Dengue

Common Name(s)

Dengue, Dengue virus, susceptibility to

Dengue is a virus that is carried by mosquitos and affects over 100 million people worldwide each year. The virus is passed to humans through mosquito bites. Those who inhabit or visit tropical or sub-tropical regions, particularly in urban or suburban areas, are most at risk for infection. Symptoms of Dengue include a high fever, intense headache or aching behind the eyes, joint pain, easy bruising, gum or nose bleeds, bone and muscle pain, swollen glands, and a rash. Symptoms usually appear 4-10 days after infection and last for 2-7 days.

There are four types of dengue virus: DEN-1, DEN-2, DEN-3, and DEN-4. Once an individual has recovered from one of these types, that individual will not develop symptoms from that same type again. When an individual is infected by a different type, however, there is a risk for severe dengue. Symptoms of severe dengue include vomiting (sometimes bloody), tiredness, severe stomach pain, fast breathing, restlessness, and bleeding gums. These symptoms occur after the high fever of dengue has dropped. Severe dengue requires immediate treatment, as it can cause the liquid part of the blood (plasma) to leak from small blood vessels (capillaries). This condition leads to severe loss of blood volume (shock) and can be life-threatening. Other complications may include internal bleeding, difficulty breathing, and accumulation of fluid in the body.

Severe dengue is treated by fluid replacement therapy. Dengue prevention methods focus on avoiding mosquitos, such as by getting rid of stagnant water in containers where mosquitos lay eggs and using bed nets during the night and mosquito repellant when outdoors. If you have been diagnosed with dengue, talk to your doctor about current treatment options. In addition, consult a medical professional for advice before traveling to areas where there is a potential to be infected by the dengue virus.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dengue" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dengue" returned 3490 free, full-text research articles on human participants. First 3 results:

Detecting the impact of temperature on transmission of Zika, dengue, and chikungunya using mechanistic models.
 

Author(s): Erin A Mordecai, Jeremy M Cohen, Michelle V Evans, Prithvi Gudapati, Leah R Johnson, Catherine A Lippi, Kerri Miazgowicz, Courtney C Murdock, Jason R Rohr, Sadie J Ryan, Van Savage, Marta S Shocket, Anna Stewart Ibarra, Matthew B Thomas, Daniel P Weikel

Journal:

 

Recent epidemics of Zika, dengue, and chikungunya have heightened the need to understand the seasonal and geographic range of transmission by Aedes aegypti and Ae. albopictus mosquitoes. We use mechanistic transmission models to derive predictions for how the probability and magnitude ...

Last Updated: 27 Apr 2017

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The value of daily platelet counts for predicting dengue shock syndrome: Results from a prospective observational study of 2301 Vietnamese children with dengue.
 

Author(s): Phung Khanh Lam, Tran Van Ngoc, Truong Thi Thu Thuy, Nguyen Thi Hong Van, Tran Thi Nhu Thuy, Dong Thi Hoai Tam, Nguyen Minh Dung, Nguyen Thi Hanh Tien, Nguyen Tan Thanh Kieu, Cameron Simmons, Bridget Wills, Marcel Wolbers

Journal:

 

Dengue is the most important mosquito-borne viral infection to affect humans. Although it usually manifests as a self-limited febrile illness, complications may occur as the fever subsides. A systemic vascular leak syndrome that sometimes progresses to life-threatening hypovolaemic ...

Last Updated: 27 Apr 2017

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Serological evidence for transmission of multiple dengue virus serotypes in Papua New Guinea and West Papua prior to 1963.
 

Author(s): Dagwin Luang-Suarkia, Timo Ernst, Michael P Alpers, Ralph Garruto, David Smith, Allison Imrie

Journal:

 

Little is known about the natural history of dengue in Papua New Guinea (PNG). We assessed dengue virus (DENV)-specific neutralizing antibody profiles in serum samples collected from northern and southern coastal areas and the highland region of New Guinea between 1959 and 1963. Neutralizing ...

Last Updated: 24 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dengue" returned 269 free, full-text review articles on human participants. First 3 results:

Current Status of Dengue Therapeutics Research and Development.
 

Author(s): Jenny G H Low, Eng Eong Ooi, Subhash G Vasudevan

Journal: J. Infect. Dis.. 2017 Mar;215(suppl_2):S96-S102.

 

Dengue is a significant global health problem. Even though a vaccine against dengue is now available, which is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus serotypes remains to be definitively determined. Consequently, drugs directed ...

Last Updated: 13 Apr 2017

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Dengue infection in the nervous system: lessons learned for Zika and Chikungunya.
 

Author(s): Marzia Puccioni-Sohler, Natalia Roveroni, Carolina Rosadas, Fernando Ferry, Jose Mauro Peralta, Amilcar Tanuri

Journal: Arq Neuropsiquiatr. 2017 Feb;75(2):123-126.

 

Dengue, Zika and Chikungunya are emerging arboviruses and important causes of acute febrile disease in tropical areas. Although dengue does not represent a new condition, a geographic expansion over time has occurred with the appearance of severe neurological complications. Neglect ...

Last Updated: 22 Feb 2017

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Dengue-associated hemophagocytic lymphohistiocytosis in an adult: A case report and literature review.
 

Author(s): Sang Mi Chung, Joon Young Song, Wonshik Kim, Min Joo Choi, Ji Ho Jeon, Seonghui Kang, Eunju Jung, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim

Journal: Medicine (Baltimore). 2017 02;96(8):e6159.

 

Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand.

Last Updated: 22 Feb 2017

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 5 Apr 2017

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