Dengue Fever

Common Name(s)

Dengue Fever, DENGUE VIRUS, SUSCEPTIBILITY TO

Dengue virus is a flavivirus belonging to the family Flaviviridae. Its principal vector is Aedes aegypti, a highly urbanized, daytime-biting mosquito that breeds in stored water. There are 4 antigenetically variant serotypes of dengue virus, DEN-1 to DEN-4, and type-specific immunity against one serotype cannot block infection with another serotype. Disease manifestations following dengue infection range from subclinical infection to severe and fatal disease, with age, gender, genotype, immunologic status, and flavivirus infection history of the host all influencing disease severity. Primary infection is mainly associated with dengue fever (DF). Symptoms of DF typically appear 4 to 7 days after the mosquito bite and include high fever, headache, retroocular pain, conjunctival changes, and facial flushing. Although primary dengue infections are mostly recovered, a secondary infection with a different serotype of the virus leads to the complex condition of dengue hemorrhagic fever (DHF) with plasma leakage and thrombocytopenia or a more fatal condition, dengue shock syndrome (DSS). High fever, hemorrhagic phenomenon, hepatomegaly, and circulatory failure are mainly associated with DHF. Hemorrhages in DHF are seen in skin, subcutaneous tissues, heart, liver, and gastrointestinal tract. An estimated 50 to 100 million illnesses due to dengue infection occur annually, including 250,000 to 500,000 cases of DHF and 24,000 deaths. About 2.5 billion people are estimated to be at risk, particularly those living in tropical and subtropical areas of Asia and Latin America (reviews by {2:Faheem et al. (2011)}, {10:Whitehorn and Simmons (2011)}, and {3:Guzman et al. (2010)}).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dengue Fever" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dengue Fever" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dengue Fever" returned 444 free, full-text research articles on human participants. First 3 results:

The changing incidence of dengue haemorrhagic fever in Indonesia: a 45-year registry-based analysis.
 

Author(s): Mulya Rahma Karyanti, Cuno S P M Uiterwaal, Rita Kusriastuti, Sri Rezeki Hadinegoro, Maroeska M Rovers, Hans Heesterbeek, Arno W Hoes, Patricia Bruijning-Verhagen

Journal:

 

Increases in human population size, dengue vector-density and human mobility cause rapid spread of dengue virus in Indonesia. We investigated the changes in dengue haemorrhagic fever (DHF) incidence in Indonesia over a 45-year period and determined age-specific trends in annual DHF incidence.

Last Updated: 8 Aug 2014

Go To URL
Dengue hemorrhagic fever: a rare cause of pituitary apoplexy.
 

Author(s): Sudhansu Sekhar Mishra, Souvagya Panigrahi, Srikanta Das

Journal: Neurol India. ;62(1):92-3.

 

Last Updated: 10 Mar 2014

Go To URL
Ludwig's angina after severe thrombocytopenic purpura associated with dengue fever.
 

Author(s): Maria Antonia Campos, Mário Lúcio Cerqueira Junior Prota, Carlos Augusto Gomes, Karina Peisino do Amaral, Diogo Campos Almeida

Journal: Rev. Soc. Bras. Med. Trop.. ;47(1):116-8.

 

Here, we report a case of Ludwig's angina, which required surgery because of toothache. The patient had dengue and severe thrombocytopenia as confirmed by clinical and laboratory diagnoses. However, dengue is not included among the predisposing factors for Ludwig's angina.

Last Updated: 7 Mar 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dengue Fever" returned 29 free, full-text review articles on human participants. First 3 results:

Biopsy proven acute tubular necrosis due to rhabdomyolysis in a dengue fever patient: a case report and review of literature.
 

Author(s): Liliany P Repizo, Denise M Malheiros, Luis Yu, Rui T Barros, Emmanuel A Burdmann

Journal: Rev. Inst. Med. Trop. Sao Paulo. ;56(1):85-8.

 

Renal histology results are very scarce in dengue-associated rhabdomyolysis patients developing acute kidney injury (AKI). We report a case of dengue fever-induced AKI associated to rhabdomyolysis with a renal biopsy showing acute tubular necrosis (ATN) and renal deposition of myoglobin. ...

Last Updated: 20 Feb 2014

Go To URL
Is there a risk of yellow fever virus transmission in South Asian countries with hyperendemic dengue?
 

Author(s): Suneth B Agampodi, Kolitha Wickramage

Journal: Biomed Res Int. 2013 ;2013():905043.

 

The fact that yellow fever (YF) has never occurred in Asia remains an "unsolved mystery" in global health. Most countries in Asia with high Aedes aegypti mosquito density are considered "receptive" for YF transmission. Recently, health officials in Sri Lanka issued a public health ...

Last Updated: 24 Dec 2013

Go To URL
Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome.
 

Author(s): Jih-Jin Tsai, Kulkanya Chokephaibulkit, Po-Chih Chen, Li-Teh Liu, Hui-Mien Hsiao, Yu-Chih Lo, Guey Chuen Perng

Journal:

 

Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making it an escalating global health problem of today. Dengue presents with spectrum ...

Last Updated: 16 Dec 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Immunologic Mechanisms of Immune Interference and/or Cross-Neutralizing Immunity After CYD Tetravalent Dengue Vaccine
 

Status: Recruiting

Condition Summary: Dengue; Dengue Fever; Dengue Hemorrhagic Fever

 

Last Updated: 18 Sep 2014

Go to URL
Laboratory Diagnosis and Prognosis of Severe Dengue
 

Status: Recruiting

Condition Summary: Dengue Fever

 

Last Updated: 25 Jun 2014

Go to URL

Last Updated: 9 Feb 2014

Go to URL