Acute Promyelocytic Leukemia

Common Name(s)

Acute Promyelocytic Leukemia

Acute promyelocytic leukemia is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by a translocation of chromosomes 15 and 17. Acute promyelocytic leukemia usually occurs in middle-aged adults. Symptoms may include both bleeding and forming blood clots.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Promyelocytic Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Promyelocytic Leukemia" returned 652 free, full-text research articles on human participants. First 3 results:

Outpatient oral treatment for acute promyelocytic leukemia.
 

Author(s): Francesco Lo-Coco, Laura Cicconi

Journal: N. Engl. J. Med.. 2015 Feb;372(9):885.

 

Last Updated: 26 Feb 2015

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Oral arsenic and retinoic acid for non-high-risk acute promyelocytic leukemia.
 

Author(s): Hong-Hu Zhu, Xiao-Jun Huang

Journal: N. Engl. J. Med.. 2014 Dec;371(23):2239-41.

 

Last Updated: 4 Dec 2014

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Catechins induced acute promyelocytic leukemia cell apoptosis and triggered PML-RARĪ± oncoprotein degradation.
 

Author(s): Li Zhang, Qiu-Sheng Chen, Peng-Peng Xu, Ying Qian, Ai-Hua Wang, Dan Xiao, Yan Zhao, Yan Sheng, Xiang-Qin Wen, Wei-Li Zhao

Journal:

 

It has recently been reported that the extracts of green tea polyphenol have cancer preventive effects. In this study, we investigated the effect of the natural composition from green tea leaves Catechins on acute promyelocytic leukemia (APL).

Last Updated: 4 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Promyelocytic Leukemia" returned 65 free, full-text review articles on human participants. First 3 results:

Rare presentation of pediatric acute promyelocytic leukemia as multiple lytic bone lesions: case report and review of literature.
 

Author(s): Manjusha Nair, P Kusumakumary, P Sindhu Nair

Journal: J Cancer Res Ther. ;10(2):381-3.

 

Acute promyelocytic leukemia (APL) is an uncommon malignancy in the pediatric population, accounting for only 5-10% of pediatric acute myeloid leukemias, and for this disease to present with bone lesions at diagnosis is extremely unusual. We wish to convey that very rarely, in a pediatric ...

Last Updated: 15 Jul 2014

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Retinoid receptor signaling and autophagy in acute promyelocytic leukemia.
 

Author(s): Nina Orfali, Sharon L McKenna, Mary R Cahill, Lorraine J Gudas, Nigel P Mongan

Journal: Exp. Cell Res.. 2014 May;324(1):1-12.

 

Retinoids are a family of signaling molecules derived from vitamin A with well established roles in cellular differentiation. Physiologically active retinoids mediate transcriptional effects on cells through interactions with retinoic acid (RARs) and retinoid-X (RXR) receptors. Chromosomal ...

Last Updated: 28 Apr 2014

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How we prevent and treat differentiation syndrome in patients with acute promyelocytic leukemia.
 

Author(s): Miguel A Sanz, Pau Montesinos

Journal: Blood. 2014 May;123(18):2777-82.

 

Differentiation syndrome (DS), formerly known as retinoic acid syndrome, is a relatively common and potentially severe complication seen in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and/or arsenic trioxide. The full-blown syndrome consists of ...

Last Updated: 5 May 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment Protocol for Relapsed Acute Promyelocytic Leukemia (APL) With Arsenic
 

Status: Recruiting

Condition Summary: Relapsed Acute Promyelocytic Leukemia; Refractory Acute Promyelocytic Leukemia

 

Last Updated: 22 Oct 2007

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Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia
 

Status: Not yet recruiting

Condition Summary: Adult Acute Myeloid Leukemia; Adult Acute Promyelocytic Leukemia; Childhood Acute Promyelocytic Leukemia; Myeloid Malignancies

 

Last Updated: 14 Jan 2015

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Gemtuzumab Ozogamicin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Acute Promyelocytic Leukemia
 

Status: Recruiting

Condition Summary: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Promyelocytic Leukemia (M3); Childhood Acute Promyelocytic Leukemia (M3); Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Myeloid Leukemia

 

Last Updated: 18 Aug 2014

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