Dementia

Common Name(s)

Dementia

Dementia is not a disease, but is a term that describes a loss of cognitive functioning, such as thinking, remembering, and reasoning, and behavioral abilities to the extent that it interferes with a person’s daily life. Many conditions cause dementia and symptoms may vary depending on the cause. However, common symptoms include memory loss, difficulty communicating, difficulty planning and organizing, difficulty with motor functions, personality changes, disorientation, paranoia, inability to reason and inappropriate behavior. A physician can diagnose dementias after taking into account medical history and performance on a number of tests such as cognitive and neuropsychological tests, brain scans, blood tests, and psychiatric evaluation. Most types of dementia cannot be cured, however medication and occupational therapy can be used to manage symptoms.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dementia" for support, advocacy or research.

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Alzheimer's Disease Education and Referral Center

The Alzheimer's Disease Education and Referral Center was established by the National Institute on Aging (NIA) to provide information to health professionals, patients and their families and the public about Alzheimer's disease and other memory disorders.

Last Updated: 30 Oct 2014

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 10 Dec 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dementia" for support, advocacy or research.

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Alzheimer's Disease Education and Referral Center

The Alzheimer's Disease Education and Referral Center was established by the National Institute on Aging (NIA) to provide information to health professionals, patients and their families and the public about Alzheimer's disease and other memory disorders.

http://www.nia.nih.gov/alzheimers

Last Updated: 30 Oct 2014

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 10 Dec 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dementia" returned 3892 free, full-text research articles on human participants. First 3 results:

Regulation of postsynaptic function by the dementia-related ESCRT-III subunit CHMP2B.
 

Author(s): Romain Chassefeyre, José Martínez-Hernández, Federica Bertaso, Nathalie Bouquier, Béatrice Blot, Marine Laporte, Sandrine Fraboulet, Yohann Couté, Anny Devoy, Adrian M Isaacs, Karin Pernet-Gallay, Rémy Sadoul, Laurent Fagni, Yves Goldberg

Journal: J. Neurosci.. 2015 Feb;35(7):3155-73.

 

The charged multivesicular body proteins (Chmp1-7) are an evolutionarily conserved family of cytosolic proteins that transiently assembles into helical polymers that change the curvature of cellular membrane domains. Mutations in human CHMP2B cause frontotemporal dementia, suggesting ...

Last Updated: 20 Feb 2015

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[3. Diseases of the brain 3: neurodegenerative diseases causing dementia].
 

Author(s): Yoshiyuki Nishio

Journal: Nihon Hoshasen Gijutsu Gakkai Zasshi. 2015 Jan;71(1):72-6.

 

Last Updated: 12 Feb 2015

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Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis.
 

Author(s): Jonathan D Rohrer, Jennifer M Nicholas, David M Cash, John van Swieten, Elise Dopper, Lize Jiskoot, Rick van Minkelen, Serge A Rombouts, M Jorge Cardoso, Shona Clegg, Miklos Espak, Simon Mead, David L Thomas, Enrico De Vita, Mario Masellis, Sandra E Black, Morris Freedman, Ron Keren, Bradley J MacIntosh, Ekaterina Rogaeva, David Tang-Wai, Maria Carmela Tartaglia, Robert Laforce, Fabrizio Tagliavini, Pietro Tiraboschi, Veronica Redaelli, Sara Prioni, Marina Grisoli, Barbara Borroni, Alessandro Padovani, Daniela Galimberti, Elio Scarpini, Andrea Arighi, Giorgio Fumagalli, James B Rowe, Ian Coyle-Gilchrist, Caroline Graff, Marie Fallström, Vesna Jelic, Anne Kinhult Ståhlbom, Christin Andersson, Håkan Thonberg, Lena Lilius, Giovanni B Frisoni, Michela Pievani, Martina Bocchetta, Luisa Benussi, Roberta Ghidoni, Elizabeth Finger, Sandro Sorbi, Benedetta Nacmias, Gemma Lombardi, Cristina Polito, Jason D Warren, Sebastien Ourselin, Nick C Fox, Martin N Rossor

Journal: Lancet Neurol. 2015 Mar;14(3):253-62.

 

Frontotemporal dementia is a highly heritable neurodegenerative disorder. In about a third of patients, the disease is caused by autosomal dominant genetic mutations usually in one of three genes: progranulin (GRN), microtubule-associated protein tau (MAPT), or chromosome 9 open reading ...

Last Updated: 2 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dementia" returned 561 free, full-text review articles on human participants. First 3 results:

A systematic review of intervention studies to prevent hospitalizations of community-dwelling older adults with dementia.
 

Author(s): Elizabeth A Phelan, Katrina J Debnam, Lynda A Anderson, Steven B Owens

Journal: Med Care. 2015 Feb;53(2):207-13.

 

To conduct a systematic literature review to determine if there were any intervention strategies that had any measurable effect on acute-care hospitalizations among community-dwelling adults with dementia.

Last Updated: 15 Jan 2015

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[Pharmacological and other options in preventing dementia: a literature review].
 

Author(s): Gábor Csukly, Enikő Sirály, Zoltán Hidasi, Pál Salacz, Ádám Szabó, Éva Csibri

Journal: Neuropsychopharmacol Hung. 2014 Sep;16(3):121-6.

 

At present 34 million people live with Alzheimer's disease around the world. This figure is expected to triple in the next 40 years. The major cause of this increase is the well-known aging of the society in Europe and in the US as well.

Last Updated: 28 Oct 2014

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The role of gastrostomy tube placement in advanced dementia with dysphagia: a critical review.
 

Author(s): Leanne S Goldberg, Kenneth W Altman

Journal:

 

Over 4.5 million people in North America had a diagnosis of dementia in the year 2000, and more than half had advanced disease with potential aspiration risk. There is much controversy regarding the use and timing of enteral feeding support in these patients with dysphagia. The management ...

Last Updated: 24 Oct 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluating the Effects of Music Interventions on Hospitalised People With Dementia
 

Status: Not yet recruiting

Condition Summary: Dementia; Alzheimer's Disease; Dementia, Vascular; Lewy Body Disease

 

Last Updated: 14 Mar 2007

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Young Onset Dementia - the Difficult Diagnosis and the Stressful Life for the Whole Family
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia; Alzheimer's Disease.

 

Last Updated: 24 Apr 2015

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Study of Social Behavior and Emotion in Frontotemporal Dementia, Alzheimer's Disease and Controls
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia; Frontotemporal Degeneration; Alzheimer's Disease; Social Behavior

 

Last Updated: 27 Oct 2011

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