Cushing's Syndrome

Common Name(s)

Cushing's Syndrome, Cushing Syndrome

Cushing's syndrome is an endocrine disorder caused by prolonged exposure of the body's tissues to high levels of cortisol (a hormone produced by the adrenal gland). It most commonly affects adults between age 20 and 50 years. Signs and symptoms of Cushing's syndrome include upper body obesity, fatigue, muscle weakness, high blood pressure, backache, high blood sugar, easy bruising and bluish-red stretch marks on the skin. Affected women may also experience irregular menstrual periods and increased growth of body and facial hair. This condition may be caused by a variety of factors including long-term use of corticosteroid medications, tumors in the pituitary gland or adrenal adenomas.Treatment depends on the underlying cause, but may include decreasing the dosage of corticosteroids or surgery to remove tumors.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cushing's Syndrome" for support, advocacy or research.

Cushing's Support & Research Foundation

The Cushing's Support and Research Foundation was established in 1995 to provide information and support to Cushing's patients and their families.

Last Updated: 12 Nov 2012

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Fibrous Dysplasia Foundation

The Fibrous Dysplasia Foundation provides information, advocacy and support for patients, medical professionals and the general public and promote research for diagnosis, treatment and a cure for Fibrous Dysplasia (FD) and McCune-Albright's Syndrome (MAS), Cherubism and related diseases. Our goal is to improve the quality of life for affected individuals and their families.

Last Updated: 12 Dec 2012

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

Last Updated: 18 Jun 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cushing's Syndrome" for support, advocacy or research.

Cushing's Support & Research Foundation

The Cushing's Support and Research Foundation was established in 1995 to provide information and support to Cushing's patients and their families.

http://csrf.net/

Last Updated: 12 Nov 2012

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Fibrous Dysplasia Foundation

The Fibrous Dysplasia Foundation provides information, advocacy and support for patients, medical professionals and the general public and promote research for diagnosis, treatment and a cure for Fibrous Dysplasia (FD) and McCune-Albright's Syndrome (MAS), Cherubism and related diseases. Our goal is to improve the quality of life for affected individuals and their families.

http://www.fibrousdysplasia.org/

Last Updated: 12 Dec 2012

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

http://www.magicfoundation.org

Last Updated: 18 Jun 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cushing's Syndrome" returned 448 free, full-text research articles on human participants. First 3 results:

Severe Cushing's syndrome related to a small pulmonary carcinoid with widespread dissemination.
 

Author(s): Filippo Lococo, Aurelio Negro, Francesca Zanelli, Riccardo Valli, Angelina Filice, Cristian Rapicetta, Massimiliano Paci

Journal: Intern. Med.. 2015 ;54(5):477-80.

 

Cushing's syndrome (CS) is characterized by the overproduction of cortisol that may result in significant morbidity and mortality if left untreated. CS is very rarely caused by ectopic adrenocorticotropic hormone production from several tumors, although pulmonary neuroendocrine tumors ...

Last Updated: 11 Mar 2015

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[Technical and functional aspects of catheterization of inferior petrosal sinuses in ACTH dependent Cushing's syndrome].
 

Author(s): João Miguel de Almeida Silva, Guilherme Brasileiro de Aguiar, Mario Luiz Marques Conti, Américo Rubens Leite dos Santos, José Viana Lima Junior, José Carlos Esteves Veiga

Journal: Arq Bras Endocrinol Metabol. 2014 Oct;58(7):758-64.

 

To describe and analyze technique for bilateral catheterization of inferior petrosal sinus in our service, discussing the difficulties and success rates found.

Last Updated: 6 Nov 2014

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Bilateral laparoscopic adrenalectomy in a pregnant woman with Cushing's syndrome.
 

Author(s): Mohammad Aslzare, Mohammad Alipour, Morteza Taghavi, Alireza Ghoreifi

Journal:

 

Last Updated: 1 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cushing's Syndrome" returned 44 free, full-text review articles on human participants. First 3 results:

Therapy of endocrine disease: steroidogenesis enzyme inhibitors in Cushing's syndrome.
 

Author(s): Eleni Daniel, John D C Newell-Price

Journal: Eur. J. Endocrinol.. 2015 Jun;172(6):R263-80.

 

Steroidogenesis enzyme inhibitors are the mainstay of medical therapy in Cushing's syndrome (CS). Ketoconazole (KTZ) and metyrapone are the most commonly used agents. Although there is considerable experience of their use in individual specialist centres, these drugs have not been ...

Last Updated: 29 Apr 2015

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Systemic therapy of Cushing's syndrome.
 

Author(s): Niels Eckstein, Bodo Haas, Moritz David Sebastian Hass, Vladlena Pfeifer

Journal:

 

Cushing's disease (CD) in a stricter sense derives from pathologic adrenocorticotropic hormone (ACTH) secretion usually triggered by micro- or macroadenoma of the pituitary gland. It is, thus, a form of secondary hypercortisolism. In contrast, Cushing's syndrome (CS) describes the ...

Last Updated: 8 Aug 2014

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Physiological basis for the etiology, diagnosis, and treatment of adrenal disorders: Cushing's syndrome, adrenal insufficiency, and congenital adrenal hyperplasia.
 

Author(s): Hershel Raff, Susmeeta T Sharma, Lynnette K Nieman

Journal: Compr Physiol. 2014 Apr;4(2):739-69.

 

The hypothalamic-pituitary-adrenal (HPA) axis is a classic neuroendocrine system. One of the best ways to understand the HPA axis is to appreciate its dynamics in the variety of diseases and syndromes that affect it. Excess glucocorticoid activity can be due to endogenous cortisol ...

Last Updated: 9 Apr 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome
 

Status: Recruiting

Condition Summary: Cushing Syndrome

 

Last Updated: 12 Jun 2015

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Last Updated: 23 Jun 2011

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Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome
 

Status: Not yet recruiting

Condition Summary: Cushing's Syndrome; Ectopic Corticotropin Syndrome; Adrenal Adenoma; Adrenal Carcinoma; AIMAH; PPNAD

 

Last Updated: 10 Jun 2015

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