Cutaneous sclerosis

Common Name(s)

Cutaneous sclerosis

Cutaneous sclerosis is a rare disease in which the skin develops thicker layers and or scars. While this condition primarily affects the skin, these symptoms can also be found in other tissues and joints. Individuals with cutaneous sclerosis have an overproduction of collagen (a protein needed for connective tissue) by the skin cells during the healing process. Although the cause is not always known, it is seen in 10-20% of persons with graft-versus-host disease (please also visit: graft versus host disease.) which occurs after a transplant of cells, tissues, or organs.

Symptoms of cutaneous sclerosis include visible changes to the skin where is looks thick, feels tight and does not move easily. The diagnosis is confirmed by taking a skin sample and studying it under a microscope. Cutaneous sclerosis is often treated by oral steroids and immunosuppressive treatments to decrease the activity of the immune system (your body’s response to infection). Other more specialized treatments are sometimes needed if these fail. If you or a family member has been diagnosed with cutaneous sclerosis, talk with your doctor or specialist about the most current treatment options. There are support groups for more general scleroderma diagnosis, which provide additional resources.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous sclerosis" for support, advocacy or research.

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cutaneous sclerosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cutaneous sclerosis" returned 76 free, full-text research articles on human participants. First 3 results:

CNS and cutaneous involvement in tuberous sclerosis complex.
 

Author(s): Fernanda Frotte Bopp Salomon, Miriam Menna Barreto, Gláucia Zanetti, Rosana Souza Rodrigues, Emerson Leandro Gasparetto, Edson Marchiori

Journal: Arq Neuropsiquiatr. 2015 Sep;73(9):813.

 

Last Updated: 10 Sep 2015

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Cutaneous Adverse Events Associated with Interferon-β Treatment of Multiple Sclerosis.
 

Author(s): Annette Kolb-Mäurer, Matthias Goebeler, Mathias Mäurer

Journal:

 

Interferons are widely used platform therapies as disease-modifying treatment of patients with multiple sclerosis. Although interferons are usually safe and well tolerated, they frequently cause dermatological side effects. Here, we present a multiple sclerosis (MS) patient treated ...

Last Updated: 7 Jul 2015

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Gene expression changes reflect clinical response in a placebo-controlled randomized trial of abatacept in patients with diffuse cutaneous systemic sclerosis.
 

Author(s): Eliza F Chakravarty, Viktor Martyanov, David Fiorentino, Tammara A Wood, David James Haddon, Justin Ansel Jarrell, Paul J Utz, Mark C Genovese, Michael L Whitfield, Lorinda Chung

Journal:

 

Systemic sclerosis is an autoimmune disease characterized by inflammation and fibrosis of the skin and internal organs. We sought to assess the clinical and molecular effects associated with response to intravenous abatacept in patients with diffuse cutaneous systemic.

Last Updated: 30 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cutaneous sclerosis" returned 1 free, full-text review articles on human participants. First 3 results:

[Efficacy of anti-thymocyte globulin and cyclosporin A combined therapy in aplastic anemia complicated with limited cutaneous systemic sclerosis].
 

Author(s): Eiichi Suematsu, Tomoya Miyamura, Kensaku Idutsu, Rumi Minami, Masahiro Yamamoto

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2005 Apr;28(2):99-103.

 

We reported here on a case of limited cutaneous systemic sclerosis (lcSSc) with aplastic anemia treated by anti-thymocyte globulin and cyclosporin A. The use of this therapy resulted not only in marrow recovery but also in resolution of the skin sclerosis. A 68 year-old woman was ...

Last Updated: 2 May 2005

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Proof-of-concept Trial of IVA337 in Diffuse Cutaneous Systemic Sclerosis
 

Status: Recruiting

Condition Summary: Scleroderma, Diffuse; Diffuse Cutaneous Systemic Sclerosis

 

Last Updated: 29 Mar 2016

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A Study of Subcutaneous Abatacept to Treat Diffuse Cutaneous Systemic Sclerosis
 

Status: Recruiting

Condition Summary: Diffuse Cutaneous Systemic Sclerosis

 

Last Updated: 1 Apr 2016

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Safety, Tolerability, Efficacy, and Pharmacokinetics of JBT-101 in Systemic Sclerosis
 

Status: Recruiting

Condition Summary: Diffuse Cutaneous Systemic Sclerosis

 

Last Updated: 2 May 2016

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