Darier Disease

Common Name(s)

Darier Disease, Keratosis follicularis

Darier disease is an inherited skin condition characterized by wart-like blemishes on the body usually located on the scalp, forehead, upper arms, chest, back, knees, elbows, and behind the ear. Other features of Darier disease include nail abnormalities, such as red and white streaks in the nails with an irregular texture, and small pits in the palms of the hands and soles of the feet. The severity of the disease varies over time. A form of Darier disease known as the linear or segmental form is characterized by blemishes on localized areas of the skin.  Darier disease is not an infection and the blemishes are not contagious. Symptoms usually first appear in late childhood or early adulthood. This condition is caused by mutations in the ATP2A2 gene and inherited in an autosomal dominant fashion.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Darier Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Darier Disease" returned 20 free, full-text research articles on human participants. First 3 results:

Improvement of Darier disease with diclofenac sodium 3% gel.
 

Author(s): Fernando Millán-Parrilla, Beatriz Rodrigo-Nicolás, Paula Molés-Poveda, Miquel Armengot-Carbó, Esther Quecedo-Estébanez, Enrique Gimeno-Carpio

Journal: J. Am. Acad. Dermatol.. 2014 Apr;70(4):e89-90.

 

Last Updated: 17 Mar 2014

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Darier-white disease.
 

Author(s): Nirupama Parwanda, Neeti Kumari, Praveen Bhardwaj

Journal: Indian Pediatr. 2013 Jul;50(7):717-8.

 

Last Updated: 14 Aug 2013

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Darier disease with oral and esophageal involvement: a case report.
 

Author(s): Magesh Karuppur Thiagarajan, Malathi Narasimhan, Anandan Sankarasubramanian

Journal: Indian J Dent Res. ;22(6):843-6.

 

A 58-year-old man presented with itchy papular eruptions all over the body since 15 years. Intraoral examination revealed raised papular lesions on the labial mucosa, hard palate, and tongue. The histopathology of the oral and skin lesions was confirmative of Darier disease (DD). ...

Last Updated: 9 Apr 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Darier Disease" returned 1 free, full-text review articles on human participants. First 3 results:

Darier disease : a disease model of impaired calcium homeostasis in the skin.
 

Author(s): Magali Savignac, Anissa Edir, Marina Simon, Alain Hovnanian

Journal: Biochim. Biophys. Acta. 2011 May;1813(5):1111-7.

 

The importance of extracellular calcium in epidermal differentiation and intra-epidermal cohesion has been recognized for many years. Darier disease (DD) was the first genetic skin disease caused by abnormal epidermal calcium homeostasis to be identified. DD is characterized by loss ...

Last Updated: 18 Apr 2011

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.