Dengue Fever

Common Name(s)

Dengue Fever, DENGUE VIRUS, SUSCEPTIBILITY TO

Dengue virus is a flavivirus belonging to the family Flaviviridae. Its principal vector is Aedes aegypti, a highly urbanized, daytime-biting mosquito that breeds in stored water. There are 4 antigenetically variant serotypes of dengue virus, DEN-1 to DEN-4, and type-specific immunity against one serotype cannot block infection with another serotype. Disease manifestations following dengue infection range from subclinical infection to severe and fatal disease, with age, gender, genotype, immunologic status, and flavivirus infection history of the host all influencing disease severity. Primary infection is mainly associated with dengue fever (DF). Symptoms of DF typically appear 4 to 7 days after the mosquito bite and include high fever, headache, retroocular pain, conjunctival changes, and facial flushing. Although primary dengue infections are mostly recovered, a secondary infection with a different serotype of the virus leads to the complex condition of dengue hemorrhagic fever (DHF) with plasma leakage and thrombocytopenia or a more fatal condition, dengue shock syndrome (DSS). High fever, hemorrhagic phenomenon, hepatomegaly, and circulatory failure are mainly associated with DHF. Hemorrhages in DHF are seen in skin, subcutaneous tissues, heart, liver, and gastrointestinal tract. An estimated 50 to 100 million illnesses due to dengue infection occur annually, including 250,000 to 500,000 cases of DHF and 24,000 deaths. About 2.5 billion people are estimated to be at risk, particularly those living in tropical and subtropical areas of Asia and Latin America (reviews by {2:Faheem et al. (2011)}, {12:Whitehorn and Simmons (2011)}, and {3:Guzman et al. (2010)}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dengue Fever" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dengue Fever" returned 569 free, full-text research articles on human participants. First 3 results:

Notes from the Field: Outbreak of Locally Acquired Cases of Dengue Fever--Hawaii, 2015.
 

Author(s): David Johnston, Melissa Viray, Jenny Ushiroda, A Christian Whelen, Rebecca Sciulli, Remedios Gose, Roland Lee, Eric Honda, Sarah Y Park,

Journal:

 

On October 21, 2015, the Hawaii Department of Health (HDOH) was notified of a positive dengue immunoglobulin M (IgM) antibody result in a woman residing on Hawaii Island (also known as the Big Island). The patient had no history of travel off the island, and other family members reported ...

Last Updated: 22 Jan 2016

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Comment on "Is There a Risk of Yellow Fever Virus Transmission in South Asian Countries with Hyperendemic Dengue?".
 

Author(s): John T Cathey

Journal: Biomed Res Int. 2015 ;2015():154146.

 

Last Updated: 22 Dec 2015

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The Pattern of Adipose Tissue Accumulation during Early Infancy Provides an Environment for the Development of Dengue Hemorrhagic Fever.
 

Author(s): Daniel H Libraty, Pengyan Wang, Zhiru Guo, Venelle Bigcas, Job D Brion, Rosario Z Capeding

Journal:

 

Dengue is the most prevalent arthropod-borne viral illness in humans with half of the world's population at risk. During early infancy, severe dengue can develop after a primary dengue virus infection. There has been a clinical observation that severe dengue during the first year ...

Last Updated: 5 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dengue Fever" returned 40 free, full-text review articles on human participants. First 3 results:

[Epidemiology of dengue fever in China since 1978].
 

Author(s): Yiquan Xiong, Qing Chen

Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2014 Dec;34(12):1822-5.

 

Since 1978, dengue fever occurred endemically and epidemically every 4 to 7 years in China, affecting commonly people aged between 20 and 60 years with similar incidences in males and females. Four serotypes of dengue virus have been identified in China, with DENV-1 as the predominant ...

Last Updated: 24 Dec 2014

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Dengue fever: a Wikipedia clinical review.
 

Author(s): James M Heilman, Jacob De Wolff, Graham M Beards, Brian J Basden

Journal:

 

Dengue fever, also known as breakbone fever, is a mosquito-borne infectious tropical disease caused by the dengue virus. Symptoms include fever, headache, muscle and joint pains, and a characteristic skin rash that is similar to measles. In a small proportion of cases, the disease ...

Last Updated: 26 Nov 2014

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Dengue haemorrhagic fever presenting with cholestatic hepatitis: two case reports and a review of literature.
 

Author(s): Jevon Yudhishdran, Rayno Navinan, Asoka Ratnatilaka, Sivakumar Jeyalakshmy

Journal:

 

Dengue fever is a common mosquito borne viral fever in South Asia, which causes significant morbidity and mortality. Dengue fever is well known to involve the liver, especially in dengue hemorrhagic fever. The hepatic involvement is usually that of a mild hepatitis with transaminase ...

Last Updated: 1 Sep 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety and Immunogenicity of a Tetravalent Dengue Vaccine in HIV-Positive Adults
 

Status: Not yet recruiting

Condition Summary: Dengue Fever; Dengue Hemorrhagic Fever; Human Immunodeficiency Virus

 

Last Updated: 12 Apr 2016

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Study of a Booster Dose of a Tetravalent Dengue Vaccine in Subjects Who Previously Completed the 3-dose Schedule
 

Status: Recruiting

Condition Summary: Dengue Fever; Dengue Hemorrhagic Fever

 

Last Updated: 15 Apr 2016

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Immunogenicity and Safety of 3-Dose and Booster Dose of Tetravalent Dengue Vaccine in Healthy Subjects 9 to 50 Years of Age
 

Status: Recruiting

Condition Summary: Dengue Fever; Dengue Hemorrhagic Fever

 

Last Updated: 3 May 2016

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