Dementia

Common Name(s)

Dementia

Dementia is not a disease, but is a term that describes a loss of cognitive functioning, such as thinking, remembering, and reasoning, and behavioral abilities to the extent that it interferes with a person’s daily life. Many conditions cause dementia and symptoms may vary depending on the cause. However, common symptoms include memory loss, difficulty communicating, difficulty planning and organizing, difficulty with motor functions, personality changes, disorientation, paranoia, inability to reason and inappropriate behavior. A physician can diagnose dementias after taking into account medical history and performance on a number of tests such as cognitive and neuropsychological tests, brain scans, blood tests, and psychiatric evaluation. Most types of dementia cannot be cured, however medication and occupational therapy can be used to manage symptoms.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dementia" for support, advocacy or research.

Logo
Alzheimer's Disease Education and Referral Center

The Alzheimer's Disease Education and Referral Center was established by the National Institute on Aging (NIA) to provide information to health professionals, patients and their families and the public about Alzheimer's disease and other memory disorders.

Last Updated: 30 Oct 2014

View Details
Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 10 Dec 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dementia" for support, advocacy or research.

Logo
Alzheimer's Disease Education and Referral Center

The Alzheimer's Disease Education and Referral Center was established by the National Institute on Aging (NIA) to provide information to health professionals, patients and their families and the public about Alzheimer's disease and other memory disorders.

http://www.nia.nih.gov/alzheimers

Last Updated: 30 Oct 2014

View Details
Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 10 Dec 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dementia" returned 4005 free, full-text research articles on human participants. First 3 results:

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
 

Author(s): Willemijn J Jansen, Rik Ossenkoppele, Dirk L Knol, Betty M Tijms, Philip Scheltens, Frans R J Verhey, Pieter Jelle Visser, , Pauline Aalten, Dag Aarsland, Daniel Alcolea, Myriam Alexander, Ina S Almdahl, Steven E Arnold, Inês Baldeiras, Henryk Barthel, Bart N M van Berckel, Kristen Bibeau, Kaj Blennow, David J Brooks, Mark A van Buchem, Vincent Camus, Enrica Cavedo, Kewei Chen, Gael Chetelat, Ann D Cohen, Alexander Drzezga, Sebastiaan Engelborghs, Anne M Fagan, Tormod Fladby, Adam S Fleisher, Wiesje M van der Flier, Lisa Ford, Stefan Förster, Juan Fortea, Nadia Foskett, Kristian S Frederiksen, Yvonne Freund-Levi, Giovanni B Frisoni, Lutz Froelich, Tomasz Gabryelewicz, Kiran Dip Gill, Olymbia Gkatzima, Estrella Gómez-Tortosa, Mark Forrest Gordon, Timo Grimmer, Harald Hampel, Lucrezia Hausner, Sabine Hellwig, Sanna-Kaisa Herukka, Helmut Hildebrandt, Lianna Ishihara, Adrian Ivanoiu, William J Jagust, Peter Johannsen, Ramesh Kandimalla, Elisabeth Kapaki, Aleksandra Klimkowicz-Mrowiec, William E Klunk, Sebastian Köhler, Norman Koglin, Johannes Kornhuber, Milica G Kramberger, Koen Van Laere, Susan M Landau, Dong Young Lee, Mony de Leon, Viviana Lisetti, Alberto Lleó, Karine Madsen, Wolfgang Maier, Jan Marcusson, Niklas Mattsson, Alexandre de Mendonça, Olga Meulenbroek, Philipp T Meyer, Mark A Mintun, Vincent Mok, José Luis Molinuevo, Hanne M Møllergård, John C Morris, Barbara Mroczko, Stefan Van der Mussele, Duk L Na, Andrew Newberg, Agneta Nordberg, Arto Nordlund, Gerald P Novak, George P Paraskevas, Lucilla Parnetti, Gayan Perera, Oliver Peters, Julius Popp, Sudesh Prabhakar, Gil D Rabinovici, Inez H G B Ramakers, Lorena Rami, Catarina Resende de Oliveira, Juha O Rinne, Karen M Rodrigue, Eloy Rodríguez-Rodríguez, Catherine M Roe, Uros Rot, Christopher C Rowe, Eckart Rüther, Osama Sabri, Páscual Sanchez-Juan, Isabel Santana, Marie Sarazin, Johannes Schröder, Christin Schütte, Sang W Seo, Femke Soetewey, Hilkka Soininen, Luiza Spiru, Hanne Struyfs, Charlotte E Teunissen, Magda Tsolaki, Rik Vandenberghe, Marcel M Verbeek, Victor L Villemagne, Stephanie J B Vos, Linda J C van Waalwijk van Doorn, Gunhild Waldemar, Anders Wallin, Åsa K Wallin, Jens Wiltfang, David A Wolk, Marzena Zboch, Henrik Zetterberg

Journal: JAMA. 2015 May;313(19):1924-38.

 

Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.

Last Updated: 20 May 2015

Go To URL
Functional MRI of music emotion processing in frontotemporal dementia.
 

Author(s): Jennifer L Agustus, Colin J Mahoney, Laura E Downey, Rohani Omar, Miriam Cohen, Mark J White, Sophie K Scott, Laura Mancini, Jason D Warren

Journal: Ann. N. Y. Acad. Sci.. 2015 Mar;1337():232-40.

 

Frontotemporal dementia is an important neurodegenerative disorder of younger life led by profound emotional and social dysfunction. Here we used fMRI to assess brain mechanisms of music emotion processing in a cohort of patients with frontotemporal dementia (n = 15) in relation to ...

Last Updated: 16 Mar 2015

Go To URL
Regulation of postsynaptic function by the dementia-related ESCRT-III subunit CHMP2B.
 

Author(s): Romain Chassefeyre, José Martínez-Hernández, Federica Bertaso, Nathalie Bouquier, Béatrice Blot, Marine Laporte, Sandrine Fraboulet, Yohann Couté, Anny Devoy, Adrian M Isaacs, Karin Pernet-Gallay, Rémy Sadoul, Laurent Fagni, Yves Goldberg

Journal: J. Neurosci.. 2015 Feb;35(7):3155-73.

 

The charged multivesicular body proteins (Chmp1-7) are an evolutionarily conserved family of cytosolic proteins that transiently assembles into helical polymers that change the curvature of cellular membrane domains. Mutations in human CHMP2B cause frontotemporal dementia, suggesting ...

Last Updated: 20 Feb 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dementia" returned 596 free, full-text review articles on human participants. First 3 results:

Assessment and management of behavioral and psychological symptoms of dementia.
 

Author(s): Helen C Kales, Laura N Gitlin, Constantine G Lyketsos

Journal:

 

Behavioral and psychological symptoms of dementia include agitation, depression, apathy, repetitive questioning, psychosis, aggression, sleep problems, wandering, and a variety of inappropriate behaviors. One or more of these symptoms will affect nearly all people with dementia over ...

Last Updated: 3 Mar 2015

Go To URL
Persistence and adherence with dementia pharmacotherapy: relevance of patient, provider, and system factors.
 

Author(s): Colleen J Maxwell, Kathryn Stock, Dallas Seitz, Nathan Herrmann

Journal: Can J Psychiatry. 2014 Dec;59(12):624-31.

 

This paper provides a comprehensive review of studies examining adherence and (or) persistence with dementia pharmacotherapy during the past decade, including a summary of the key patient-, drug-, system-, and provider-level factors associated with these measures. Estimates of adherence ...

Last Updated: 23 Feb 2015

Go To URL
Cognitive assessments in multicultural populations using the Rowland Universal Dementia Assessment Scale: a systematic review and meta-analysis.
 

Author(s): Raza M Naqvi, Sehrish Haider, George Tomlinson, Shabbir Alibhai

Journal: CMAJ. 2015 Mar;187(5):E169-75.

 

Canada has a growing multinational immigrant population. Many commonly used cognitive assessment tools have known cultural biases and are difficult to use in ethnically diverse patient populations. The Rowland Universal Dementia Assessment Scale (RUDAS) is a cognitive assessment tool ...

Last Updated: 17 Mar 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluating the Effects of Music Interventions on Hospitalised People With Dementia
 

Status: Not yet recruiting

Condition Summary: Dementia; Alzheimer's Disease; Dementia, Vascular; Lewy Body Disease

 

Last Updated: 14 Mar 2007

Go to URL
Young Onset Dementia - the Difficult Diagnosis and the Stressful Life for the Whole Family
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia; Alzheimer's Disease.

 

Last Updated: 24 Apr 2015

Go to URL
Study of Social Behavior and Emotion in Frontotemporal Dementia, Alzheimer's Disease and Controls
 

Status: Recruiting

Condition Summary: Frontotemporal Dementia; Frontotemporal Degeneration; Alzheimer's Disease; Social Behavior

 

Last Updated: 27 Oct 2011

Go to URL