Deafness

Common Name(s)

Deafness, Hearing loss, Hearing impairment

Hearing loss is considered to be anything from slight to profound impairment in the ability of a person to detect frequencies and intensities of sound. It can be acquired during life (due to injury, infection, illness, exposure to very loud noises or aging) or present at birth (congenital). It can be inherited. Hearing loss can be isolated (no other symptoms) or part of a syndrome. It can be progressive (gets worse over time) or stable. Hearing loss can occur in one or both ears, and affect different areas of the ears. There are three main types of hearing loss: conductive hearing loss, sensorineural hearing loss, and mixed hearing loss.

Deafness is the most profound form of hearing loss, where an individual can hear very little. In children, deafness is defined in children whose hearing loss is greater than 90 dB, but deafness can also occur as one ages or as part of a genetic condition such as Usher’s syndrome, illness such as Meniere’s disease, or any of the other acquired causes.

Symptoms of hearing loss or deafness include delayed development of speech or unclear speech, playing music loudly or having the volume on the television turned up, and consistent need to ask for others to repeat what they said during conversation. Diagnosis depends on the age of the individual but may include a range of tests to determine the cause. Treatment depends on the cause of the hearing loss and the type of hearing loss (conductive versus sensorineural versus mixed). If you or a family member has been diagnosed with hearing loss or deafness, talk to your doctor and audiologist about the most current treatment options. Support groups are a great source of information and will help connect you with others affected by hearing loss. If the hearing loss is part of a syndrome or is inherited, talking with a genetic counselor will help you understand more about the way it may run in your family.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Deafness" for support, advocacy or research.

Usher Syndrome Coalition

The Usher Syndrome Coalition's mission is to raise awareness and accelerate research for the most common cause of combined deafness and blindness. The Coalition also provides information and support to individuals and families affected by Usher syndrome.

Last Updated: 31 Oct 2014

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BEGINNINGS For Parents of Children Who Are Deaf or Hard of Hearing, Inc.

BEGINNINGS provides emotional support and access to unbiased information to families with deaf or hard of hearing children, age birth through 21. BEGINNINGS provides an impartial approach to meeting the diverse needs of these families and the professionals who serve them. These services are also available to deaf parents who have hearing children. The mission of BEGINNINGS is to inform and empower parents as they make decisions about their child. In addition, BEGINNINGS is also committed to providing technical assistance to professionals who work with these families.

Last Updated: 27 Jul 2015

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Hands & Voices

Hands & Voices is dedicated to supporting families with children who are Deaf or Hard of Hearing without a bias around communication modes or methodology. We're a parent-driven, non-profit organization providing families with the resources, networks, and information they need to improve communication access and educational outcomes for their children. Our outreach activities, parent/professional collaboration, and advocacy efforts are focused on enabling Deaf and Hard-of-Hearing children to reach their highest potential.

Last Updated: 26 Mar 2013

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Hearing Loss Association of America

The mission of HLAA is to open the world of communication to people with hearing loss by providing information, education, support and advocacy.

Last Updated: 27 Jul 2015

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Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

Last Updated: 15 Apr 2013

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Zellweger Baby Support Network

This organization was started by a small group of parents whose lives have been affected in some way by a rare disorder. Our gift, in honor of our children, was to start this site, so we can help families and to raise awareness of these rare disorders. If your child has been diagnosed with Zellweger syndrome, a peroxisomal disorder or another rare disorder, we are here to help you. You are not alone! Our mission is to promote, advance, and improve awareness of Zellweger syndrome and other peroxisomal disorders, to assist, support, and aid, financially or otherwise, individuals and families affected by Zellweger syndrome. We will help you learn more about these disorders. We will provide emotional support, and we can help you to create a journal site for your child so that family and friends can be kept up to date on your child. We will pray with you and for you as you journey through life with your special angel. We know this is a hard time for you; you want answers, informa

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Deafness" for support, advocacy or research.

Usher Syndrome Coalition

The Usher Syndrome Coalition's mission is to raise awareness and accelerate research for the most common cause of combined deafness and blindness. The Coalition also provides information and support to individuals and families affected by Usher syndrome.

http://www.usher-syndrome.org

Last Updated: 31 Oct 2014

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BEGINNINGS For Parents of Children Who Are Deaf or Hard of Hearing, Inc.

BEGINNINGS provides emotional support and access to unbiased information to families with deaf or hard of hearing children, age birth through 21. BEGINNINGS provides an impartial approach to meeting the diverse needs of these families and the professionals who serve them. These services are also available to deaf parents who have hearing children. The mission of BEGINNINGS is to inform and empower parents as they make decisions about their child. In addition, BEGINNINGS is also committed to providing technical assistance to professionals who work with these families.

http://www.ncbegin.org

Last Updated: 27 Jul 2015

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Hands & Voices

Hands & Voices is dedicated to supporting families with children who are Deaf or Hard of Hearing without a bias around communication modes or methodology. We're a parent-driven, non-profit organization providing families with the resources, networks, and information they need to improve communication access and educational outcomes for their children. Our outreach activities, parent/professional collaboration, and advocacy efforts are focused on enabling Deaf and Hard-of-Hearing children to reach their highest potential.

http://www.handsandvoices.org

Last Updated: 26 Mar 2013

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Hearing Loss Association of America

The mission of HLAA is to open the world of communication to people with hearing loss by providing information, education, support and advocacy.

http://www.hearingloss.org

Last Updated: 27 Jul 2015

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Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

http://www.oklahomafamilynetwork.org

Last Updated: 15 Apr 2013

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Zellweger Baby Support Network

This organization was started by a small group of parents whose lives have been affected in some way by a rare disorder. Our gift, in honor of our children, was to start this site, so we can help families and to raise awareness of these rare disorders. If your child has been diagnosed with Zellweger syndrome, a peroxisomal disorder or another rare disorder, we are here to help you. You are not alone! Our mission is to promote, advance, and improve awareness of Zellweger syndrome and other peroxisomal disorders, to assist, support, and aid, financially or otherwise, individuals and families affected by Zellweger syndrome. We will help you learn more about these disorders. We will provide emotional support, and we can help you to create a journal site for your child so that family and friends can be kept up to date on your child. We will pray with you and for you as you journey through life with your special angel. We know this is a hard time for you; you want answers, informa

http://www.zbsn.org

Last Updated: 20 Feb 2013

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General Support Organizations

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General Resources

Usher Syndrome Registry

The Usher Syndrome Registry bridges the gap between researchers and patients. Building the registry is a fundamental step towards quickening the pace of discovery and ensuring access to patients as more clinical trials are launched.

Updated 31 Oct 2014

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Usher Syndrome Conference Calls

The Coalition holds monthly conference calls in which leading experts talk about the latest news and research impacting families with Usher Syndrome. Live captioning is provided. Transcripts and past presentations can be found on our website.

Updated 31 Oct 2014

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Blogs

Usher Syndrome Blog

The Usher Syndrome Blog touches on a lot of issues that Usher families face.

Updated 31 Oct 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Deafness" returned 707 free, full-text research articles on human participants. First 3 results:

Novel domain-specific POU3F4 mutations are associated with X-linked deafness: examples from different populations.
 

Author(s): Guney Bademci, Akeem Lasisi, Kemal O Yariz, Paola Montenegro, Ibis Menendez, Rodrigo Vinueza, Rosario Paredes, Germania Moreta, Asli Subasioglu, Susan Blanton, Suat Fitoz, Armagan Incesulu, Levent Sennaroglu, Mustafa Tekin

Journal:

 

Mutations in the POU3F4 gene cause X-linked deafness type 3 (DFN3), which is characterized by inner ear anomalies.

Last Updated: 1 May 2015

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Myosin VI deafness mutation prevents the initiation of processive runs on actin.
 

Author(s): Olena Pylypenko, Lin Song, Ai Shima, Zhaohui Yang, Anne M Houdusse, H Lee Sweeney

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2015 Mar;112(11):E1201-9.

 

Mutations in the reverse-direction myosin, myosin VI, are associated with deafness in humans and mice. A myosin VI deafness mutation, D179Y, which is in the transducer of the motor, uncoupled the release of the ATP hydrolysis product, inorganic phosphate (Pi), from dependency on actin ...

Last Updated: 18 Mar 2015

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Distal renal tubular acidosis with nerve deafness secondary to ATP6B1 gene mutation.
 

Author(s): Parvathina Sriram Naveen, Lokanatha Srikanth, Katari Venkatesh, Potukuchi Venkata Gurunadha Krishna Sarma, Naga Sridhar, Chennu Krishnakishore, Yanala Sandeep, Yadla Manjusha, Vishnubhotla Sivakumar

Journal: Saudi J Kidney Dis Transpl. 2015 Jan;26(1):119-21.

 

Autosomal recessive distal renal tubular acidosis (dRTA) is associated with mutation in the ATP6B1 gene encoding the B1 subunit of H + -ATPase, one of the key membrane transporters for net acid excretion of α-intercalated cells of medullary collecting ducts. Sensori-neural deafness ...

Last Updated: 12 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Deafness" returned 45 free, full-text review articles on human participants. First 3 results:

Gene therapy for deafness.
 

Author(s): D C Kohrman, Y Raphael

Journal: Gene Ther.. 2013 Dec;20(12):1119-23.

 

Hearing loss is the most common sensory deficit in humans and can result from genetic, environmental or combined etiologies that prevent normal function of the cochlea, the peripheral sensory organ. Recent advances in understanding the genetic pathways that are critical for the development ...

Last Updated: 5 Dec 2013

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Genetics of hearing and deafness.
 

Author(s): Simon Angeli, Xi Lin, Xue Zhong Liu

Journal: Anat Rec (Hoboken). 2012 Nov;295(11):1812-29.

 

This article is a review of the genes and genetic disorders that affect hearing in humans and a few selected mouse models of deafness. Genetics is playing an increasingly critical role in the practice of medicine. This is not only in part to the importance that genetic knowledge has ...

Last Updated: 23 Oct 2012

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Genetics: advances in genetic testing for deafness.
 

Author(s): A Eliot Shearer, Richard J H Smith

Journal: Curr. Opin. Pediatr.. 2012 Dec;24(6):679-86.

 

To provide an update on recently discovered human deafness genes and to describe advances in comprehensive genetic testing platforms for deafness, both of which have been enabled by new massively parallel sequencing technologies.

Last Updated: 13 Nov 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Outcomes In Children With Developmental Delay And Deafness
 

Status: Recruiting

Condition Summary: Deafness; Hearing Loss

 

Last Updated: 20 Feb 2015

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Cochlear Implantation for Treatment of Single-sided Deafness
 

Status: Not yet recruiting

Condition Summary: Total Unilateral Deafness; Unilateral Partial Deafness

 

Last Updated: 21 Aug 2015

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