, Jolanta Dorszewska, Janusz Rybakowski

Journal: Psychiatr. Pol.. ;48(6):1117-26.

 

The aim of the study was to evaluate a relationship between concentrations of hoocysteine (HCY), vitamin B12 and folic acid and disturbances of cognitive functions during acute episode of bipolar depression.

Last Updated: 26 Feb 2015

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Providing guideline-concordant assessment and monitoring for major depression in primary care.
 

Author(s): J Sloan Manning, W Clay Jackson

Journal: J Clin Psychiatry. 2015 Jan;76(1):e3.

 

Last Updated: 5 Feb 2015

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Validation of the Center for Epidemiologic Studies Depression Scale in black single mothers.
 

Author(s): Rahshida Atkins

Journal: J Nurs Meas. 2014 ;22(3):511-24.

 

The purpose of this study was to investigate the factor structure of the Center for Epidemiologic Studies Depression (CES-D) scale in a community sample of Black single mothers and to evaluate the scale's construct validity.

Last Updated: 22 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Depression" returned 1042 free, full-text review articles on human participants. First 3 results:

Treating depression in primary care: initial and follow-up treatment strategies.
 

Author(s): J Sloan Manning, W Clay Jackson

Journal: J Clin Psychiatry. 2015 Feb;76(2):e5.

 

Last Updated: 6 Mar 2015

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[Cognitive dysfunctions in depression - underestimated symptom or new dimension?].
 

Author(s): Marek Jarema, Dominika Dudek, Andrzej Czernikiewicz

Journal: Psychiatr. Pol.. ;48(6):1105-16.

 

Cognitive deficits constitute an integral part of clinical picture of depression, but often not enough attention has been paid to these deficits, mainly because of the presumption that they are secondary to typical depressive symptoms. It is considered that cognitive impairment is ...

Last Updated: 26 Feb 2015

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Managing the side effects associated with commonly used treatments for bipolar depression.
 

Author(s): David E Kemp

Journal: J Affect Disord. 2014 Dec;169 Suppl 1():S34-44.

 

The most commonly used pharmacologic therapies for bipolar depression are mood stabilizers, atypical antipsychotics, and antidepressants. This paper reviews common side effects associated with these medications and provides recommendations for managing adverse medication effects in ...

Last Updated: 23 Dec 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Triple Chronotherapy for Perinatal Depression
 

Status: Recruiting

Condition Summary: Depression; Major Depressive Disorder; Postpartum Depression

 

Last Updated: 16 Dec 2014

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Evaluating the Efficacy of Adjunctive Minocycline for the Treatment of Bipolar Depression
 

Status: Recruiting

Condition Summary: Bipolar Disorder; Bipolar Depression; Bipolar I Depression; Bipolar II Depression

 

Last Updated: 25 Jul 2011

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Deep Brain Stimulation (DBS) for Treatment-Resistant Depression (TRD)
 

Status: Recruiting

Condition Summary: Treatment Resistant Depression; Depressive Disorder, Treatment-Resistant; Depression, Bipolar

 

Last Updated: 6 Dec 2014

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