Dengue

Common Name(s)

Dengue, Dengue virus, susceptibility to

Dengue is a virus that is carried by mosquitos and affects over 100 million people worldwide each year. The virus is passed to humans through mosquito bites. Those who inhabit or visit tropical or sub-tropical regions, particularly in urban or suburban areas, are most at risk for infection. Symptoms of Dengue include a high fever, intense headache or aching behind the eyes, joint pain, easy bruising, gum or nose bleeds, bone and muscle pain, swollen glands, and a rash. Symptoms usually appear 4-10 days after infection and last for 2-7 days.

There are four types of dengue virus: DEN-1, DEN-2, DEN-3, and DEN-4. Once an individual has recovered from one of these types, that individual will not develop symptoms from that same type again. When an individual is infected by a different type, however, there is a risk for severe dengue. Symptoms of severe dengue include vomiting (sometimes bloody), tiredness, severe stomach pain, fast breathing, restlessness, and bleeding gums. These symptoms occur after the high fever of dengue has dropped. Severe dengue requires immediate treatment, as it can cause the liquid part of the blood (plasma) to leak from small blood vessels (capillaries). This condition leads to severe loss of blood volume (shock) and can be life-threatening. Other complications may include internal bleeding, difficulty breathing, and accumulation of fluid in the body.

Severe dengue is treated by fluid replacement therapy. Dengue prevention methods focus on avoiding mosquitos, such as by getting rid of stagnant water in containers where mosquitos lay eggs and using bed nets during the night and mosquito repellant when outdoors. If you have been diagnosed with dengue, talk to your doctor about current treatment options. In addition, consult a medical professional for advice before traveling to areas where there is a potential to be infected by the dengue virus.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dengue" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dengue" returned 3366 free, full-text research articles on human participants. First 3 results:

Potential Harm of Prophylactic Platelet Transfusion in Adult Dengue Patients.
 

Author(s): Tau-Hong Lee, Joshua G X Wong, Yee-Sin Leo, Tun-Linn Thein, Ee-Ling Ng, Linda K Lee, David C Lye

Journal:

 

Thrombocytopenia is a hallmark of dengue infection, and bleeding is a dreaded complication of dengue fever. Prophylactic platelet transfusion has been used to prevent bleeding in the management of dengue fever, although the evidence for its benefit is lacking. In adult dengue patients ...

Last Updated: 26 Mar 2016

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Laboratory-Enhanced Dengue Sentinel Surveillance in Colombo District, Sri Lanka: 2012-2014.
 

Author(s): Hasitha Tissera, Ananda Amarasinghe, Sunethra Gunasena, Aruna Dharshan DeSilva, Leong Wei Yee, October Sessions, Chanaka Muthukuda, Paba Palihawadana, Wolfgang Lohr, Peter Byass, Duane J Gubler, Annelies Wilder-Smith

Journal:

 

Dengue has emerged as a significant public health problem in Sri Lanka. Historically surveillance was passive, with mandatory dengue notifications based on clinical diagnosis with only limited laboratory confirmation. To obtain more accurate data on the disease burden of dengue, we ...

Last Updated: 1 Mar 2016

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Metabolomics-Based Discovery of Small Molecule Biomarkers in Serum Associated with Dengue Virus Infections and Disease Outcomes.
 

Author(s): Natalia V Voge, Rushika Perera, Sebabrata Mahapatra, Lionel Gresh, Angel Balmaseda, María A Loroño-Pino, Amber S Hopf-Jannasch, John T Belisle, Eva Harris, Carol D Blair, Barry J Beaty

Journal:

 

Epidemic dengue fever (DF) and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) are overwhelming public health capacity for diagnosis and clinical care of dengue patients throughout the tropical and subtropical world. The ability to predict severe dengue disease outcomes (DHF/DSS) ...

Last Updated: 26 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dengue" returned 231 free, full-text review articles on human participants. First 3 results:

Relevance of Non-communicable Comorbidities for the Development of the Severe Forms of Dengue: A Systematic Literature Review.
 

Author(s): Joao Toledo, Leyanna George, Eric Martinez, Adhara Lazaro, Wai Wai Han, Giovanini E Coelho, Silvia Runge Ranzinger, Olaf Horstick

Journal:

 

Patients with dengue fever and comorbidities seem to be at higher risk of developing complications and/or severe dengue compared to healthier individuals. This study systematically reviews the evidence related to comorbidities and dengue. A systematic literature review was performed ...

Last Updated: 5 Jan 2016

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Tackling dengue fever: Current status and challenges.
 

Author(s): Taoufik Nedjadi, Sherif El-Kafrawy, Sayed S Sohrab, Philippe Desprès, Ghazi Damanhouri, Esam Azhar

Journal:

 

According to recent statistics, 96 million apparent dengue infections were estimated worldwide in 2010. This figure is by far greater than the WHO prediction which indicates the rapid spread of this disease posing a growing threat to the economy and a major challenge to clinicians ...

Last Updated: 9 Dec 2015

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Guillain-Barre syndrome following dengue fever and literature review.
 

Author(s): Dissanayake Mudiyanselage Priyantha Udaya Kumara Ralapanawa, Senanayake Abeysinghe Mudiyanselage Kularatne, Widana Arachilage Thilak Ananda Jayalath

Journal:

 

Dengue is an arboviral infection that classically presents with fever, joint pain, headaches, skin flush and morbilliform rashes. The incidence of neurological symptoms and complications in dengue varies from 1 to 25% that include encephalopathy, Guillain-Barre syndrome (GBS), acute ...

Last Updated: 28 Nov 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety and Immunogenicity of a Tetravalent Dengue Vaccine in HIV-Positive Adults
 

Status: Not yet recruiting

Condition Summary: Dengue Fever; Dengue Hemorrhagic Fever; Human Immunodeficiency Virus

 

Last Updated: 12 Apr 2016

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Study of a Booster Dose of a Tetravalent Dengue Vaccine in Subjects Who Previously Completed the 3-dose Schedule
 

Status: Recruiting

Condition Summary: Dengue Fever; Dengue Hemorrhagic Fever

 

Last Updated: 15 Apr 2016

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Immunogenicity and Safety of 3-Dose and Booster Dose of Tetravalent Dengue Vaccine in Healthy Subjects 9 to 50 Years of Age
 

Status: Recruiting

Condition Summary: Dengue Fever; Dengue Hemorrhagic Fever

 

Last Updated: 3 May 2016

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