Cutaneous T-Cell Lymphoma

Common Name(s)

Cutaneous T-Cell Lymphoma, Cutaneous T-Cell Lymphomas

Cutaneous T-cell lymphomas (CTCLs) are a group of disorders characterized by an abnormal accumulation of cancerous T-cells (a type of white blood cells) in the skin resulting in an itchy, red rash that can thicken or form a tumor. CTCLs belong to a larger group of disorders known asnon-Hodgkin's lymphomas. The most common types are mycosis fungoides and SŽzary syndrome. In some cases, cancerous T-cells may spread to the lymph nodes and eventually to other body tissues and organs, potentially resulting in life-threatening complications. The specific signs and symptoms vary from person to person. The exact cause of these conditions is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous T-Cell Lymphoma" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

Last Updated: 6 Jan 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous T-Cell Lymphoma" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

http://www.clfoundation.org

Last Updated: 6 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cutaneous T-Cell Lymphoma" returned 291 free, full-text research articles on human participants. First 3 results:

miR-223 regulates cell growth and targets proto-oncogenes in mycosis fungoides/cutaneous T-cell lymphoma.
 

Author(s): Laura Y McGirt, Clare M Adams, Devin A Baerenwald, Jeffrey P Zwerner, John A Zic, Christine M Eischen

Journal: J. Invest. Dermatol.. 2014 Apr;134(4):1101-7.

 

The pathogenesis of the cutaneous T-cell lymphoma (CTCL), mycosis fungoides (MF), is unclear. MicroRNA (miRNA) are small noncoding RNAs that target mRNA leading to reduced mRNA translation. Recently, specific miRNA were shown to be altered in CTCL. We detected significantly reduced ...

Last Updated: 20 Mar 2014

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Central nervous system involvement in cutaneous T-cell lymphoma: 2 illustrative cases and a review of current literature.
 

Author(s): Ge Zhao, Marc C Chamberlain, Sandeep P Khot, Andrei Shustov, John E Olerud, Michi M Shinohara

Journal: Clin Lymphoma Myeloma Leuk. 2014 Feb;14(1):e25-30.

 

Last Updated: 27 Jan 2014

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Cutaneous T-cell non Hodgkin lymphoma in a patient with idiopathic CD4+ lymphocytopenia.
 

Author(s): Najeeba Riyaz, Sarita Sasidharanpillai, Anza Khader, Jayasree Puravoor

Journal: Indian J Dermatol Venereol Leprol. ;79(6):831-3.

 

Last Updated: 1 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cutaneous T-Cell Lymphoma" returned 28 free, full-text review articles on human participants. First 3 results:

Novel biomarkers, dysregulated epigenetics, and therapy in cutaneous T-cell lymphoma.
 

Author(s): Henry K Wong

Journal: Discov Med. 2013 Sep;16(87):71-8.

 

Cutaneous T cell lymphomas (CTCL) are a diverse group of lymphoid malignancies that develop in the skin. The most common variants are mycosis fungoides (MF) and Sezary syndrome (SS). These skin lymphomas can be challenging to differentiate from non-malignant inflammatory skin disorders ...

Last Updated: 3 Sep 2013

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Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma.
 

Author(s): Andreas Willerslev-Olsen, Thorbjørn Krejsgaard, Lise M Lindahl, Charlotte Menne Bonefeld, Mariusz A Wasik, Sergei B Koralov, Carsten Geisler, Mogens Kilian, Lars Iversen, Anders Woetmann, Niels Odum

Journal:

 

In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus ...

Last Updated: 16 Aug 2013

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[Hydroa vacciniforme-like cutaneous T cell lymphoma: two cases report and literature review].
 

Author(s): Jiang Xiao, Xiao-dong Liu, Yi-wei Jiao

Journal: Zhonghua Xue Ye Xue Za Zhi. 2012 Jun;33(6):493-5.

 

Last Updated: 12 Sep 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Outcomes of Cutaneous T-Cell Lymphoma and Graft-Versus-Host Disease With Extracorporeal Photopheresis Treatment
 

Status: Recruiting

Condition Summary: Cutaneous T Cell Lymphoma; Graft Versus Host Disease

 

Last Updated: 13 Oct 2014

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Micro Needle Array-Doxorubicin (MNA-D) in Patients With Cutaneous T-cell Lymphoma (CTCL)
 

Status: Not yet recruiting

Condition Summary: Cutaneous T Cell Lymphoma

 

Last Updated: 14 Jul 2014

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Therapeutic Efficacy of Topical Sirolimus in Early Stage Cutaneous T-cell Lymphoma (CTCL)
 

Status: Recruiting

Condition Summary: Cutaneous T-cell Lymphoma (CTCL)

 

Last Updated: 13 Nov 2014

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