Cutis Laxa

Common Name(s)

Cutis Laxa

Cutis laxa is a connective tissue disorder characterized by skin that is sagging and not stretchy. The skin often hangs in loose folds, causing the face and other parts of the body to have a droopy appearance. Cutis laxa can also affect connective tissue in other parts of the body, including the heart, blood vessels, joints, intestines, and lungs. Depending on which organs and tissues are affected, the signs and symptoms can range from mild to life-threatening.
 
There are several different forms of cutis laxa, which are distinguished by their pattern of inheritance: autosomal dominant, autosomal recessive, or X-linked. In general, the autosomal recessive forms tend to be more severe than the autosomal dominant form. The X-linked form of cutis laxa is often called occipital horn syndrome. Click on the links below to view information about the different types of cutis laxa.

Cutis laxa, autosomal dominant
Cutis laxa, autosomal recessive type 1
Cutis laxa, autosomal recessive type 2A
Cutis laxa, autosomal recessive type 2B
Occipital horn syndrome
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutis Laxa" for support, advocacy or research.

Cutis Laxa Internationale

Our mission is to break the sufferers' loneliness and isolation, to support research and to disseminate information on Cutis Laxa by all means.

Last Updated: 3 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutis Laxa" for support, advocacy or research.

Cutis Laxa Internationale

Our mission is to break the sufferers' loneliness and isolation, to support research and to disseminate information on Cutis Laxa by all means.

http://asso.orpha.net/cutislax/gb01-cutis_laxa_homepage.htm

Last Updated: 3 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cutis Laxa" returned 68 free, full-text research articles on human participants. First 3 results:

Acral localized acquired cutis laxa: report of a case associated with inflammatory arthritis.
 

Author(s): Tess Peters, Cheryl Barnabe, Wedad Hanna, Duane Barber, Richard M Haber

Journal: J. Am. Acad. Dermatol.. 2015 Jan;72(1):e38-40.

 

Last Updated: 16 Dec 2014

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Acquired cutis laxa of face with multiple myeloma.
 

Author(s): Tulika A Yadav, Atul M Dongre, Uday S Khopkar

Journal: Indian J Dermatol Venereol Leprol. ;80(5):454-6.

 

Last Updated: 9 Sep 2014

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Biomechanical properties of the skin in cutis laxa.
 

Author(s): Beth A Kozel, Chi-Ting Su, Joshua R Danback, Ryan L Minster, Suneeta Madan-Khetarpal, Juliann S McConnell, Meghan K Mac Neal, Kara L Levine, Robert C Wilson, Frank C Sciurba, Zsolt Urban

Journal: J. Invest. Dermatol.. 2014 Nov;134(11):2836-8.

 

Last Updated: 16 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cutis Laxa" returned 8 free, full-text review articles on human participants. First 3 results:

[Acquired cutis laxa associated with monoclonal gammopathy and lambda light chain deposition disease].
 

Author(s): Antonio J Gonzalez-Rodriguez, Rebeca Bella-Navarro, Dolores Ramon Quiles, Esperanza Jorda-Cuevas

Journal:

 

Cutis laxa is a rare entity characterized clinically by redundant skin that gives an appearance of premature aging. The appearance relates to a loss of elasticity because of the destruction of elastic fibers that affects the skin and other organs. It may be associated with inflammatory ...

Last Updated: 23 May 2014

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Cutis laxa: intersection of elastic fiber biogenesis, TGFβ signaling, the secretory pathway and metabolism.
 

Author(s): Zsolt Urban, Elaine C Davis

Journal: Matrix Biol.. 2014 Jan;33():16-22.

 

Cutis laxa (CL), a disease characterized by redundant and inelastic skin, displays extensive locus heterogeneity. Together with geroderma osteodysplasticum and arterial tortuosity syndrome, which show phenotypic overlap with CL, eleven CL-related genes have been identified to date, ...

Last Updated: 24 Feb 2014

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Last Updated: 16 Nov 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Effect of Eyelid Surgery on Dry Eye - a Prospective Study
 

Status: Not yet recruiting

Condition Summary: Dry Eye Syndrome; Ptosis; Dermatochalasis

 

Last Updated: 14 Jun 2015

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Retrospective Evaluation of Combination Treatment With the Ulthera System
 

Status: Recruiting

Condition Summary: Skin Laxity

 

Last Updated: 11 May 2015

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Gene Expression Following Ultherapy® Treatment
 

Status: Recruiting

Condition Summary: Skin Laxity

 

Last Updated: 7 May 2015

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