Dengue Fever

Common Name(s)

Dengue Fever, DENGUE VIRUS, SUSCEPTIBILITY TO

Dengue virus is a flavivirus belonging to the family Flaviviridae. Its principal vector is Aedes aegypti, a highly urbanized, daytime-biting mosquito that breeds in stored water. There are 4 antigenetically variant serotypes of dengue virus, DEN-1 to DEN-4, and type-specific immunity against one serotype cannot block infection with another serotype. Disease manifestations following dengue infection range from subclinical infection to severe and fatal disease, with age, gender, genotype, immunologic status, and flavivirus infection history of the host all influencing disease severity. Primary infection is mainly associated with dengue fever (DF). Symptoms of DF typically appear 4 to 7 days after the mosquito bite and include high fever, headache, retroocular pain, conjunctival changes, and facial flushing. Although primary dengue infections are mostly recovered, a secondary infection with a different serotype of the virus leads to the complex condition of dengue hemorrhagic fever (DHF) with plasma leakage and thrombocytopenia or a more fatal condition, dengue shock syndrome (DSS). High fever, hemorrhagic phenomenon, hepatomegaly, and circulatory failure are mainly associated with DHF. Hemorrhages in DHF are seen in skin, subcutaneous tissues, heart, liver, and gastrointestinal tract. An estimated 50 to 100 million illnesses due to dengue infection occur annually, including 250,000 to 500,000 cases of DHF and 24,000 deaths. About 2.5 billion people are estimated to be at risk, particularly those living in tropical and subtropical areas of Asia and Latin America (reviews by {2:Faheem et al. (2011)}, {10:Whitehorn and Simmons (2011)}, and {3:Guzman et al. (2010)}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dengue Fever" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dengue Fever" returned 499 free, full-text research articles on human participants. First 3 results:

Improved dengue fever prevention through innovative intervention methods in the city of Salto, Uruguay.
 

Author(s): César Basso, Elsa García da Rosa, Sonnia Romero, Cristina González, Rosario Lairihoy, Ingrid Roche, Ruben M Caffera, Ricardo da Rosa, Marisel Calfani, Eduardo Alfonso-Sierra, Max Petzold, Axel Kroeger, Johannes Sommerfeld

Journal: Trans. R. Soc. Trop. Med. Hyg.. 2015 Feb;109(2):134-42.

 

Uruguay is located at the southern border of Aedes aegypti distribution on the South American sub-continent. The reported dengue cases in the country are all imported from surrounding countries. One of the cities at higher risk of local dengue transmission is Salto, a border city ...

Last Updated: 21 Jan 2015

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Autochthonous dengue fever imported to England from Japan, 2014.
 

Author(s): Gotaro Kojima

Journal: Emerging Infect. Dis.. 2015 Jan;21(1):182-4.

 

Last Updated: 23 Dec 2014

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Dengue fever: a new challenge for China?
 

Author(s): Chengshen Jiang, John S Schieffelin, Jian Li, Wenjie Sun

Journal:

 

Last Updated: 20 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dengue Fever" returned 36 free, full-text review articles on human participants. First 3 results:

Dengue fever: a Wikipedia clinical review.
 

Author(s): James M Heilman, Jacob De Wolff, Graham M Beards, Brian J Basden

Journal:

 

Dengue fever, also known as breakbone fever, is a mosquito-borne infectious tropical disease caused by the dengue virus. Symptoms include fever, headache, muscle and joint pains, and a characteristic skin rash that is similar to measles. In a small proportion of cases, the disease ...

Last Updated: 26 Nov 2014

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Dengue haemorrhagic fever presenting with cholestatic hepatitis: two case reports and a review of literature.
 

Author(s): Jevon Yudhishdran, Rayno Navinan, Asoka Ratnatilaka, Sivakumar Jeyalakshmy

Journal:

 

Dengue fever is a common mosquito borne viral fever in South Asia, which causes significant morbidity and mortality. Dengue fever is well known to involve the liver, especially in dengue hemorrhagic fever. The hepatic involvement is usually that of a mild hepatitis with transaminase ...

Last Updated: 1 Sep 2014

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Predictive symptoms and signs of severe dengue disease for patients with dengue fever: a meta-analysis.
 

Author(s): H Zhang, Y P Zhou, H J Peng, X H Zhang, F Y Zhou, Z H Liu, X G Chen

Journal: Biomed Res Int. 2014 ;2014():359308.

 

The aim of the meta-analysis was to provide more solid evidence for the reliability of the new classification. A systematic literature search was performed using PubMed, Armed Forces Pest Management Board Literature Retrieval System, and Google Scholar up to August 2012. A pooled ...

Last Updated: 6 Aug 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Immunologic Mechanisms of Immune Interference and/or Cross-Neutralizing Immunity After CYD Tetravalent Dengue Vaccine
 

Status: Recruiting

Condition Summary: Dengue; Dengue Fever; Dengue Hemorrhagic Fever

 

Last Updated: 18 Mar 2015

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Last Updated: 9 Feb 2014

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Laboratory Diagnosis and Prognosis of Severe Dengue
 

Status: Recruiting

Condition Summary: Dengue Fever

 

Last Updated: 25 Jun 2014

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