Demyelinating Diseases

Common Name(s)

Demyelinating Diseases, Hypomyelination

Demyelinating diseases are conditions resulting in damage to brain or nerves, which connects the muscles to the brain to create movement. These disorders specifically affect the protective covering that surrounds nerve fibers consequently causing neurological problems. Symptoms vary according to the disease location, however seizures, headaches, delirium, confusion or slurred speech most commonly occur. Some may also experience pain, numbness, vision, hearing, or bladder problems. Diagnostic tests vary depending on the specific condition, however most demyelinating diseases can be identified from a brain scan and nerve test. No cures exist for demyelinating diseases; the goal of treatment is management of symptoms. Treatment will often include medications and occupational ot physical therapy if needed.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Demyelinating Diseases" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Demyelinating Diseases" returned 26 free, full-text research articles on human participants. First 3 results:

Seroprevalence of NMO-IgG Antibody in Neuromyelitis optica (NMO) and Its Specificity in Differentiating NMO from Other Demyelinating Diseases with Overlap Symptoms: An Iranian Experience.
 

Author(s): Mohammad Hossein Harirchian, Abbas Tafakhori, Shervin Taslimi, Vajiheh Aghamollaii, Reza Shahsiah, Taha Gholipour, Fatemezahra Mohammadi, Ameneh Zare-Shahabadi

Journal: Iran J Allergy Asthma Immunol. 2015 Feb;14(1):98-104.

 

Neuromyelitis optica is an inflammatory demyelinating disease (IDD) of the CNS, which mainly affects optic nerve and spinal cord. Autoantibodies against aquaporin-4 also known as NMO-IgG have been implicated in the pathogenesis of NMO. We evaluated the sensitivity and specificity ...

Last Updated: 22 Dec 2014

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Serum thyroid-stimulating hormone and anti-thyroglobulin antibody are independently associated with lesions in spinal cord in central nervous system demyelinating diseases.
 

Author(s): Youming Long, Yangbo Zheng, Mengyu Chen, Bin Zhang, Cong Gao, Fulan Shan, Ning Yang, Yongxiang Fan

Journal:

 

Transverse myelitis (TM) is associated with neuromyelitis optica (NMO) and multiple sclerosis (MS). Early recognition of useful parameters may be helpful to distinguish their difference. This retrospective study analyzed thyroid parameters from 243 serum samples (relapse = 128; remission ...

Last Updated: 6 Aug 2014

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Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases.
 

Author(s): Benoit Aubé, Sébastien A Lévesque, Alexandre Paré, Émilie Chamma, Hania Kébir, Roser Gorina, Marc-André Lécuyer, Jorge I Alvarez, Yves De Koninck, Britta Engelhardt, Alexandre Prat, Daniel Côté, Steve Lacroix

Journal: J. Immunol.. 2014 Sep;193(5):2438-54.

 

Disruption of the blood-brain and blood-spinal cord barriers (BBB and BSCB, respectively) and immune cell infiltration are early pathophysiological hallmarks of multiple sclerosis (MS), its animal model experimental autoimmune encephalomyelitis (EAE), and neuromyelitis optica (NMO). ...

Last Updated: 16 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Demyelinating Diseases" returned 15 free, full-text review articles on human participants. First 3 results:

Physiological Dynamics in Demyelinating Diseases: Unraveling Complex Relationships through Computer Modeling.
 

Author(s): Jay S Coggan, Stefan Bittner, Klaus M Stiefel, Sven G Meuth, Steven A Prescott

Journal:

 

Despite intense research, few treatments are available for most neurological disorders. Demyelinating diseases are no exception. This is perhaps not surprising considering the multifactorial nature of these diseases, which involve complex interactions between immune system cells, ...

Last Updated: 15 Sep 2015

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Cerebrospinal fluid analysis in the context of CNS demyelinating diseases.
 

Author(s): Sandro Luiz de Andrade Matas, Felipe von Glehn, Gustavo Bruniera Peres Fernandes, Carlos Augusto Senne Soares

Journal: Arq Neuropsiquiatr. 2013 Sep;71(9B):685-8.

 

The central nervous system demyelinating diseases are a group of disorders with different etiologies, characterized by inflammatory lesions that are associated with loss of myelin and eventually axonal damage. In this group the most studied ones are multiple sclerosis (MS), neuromyelitis ...

Last Updated: 21 Oct 2013

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Consensus Statement on medication use in multiple sclerosis by the Spanish Society of Neurology's study group for demyelinating diseases.
 

Author(s): A García-Merino, O Fernández, X Montalbán, C de Andrés, C Oreja-Guevara, A Rodríguez-Antigüedad, T Arbizu,

Journal: Neurologia. ;28(6):375-8.

 

Treatments for multiple sclerosis therapy are rapidly evolving. It is believed that new drugs will be approved in the near future, thereby changing current indications for treatment. In this context, the Spanish Society of Neurology's study group on demyelinating diseases, which evaluates ...

Last Updated: 15 Jul 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Biomarker for Metachromatic Leukodystrophy Disease
 

Status: Recruiting

Condition Summary: Leukodystrophy, Metachromatic; Hereditary Central Nervous System Demyelinating Diseases; Brain Diseases, Metabolic, Inborn; Sphingolipidoses; Lysosomal Storage Diseases, Nervous System

 

Last Updated: 1 Sep 2016

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Oligodendrocyte Progenitor Cell Culture From Human Brain
 

Status: Recruiting

Condition Summary: Demyelinating Diseases

 

Last Updated: 2 Aug 2008

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Global Demyelinating Disease Registry
 

Status: Recruiting

Condition Summary: Multiple Sclerosis

 

Last Updated: 29 Aug 2016

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