Cutaneous T-Cell Lymphoma

Common Name(s)

Cutaneous T-Cell Lymphoma, Cutaneous T-Cell Lymphomas

Cutaneous T-cell lymphomas (CTCLs) are a group of disorders characterized by an abnormal accumulation of cancerous T-cells (a type of white blood cells) in the skin resulting in an itchy, red rash that can thicken or form a tumor. CTCLs belong to a larger group of disorders known asnon-Hodgkin's lymphomas. The most common types are mycosis fungoides and SŽzary syndrome. In some cases, cancerous T-cells may spread to the lymph nodes and eventually to other body tissues and organs, potentially resulting in life-threatening complications. The specific signs and symptoms vary from person to person. The exact cause of these conditions is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous T-Cell Lymphoma" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

Last Updated: 6 Jan 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous T-Cell Lymphoma" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

http://www.clfoundation.org

Last Updated: 6 Jan 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cutaneous T-Cell Lymphoma" returned 294 free, full-text research articles on human participants. First 3 results:

B-lymphoid tyrosine kinase (Blk) is an oncogene and a potential target for therapy with dasatinib in cutaneous T-cell lymphoma (CTCL).
 

Author(s): D L Petersen, T Krejsgaard, J Berthelsen, S Fredholm, A Willerslev-Olsen, N A Sibbesen, C M Bonefeld, M H Andersen, C Francavilla, J V Olsen, T Hu, M Zhang, M A Wasik, C Geisler, A Woetmann, N Odum

Journal: Leukemia. 2014 Oct;28(10):2109-12.

 

Last Updated: 8 Oct 2014

Go To URL
Minimal residual disease monitoring with high-throughput sequencing of T cell receptors in cutaneous T cell lymphoma.
 

Author(s): Wen-Kai Weng, Randall Armstrong, Sally Arai, Cindy Desmarais, Richard Hoppe, Youn H Kim

Journal: Sci Transl Med. 2013 Dec;5(214):214ra171.

 

Mycosis fungoides (MF) and the leukemic presentation Sézary syndrome (SS) are clonal T cell lymphomas arising from the skin and are considered noncurable with standard therapies. To develop a specific and sensitive monitoring tool, we tested the ability of high-throughput sequencing ...

Last Updated: 5 Dec 2013

Go To URL
miR-223 regulates cell growth and targets proto-oncogenes in mycosis fungoides/cutaneous T-cell lymphoma.
 

Author(s): Laura Y McGirt, Clare M Adams, Devin A Baerenwald, Jeffrey P Zwerner, John A Zic, Christine M Eischen

Journal: J. Invest. Dermatol.. 2014 Apr;134(4):1101-7.

 

The pathogenesis of the cutaneous T-cell lymphoma (CTCL), mycosis fungoides (MF), is unclear. MicroRNA (miRNA) are small noncoding RNAs that target mRNA leading to reduced mRNA translation. Recently, specific miRNA were shown to be altered in CTCL. We detected significantly reduced ...

Last Updated: 20 Mar 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cutaneous T-Cell Lymphoma" returned 29 free, full-text review articles on human participants. First 3 results:

Novel biomarkers, dysregulated epigenetics, and therapy in cutaneous T-cell lymphoma.
 

Author(s): Henry K Wong

Journal: Discov Med. 2013 Sep;16(87):71-8.

 

Cutaneous T cell lymphomas (CTCL) are a diverse group of lymphoid malignancies that develop in the skin. The most common variants are mycosis fungoides (MF) and Sezary syndrome (SS). These skin lymphomas can be challenging to differentiate from non-malignant inflammatory skin disorders ...

Last Updated: 3 Sep 2013

Go To URL
Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma.
 

Author(s): Andreas Willerslev-Olsen, Thorbjørn Krejsgaard, Lise M Lindahl, Charlotte Menne Bonefeld, Mariusz A Wasik, Sergei B Koralov, Carsten Geisler, Mogens Kilian, Lars Iversen, Anders Woetmann, Niels Odum

Journal:

 

In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus ...

Last Updated: 16 Aug 2013

Go To URL
Lessons learned from gene expression profiling of cutaneous T-cell lymphoma.
 

Author(s): B O Dulmage, L J Geskin

Journal: Br. J. Dermatol.. 2013 Dec;169(6):1188-97.

 

Gene expression studies of cutaneous T-cell lymphoma (CTCL) span a decade, yet the pathogenesis is poorly understood and diagnosis remains a challenge. This review examines the varied approaches to gene expression analysis of CTCL, with emphasis on cell populations, control selection ...

Last Updated: 4 Dec 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Outcomes of Cutaneous T-Cell Lymphoma and Graft-Versus-Host Disease With Extracorporeal Photopheresis Treatment
 

Status: Recruiting

Condition Summary: Cutaneous T Cell Lymphoma; Graft Versus Host Disease

 

Last Updated: 13 Oct 2014

Go to URL
Multi-center Phase 2 Open-label Efficacy & Safety Study of Selinexor (KPT-330) in Relapsed/Refractory Peripheral T-cell Lymphoma & Cutaneous T Cell Lymphoma
 

Status: Not yet recruiting

Condition Summary: Peripheral T Cell Lymphoma (PTCL); Cutaneous T-cell Lymphoma (CTCL)

 

Last Updated: 15 Dec 2014

Go to URL
Micro Needle Array-Doxorubicin (MNA-D) in Patients With Cutaneous T-cell Lymphoma (CTCL)
 

Status: Not yet recruiting

Condition Summary: Cutaneous T Cell Lymphoma

 

Last Updated: 14 Jul 2014

Go to URL