Cushing's Syndrome

Common Name(s)

Cushing's Syndrome, Cushing Syndrome

Cushing's syndrome is an endocrine disorder caused by prolonged exposure of the body's tissues to high levels of cortisol (a hormone produced by the adrenal gland). It most commonly affects adults between age 20 and 50 years. Signs and symptoms of Cushing's syndrome include upper body obesity, fatigue, muscle weakness, high blood pressure, backache, high blood sugar, easy bruising and bluish-red stretch marks on the skin. Affected women may also experience irregular menstrual periods and increased growth of body and facial hair. This condition may be caused by a variety of factors including long-term use of corticosteroid medications, tumors in the pituitary gland or adrenal adenomas.Treatment depends on the underlying cause, but may include decreasing the dosage of corticosteroids or surgery to remove tumors.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cushing's Syndrome" for support, advocacy or research.

Cushing's Support & Research Foundation

The Cushing's Support and Research Foundation was established in 1995 to provide information and support to Cushing's patients and their families.

Last Updated: 12 Nov 2012

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Fibrous Dysplasia Foundation

The Fibrous Dysplasia Foundation provides information, advocacy and support for patients, medical professionals and the general public and promote research for diagnosis, treatment and a cure for Fibrous Dysplasia (FD) and McCune-Albright's Syndrome (MAS), Cherubism and related diseases. Our goal is to improve the quality of life for affected individuals and their families.

Last Updated: 12 Dec 2012

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

Last Updated: 18 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cushing's Syndrome" for support, advocacy or research.

Cushing's Support & Research Foundation

The Cushing's Support and Research Foundation was established in 1995 to provide information and support to Cushing's patients and their families.

http://csrf.net/

Last Updated: 12 Nov 2012

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Fibrous Dysplasia Foundation

The Fibrous Dysplasia Foundation provides information, advocacy and support for patients, medical professionals and the general public and promote research for diagnosis, treatment and a cure for Fibrous Dysplasia (FD) and McCune-Albright's Syndrome (MAS), Cherubism and related diseases. Our goal is to improve the quality of life for affected individuals and their families.

http://www.fibrousdysplasia.org/

Last Updated: 12 Dec 2012

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

http://www.magicfoundation.org

Last Updated: 18 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cushing's Syndrome" returned 574 free, full-text research articles on human participants. First 3 results:

The 10:00-11:00 pm urine cortisol/creatinine ratio. An alternative to late-night salivary cortisol for the diagnosis of Cushing's syndrome.
 

Author(s): Oscar D Bruno, María A Rossi, Lea Juárez-Allen, Héctor A Serra, María C Albiero

Journal: Medicina (B Aires). 2015 ;75(6):373-8.

 

The aim of this study was to investigate interchangeability of two tests to diagnose Cushing's syndrome. We compared 10:00-11:00 PM urinary free cortisol/creatinine ratio (UFC/Cr) with late night 11:00 PM salivary cortisol (LNSC) in normal and obese controls vs. patients with Cushing's ...

Last Updated: 28 Dec 2015

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PRKAR1A-negative familial Cushing's syndrome: two case reports.
 

Author(s): Lee Ling Lim, Normayah Kitan, Sharmila Sunita Paramasivam, Jeyakantha Ratnasingam, Luqman Ibrahim, Siew Pheng Chan, Alexander Tong Boon Tan, Shireene Ratna Vethakkan

Journal:

 

Determining the etiology of Cushing's syndrome is very challenging to endocrinologists, with most of the difficulty arising from subtype differentiation of adrenocorticotropic hormone-dependent Cushing's syndrome. We present the pitfalls of evaluating a rare cause of adrenocorticotropic ...

Last Updated: 1 Dec 2015

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Remarkable Adrenocortical Hyperplasia in Adrenocorticotropin-dependent Cushing's Syndrome.
 

Author(s): Satoshi Murao

Journal: Intern. Med.. 2015 ;54(21):2783-4.

 

Last Updated: 2 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cushing's Syndrome" returned 65 free, full-text review articles on human participants. First 3 results:

Genetics of primary bilateral macronodular adrenal hyperplasia: a model for early diagnosis of Cushing's syndrome?
 

Author(s): Ludivine Drougat, Stéphanie Espiard, Jerôme Bertherat

Journal: Eur. J. Endocrinol.. 2015 Oct;173(4):M121-31.

 

Long-term consequences of cortisol excess are frequent despite appropriate treatment after cure of Cushing's syndrome. This might be due to diagnostic delay, often difficult to reduce in rare diseases. The identification of a genetic predisposing factor might help to improve early ...

Last Updated: 4 Sep 2015

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Conventional and Nuclear Medicine Imaging in Ectopic Cushing's Syndrome: A Systematic Review.
 

Author(s): Andrea M Isidori, Emilia Sbardella, Maria Chiara Zatelli, Mara Boschetti, Giovanni Vitale, Annamaria Colao, Rosario Pivonello,

Journal: J. Clin. Endocrinol. Metab.. 2015 Sep;100(9):3231-44.

 

Ectopic Cushing's Syndrome (ECS) can be a diagnostic challenge with the hormonal source difficult to find. This study analyzes the accuracy of imaging studies in ECS localization.

Last Updated: 16 Nov 2015

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Cushing's syndrome: update on signs, symptoms and biochemical screening.
 

Author(s): Lynnette K Nieman

Journal: Eur. J. Endocrinol.. 2015 Oct;173(4):M33-8.

 

Endogenous pathologic hypercortisolism, or Cushing's syndrome, is associated with poor quality of life, morbidity, and increased mortality. Early diagnosis may mitigate against this natural history of the disorder. The clinical presentation of Cushing's syndrome varies, in part related ...

Last Updated: 28 Aug 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome
 

Status: Recruiting

Condition Summary: Cushing Syndrome

 

Last Updated: 10 Jun 2016

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Last Updated: 16 Nov 2015

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Study to Evaluate CORT125134 in Patients With Cushing's Syndrome
 

Status: Not yet recruiting

Condition Summary: Cushing's Syndrome

 

Last Updated: 15 Jun 2016

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