Acute Promyelocytic Leukemia

Common Name(s)

Acute Promyelocytic Leukemia

Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by a translocation of chromosomes 15 and 17. Acute promyelocytic leukemia usually occurs in middle-aged adults. Symptoms may include both bleeding and forming blood clots.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Promyelocytic Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Promyelocytic Leukemia" returned 653 free, full-text research articles on human participants. First 3 results:

Resistance to arsenic therapy in acute promyelocytic leukemia.
 

Author(s): Hong-Hu Zhu, Ya-Zhen Qin, Xiao-Jun Huang

Journal: N. Engl. J. Med.. 2014 May;370(19):1864-6.

 

Last Updated: 8 May 2014

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A case of therapy-related acute myeloid leukemia with a normal karyotype after sustained molecular complete remission of acute promyelocytic leukemia.
 

Author(s): Sang Hyuk Park, Hyun-Sook Chi, Young-Uk Cho, Seongsoo Jang, Chan-Jeoung Park, Je-Hwan Lee

Journal: Ann Lab Med. 2014 Jan;34(1):68-70.

 

Last Updated: 14 Jan 2014

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FLT3-ITD confers poor prognosis in patients with acute promyelocytic leukemia treated with AIDA protocols: long-term follow-up analysis.
 

Author(s): Massimo Breccia, Giuseppina Loglisci, Maria Giovanna Loglisci, Roberto Ricci, Daniela Diverio, Roberto Latagliata, Robin FoĆ , Francesco Lo-Coco

Journal: Haematologica. 2013 Dec;98(12):e161-3.

 

Last Updated: 10 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Promyelocytic Leukemia" returned 65 free, full-text review articles on human participants. First 3 results:

Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia.
 

Author(s): Guilherme Augusto Dos Santos, Lev Kats, Pier Paolo Pandolfi

Journal: J. Exp. Med.. 2013 Dec;210(13):2793-802.

 

Acute promyelocytic leukemia (APL) is a hematological malignancy driven by a chimeric oncoprotein containing the C terminus of the retinoic acid receptor-a (RARa) fused to an N-terminal partner, most commonly promyelocytic leukemia protein (PML). Mechanistically, PML-RARa acts as ...

Last Updated: 17 Dec 2013

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Management of elderly patients with acute promyelocytic leukemia: progress and problems.
 

Author(s): Eva Lengfelder, Wolf-Karsten Hofmann, Florian Nolte

Journal: Ann. Hematol.. 2013 Sep;92(9):1181-8.

 

Despite substantial progress in the management and outcome of acute promyelocytic leukemia (APL) during the last decades, older age remains a prominent negative prognostic factor. The improvement of long-term stabilization and cure of older APL patients is therefore a particular challenge. ...

Last Updated: 6 Aug 2013

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[Thrombosis of the cerebral veins and sinuses in acute promyelocytic leukemia after all-trans retinoic acid treatment: a case report and literature review].
 

Author(s): Lu-xi Song, Li-yu Zhou, Xiao Li

Journal: Zhonghua Xue Ye Xue Za Zhi. 2012 Nov;33(11):948-50.

 

Last Updated: 31 Jan 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment Protocol for Relapsed Acute Promyelocytic Leukemia (APL) With Arsenic
 

Status: Recruiting

Condition Summary: Relapsed Acute Promyelocytic Leukemia; Refractory Acute Promyelocytic Leukemia

 

Last Updated: 22 Oct 2007

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Gemtuzumab Ozogamicin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Acute Promyelocytic Leukemia
 

Status: Recruiting

Condition Summary: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Promyelocytic Leukemia (M3); Childhood Acute Promyelocytic Leukemia (M3); Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Myeloid Leukemia

 

Last Updated: 18 Aug 2014

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Study of NRX 195183 Therapy for Patients With Relapsed or Refractory Acute Promyelocytic Leukemia
 

Status: Recruiting

Condition Summary: Acute Promyelocytic Leukemia

 

Last Updated: 9 May 2008

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