Depression

Common Name(s)

Depression

Depression is a condition in which a person feels discouraged, sad, hopeless, unmotivated, or disinterested in life in general. When these feelings last for a short period of time, it may be a case of "the blues." But when such feelings last for more than two weeks and interfere with daily activities such as taking care of family, spending time with friends, or going to work or school, it is a major depressive episode. Other symptoms may include changes in appetite and sleeping pattern, feelings of worthlessness or guilt, inability to concentrate, inability to find pleasure in former interests, social withdrawal, irritability, anger, anxiety, indecisiveness and unexplained aches and pains. Individuals with recurrent thoughts of suicide and death should seek immediate help either by contacting a suicide help line or going to a medical emergency center.

Depression is a medical illness involving an imbalance of brain chemicals. It is not a sign of personal weakness or character flaw. The exact cause of depression is unknown at this time. However, it is believed that depression may be caused by a combination of genetics and a stressful environment or life situation. Treatment of depression may include becoming involved with support groups, medications, and attending counseling sessions. Talk to your doctor to decide on the best treatment options if you or a family member has depression. Support groups are also a good source of up to date information and can help connect you with others affected by depression. Please also see: major depression, dysthymia, bipolar disorder, and postpartum depression.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Depression" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

Last Updated: 24 Jun 2015

View Details
Logo
Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

Last Updated: 15 Apr 2014

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

View Details
National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

Last Updated: 6 Apr 2015

View Details
Logo
Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

Last Updated: 15 Apr 2013

View Details
Logo
The Balanced Mind Foundation

The Balanced Mind Foundation guides families raising children with mood disorders to the answers, support and stability they seek.

Last Updated: 18 Oct 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Depression" for support, advocacy or research.

Logo
Anxiety and Depression Association of America

Our mission is to promote the prevention, treatment, and cure of anxiety, depression, and stress-related disorders through education, practice, and research.

http://www.adaa.org

Last Updated: 24 Jun 2015

View Details
Logo
Depression and Bipolar Support Alliance

The mission of DBSA is to provide hope, help, support and education to improve the lives of people who have mood disorders.

http://www.ndmda.org

Last Updated: 15 Apr 2014

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
National Alliance on Mental Illness

NAMI is the National Alliance on Mental Illness, the nation's largest grassroots mental health organization dedicated to building better lives for the millions of Americans affected by mental illness. NAMI, NAMI State Organizations and hundreds of local NAMI Affiliates advocate for access to services, treatment, supports and research and are committed to raising awareness and building a community of hope for all of those in need.

http://www.nami.org

Last Updated: 6 Apr 2015

View Details
Logo
Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

http://www.oklahomafamilynetwork.org

Last Updated: 15 Apr 2013

View Details
Logo
The Balanced Mind Foundation

The Balanced Mind Foundation guides families raising children with mood disorders to the answers, support and stability they seek.

http://www.thebalancedmind.org

Last Updated: 18 Oct 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

Depression

A brochure for individuals and families discussing symptoms, causes, treatment and recovery supports.

Updated 29 Jan 2013

Go To URL
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Depression" returned 11742 free, full-text research articles on human participants. First 3 results:

Prevalence of depression and suicidal ideation increases proportionally with renal function decline, beginning from early stages of chronic kidney disease.
 

Author(s): Jong H Jhee, Eun Lee, Min-Uk Cha, Misol Lee, Hyoungnae Kim, Seohyun Park, Hae-Ryong Yun, Su-Young Jung, Youn K Kee, Chang-Yun Yoon, Seung H Han, Tae-Hyun Yoo, Shin-Wook Kang, Jung T Park

Journal: Medicine (Baltimore). 2017 Nov;96(44):e8476.

 

Depression and suicidal ideation are prevalent mental health problems in patients with chronic kidney disease (CKD. However, the association between mental health problems and kidney disease has been investigated in severe cases only. Thus, this study evaluated the relationship between ...

Last Updated: 2 Nov 2017

Go To URL
Depression and mortality in a longitudinal study: 1952-2011.
 

Author(s): Stephen E Gilman, Ewa Sucha, Mila Kingsbury, Nicholas J Horton, Jane M Murphy, Ian Colman

Journal: CMAJ. 2017 Oct;189(42):E1304-E1310.

 

Many studies have shown that depression increases mortality risk. We aimed to investigate the duration of time over which depression is associated with increased risk of mortality, secular trends in the association between depression and mortality, and sex differences in the association ...

Last Updated: 24 Oct 2017

Go To URL
Executive dysfunction in late-life depression.
 

Author(s): Anna Rajtar-Zembaty, Andrzej Sałakowski, Jakub Rajtar-Zembaty, Anna Starowicz-Filip

Journal: Psychiatr. Pol.. 2017 Aug;51(4):705-718.

 

Nowadays there are numerous reports stressing the occurrence of cognitive functions disorders in late-life depression (LLD). More and more frequently the studies stress the role of executive dysfunctions in LLD. The purpose of the study was an evaluation of the components of executive ...

Last Updated: 7 Oct 2017

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Depression" returned 1691 free, full-text review articles on human participants. First 3 results:

A systematic review of the effectiveness of self-management interventions in people with multiple sclerosis at improving depression, anxiety and quality of life.
 

Author(s): Tara Kidd, Nicola Carey, Freda Mold, Sue Westwood, Maria Miklaucich, Emmanouela Konstantara, Annette Sterr, Debbie Cooke

Journal:

 

Self-management interventions have become increasingly popular in the management of long-term health conditions; however, little is known about their impact on psychological well-being in people with Multiple Sclerosis (MS).

Last Updated: 11 Oct 2017

Go To URL
Ketamine for Depression, 5: Potential Pharmacokinetic and Pharmacodynamic Drug Interactions.
 

Author(s): Chittaranjan Andrade

Journal: J Clin Psychiatry. 2017 Jul;78(7):e858-e861.

 

Ketamine, administered in subanesthetic doses, is gaining recognition as an off-label treatment for severe and even treatment-refractory depression. This article explores potential pharmacokinetic and pharmacodynamic drug interactions of relevance to the use of ketamine in depression. ...

Last Updated: 31 Aug 2017

Go To URL
Prevalence and factors associated with depression in people living with HIV in sub-Saharan Africa: A systematic review and meta-analysis.
 

Author(s): Charlotte Bernard, François Dabis, Nathalie de Rekeneire

Journal:

 

Depression, one of the most common psychiatric disorders, is two- to three-times more prevalent in people living with HIV (PLHIV) than in the general population in many settings as shown in western countries but remains neglected in sub-Saharan Africa (SSA). We aimed to summarize ...

Last Updated: 7 Aug 2017

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment Response of Geriatric Depression
 

Status: Recruiting

Condition Summary: Depression

 

Last Updated: 17 Feb 2017

Go to URL
A Family Depression Prevention Program
 

Status: Recruiting

Condition Summary: Depression

 

Last Updated: 7 Apr 2017

Go to URL
Inflammatory Markers and Resistant Depression
 

Status: Not yet recruiting

Condition Summary: Depression

 

Last Updated: 25 Jul 2016

Go to URL