Cutaneous sclerosis

Common Name(s)

Cutaneous sclerosis

Cutaneous sclerosis is a rare disease in which the skin develops thicker layers and or scars. While this condition primarily affects the skin, these symptoms can also be found in other tissues and joints. Individuals with cutaneous sclerosis have an overproduction of collagen (a protein needed for connective tissue) by the skin cells during the healing process. Although the cause is not always known, it is seen in 10-20% of persons with graft-versus-host disease (please also visit: graft versus host disease.) which occurs after a transplant of cells, tissues, or organs.

Symptoms of cutaneous sclerosis include visible changes to the skin where is looks thick, feels tight and does not move easily. The diagnosis is confirmed by taking a skin sample and studying it under a microscope. Cutaneous sclerosis is often treated by oral steroids and immunosuppressive treatments to decrease the activity of the immune system (your body’s response to infection). Other more specialized treatments are sometimes needed if these fail. If you or a family member has been diagnosed with cutaneous sclerosis, talk with your doctor or specialist about the most current treatment options. There are support groups for more general scleroderma diagnosis, which provide additional resources.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous sclerosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cutaneous sclerosis" returned 69 free, full-text research articles on human participants. First 3 results:

The American College of Rheumatology Provisional Composite Response Index for Clinical Trials in Early Diffuse Cutaneous Systemic Sclerosis.
 

Author(s): Dinesh Khanna, Veronica J Berrocal, Edward H Giannini, James R Seibold, Peter A Merkel, Maureen D Mayes, Murray Baron, Philip J Clements, Virginia Steen, Shervin Assassi, Elena Schiopu, Kristine Phillips, Robert W Simms, Yannick Allanore, Christopher P Denton, Oliver Distler, Sindhu R Johnson, Marco Matucci-Cerinic, Janet E Pope, Susanna M Proudman, Jeffrey Siegel, Weng Kee Wong, Athol U Wells, Daniel E Furst

Journal: Arthritis Care Res (Hoboken). 2016 Feb;68(2):167-78.

 

Early diffuse cutaneous systemic sclerosis (dcSSc) is characterized by rapid changes in the skin and internal organs. The objective of this study was to develop a composite response index in dcSSc (CRISS) for use in randomized controlled trials (RCTs).

Last Updated: 25 Jan 2016

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The HLA-B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients.
 

Author(s): Stefania Lenna, Shervin Assassi, G Alessandra Farina, Julio C Mantero, Raffaella Scorza, Robert Lafyatis, Harrison W Farber, Maria Trojanowska

Journal:

 

HLA-B*35 is associated with increased risk of developing pulmonary hypertension in SSc patients. We previously reported that HLA-B*35 induces endothelial cell dysfunction via activation of ER stress/UPR and upregulation of the inflammatory response. Because PBMCs from lcSSc-PAH patients ...

Last Updated: 16 Dec 2015

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A Randomized Phase II Crossover Study of Imatinib or Rituximab for Cutaneous Sclerosis after Hematopoietic Cell Transplantation.
 

Author(s): Sally Arai, Joseph Pidala, Iskra Pusic, Xiaoyu Chai, Samantha Jaglowski, Nandita Khera, Jeanne Palmer, George L Chen, Madan H Jagasia, Sebastian A Mayer, William A Wood, Michael Green, Teresa S Hyun, Yoshihiro Inamoto, Barry E Storer, David B Miklos, Howard M Shulman, Paul J Martin, Stefanie Sarantopoulos, Stephanie J Lee, Mary E D Flowers

Journal: Clin. Cancer Res.. 2016 Jan;22(2):319-27.

 

Cutaneous sclerosis occurs in 20% of patients with chronic graft-versus-host disease (GVHD) and can compromise mobility and quality of life.

Last Updated: 16 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cutaneous sclerosis" returned 2 free, full-text review articles on human participants. First 3 results:

The American College of Rheumatology Provisional Composite Response Index for Clinical Trials in Early Diffuse Cutaneous Systemic Sclerosis.
 

Author(s): Dinesh Khanna, Veronica J Berrocal, Edward H Giannini, James R Seibold, Peter A Merkel, Maureen D Mayes, Murray Baron, Philip J Clements, Virginia Steen, Shervin Assassi, Elena Schiopu, Kristine Phillips, Robert W Simms, Yannick Allanore, Christopher P Denton, Oliver Distler, Sindhu R Johnson, Marco Matucci-Cerinic, Janet E Pope, Susanna M Proudman, Jeffrey Siegel, Weng Kee Wong, Athol U Wells, Daniel E Furst

Journal: Arthritis Rheumatol. 2016 Feb;68(2):299-311.

 

Early diffuse cutaneous systemic sclerosis (dcSSc) is characterized by rapid changes in the skin and internal organs. The objective of this study was to develop a composite response index in dcSSc (CRISS) for use in randomized controlled trials (RCTs).

Last Updated: 26 Jan 2016

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[Efficacy of anti-thymocyte globulin and cyclosporin A combined therapy in aplastic anemia complicated with limited cutaneous systemic sclerosis].
 

Author(s): Eiichi Suematsu, Tomoya Miyamura, Kensaku Idutsu, Rumi Minami, Masahiro Yamamoto

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2005 Apr;28(2):99-103.

 

We reported here on a case of limited cutaneous systemic sclerosis (lcSSc) with aplastic anemia treated by anti-thymocyte globulin and cyclosporin A. The use of this therapy resulted not only in marrow recovery but also in resolution of the skin sclerosis. A 68 year-old woman was ...

Last Updated: 2 May 2005

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of Subcutaneous Abatacept to Treat Diffuse Cutaneous Systemic Sclerosis
 

Status: Recruiting

Condition Summary: Diffuse Cutaneous Systemic Sclerosis

 

Last Updated: 20 Dec 2016

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Proof-of-concept Trial of IVA337 in Diffuse Cutaneous Systemic Sclerosis
 

Status: Recruiting

Condition Summary: Scleroderma, Diffuse; Diffuse Cutaneous Systemic Sclerosis

 

Last Updated: 13 Jun 2016

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Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension
 

Status: Recruiting

Condition Summary: Scleroderma, Diffuse; Scleroderma, Systemic; Scleroderma, Limited; Sclerosis, Progressive Systemic; Skin Diseases; Connective Tissue Diseases; Pathologic Processes; Autoimmune Diseases

 

Last Updated: 22 Feb 2017

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