Cyclic Neutropenia

Common Name(s)

Cyclic Neutropenia, Cyclic Hematopoiesis

Cyclic neutropenia is a rare blood disorder characterized by recurrent episodes of abnormally low levels of neutrophils (a type of white blood cell) in the body. Neutrophils are instrumental in fighting off infection by surrounding and destroying bacteria that enter the body. Symptoms of cyclic neutropenia may include fever, a general feeling of ill health, and/or sores (ulcers) of the mucous membranes of the mouth. Individuals with low levels of neutrophils (neutropenia) are highly susceptible to recurrent infections. Cyclic neutropenia may be inherited or acquired. Some cases are present at birth and appear to occur randomly for no apparent reason (sporadic). Inherited cases appear to be transmitted in an autosomal dominant fashion and caused by mutations in the ELANE gene.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cyclic Neutropenia" for support, advocacy or research.

National Neutropenia Network Inc.

To promote awareness, education, and research, and to provide a support system for patients with severe chronic neutropenia and their families through a national resource network.

Last Updated: 29 Apr 2014

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cyclic Neutropenia" for support, advocacy or research.

National Neutropenia Network Inc.

To promote awareness, education, and research, and to provide a support system for patients with severe chronic neutropenia and their families through a national resource network.

http://www.neutropenianet.org/

Last Updated: 29 Apr 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cyclic Neutropenia" returned 43 free, full-text research articles on human participants. First 3 results:

Cyclic neutropenia with a novel gene mutation presenting with a necrotizing soft tissue infection and severe sepsis: case report.
 

Author(s): Yoon Jung Boo, Myung Hyun Nam, Eun Hee Lee, Kuang Chul Lee

Journal:

 

Cyclic neutropenia is a rare disease. We report a 31-month-old girl with congenital cyclic neutropenia with a novel mutation in the ELANE gene who developed an acute necrotizing soft-tissue infection on her left axillary legion.

Last Updated: 17 Apr 2015

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A case of cyclic neutropenia in adults.
 

Author(s): Muhammad Sohail Mansoor, Muhammad Bilal Salman Khan

Journal: J Pak Med Assoc. 2012 Mar;62(3):289-90.

 

A 22 years old patient presented with recurrent episodes of diarrhoea, pharyngitis, apthous ulcers and fever for the past 6 months. The episodes lasted a week each time. The patient was admitted and blood studies revealed neutropenia with increased number of Large Granular Lymphocytes. ...

Last Updated: 5 Jul 2012

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Severe periodontitis in a patient with cyclic neutropenia: a case report of long-term follow-up.
 

Author(s): Rui Fang Lu, Huan Xin Meng

Journal: Chin J Dent Res. 2012 ;15(2):159-63.

 

Cyclic neutropenia is a rare haematologic disorder. This case report presents a 6-year-old girl who was referred in order to treat gingival recession, and was finally diagnosed as having cyclic neutropenia based on an oral examination, complete blood counts and a sternal puncture ...

Last Updated: 19 Mar 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cyclic Neutropenia" returned 3 free, full-text review articles on human participants. First 3 results:

ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology.
 

Author(s): Marshall S Horwitz, Seth J Corey, H Leighton Grimes, Timothy Tidwell

Journal: Hematol. Oncol. Clin. North Am.. 2013 Feb;27(1):19-41, vii.

 

The 2 main forms of hereditary neutropenia are cyclic (CN) and severe congenital (SCN) neutropenia. CN is an autosomal dominant disorder in which neutrophil counts fluctuate with 21-day periodicity. SCN consists of static neutropenia, with promyelocytic maturation arrest in the bone ...

Last Updated: 28 Jan 2013

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Neutrophil elastase in cyclic and severe congenital neutropenia.
 

Author(s): Marshall S Horwitz, Zhijun Duan, Brice Korkmaz, Hu-Hui Lee, Matthew E Mealiffe, Stephen J Salipante

Journal: Blood. 2007 Mar;109(5):1817-24.

 

Mutations in ELA2 encoding the neutrophil granule protease, neutrophil elastase (NE), are the major cause of the 2 main forms of hereditary neutropenia, cyclic neutropenia and severe congenital neutropenia (SCN). Genetic evaluation of other forms of neutropenia in humans and model ...

Last Updated: 21 Feb 2007

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A patient with cyclic neutropenia complicated by severe persistent neutropenia successfully delivered a healthy baby.
 

Author(s): T Abe, H Azuma, A Watanabe, T Shigekiyo, S Endou, R Pou, R Fukui, K Maeda, T Aono, T Matsumoto

Journal: Intern. Med.. 2000 Aug;39(8):663-6.

 

We describe a 24-year-old pregnant woman complicated by cyclic neutropenia (CN), who was successfully treated with granulocyte-colony stimulating factor (G-CSF). Her white blood cell (WBC) and neutrophil count fluctuated from 2,600 to 4,600/microl, and 26 to 2,530/microl, respectively. ...

Last Updated: 21 Nov 2000

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Profiling Granulocyte Counts in Patients on Chemotherapy
 

Status: Not yet recruiting

Condition Summary: Neoplasms; Neutropenia; Febrile Neutropenia

 

Last Updated: 15 Jun 2016

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Safety and Efficacy of YPEG-rhG-CSF in Cancer Patients Receiving Chemotherapy
 

Status: Recruiting

Condition Summary: Non Small Cell Lung Cancer; Breast Cancer

 

Last Updated: 20 Jun 2016

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