Cutaneous Sclerosis

Common Name(s)

Cutaneous Sclerosis

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous Sclerosis" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous Sclerosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cutaneous Sclerosis" returned 58 free, full-text research articles on human participants. First 3 results:

Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension.
 

Author(s): Stefania Lenna, Alessandra G Farina, Viktor Martyanov, Romy B Christmann, Tammara A Wood, Harrison W Farber, Raffaella Scorza, Michael L Whitfield, Robert Lafyatis, Maria Trojanowska

Journal: Arthritis Rheum.. 2013 May;65(5):1357-66.

 

Pulmonary arterial hypertension (PAH), a common complication of limited cutaneous systemic sclerosis (lcSSc), is associated with alterations of markers of inflammation and vascular damage in peripheral blood mononuclear cells (PBMCs). Endoplasmic reticulum (ER) stress and the unfolded ...

Last Updated: 24 Apr 2013

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Topical rapamycin therapy to alleviate the cutaneous manifestations of tuberous sclerosis complex: a double-blind, randomized, controlled trial to evaluate the safety and efficacy of topically applied rapamycin.
 

Author(s): Mary Kay Koenig, Adelaide A Hebert, Joan Roberson, Joshua Samuels, John Slopis, Audrey Woerner, Hope Northrup

Journal: Drugs R D. 2012 Sep;12(3):121-6.

 

Facial angiofibromas are disfiguring facial lesions, present in up to 80% of patients with tuberous sclerosis complex. Recent elucidation of the complex cell signaling pathways that are disrupted in tuberous sclerosis indicates that rapamycin may be successful in alleviating the appearance ...

Last Updated: 6 Sep 2012

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Supernatants from culture of type I collagen-stimulated PBMC from patients with cutaneous systemic sclerosis versus localized scleroderma demonstrate suppression of MMP-1 by fibroblasts.
 

Author(s): Monica Brown, Arnold E Postlethwaite, Linda K Myers, Karen A Hasty

Journal: Clin. Rheumatol.. 2012 Jun;31(6):973-81.

 

Systemic sclerosis (SSc) is a chronic fibrosing disease characterized by vasculopathy, autoimmunity, and an accumulation of collagen in tissues. Numerous studies have shown that compared to healthy or diseased controls, the peripheral blood mononuclear cells (PBMC) from patients with ...

Last Updated: 30 May 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cutaneous Sclerosis" returned 1 free, full-text review articles on human participants. First 3 results:

[Efficacy of anti-thymocyte globulin and cyclosporin A combined therapy in aplastic anemia complicated with limited cutaneous systemic sclerosis].
 

Author(s): Eiichi Suematsu, Tomoya Miyamura, Kensaku Idutsu, Rumi Minami, Masahiro Yamamoto

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2005 Apr;28(2):99-103.

 

We reported here on a case of limited cutaneous systemic sclerosis (lcSSc) with aplastic anemia treated by anti-thymocyte globulin and cyclosporin A. The use of this therapy resulted not only in marrow recovery but also in resolution of the skin sclerosis. A 68 year-old woman was ...

Last Updated: 2 May 2005

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Immune Mediated Disorders After Allogeneic Hematopoietic Cell Transplantation
 

Status: Recruiting

Condition Summary: Graft vs Host Disease; Cutaneous Sclerosis; Bronchiolitis Obliterans

 

Last Updated: 3 Mar 2014

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Imatinib and Rituximab in Treating Cutaneous Sclerosis in Patients With Chronic Graft-Versus-Host Disease
 

Status: Recruiting

Condition Summary: Graft Versus Host Disease; Systemic Scleroderma

 

Last Updated: 29 Apr 2014

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A Study of Subcutaneous Abatacept to Treat Diffuse Cutaneous Systemic Sclerosis
 

Status: Not yet recruiting

Condition Summary: Diffuse Cutaneous Systemic Sclerosis

 

Last Updated: 9 Jun 2014

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