Cutaneous T-cell lymphoma

Common Name(s)

Cutaneous T-cell lymphoma

Cutaneous T-cell lymphomas (CTCLs) are a group of disorders characterized by an abnormal accumulation of cancerous T-cells (a type of white blood cells) in the skin resulting in an itchy, red rash that can thicken or form a tumor. CTCLs belong to a larger group of disorders known asnon-Hodgkin's lymphomas. The most common types are mycosis fungoides and SŽzary syndrome. In some cases, cancerous T-cells may spread to the lymph nodes and eventually to other body tissues and organs, potentially resulting in life-threatening complications. The specific signs and symptoms vary from person to person. The exact cause of these conditions is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous T-cell lymphoma" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

Last Updated: 6 Jan 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous T-cell lymphoma" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

http://www.clfoundation.org

Last Updated: 6 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cutaneous T-cell lymphoma" returned 294 free, full-text research articles on human participants. First 3 results:

Rapid deterioration in a patient with primary aggressive cutaneous epidermotropic CD8+ cytotoxic T-cell ('Berti') lymphoma after administration of adalimumab.
 

Author(s): Sarah M Jacks, Brent R Taylor, Raford P Rogers, Jonathan S Ralston, John S Metcalf, John Lazarchick

Journal: J. Am. Acad. Dermatol.. 2014 Sep;71(3):e86-7.

 

Last Updated: 16 Aug 2014

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B-lymphoid tyrosine kinase (Blk) is an oncogene and a potential target for therapy with dasatinib in cutaneous T-cell lymphoma (CTCL).
 

Author(s): D L Petersen, T Krejsgaard, J Berthelsen, S Fredholm, A Willerslev-Olsen, N A Sibbesen, C M Bonefeld, M H Andersen, C Francavilla, J V Olsen, T Hu, M Zhang, M A Wasik, C Geisler, A Woetmann, N Odum

Journal: Leukemia. 2014 Oct;28(10):2109-12.

 

Last Updated: 8 Oct 2014

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Primary cutaneous T cell lymphoma with bone marrow infiltration and erythroblastopenia--a rare association.
 

Author(s): Sreejesh Sreedharanunni, Man Updesh Singh Sachdeva, Bishan Radotra, Anusree Prabhakaran, Gaurav Prakash

Journal: Hematol Oncol Stem Cell Ther. 2014 Jun;7(2):99-101.

 

Last Updated: 9 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cutaneous T-cell lymphoma" returned 30 free, full-text review articles on human participants. First 3 results:

Novel biomarkers, dysregulated epigenetics, and therapy in cutaneous T-cell lymphoma.
 

Author(s): Henry K Wong

Journal: Discov Med. 2013 Sep;16(87):71-8.

 

Cutaneous T cell lymphomas (CTCL) are a diverse group of lymphoid malignancies that develop in the skin. The most common variants are mycosis fungoides (MF) and Sezary syndrome (SS). These skin lymphomas can be challenging to differentiate from non-malignant inflammatory skin disorders ...

Last Updated: 3 Sep 2013

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Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma.
 

Author(s): Andreas Willerslev-Olsen, Thorbjørn Krejsgaard, Lise M Lindahl, Charlotte Menne Bonefeld, Mariusz A Wasik, Sergei B Koralov, Carsten Geisler, Mogens Kilian, Lars Iversen, Anders Woetmann, Niels Odum

Journal:

 

In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus ...

Last Updated: 16 Aug 2013

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Lessons learned from gene expression profiling of cutaneous T-cell lymphoma.
 

Author(s): B O Dulmage, L J Geskin

Journal: Br. J. Dermatol.. 2013 Dec;169(6):1188-97.

 

Gene expression studies of cutaneous T-cell lymphoma (CTCL) span a decade, yet the pathogenesis is poorly understood and diagnosis remains a challenge. This review examines the varied approaches to gene expression analysis of CTCL, with emphasis on cell populations, control selection ...

Last Updated: 4 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy & Safety Study of Selinexor (KPT-330) in Relapsed/Refractory Peripheral T-cell Lymphoma & Cutaneous T-cell Lymphoma
 

Status: Not yet recruiting

Condition Summary: Peripheral T-cell Lymphoma (PTCL); Cutaneous T-cell Lymphoma (CTCL)

 

Last Updated: 13 Feb 2015

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Doxycycline for the Treatment of Cutaneous T-Cell Lymphoma
 

Status: Not yet recruiting

Condition Summary: Cutaneous T-cell Lymphoma; Mycosis Fungoides; Sezary Syndrome

 

Last Updated: 13 Jan 2015

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Outcomes of Cutaneous T-Cell Lymphoma and Graft-Versus-Host Disease With Extracorporeal Photopheresis Treatment
 

Status: Recruiting

Condition Summary: Cutaneous T Cell Lymphoma; Graft Versus Host Disease

 

Last Updated: 13 Oct 2014

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