Primary Addison's disease

Common Name(s)

Primary Addison's disease

Primary Addison’s disease is caused by a damaged adrenal gland. The adrenal glands are located at the top of each kidney and make certain steroid hormones. If the gland is damaged, it may not make enough cortisol and aldosterone. Cortisol helps regulate blood sugar levels, how the body makes energy and how it responds to stress and injury. Aldosterone helps maintain blood pressure by balancing potassium, salt and fluid levels. When these two hormones levels are low, symptoms include muscle weakness, weight loss, change in skin color, nausea, depression, and low blood pressure. The symptoms can begin anytime during childhood or adulthood.

There are many causes of Addison’s disease. Sometimes your own immune system attacks your adrenal gland by mistake (autoimmune disease). This can be caused by a mutation (change) to the HLA-DRB1 gene, which makes a protein called the HLA complex. The HLA complex lets the immune system know the adrenal gland is part of its own body. When the HLA complex does not work correctly, the immune system attacks and damages the adrenal gland. Addison’s disease can also be caused by other disorders including adrenoleukodystrophy (ALD). ALD is caused by a build-up of very long chain fatty acids (VLCFAs), which damages the adrenal glands. Many babies are screened for ALD at birth. For more information, visit Baby’s First Test. Infections, cancer and certain medications can also damage the adrenal gland.

Primary Addison’s disease can be confirmed by testing cortisol and aldosterone blood levels. Addison’s disease can be effectively treated with steroids and medication. If you or a family member has been diagnosed with primary Addison’s disease, talk with your doctor and specialists about the most current treatment options. Genetic counselors and support groups are also a good source of information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary Addison's disease" for support, advocacy or research.

Fight ALD

Our mission is to save the lives of our boys by bringing about awareness through education--to our community and medical professionals--about the early onset symptoms of X-ALD (Adrenoleukodystrophy), the simple diagnostic blood test, and treatments. We also have information about the adult onset, AMN (Adrenomyeloneuropathy). Our current goal is to get ALD newborn screening added to the Recommended Uniform Screening Panel (RUSP) to allow for early diagnosis and life saving interventive treatment for all at risk babies in the US.

Last Updated: 20 May 2015

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Primary Addison's disease" for support, advocacy or research.

Fight ALD

Our mission is to save the lives of our boys by bringing about awareness through education--to our community and medical professionals--about the early onset symptoms of X-ALD (Adrenoleukodystrophy), the simple diagnostic blood test, and treatments. We also have information about the adult onset, AMN (Adrenomyeloneuropathy). Our current goal is to get ALD newborn screening added to the Recommended Uniform Screening Panel (RUSP) to allow for early diagnosis and life saving interventive treatment for all at risk babies in the US.

http://www.fightald.org

Last Updated: 20 May 2015

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Primary Addison's disease" returned 2 free, full-text research articles on human participants. First 3 results:

Nocturnal hypoglycemia identified by a continuous glucose monitoring system in patients with primary adrenal insufficiency (Addison's Disease).
 

Author(s): Gesine Meyer, Annika Hackemann, Juergen Reusch, Klaus Badenhoop

Journal: Diabetes Technol. Ther.. 2012 May;14(5):386-8.

 

Hypoglycemia can be a symptom in patients with Addison's disease. The common regimen of replacement therapy with oral glucocorticoids results in unphysiological low cortisol levels in the early morning, the time of highest insulin sensitivity. Therefore patients with Addison's disease ...

Last Updated: 2 May 2012

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Addison's disease, hypertension, renal and hepatic microthrombosis in 'primary' antiphospholipid syndrome.
 

Author(s): S Inam, K Sidki, A R al-Marshedy, R Judzewitsch

Journal: Postgrad Med J. 1991 Apr;67(786):385-8.

 

We describe a 14 year old boy with antiphospholipid syndrome who initially presented at the age of 10 with recurrent loin pain, fever, weight loss, leucocytosis, thrombocytopenia, hypertension and haematuria. He had primary adrenal insufficiency with bilaterally enlarged adrenals ...

Last Updated: 15 Aug 1991

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Primary Addison's disease" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Continuous Subcutaneous Hydrocortisone Infusion In Addison`s Disease and Type 1 Diabetes
 

Status: Recruiting

Condition Summary: Addison Disease; Type 1 Diabetes

 

Last Updated: 27 Mar 2015

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Exercise Capacity and Recovery in Addison's Disease
 

Status: Not yet recruiting

Condition Summary: Addison's Disease

 

Last Updated: 2 Aug 2012

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Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal Hyperplasia
 

Status: Recruiting

Condition Summary: Addison Disease; Adrenal Hyperplasia Congenital

 

Last Updated: 27 Mar 2015

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