Cutaneous T-cell lymphoma

Common Name(s)

Cutaneous T-cell lymphoma

Cutaneous T-cell lymphomas (CTCLs) are a group of disorders characterized by an abnormal accumulation of cancerous T-cells (a type of white blood cells) in the skin resulting in an itchy, red rash that can thicken or form a tumor. CTCLs belong to a larger group of disorders known asnon-Hodgkin's lymphomas. The most common types are mycosis fungoides and SŽzary syndrome. In some cases, cancerous T-cells may spread to the lymph nodes and eventually to other body tissues and organs, potentially resulting in life-threatening complications. The specific signs and symptoms vary from person to person. The exact cause of these conditions is unknown.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous T-cell lymphoma" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

Last Updated: 6 Jan 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous T-cell lymphoma" for support, advocacy or research.

Cutaneous Lymphoma Foundation

The Cutaneous Lymphoma Foundation is an independent, nonprofit patient advocacy organization whose mission is supporting every person with cutaneous lymphoma by promoting awareness and education, advancing patient care and facilitating research.

http://www.clfoundation.org

Last Updated: 6 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cutaneous T-cell lymphoma" returned 452 free, full-text research articles on human participants. First 3 results:

Cutaneous Adverse Reaction to Mogamulizumab May Indicate Favourable Prognosis in Adult T-cell Leukaemia-lymphoma.
 

Author(s): Kentaro Yonekura, Masahito Tokunaga, Nobuyo Kawakami, Koichiro Takeda, Tamotsu Kanzaki, Nobuaki Nakano, Ayumu Kubota, Shogo Takeuchi, Yoshifusa Takatsuka, Masao Seto, Atae Utsunomiya

Journal: Acta Derm. Venereol.. 2016 Nov;96(7):1000-1002.

 

is missing (Short communication).

Last Updated: 2 May 2016

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Cutaneous T-cell Lymphoma and Pruritus: The Expression of IL-31 and its Receptors in the Skin.
 

Author(s): Leigh A Nattkemper, Maria-Estela Martinez-Escala, Ari B Gelman, Elisha M Singer, Alain H Rook, Joan Guitart, Gil Yosipovitch

Journal: Acta Derm. Venereol.. 2016 Nov;96(7):894-898.

 

Approximately 88% of cutaneous T-cell lymphoma (CTCL) patients are affected by pruritus that responds poorly to current antipruritic therapies. Interleukin (IL)-31, a Th2 cytokine, has been found to be increased in the serum of CTCL patients and to correlate with itch severity. This ...

Last Updated: 11 May 2016

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Primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma: A case report and significance of timely ancillary testing.
 

Author(s): Vikas S Kavishwar, Chadha Kirti, Raut Kush, Kolekar Sunita, Chheda Pratiksha

Journal: Indian J Pathol Microbiol. ;59(1):131-2.

 

Last Updated: 10 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cutaneous T-cell lymphoma" returned 43 free, full-text review articles on human participants. First 3 results:

Proteomic Approaches to Biomarker Discovery in Cutaneous T-Cell Lymphoma.
 

Author(s): Alexandra Ion, Iris Maria Popa, Laura Maria Lucia Papagheorghe, Cristina Lisievici, Mihai Lupu, Vlad Voiculescu, Constantin Caruntu, Daniel Boda

Journal: Dis. Markers. 2016 ;2016():9602472.

 

Cutaneous T-cell lymphoma (CTCL) is the most frequently encountered type of skin lymphoma in humans. CTCL encompasses multiple variants, but the most common types are mycosis fungoides (MF) and Sezary syndrome (SS). While most cases of MF run a mild course over a period of many years, ...

Last Updated: 8 Nov 2016

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Romidepsin for the treatment of relapsed/refractory cutaneous T-cell lymphoma (mycosis fungoides/Sézary syndrome): Use in a community setting.
 

Author(s): Sunil A Reddy

Journal: Crit. Rev. Oncol. Hematol.. 2016 Oct;106():99-107.

 

Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of rare non-Hodgkin lymphomas that arise in the skin. In advanced stages, CTCL becomes systemic and is associated with poor prognosis. Diagnosis of CTCL and treatment of early-stage disease with topical therapies often occurs ...

Last Updated: 17 Sep 2016

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Cutaneous T-cell lymphoma: 2016 update on diagnosis, risk-stratification, and management.
 

Author(s): Ryan A Wilcox

Journal: Am. J. Hematol.. 2016 Jan;91(1):151-65.

 

Cutaneous T-cell lymphomas are a heterogenous group of T-cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS).

Last Updated: 15 Jan 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Micro Needle Array-Doxorubicin (MNA-D) in Patients With Cutaneous T-cell Lymphoma (CTCL)
 

Status: Recruiting

Condition Summary: Cutaneous T Cell Lymphoma

 

Last Updated: 23 Mar 2017

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A Trial of E7777 in Persistent and Recurrent Cutaneous T-Cell Lymphoma
 

Status: Recruiting

Condition Summary: Persistent or Recurrent Cutaneous T-Cell Lymphoma

 

Last Updated: 10 Mar 2017

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Poly ICLC, Radiation, and Romidepsin for Advanced Cutaneous T Cell Lymphoma
 

Status: Recruiting

Condition Summary: Cutaneous T-cell Lymphoma

 

Last Updated: 28 Dec 2016

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