Dengue Fever

Common Name(s)

Dengue Fever, DENGUE VIRUS, SUSCEPTIBILITY TO

Dengue virus is a flavivirus belonging to the family Flaviviridae. Its principal vector is Aedes aegypti, a highly urbanized, daytime-biting mosquito that breeds in stored water. There are 4 antigenetically variant serotypes of dengue virus, DEN-1 to DEN-4, and type-specific immunity against one serotype cannot block infection with another serotype. Disease manifestations following dengue infection range from subclinical infection to severe and fatal disease, with age, gender, genotype, immunologic status, and flavivirus infection history of the host all influencing disease severity. Primary infection is mainly associated with dengue fever (DF). Symptoms of DF typically appear 4 to 7 days after the mosquito bite and include high fever, headache, retroocular pain, conjunctival changes, and facial flushing. Although primary dengue infections are mostly recovered, a secondary infection with a different serotype of the virus leads to the complex condition of dengue hemorrhagic fever (DHF) with plasma leakage and thrombocytopenia or a more fatal condition, dengue shock syndrome (DSS). High fever, hemorrhagic phenomenon, hepatomegaly, and circulatory failure are mainly associated with DHF. Hemorrhages in DHF are seen in skin, subcutaneous tissues, heart, liver, and gastrointestinal tract. An estimated 50 to 100 million illnesses due to dengue infection occur annually, including 250,000 to 500,000 cases of DHF and 24,000 deaths. About 2.5 billion people are estimated to be at risk, particularly those living in tropical and subtropical areas of Asia and Latin America (reviews by {2:Faheem et al. (2011)}, {10:Whitehorn and Simmons (2011)}, and {3:Guzman et al. (2010)}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dengue Fever" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dengue Fever" returned 444 free, full-text research articles on human participants. First 3 results:

Dengue hemorrhagic fever: a rare cause of pituitary apoplexy.
 

Author(s): Sudhansu Sekhar Mishra, Souvagya Panigrahi, Srikanta Das

Journal: Neurol India. ;62(1):92-3.

 

Last Updated: 10 Mar 2014

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Ludwig's angina after severe thrombocytopenic purpura associated with dengue fever.
 

Author(s): Maria Antonia Campos, Mário Lúcio Cerqueira Junior Prota, Carlos Augusto Gomes, Karina Peisino do Amaral, Diogo Campos Almeida

Journal: Rev. Soc. Bras. Med. Trop.. ;47(1):116-8.

 

Here, we report a case of Ludwig's angina, which required surgery because of toothache. The patient had dengue and severe thrombocytopenia as confirmed by clinical and laboratory diagnoses. However, dengue is not included among the predisposing factors for Ludwig's angina.

Last Updated: 7 Mar 2014

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Dengue Fever epidemiological status and relationship with meteorological variables in Guangzhou, Southern China, 2007-2012.
 

Author(s): Tie Gang Li, Zhi Cong Yang, Lei Luo, Biao DI, Ming Wang

Journal: Biomed. Environ. Sci.. 2013 Dec;26(12):994-7.

 

Ecological methodology plus negative binomial regression were used to identify dengue fever (DF) epidemiological status and its relationship with meteorological variables. From 2007 to 2012, annual incidence rate of DF in Guangzhou was 0.33, 0.11, 0.15, 0.64, 0.45, and 1.34 (per 100 ...

Last Updated: 7 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dengue Fever" returned 27 free, full-text review articles on human participants. First 3 results:

Biopsy proven acute tubular necrosis due to rhabdomyolysis in a dengue fever patient: a case report and review of literature.
 

Author(s): Liliany P Repizo, Denise M Malheiros, Luis Yu, Rui T Barros, Emmanuel A Burdmann

Journal: Rev. Inst. Med. Trop. Sao Paulo. ;56(1):85-8.

 

Renal histology results are very scarce in dengue-associated rhabdomyolysis patients developing acute kidney injury (AKI). We report a case of dengue fever-induced AKI associated to rhabdomyolysis with a renal biopsy showing acute tubular necrosis (ATN) and renal deposition of myoglobin. ...

Last Updated: 20 Feb 2014

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Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome.
 

Author(s): Jih-Jin Tsai, Kulkanya Chokephaibulkit, Po-Chih Chen, Li-Teh Liu, Hui-Mien Hsiao, Yu-Chih Lo, Guey Chuen Perng

Journal:

 

Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making it an escalating global health problem of today. Dengue presents with spectrum ...

Last Updated: 16 Dec 2013

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The role of endothelial activation in dengue hemorrhagic fever and hantavirus pulmonary syndrome.
 

Author(s): Christina F Spiropoulou, Anon Srikiatkhachorn

Journal: Virulence. 2013 Aug;4(6):525-36.

 

The loss of the endothelium barrier and vascular leakage play a central role in the pathogenesis of hemorrhagic fever viruses. This can be caused either directly by the viral infection and damage of the vascular endothelium, or indirectly by a dysregulated immune response resulting ...

Last Updated: 27 Aug 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Immunologic Mechanisms of Immune Interference and/or Cross-Neutralizing Immunity After CYD Tetravalent Dengue Vaccine
 

Status: Recruiting

Condition Summary: Dengue; Dengue Fever; Dengue Hemorrhagic Fever

 

Last Updated: 12 Mar 2014

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Last Updated: 9 Feb 2014

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Laboratory Diagnosis and Prognosis of Severe Dengue
 

Status: Recruiting

Condition Summary: Dengue Fever

 

Last Updated: 25 Jun 2014

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