Acute Promyelocytic Leukemia

Common Name(s)

Acute Promyelocytic Leukemia

Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by a translocation of chromosomes 15 and 17. Acute promyelocytic leukemia usually occurs in middle-aged adults. Symptoms may include both bleeding and forming blood clots.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Promyelocytic Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Promyelocytic Leukemia" returned 658 free, full-text research articles on human participants. First 3 results:

Late onset post-transfusion hepatitis E developing during chemotherapy for acute promyelocytic leukemia.
 

Author(s): Kyoko Fuse, Yuichi Matsuyama, Masato Moriyama, Shukuko Miyakoshi, Yasuhiko Shibasaki, Jun Takizawa, Tatsuo Furukawa, Ichiro Fuse, Hiro Matsumura, Shigeharu Uchida, Yoshifumi Takahashi, Kenya Kamimura, Hiroyuki Abe, Takeshi Suda, Yutaka Aoyagi, Hirohito Sone, Masayoshi Masuko

Journal: Intern. Med.. 2015 ;54(6):657-61.

 

We herein report the case of a leukemia patient who developed hepatitis E seven months after undergoing a transfusion with contaminated blood products. The latency period in this case was significantly longer than that of typical hepatitis E. Recently, chronic infection with hepatitis ...

Last Updated: 19 Mar 2015

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Outpatient oral treatment for acute promyelocytic leukemia.
 

Author(s): Francesco Lo-Coco, Laura Cicconi

Journal: N. Engl. J. Med.. 2015 Feb;372(9):885.

 

Last Updated: 26 Feb 2015

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Possible benefit of consolidation therapy with high-dose cytarabine on overall survival of adults with non-promyelocytic acute myeloid leukemia.
 

Author(s): M C Azevedo, E D R P Velloso, V Buccheri, D A F Chamone, P E Dorlhiac-Llacer

Journal: Braz. J. Med. Biol. Res.. 2015 Feb;48(2):178-85.

 

In adults with non-promyelocytic acute myeloid leukemia (AML), high-dose cytarabine consolidation therapy has been shown to influence survival in selected patients, although the appropriate doses and schemes have not been defined. We evaluated survival after calculating the actual ...

Last Updated: 5 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Promyelocytic Leukemia" returned 65 free, full-text review articles on human participants. First 3 results:

Rare presentation of pediatric acute promyelocytic leukemia as multiple lytic bone lesions: case report and review of literature.
 

Author(s): Manjusha Nair, P Kusumakumary, P Sindhu Nair

Journal: J Cancer Res Ther. ;10(2):381-3.

 

Acute promyelocytic leukemia (APL) is an uncommon malignancy in the pediatric population, accounting for only 5-10% of pediatric acute myeloid leukemias, and for this disease to present with bone lesions at diagnosis is extremely unusual. We wish to convey that very rarely, in a pediatric ...

Last Updated: 15 Jul 2014

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Retinoid receptor signaling and autophagy in acute promyelocytic leukemia.
 

Author(s): Nina Orfali, Sharon L McKenna, Mary R Cahill, Lorraine J Gudas, Nigel P Mongan

Journal: Exp. Cell Res.. 2014 May;324(1):1-12.

 

Retinoids are a family of signaling molecules derived from vitamin A with well established roles in cellular differentiation. Physiologically active retinoids mediate transcriptional effects on cells through interactions with retinoic acid (RARs) and retinoid-X (RXR) receptors. Chromosomal ...

Last Updated: 28 Apr 2014

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How we prevent and treat differentiation syndrome in patients with acute promyelocytic leukemia.
 

Author(s): Miguel A Sanz, Pau Montesinos

Journal: Blood. 2014 May;123(18):2777-82.

 

Differentiation syndrome (DS), formerly known as retinoic acid syndrome, is a relatively common and potentially severe complication seen in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and/or arsenic trioxide. The full-blown syndrome consists of ...

Last Updated: 5 May 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment Protocol for Relapsed Acute Promyelocytic Leukemia (APL) With Arsenic
 

Status: Recruiting

Condition Summary: Relapsed Acute Promyelocytic Leukemia; Refractory Acute Promyelocytic Leukemia

 

Last Updated: 22 Oct 2007

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Gemtuzumab Ozogamicin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Acute Promyelocytic Leukemia
 

Status: Recruiting

Condition Summary: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Promyelocytic Leukemia (M3); Childhood Acute Promyelocytic Leukemia (M3); Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Myeloid Leukemia

 

Last Updated: 27 Jul 2015

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Study of NRX 195183 Therapy for Patients With Relapsed or Refractory Acute Promyelocytic Leukemia
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 9 May 2008

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