Cutaneous sclerosis

Common Name(s)

Cutaneous sclerosis

Cutaneous sclerosis is a rare disease in which the skin develops thicker layers and or scars. While this condition primarily affects the skin, these symptoms can also be found in other tissues and joints. Individuals with cutaneous sclerosis have an overproduction of collagen (a protein needed for connective tissue) by the skin cells during the healing process. Although the cause is not always known, it is seen in 10-20% of persons with graft-versus-host disease (please also visit: graft versus host disease.) which occurs after a transplant of cells, tissues, or organs.

Symptoms of cutaneous sclerosis include visible changes to the skin where is looks thick, feels tight and does not move easily. The diagnosis is confirmed by taking a skin sample and studying it under a microscope. Cutaneous sclerosis is often treated by oral steroids and immunosuppressive treatments to decrease the activity of the immune system (your body’s response to infection). Other more specialized treatments are sometimes needed if these fail. If you or a family member has been diagnosed with cutaneous sclerosis, talk with your doctor or specialist about the most current treatment options. There are support groups for more general scleroderma diagnosis, which provide additional resources.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous sclerosis" for support, advocacy or research.

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous sclerosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cutaneous sclerosis" returned 67 free, full-text research articles on human participants. First 3 results:

Multiple ungual fibromas as an only cutaneous manifestation of tuberous sclerosis complex.
 

Author(s): Ezgi Unlu, Ilknur Balta, Serhan Unlu

Journal: Indian J Dermatol Venereol Leprol. ;80(5):464-5.

 

Last Updated: 9 Sep 2014

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Serum levels of soluble carbonic anhydrase IX are decreased in patients with diffuse cutaneous systemic sclerosis compared to those with limited cutaneous systemic sclerosis.
 

Author(s): Katsunari Makino, Masatoshi Jinnin, Takamitsu Makino, Ikko Kajihara, Satoshi Fukushima, Yuji Inoue, Hironobu Ihn

Journal: Biosci Trends. 2014 Jun;8(3):144-8.

 

Hypoxia may play an important role in the pathogenesis of systemic sclerosis (SSc). Carbonic anhydrase IX (CA IX) is one of the hypoxia markers and its extracellular domain can be released into the serum. However, the clinical significance of serum CA IX levels in SSc is still unknown. ...

Last Updated: 17 Jul 2014

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A patient with diffuse cutaneous systemic sclerosis complicated by antineutrophil-cytoplasmic antibody-associated vasculitis exhibiting honeycomb lung without volume loss.
 

Author(s): Hiroyuki Yamashita, Yuko Takahashi, Hiroshi Kaneko, Toshikazu Kano, Akio Mimori

Journal: Intern. Med.. 2014 ;53(7):801-4.

 

We herein report the case of a 72-year-old woman with diffuse cutaneous systemic sclerosis (SSc) complicated by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis who exhibited honeycomb lung without volume loss. On admission, chest computed tomography (CT) revealed ...

Last Updated: 3 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cutaneous sclerosis" returned 1 free, full-text review articles on human participants. First 3 results:

[Efficacy of anti-thymocyte globulin and cyclosporin A combined therapy in aplastic anemia complicated with limited cutaneous systemic sclerosis].
 

Author(s): Eiichi Suematsu, Tomoya Miyamura, Kensaku Idutsu, Rumi Minami, Masahiro Yamamoto

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2005 Apr;28(2):99-103.

 

We reported here on a case of limited cutaneous systemic sclerosis (lcSSc) with aplastic anemia treated by anti-thymocyte globulin and cyclosporin A. The use of this therapy resulted not only in marrow recovery but also in resolution of the skin sclerosis. A 68 year-old woman was ...

Last Updated: 2 May 2005

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of Subcutaneous Abatacept to Treat Diffuse Cutaneous Systemic Sclerosis
 

Status: Recruiting

Condition Summary: Diffuse Cutaneous Systemic Sclerosis

 

Last Updated: 28 Apr 2015

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Safety, Tolerability, Efficacy, and Pharmacokinetics of JBT-101 in Systemic Sclerosis
 

Status: Not yet recruiting

Condition Summary: Diffuse Cutaneous Systemic Sclerosis

 

Last Updated: 4 Jun 2015

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CPI-613 and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma
 

Status: Recruiting

Condition Summary: Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Hepatosplenic T-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Large Granular Lymphocyte Leukemia

 

Last Updated: 31 Oct 2014

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