Cutaneous T-cell lymphoma

Common Name(s)

Cutaneous T-cell lymphoma

Cutaneous T-cell lymphomas (CTCLs) are a group of disorders characterized by an abnormal accumulation of cancerous T-cells (a type of white blood cells) in the skin resulting in an itchy, red rash that can thicken or form a tumor. CTCLs belong to a larger group of disorders known asnon-Hodgkin's lymphomas. The most common types are mycosis fungoides and SŽzary syndrome. In some cases, cancerous T-cells may spread to the lymph nodes and eventually to other body tissues and organs, potentially resulting in life-threatening complications. The specific signs and symptoms vary from person to person. The exact cause of these conditions is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous T-cell lymphoma" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

Last Updated: 6 Jan 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous T-cell lymphoma" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

http://www.clfoundation.org

Last Updated: 6 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cutaneous T-cell lymphoma" returned 322 free, full-text research articles on human participants. First 3 results:

A window into cutaneous adult T-cell leukemia/lymphoma.
 

Author(s): Drew Pratt, Elaine S Jaffe

Journal: Blood. 2015 Aug;126(7):920.

 

Last Updated: 21 Oct 2015

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Topical resiquimod can induce disease regression and enhance T-cell effector functions in cutaneous T-cell lymphoma.
 

Author(s): Alain H Rook, Joel M Gelfand, Joel C Gelfand, Maria Wysocka, Andrea B Troxel, Bernice Benoit, Christian Surber, Rosalie Elenitsas, Marie A Buchanan, Deborah S Leahy, Rei Watanabe, Ilan R Kirsch, Ellen J Kim, Rachael A Clark

Journal: Blood. 2015 Sep;126(12):1452-61.

 

Early-stage cutaneous T-cell lymphoma (CTCL) is a skin-limited lymphoma with no cure aside from stem cell transplantation. Twelve patients with stage IA-IIA CTCL were treated in a phase 1 trial of 0.03% and 0.06% topical resiquimod gel, a Toll-like receptor 7/8 agonist. Treated lesions ...

Last Updated: 19 Sep 2015

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Images in Clinical Medicine. Cutaneous T-Cell Lymphoma.
 

Author(s): Manaf Aljishi, Catherine Barrow

Journal: N. Engl. J. Med.. 2015 Jun;372(25):2437.

 

Last Updated: 18 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cutaneous T-cell lymphoma" returned 35 free, full-text review articles on human participants. First 3 results:

Cutaneous T-cell lymphoma: 2014 update on diagnosis, risk-stratification, and management.
 

Author(s): Ryan A Wilcox

Journal: Am. J. Hematol.. 2014 Aug;89(8):837-51.

 

Cutaneous T-cell lymphomas are a heterogenous group of T-cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS).

Last Updated: 21 Jul 2014

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Novel biomarkers, dysregulated epigenetics, and therapy in cutaneous T-cell lymphoma.
 

Author(s): Henry K Wong

Journal: Discov Med. 2013 Sep;16(87):71-8.

 

Cutaneous T cell lymphomas (CTCL) are a diverse group of lymphoid malignancies that develop in the skin. The most common variants are mycosis fungoides (MF) and Sezary syndrome (SS). These skin lymphomas can be challenging to differentiate from non-malignant inflammatory skin disorders ...

Last Updated: 3 Sep 2013

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Bacterial toxins fuel disease progression in cutaneous T-cell lymphoma.
 

Author(s): Andreas Willerslev-Olsen, Thorbjørn Krejsgaard, Lise M Lindahl, Charlotte Menne Bonefeld, Mariusz A Wasik, Sergei B Koralov, Carsten Geisler, Mogens Kilian, Lars Iversen, Anders Woetmann, Niels Odum

Journal:

 

In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus ...

Last Updated: 16 Aug 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Doxycycline for the Treatment of Cutaneous T-Cell Lymphoma
 

Status: Not yet recruiting

Condition Summary: Cutaneous T-cell Lymphoma; Mycosis Fungoides; Sezary Syndrome

 

Last Updated: 3 Sep 2015

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Study of E7777 in Patients With Relapsed or Refractory Peripheral T-cell Lymphoma and Cutaneous T-cell Lymphoma
 

Status: Not yet recruiting

Condition Summary: Peripheral T-cell Lymphoma; Cutaneous T-cell Lymphoma

 

Last Updated: 5 Feb 2016

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Micro Needle Array-Doxorubicin (MNA-D) in Patients With Cutaneous T-cell Lymphoma (CTCL)
 

Status: Not yet recruiting

Condition Summary: Cutaneous T Cell Lymphoma

 

Last Updated: 14 Dec 2015

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