Cushing's Syndrome

Common Name(s)

Cushing's Syndrome, Cushing Syndrome

Cushing's syndrome is an endocrine disorder caused by prolonged exposure of the body's tissues to high levels of cortisol, a hormone produced by the adrenal gland. Excess cortisol may be the result of long-term use of corticosteroid medications or tumors in the pituitary or adrenal glands. Symptoms of Cushing's syndrome include obesity, fatigue, muscle weakness, high blood pressure, high blood sugar, easy bruising and stretch marks. Treatment depends on the underlying cause, but may include decreasing the dosage of corticosteroids or removing the causative tumor.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cushing's Syndrome" for support, advocacy or research.

Cushing's Support & Research Foundation

The Cushing's Support and Research Foundation was established in 1995 to provide information and support to Cushing's patients and their families.

Last Updated: 12 Nov 2012

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Fibrous Dysplasia Foundation

The Fibrous Dysplasia Foundation provides information, advocacy and support for patients, medical professionals and the general public and promote research for diagnosis, treatment and a cure for Fibrous Dysplasia (FD) and McCune-Albright's Syndrome (MAS), Cherubism and related diseases. Our goal is to improve the quality of life for affected individuals and their families.

Last Updated: 12 Dec 2012

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

Last Updated: 7 Nov 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cushing's Syndrome" for support, advocacy or research.

Cushing's Support & Research Foundation

The Cushing's Support and Research Foundation was established in 1995 to provide information and support to Cushing's patients and their families.

http://csrf.net/

Last Updated: 12 Nov 2012

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Fibrous Dysplasia Foundation

The Fibrous Dysplasia Foundation provides information, advocacy and support for patients, medical professionals and the general public and promote research for diagnosis, treatment and a cure for Fibrous Dysplasia (FD) and McCune-Albright's Syndrome (MAS), Cherubism and related diseases. Our goal is to improve the quality of life for affected individuals and their families.

http://www.fibrousdysplasia.org/

Last Updated: 12 Dec 2012

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

http://www.magicfoundation.org

Last Updated: 7 Nov 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cushing's Syndrome" returned 421 free, full-text research articles on human participants. First 3 results:

Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome.
 

Author(s): Felix Beuschlein, Martin Fassnacht, Guillaume Assié, Davide Calebiro, Constantine A Stratakis, Andrea Osswald, Cristina L Ronchi, Thomas Wieland, Silviu Sbiera, Fabio R Faucz, Katrin Schaak, Anett Schmittfull, Thomas Schwarzmayr, Olivia Barreau, Delphine Vezzosi, Marthe Rizk-Rabin, Ulrike Zabel, Eva Szarek, Paraskevi Salpea, Antonella Forlino, Annalisa Vetro, Orsetta Zuffardi, Caroline Kisker, Susanne Diener, Thomas Meitinger, Martin J Lohse, Martin Reincke, Jérome Bertherat, Tim M Strom, Bruno Allolio

Journal: N. Engl. J. Med.. 2014 Mar;370(11):1019-28.

 

Corticotropin-independent Cushing's syndrome is caused by tumors or hyperplasia of the adrenal cortex. The molecular pathogenesis of cortisol-producing adrenal adenomas is not well understood.

Last Updated: 13 Mar 2014

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Adrenal and pituitary incidentalomas in a case of Cushing's syndrome.
 

Author(s): C Poiană, C Chiriţă, M Carşote, D Hortopan, D Ioachim, C M Corneci, B Stănescu

Journal: Chirurgia (Bucur). ;108(6):886-91.

 

Cushing's syndrome is a pathological condition where surgery may be lifesaving. The proper diagnosis depends upon the hormonal pattern of the patient, various dynamic tests and imagistic investigations. We report a case of a patient with Cushing's syndrome, with bilateral adrenal ...

Last Updated: 16 Dec 2013

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ARMC5 mutations in macronodular adrenal hyperplasia with Cushing's syndrome.
 

Author(s): Guillaume Assié, Rossella Libé, Stéphanie Espiard, Marthe Rizk-Rabin, Anne Guimier, Windy Luscap, Olivia Barreau, Lucile Lefèvre, Mathilde Sibony, Laurence Guignat, Stéphanie Rodriguez, Karine Perlemoine, Fernande René-Corail, Franck Letourneur, Bilal Trabulsi, Alix Poussier, Nathalie Chabbert-Buffet, Françoise Borson-Chazot, Lionel Groussin, Xavier Bertagna, Constantine A Stratakis, Bruno Ragazzon, Jérôme Bertherat

Journal: N. Engl. J. Med.. 2013 Nov;369(22):2105-14.

 

Corticotropin-independent macronodular adrenal hyperplasia may be an incidental finding or it may be identified during evaluation for Cushing's syndrome. Reports of familial cases and the involvement of both adrenal glands suggest a genetic origin of this condition.

Last Updated: 28 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cushing's Syndrome" returned 39 free, full-text review articles on human participants. First 3 results:

Cushing's syndrome: a structured short- and long-term management plan for patients in remission.
 

Author(s): Oskar Ragnarsson, Gudmundur Johannsson

Journal:

 

One hundred years have passed since Harvey Williams Cushing presented the first patient with the syndrome that bears his name. In patients with Cushing's syndrome (CS), body composition and lipid, carbohydrate and protein metabolism are dramatically affected and psychopathology and ...

Last Updated: 7 Oct 2013

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Urinary free cortisol in the diagnosis of Cushing's syndrome: how useful?
 

Author(s): I A Odeniyi, A O Ifedayo, O A Fasanmade, A F Olufemi

Journal: Niger J Clin Pract. ;16(3):269-72.

 

Cushing's syndrome results from chronic exposure to excessive circulating levels of glucocorticoids. To confirm the clinical suspicion, biochemical tests are needed. These biochemical tests include the measurement of excess total endogenous cortisol secretion assessed by 24-hour urinary ...

Last Updated: 17 Jun 2013

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Dilated cardiomyopathy as a presenting feature of Cushing's syndrome.
 

Author(s): Nobuyuki Shibusawa, Masanobu Yamada, Tetsu Hashida, Koshi Hashimoto, Tetsurou Satoh, Jun Horiguchi, Tetsunari Oyama, Izumi Takeyoshi, Masatomo Mori

Journal: Intern. Med.. 2013 ;52(10):1067-71.

 

Cardiovascular complications, including cardiomegaly, myocardial ischemia and left ventricular hypertrophy, are some of the major determinants of the mortality rate in patients with Cushing's syndrome. We herein report the case of a patient with Cushing's syndrome caused by an adrenal ...

Last Updated: 16 May 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism
 

Status: Recruiting

Condition Summary: Hypercortisolism; Cushing Syndrome

 

Last Updated: 10 Sep 2014

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New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome
 

Status: Recruiting

Condition Summary: Cushing Syndrome

 

Last Updated: 1 Jul 2014

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Last Updated: 23 Jun 2011

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