Dengue Fever

Common Name(s)

Dengue Fever, DENGUE VIRUS, SUSCEPTIBILITY TO

Dengue virus is a flavivirus belonging to the family Flaviviridae. Its principal vector is Aedes aegypti, a highly urbanized, daytime-biting mosquito that breeds in stored water. There are 4 antigenetically variant serotypes of dengue virus, DEN-1 to DEN-4, and type-specific immunity against one serotype cannot block infection with another serotype. Disease manifestations following dengue infection range from subclinical infection to severe and fatal disease, with age, gender, genotype, immunologic status, and flavivirus infection history of the host all influencing disease severity. Primary infection is mainly associated with dengue fever (DF). Symptoms of DF typically appear 4 to 7 days after the mosquito bite and include high fever, headache, retroocular pain, conjunctival changes, and facial flushing. Although primary dengue infections are mostly recovered, a secondary infection with a different serotype of the virus leads to the complex condition of dengue hemorrhagic fever (DHF) with plasma leakage and thrombocytopenia or a more fatal condition, dengue shock syndrome (DSS). High fever, hemorrhagic phenomenon, hepatomegaly, and circulatory failure are mainly associated with DHF. Hemorrhages in DHF are seen in skin, subcutaneous tissues, heart, liver, and gastrointestinal tract. An estimated 50 to 100 million illnesses due to dengue infection occur annually, including 250,000 to 500,000 cases of DHF and 24,000 deaths. About 2.5 billion people are estimated to be at risk, particularly those living in tropical and subtropical areas of Asia and Latin America (reviews by {2:Faheem et al. (2011)}, {10:Whitehorn and Simmons (2011)}, and {3:Guzman et al. (2010)}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dengue Fever" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dengue Fever" returned 454 free, full-text research articles on human participants. First 3 results:

Are we modelling the correct dataset? Minimizing false predictions for dengue fever in Thailand.
 

Author(s): M Aguiar, R Paul, A Sakuntabhai, N Stollenwerk

Journal: Epidemiol. Infect.. 2014 Nov;142(11):2447-59.

 

Models describing dengue epidemics are parametrized on disease incidence data and therefore high-quality data are essential. For Thailand, two different sources of long-term dengue data are available, the hard copy data from 1980 to 2005, where hospital admission cases were notified, ...

Last Updated: 30 Sep 2014

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The changing incidence of dengue haemorrhagic fever in Indonesia: a 45-year registry-based analysis.
 

Author(s): Mulya Rahma Karyanti, Cuno S P M Uiterwaal, Rita Kusriastuti, Sri Rezeki Hadinegoro, Maroeska M Rovers, Hans Heesterbeek, Arno W Hoes, Patricia Bruijning-Verhagen

Journal:

 

Increases in human population size, dengue vector-density and human mobility cause rapid spread of dengue virus in Indonesia. We investigated the changes in dengue haemorrhagic fever (DHF) incidence in Indonesia over a 45-year period and determined age-specific trends in annual DHF incidence.

Last Updated: 8 Aug 2014

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Preliminary evaluation of near infrared spectroscopy as a method to detect plasma leakage in children with dengue hemorrhagic fever.
 

Author(s): Babs Soller, Anon Srikiatkachorn, Fengmei Zou, Alan L Rothman, In-Kyu Yoon, Robert V Gibbons, Siripen Kalayanarooj, Stephen J Thomas, Sharone Green

Journal:

 

Dengue viral infections are prevalent in the tropical and sub-tropical regions of the world, resulting in substantial morbidity and mortality. Clinical manifestations range from a self-limited fever to a potential life-threatening plasma leakage syndrome (dengue hemorrhagic fever). ...

Last Updated: 26 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dengue Fever" returned 30 free, full-text review articles on human participants. First 3 results:

Deconstructing "malaria": West Africa as the next front for dengue fever surveillance and control.
 

Author(s): Justin Stoler, Rawan Al Dashti, Francis Anto, Julius N Fobil, Gordon A Awandare

Journal: Acta Trop.. 2014 Jun;134():58-65.

 

Presumptive treatment of febrile illness patients for malaria remains the norm in endemic areas of West Africa, and "malaria" remains the top source of health facility outpatient visits in many West African nations. Many other febrile illnesses, including bacterial, viral, and fungal ...

Last Updated: 28 Apr 2014

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Biopsy proven acute tubular necrosis due to rhabdomyolysis in a dengue fever patient: a case report and review of literature.
 

Author(s): Liliany P Repizo, Denise M Malheiros, Luis Yu, Rui T Barros, Emmanuel A Burdmann

Journal: Rev. Inst. Med. Trop. Sao Paulo. ;56(1):85-8.

 

Renal histology results are very scarce in dengue-associated rhabdomyolysis patients developing acute kidney injury (AKI). We report a case of dengue fever-induced AKI associated to rhabdomyolysis with a renal biopsy showing acute tubular necrosis (ATN) and renal deposition of myoglobin. ...

Last Updated: 20 Feb 2014

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Is there a risk of yellow fever virus transmission in South Asian countries with hyperendemic dengue?
 

Author(s): Suneth B Agampodi, Kolitha Wickramage

Journal: Biomed Res Int. 2013 ;2013():905043.

 

The fact that yellow fever (YF) has never occurred in Asia remains an "unsolved mystery" in global health. Most countries in Asia with high Aedes aegypti mosquito density are considered "receptive" for YF transmission. Recently, health officials in Sri Lanka issued a public health ...

Last Updated: 24 Dec 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Immunologic Mechanisms of Immune Interference and/or Cross-Neutralizing Immunity After CYD Tetravalent Dengue Vaccine
 

Status: Recruiting

Condition Summary: Dengue; Dengue Fever; Dengue Hemorrhagic Fever

 

Last Updated: 18 Sep 2014

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Laboratory Diagnosis and Prognosis of Severe Dengue
 

Status: Recruiting

Condition Summary: Dengue Fever

 

Last Updated: 25 Jun 2014

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Last Updated: 9 Feb 2014

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