Defective Apolipoprotein B-100

Common Name(s)

Defective Apolipoprotein B-100

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Defective Apolipoprotein B-100" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Defective Apolipoprotein B-100" returned 37 free, full-text research articles on human participants. First 3 results:

Decreased bone mineral density in subjects carrying familial defective apolipoprotein B-100.
 

Author(s): Laura M Yerges-Armstrong, Haiqing Shen, Kathleen A Ryan, Elizabeth A Streeten, Alan R Shuldiner, Braxton D Mitchell

Journal: J. Clin. Endocrinol. Metab.. 2013 Dec;98(12):E1999-2005.

 

Although numerous epidemiologic studies have documented associations between osteoporosis and cardiovascular disease, the mechanisms underlying this association remain to be clarified. One hypothesis is that hyperlipidemia may be a common predisposing factor to both atherosclerotic ...

Last Updated: 6 Dec 2013

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Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish.
 

Author(s): Haiqing Shen, Coleen M Damcott, Evadnie Rampersaud, Toni I Pollin, Richard B Horenstein, Patrick F McArdle, Patricia A Peyser, Lawrence F Bielak, Wendy S Post, Yen-Pei C Chang, Kathleen A Ryan, Michael Miller, John A Rumberger, Patrick F Sheedy, John Shelton, Jeffrey R O'Connell, Alan R Shuldiner, Braxton D Mitchell

Journal: Arch. Intern. Med.. 2010 Nov;170(20):1850-5.

 

Elevated low-density lipoprotein cholesterol (LDL-C) levels are a major cardiovascular disease risk factor. Genetic factors are an important determinant of LDL-C levels.

Last Updated: 9 Nov 2010

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A double heterozygote for familial hypercholesterolaemia and familial defective apolipoprotein B-100.
 

Author(s): Alison Taylor, Graham Bayly, Kunjan Patel, Laura Yarram, Maggie Williams, Julian Hamilton-Shield, Steve E Humphries, Gail Norbury

Journal: Ann. Clin. Biochem.. 2010 Sep;47(Pt 5):487-90.

 

Autosomal dominant hypercholesterolaemia is genetically heterogeneous, but most commonly (approximately 93%) caused by mutations in low-density lipoprotein receptor (LDLR), where the disease is known as familial hypercholesterolaemia (FH), or apolipoprotein B-100 (APOB) (approximately ...

Last Updated: 6 Sep 2010

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Defective Apolipoprotein B-100" returned 3 free, full-text review articles on human participants. First 3 results:

Familial defective apolipoprotein B-100 homozygote with premature coronary atherosclerosis. A case report.
 

Author(s): A Horinek, R Ceska, J Sobra, M Vrablik

Journal: J. Intern. Med.. 1999 Aug;246(2):235-6.

 

Last Updated: 2 Sep 1999

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Last Updated: 18 Mar 1993

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Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.
 

Author(s): T L Innerarity, R W Mahley, K H Weisgraber, T P Bersot, R M Krauss, G L Vega, S M Grundy, W Friedl, J Davignon, B J McCarthy

Journal: J. Lipid Res.. 1990 Aug;31(8):1337-49.

 

Familial defective apolipoprotein B-100 is a genetic disorder of apolipoprotein B-100 that causes moderate to severe hypercholesterolemia. A single amino acid mutation in apolipoprotein B diminishes the ability of low density lipoproteins to bind to the low density lipoprotein receptor. ...

Last Updated: 13 Mar 1991

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.