Demyelinating Diseases

Common Name(s)

Demyelinating Diseases, Hypomyelination

Demyelinating diseases are conditions resulting in damage to brain or nerves, which connects the muscles to the brain to create movement. These disorders specifically affect the protective covering that surrounds nerve fibers consequently causing neurological problems. Symptoms vary according to the disease location, however seizures, headaches, delirium, confusion or slurred speech most commonly occur. Some may also experience pain, numbness, vision, hearing, or bladder problems. Diagnostic tests vary depending on the specific condition, however most demyelinating diseases can be identified from a brain scan and nerve test. No cures exist for demyelinating diseases; the goal of treatment is management of symptoms. Treatment will often include medications and occupational ot physical therapy if needed.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Demyelinating Diseases" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Demyelinating Diseases" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Demyelinating Diseases" returned 18 free, full-text research articles on human participants. First 3 results:

Idiopathic inflammatory demyelinating diseases of the central nervous system in patients following allogeneic hematopoietic stem cell transplantation: a retrospective analysis of incidence, risk factors and survival.
 

Author(s): Xiao-Hui Zhang, Xiao-Jun Huang, Kai-Yan Liu, Lan-Ping Xu, Dai-Hong Liu, Huan Chen, Wei Han, Yu-Hong Chen, Feng-Rong Wang, Jing-Zhi Wang, Yu Wang, Ting Zhao, Yao Chen, Hai-Xia Fu, Min Wang

Journal: Chin. Med. J.. 2013 Mar;126(6):1096-102.

 

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for many hematological diseases, but there are many complications following allo-HSCT, among which neurological complications (NC) are one of the most commonly described ones. However, little is known ...

Last Updated: 19 Mar 2013

Go To URL
Visual evoked potentials in early diagnosis of demyelinating diseases--a case report of Devic's disease.
 

Author(s): Ewa Langwińska-Wośko, Kamil Szulborski, Karina Broniek-Kowalik

Journal: Med. Sci. Monit.. 2012 Oct;18(10):CS82-4.

 

Devic's disease, also known as neuromyelinitis optica (NMO), is a severe, rare demyelinating disorder, previously considered to be a form of multiple sclerosis (MS). The aim of this study was to present the case report of 21-year-old woman with a very early diagnosis of Devic's disease, ...

Last Updated: 28 Sep 2012

Go To URL
Pediatric demyelinating diseases: multiple sclerosis or not?
 

Author(s): Adi Vaknin-Dembinsky, Dimitrios Karussis

Journal: Isr. Med. Assoc. J.. 2012 Apr;14(4):251-3.

 

Last Updated: 8 Jun 2012

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Demyelinating Diseases" returned 13 free, full-text review articles on human participants. First 3 results:

Cerebrospinal fluid analysis in the context of CNS demyelinating diseases.
 

Author(s): Sandro Luiz de Andrade Matas, Felipe von Glehn, Gustavo Bruniera Peres Fernandes, Carlos Augusto Senne Soares

Journal: Arq Neuropsiquiatr. 2013 Sep;71(9B):685-8.

 

The central nervous system demyelinating diseases are a group of disorders with different etiologies, characterized by inflammatory lesions that are associated with loss of myelin and eventually axonal damage. In this group the most studied ones are multiple sclerosis (MS), neuromyelitis ...

Last Updated: 21 Oct 2013

Go To URL
Consensus Statement on medication use in multiple sclerosis by the Spanish Society of Neurology's study group for demyelinating diseases.
 

Author(s): A García-Merino, O Fernández, X Montalbán, C de Andrés, C Oreja-Guevara, A Rodríguez-Antigüedad, T Arbizu,

Journal: Neurologia. ;28(6):375-8.

 

Treatments for multiple sclerosis therapy are rapidly evolving. It is believed that new drugs will be approved in the near future, thereby changing current indications for treatment. In this context, the Spanish Society of Neurology's study group on demyelinating diseases, which evaluates ...

Last Updated: 15 Jul 2013

Go To URL
Brain connexins in demyelinating diseases: therapeutic potential of glial targets.
 

Author(s): Maria Luisa Cotrina, Maiken Nedergaard

Journal: Brain Res.. 2012 Dec;1487():61-8.

 

Several demyelinating syndromes have been linked to mutations in glial gap junction proteins, the connexins. Although mutations in connexins of the myelinating cells, Schwann cells and oligodendrocytes, were initially described, recent data have shown that astrocytes also play a major ...

Last Updated: 19 Nov 2012

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Natural History Study of Children With Metachromatic Leukodystrophy
 

Status: Recruiting

Condition Summary: Leukodystrophy, Metachromatic; Hereditary Central Nervous System Demyelinating Diseases; Brain Diseases, Metabolic, Inborn; Brain Diseases, Metabolic; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Sulfatidosis; Sphingolipidoses; Lysosomal Storage Diseases, Nervous System; Leukoencephalopathies; Demyelinating Diseases; Metabolism, Inborn Errors; Genetic Diseases, Inborn; Lipidoses; Lipid Metabolism, Inborn Errors; Lysosomal Storage Diseases; Metabolic Diseases; Lipid Metabolism Disorders

 

Last Updated: 26 Sep 2014

Go to URL
Biomarker for Metachromatic Leukodystrophy Disease
 

Status: Recruiting

Condition Summary: Leukodystrophy, Metachromatic; Hereditary Central Nervous System Demyelinating Diseases; Brain Diseases, Metabolic, Inborn; Sphingolipidoses; Lysosomal Storage Diseases, Nervous System

 

Last Updated: 7 Oct 2014

Go to URL
Autologous Mesenchymal Stem Cells From Adipose Tissue in Patients With Secondary Progressive Multiple Sclerosis
 

Status: Recruiting

Condition Summary: Autoimmune Diseases; Immune System Diseases; Demyelinating Diseases; Nervous System Diseases; Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System

 

Last Updated: 21 Sep 2010

Go to URL