Cushing's Syndrome

Common Name(s)

Cushing's Syndrome, Cushing Syndrome

Cushing's syndrome is an endocrine disorder caused by prolonged exposure of the body's tissues to high levels of cortisol (a hormone produced by the adrenal gland). It most commonly affects adults between age 20 and 50 years. Signs and symptoms of Cushing's syndrome include upper body obesity, fatigue, muscle weakness, high blood pressure, backache, high blood sugar, easy bruising and bluish-red stretch marks on the skin. Affected women may also experience irregular menstrual periods and increased growth of body and facial hair. This condition may be caused by a variety of factors including long-term use of corticosteroid medications, tumors in the pituitary gland or adrenal adenomas.Treatment depends on the underlying cause, but may include decreasing the dosage of corticosteroids or surgery to remove tumors.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cushing's Syndrome" for support, advocacy or research.

Cushing's Support & Research Foundation

The Cushing's Support and Research Foundation was established in 1995 to provide information and support to Cushing's patients and their families.

Last Updated: 12 Nov 2012

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Fibrous Dysplasia Foundation

The Fibrous Dysplasia Foundation provides information, advocacy and support for patients, medical professionals and the general public and promote research for diagnosis, treatment and a cure for Fibrous Dysplasia (FD) and McCune-Albright's Syndrome (MAS), Cherubism and related diseases. Our goal is to improve the quality of life for affected individuals and their families.

Last Updated: 12 Dec 2012

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

Last Updated: 18 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cushing's Syndrome" for support, advocacy or research.

Cushing's Support & Research Foundation

The Cushing's Support and Research Foundation was established in 1995 to provide information and support to Cushing's patients and their families.

http://csrf.net/

Last Updated: 12 Nov 2012

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Fibrous Dysplasia Foundation

The Fibrous Dysplasia Foundation provides information, advocacy and support for patients, medical professionals and the general public and promote research for diagnosis, treatment and a cure for Fibrous Dysplasia (FD) and McCune-Albright's Syndrome (MAS), Cherubism and related diseases. Our goal is to improve the quality of life for affected individuals and their families.

http://www.fibrousdysplasia.org/

Last Updated: 12 Dec 2012

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

http://www.magicfoundation.org

Last Updated: 18 Jun 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cushing's Syndrome" returned 578 free, full-text research articles on human participants. First 3 results:

A Rare Case of Subclinical Primary Aldosteronism and Subclinical Cushing's Syndrome without Cardiovascular Complications.
 

Author(s): Natsumi Kitajima, Toshiro Seki, Atsushi Yasuda, Masayuki Oki, Atsushi Takagi, Kazuya Hanai, Toshiro Terachi, Masafumi Fukagawa

Journal:

 

We report a rare case of subclinical primary aldosteronism (PA) and subclinical Cushing's syndrome (CS). A 49-year-old woman was referred to our hospital for the evaluation of an adrenal incidentaloma. The patient had no previous medical history and no family history of notable illness. ...

Last Updated: 7 Apr 2016

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Acute Exacerbation of Idiopathic Pulmonary Fibrosis Following Treatment for Cushing's Syndrome.
 

Author(s): Nobumasa Ohara, Masanori Kaneko, Kazuhiro Sato, Hiroyuki Usuda, Junta Tanaka, Takashi Maekawa, Hironobu Sasano, Hideki Katakami, Kenzo Kaneko, Kyuzi Kamoi

Journal: Intern. Med.. 2016 ;55(4):389-94.

 

A 64-year-old Japanese man with mild reticular shadows in both lungs developed a lung tumor causing ectopic Cushing's syndrome. He was prescribed an adrenal inhibitor, which controlled his hypercortisolemia. However, he developed acute exacerbation of idiopathic pulmonary fibrosis ...

Last Updated: 15 Feb 2016

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ACTH-secreting pancreatic neuroendocrine carcinoma with ovarian and pelvic metastases causing Cushing's syndrome: a case report.
 

Author(s): Wen-Qing Yao, Xia Wu, Gan-Di Li, Wei-Lu Wu, Wei-Ya Wang

Journal:

 

Adrenocorticotropin hormone (ACTH)-secreting pancreatic neuroendocrine carcinoma (NEC) with ovarian and pelvic metastases causing Cushing's syndrome is very rare and might be misdiagnosed. We describe a case of ACTH-secreting pancreatic poorly differentiated NEC developing bilateral ...

Last Updated: 29 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cushing's Syndrome" returned 68 free, full-text review articles on human participants. First 3 results:

THERAPY OF ENDOCRINE DISEASE: Improvement of cardiovascular risk factors after adrenalectomy in patients with adrenal tumors and subclinical Cushing's syndrome: a systematic review and meta-analysis.
 

Author(s): Irina Bancos, Fares Alahdab, Rachel K Crowley, Vasileios Chortis, Danae A Delivanis, Dana Erickson, Neena Natt, Massimo Terzolo, Wiebke Arlt, William F Young, M Hassan Murad

Journal: Eur. J. Endocrinol.. 2016 Dec;175(6):R283-R295.

 

Beneficial effects of adrenalectomy on cardiovascular risk factors in patients with subclinical Cushing's syndrome (SCS) are uncertain. We sought to conduct a systematic review and meta-analysis with the following objectives: (i) determine the effect of adrenalectomy compared with ...

Last Updated: 24 Jul 2016

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MECHANISMS IN ENDOCRINOLOGY: Tissue-specific activation of cortisol in Cushing's syndrome.
 

Author(s): Stuart A Morgan, Zaki K Hassan-Smith, Gareth G Lavery

Journal: Eur. J. Endocrinol.. 2016 Aug;175(2):R83-9.

 

Glucocorticoids are widely prescribed for their anti-inflammatory properties, but have 'Cushingoid' side effects including visceral obesity, muscle myopathy, hypertension, insulin resistance, type 2 diabetes mellitus, osteoporosis, and hepatic steatosis. These features are replicated ...

Last Updated: 7 Jul 2016

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Psychiatric disorders associated with Cushing's syndrome.
 

Author(s): Agnieszka Bratek, Agnieszka Koźmin-Burzyńska, Eliza Górniak, Krzysztof Krysta

Journal: Psychiatr Danub. 2015 Sep;27 Suppl 1():S339-43.

 

Cushing's syndrome is the term used to describe a set of symptoms associated with hypercortisolism, which in most cases is caused by hypophysial microadenoma over-secreting adrenocorticotropic hormone. This endocrine disorder is often associated with psychiatric comorbidities. The ...

Last Updated: 30 Sep 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of ATR-101 for the Treatment of Endogenous Cushing's Syndrome
 

Status: Not yet recruiting

Condition Summary: Cushing Syndrome

 

Last Updated: 10 Feb 2017

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Study to Evaluate CORT125134 in Patients With Cushing's Syndrome
 

Status: Recruiting

Condition Summary: Cushing's Syndrome

 

Last Updated: 13 Dec 2016

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Last Updated: 24 Jan 2017

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