Cutaneous T-Cell Lymphoma

Common Name(s)

Cutaneous T-Cell Lymphoma, Cutaneous T-Cell Lymphomas

Cutaneous T-cell lymphomas (CTCLs) are a group of disorders characterized by an abnormal accumulation of cancerous T-cells (a type of white blood cells) in the skin resulting in an itchy, red rash that can thicken or form a tumor. CTCLs belong to a larger group of disorders known asnon-Hodgkin's lymphomas. The most common types are mycosis fungoides and SŽzary syndrome. In some cases, cancerous T-cells may spread to the lymph nodes and eventually to other body tissues and organs, potentially resulting in life-threatening complications. The specific signs and symptoms vary from person to person. The exact cause of these conditions is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous T-Cell Lymphoma" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

Last Updated: 6 Jan 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous T-Cell Lymphoma" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

http://www.clfoundation.org

Last Updated: 6 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cutaneous T-Cell Lymphoma" returned 294 free, full-text research articles on human participants. First 3 results:

Cutaneous T-cell non Hodgkin lymphoma in a patient with idiopathic CD4+ lymphocytopenia.
 

Author(s): Najeeba Riyaz, Sarita Sasidharanpillai, Anza Khader, Jayasree Puravoor

Journal: Indian J Dermatol Venereol Leprol. ;79(6):831-3.

 

Last Updated: 1 Nov 2013

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Helical irradiation of the total skin with dose painting to replace total skin electron beam therapy for therapy-refractory cutaneous CD4+ T-cell lymphoma.
 

Author(s): Chen-Hsi Hsieh, Pei-Wei Shueng, Shih-Chiang Lin, Hui-Ju Tien, An-Cheng Shiau, Yueh-Hung Chou, Meng-Hao Wu, Jen-Yu Wang, Chi-Kuan Chen, Yu-Jen Chen

Journal: Biomed Res Int. 2013 ;2013():717589.

 

A 36-year-old woman was diagnosed with a therapy-refractory cutaneous CD4+ T-cell lymphoma, T3N0M0B0, and stage IIB. Helical irradiation of the total skin (HITS) and dose painting techniques, with 30 Gy in 40 fractions interrupted at 20 fractions with one week resting, 4 times per ...

Last Updated: 31 Oct 2013

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Expression of human endogenous retrovirus-w including syncytin-1 in cutaneous T-cell lymphoma.
 

Author(s): Pilvi Maliniemi, Michelle Vincendeau, Jens Mayer, Oliver Frank, Sonja Hahtola, Leena Karenko, Emilia Carlsson, Francois Mallet, Wolfgang Seifarth, Christine Leib-Mösch, Annamari Ranki

Journal:

 

The pathomechanism of mycosis fungoides (MF), the most common type of primary cutaneous T-cell lymphomas (CTCLs) and a malignancy of non-recirculating, skin-resident T-cells, is unknown albeit underlying viral infections have been sought for. Human endogenous retroviruses (HERVs) ...

Last Updated: 7 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cutaneous T-Cell Lymphoma" returned 25 free, full-text review articles on human participants. First 3 results:

Novel biomarkers, dysregulated epigenetics, and therapy in cutaneous T-cell lymphoma.
 

Author(s): Henry K Wong

Journal: Discov Med. 2013 Sep;16(87):71-8.

 

Cutaneous T cell lymphomas (CTCL) are a diverse group of lymphoid malignancies that develop in the skin. The most common variants are mycosis fungoides (MF) and Sezary syndrome (SS). These skin lymphomas can be challenging to differentiate from non-malignant inflammatory skin disorders ...

Last Updated: 3 Sep 2013

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Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma.
 

Author(s): Andreas Willerslev-Olsen, Thorbjørn Krejsgaard, Lise M Lindahl, Charlotte Menne Bonefeld, Mariusz A Wasik, Sergei B Koralov, Carsten Geisler, Mogens Kilian, Lars Iversen, Anders Woetmann, Niels Odum

Journal:

 

In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus ...

Last Updated: 16 Aug 2013

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[Hydroa vacciniforme-like cutaneous T cell lymphoma: two cases report and literature review].
 

Author(s): Jiang Xiao, Xiao-dong Liu, Yi-wei Jiao

Journal: Zhonghua Xue Ye Xue Za Zhi. 2012 Jun;33(6):493-5.

 

Last Updated: 12 Sep 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Dose-Escalation Trial of Carfilzomib With and Without Romidepsin in Cutaneous T-Cell Lymphoma
 

Status: Recruiting

Condition Summary: Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IIA Mycosis Fungoides/Sezary Syndrome; Stage IIB Mycosis Fungoides/Sezary Syndrome; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IIIA Mycosis Fungoides/Sezary Syndrome; Stage IIIB Mycosis Fungoides/Sezary Syndrome; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IVA Mycosis Fungoides/Sezary Syndrome; Stage IVB Mycosis Fungoides/Sezary Syndrome

 

Last Updated: 11 Aug 2014

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Vorinostat in Patients With Primary Cutaneous T-Cell Lymphoma
 

Status: Recruiting

Condition Summary: Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Mycosis Fungoides/Sezary Syndrome; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage II Mycosis Fungoides/Sezary Syndrome; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome

 

Last Updated: 20 Sep 2013

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Silicon Phthalocyanine 4 and Photodynamic Therapy in Stage IA-IIA Cutaneous T-Cell Non-Hodgkin Lymphoma
 

Status: Recruiting

Condition Summary: Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IIA Mycosis Fungoides/Sezary Syndrome

 

Last Updated: 14 Jul 2014

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