Cutaneous T-cell lymphoma

Common Name(s)

Cutaneous T-cell lymphoma

Cutaneous T-cell lymphomas (CTCLs) are a group of disorders characterized by an abnormal accumulation of cancerous T-cells (a type of white blood cells) in the skin resulting in an itchy, red rash that can thicken or form a tumor. CTCLs belong to a larger group of disorders known asnon-Hodgkin's lymphomas. The most common types are mycosis fungoides and SŽzary syndrome. In some cases, cancerous T-cells may spread to the lymph nodes and eventually to other body tissues and organs, potentially resulting in life-threatening complications. The specific signs and symptoms vary from person to person. The exact cause of these conditions is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous T-cell lymphoma" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

Last Updated: 6 Jan 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous T-cell lymphoma" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

http://www.clfoundation.org

Last Updated: 6 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cutaneous T-cell lymphoma" returned 449 free, full-text research articles on human participants. First 3 results:

Staphylococcal enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma.
 

Author(s): Andreas Willerslev-Olsen, Thorbjørn Krejsgaard, Lise M Lindahl, Ivan V Litvinov, Simon Fredholm, David L Petersen, Claudia Nastasi, Robert Gniadecki, Nigel P Mongan, Denis Sasseville, Mariusz A Wasik, Charlotte M Bonefeld, Carsten Geisler, Anders Woetmann, Lars Iversen, Mogens Kilian, Sergei B Koralov, Niels Odum

Journal: Blood. 2016 Mar;127(10):1287-96.

 

Cutaneous T-cell lymphoma (CTCL) is characterized by proliferation of malignant T cells in a chronic inflammatory environment. With disease progression, bacteria colonize the compromised skin barrier and half of CTCL patients die of infection rather than from direct organ involvement ...

Last Updated: 11 Mar 2016

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The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.
 

Author(s): Ana Carolina da Silva Almeida, Francesco Abate, Hossein Khiabanian, Estela Martinez-Escala, Joan Guitart, Cornelis P Tensen, Maarten H Vermeer, Raul Rabadan, Adolfo Ferrando, Teresa Palomero

Journal: Nat. Genet.. 2015 Dec;47(12):1465-70.

 

Sézary syndrome is a leukemic and aggressive form of cutaneous T cell lymphoma (CTCL) resulting from the malignant transformation of skin-homing central memory CD4(+) T cells. Here we performed whole-exome sequencing of tumor-normal sample pairs from 25 patients with Sézary syndrome ...

Last Updated: 1 Dec 2015

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A window into cutaneous adult T-cell leukemia/lymphoma.
 

Author(s): Drew Pratt, Elaine S Jaffe

Journal: Blood. 2015 Aug;126(7):920.

 

Last Updated: 21 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cutaneous T-cell lymphoma" returned 40 free, full-text review articles on human participants. First 3 results:

Other Chemotherapeutic Agents in Cutaneous T-Cell Lymphoma.
 

Author(s): Catherine G Chung, Brian Poligone

Journal: Dermatol Clin. 2015 Oct;33(4):787-805.

 

Traditional chemotherapies, interleukins, phosphorylase inhibitors, and proteasome inhibitors are important therapies available to patients with cutaneous T-cell lymphoma (CTCL). Traditional chemotherapies, both in combination and as single agents, are commonly used in relapsed, refractory ...

Last Updated: 5 Oct 2015

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Histone Deacetylase Inhibitors for Cutaneous T-Cell Lymphoma.
 

Author(s): Madeleine Duvic

Journal: Dermatol Clin. 2015 Oct;33(4):757-64.

 

Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin's T-cell lymphomas that present as skin lesions. Mycosis fungoides with large cell transformation has a 5-year overall survival of 32% with involved skin and 7% with extracutaneous involvement. Failure to cure advanced MF with large ...

Last Updated: 5 Oct 2015

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The Use of Interferons in the Treatment of Cutaneous T-Cell Lymphoma.
 

Author(s): Natalie Spaccarelli, Alain H Rook

Journal: Dermatol Clin. 2015 Oct;33(4):731-45.

 

Interferons are polypeptides that naturally occur in the human body as a part of the innate immune response. By harnessing these immunomodulatory functions, synthetic interferons have shown efficacy in combating various diseases including cutaneous T-cell lymphoma. This article closely ...

Last Updated: 5 Oct 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Micro Needle Array-Doxorubicin (MNA-D) in Patients With Cutaneous T-cell Lymphoma (CTCL)
 

Status: Recruiting

Condition Summary: Cutaneous T Cell Lymphoma

 

Last Updated: 23 Sep 2016

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A Trial of E7777 in Persistent and Recurrent Cutaneous T-Cell Lymphoma
 

Status: Recruiting

Condition Summary: Persistent or Recurrent Cutaneous T-Cell Lymphoma

 

Last Updated: 17 Oct 2016

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Poly ICLC, Radiation, and Romidepsin for Advanced Cutaneous T Cell Lymphoma
 

Status: Recruiting

Condition Summary: Cutaneous T-cell Lymphoma

 

Last Updated: 15 Jun 2016

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