Cushing's Syndrome

Common Name(s)

Cushing's Syndrome, Cushing Syndrome

Cushing's syndrome is an endocrine disorder caused by prolonged exposure of the body's tissues to high levels of cortisol (a hormone produced by the adrenal gland). It most commonly affects adults between age 20 and 50 years. Signs and symptoms of Cushing's syndrome include upper body obesity, fatigue, muscle weakness, high blood pressure, backache, high blood sugar, easy bruising and bluish-red stretch marks on the skin. Affected women may also experience irregular menstrual periods and increased growth of body and facial hair. This condition may be caused by a variety of factors including long-term use of corticosteroid medications, tumors in the pituitary gland or adrenal adenomas.Treatment depends on the underlying cause, but may include decreasing the dosage of corticosteroids or surgery to remove tumors.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cushing's Syndrome" for support, advocacy or research.

Cushing's Support & Research Foundation

The Cushing's Support and Research Foundation was established in 1995 to provide information and support to Cushing's patients and their families.

Last Updated: 12 Nov 2012

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Fibrous Dysplasia Foundation

The Fibrous Dysplasia Foundation provides information, advocacy and support for patients, medical professionals and the general public and promote research for diagnosis, treatment and a cure for Fibrous Dysplasia (FD) and McCune-Albright's Syndrome (MAS), Cherubism and related diseases. Our goal is to improve the quality of life for affected individuals and their families.

Last Updated: 12 Dec 2012

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

Last Updated: 13 Oct 2014

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

Last Updated: 18 Jun 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cushing's Syndrome" for support, advocacy or research.

Cushing's Support & Research Foundation

The Cushing's Support and Research Foundation was established in 1995 to provide information and support to Cushing's patients and their families.

http://csrf.net/

Last Updated: 12 Nov 2012

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Fibrous Dysplasia Foundation

The Fibrous Dysplasia Foundation provides information, advocacy and support for patients, medical professionals and the general public and promote research for diagnosis, treatment and a cure for Fibrous Dysplasia (FD) and McCune-Albright's Syndrome (MAS), Cherubism and related diseases. Our goal is to improve the quality of life for affected individuals and their families.

http://www.fibrousdysplasia.org/

Last Updated: 12 Dec 2012

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National Adrenal Diseases Foundation (NADF)

The National Adrenal Diseases Foundation informs, educates, and supports those with adrenal disease and their families to improve their quality of life.

http://www.nadf.us

Last Updated: 13 Oct 2014

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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The MAGIC Foundation

The MAGIC Foundation Mission The MAGIC Foundation is a national non-profit organization created to provide support services for the families of children afflicted with a wide variety of chronic and/or critical disorders, syndromes and diseases that affect a child’s growth. Since its inception the Foundation has grown to include support services for adults who were also impacted by these disorders.

http://www.magicfoundation.org

Last Updated: 18 Jun 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cushing's Syndrome" returned 608 free, full-text research articles on human participants. First 3 results:

Cushing's syndrome secondary to typical pulmonary carcinoid with mutation in BCOR gene: A case report.
 

Author(s): Yimin Wu, Lan Yue, Jinfan Li, Mingjing Yuan, Ying Chai

Journal: Medicine (Baltimore). 2017 Aug;96(34):e7870.

 

Typical pulmonary carcinoid is a kind of low-grade malignancy neuroendocrine tumor. Cushing's syndrome is a very rare clinical feature of typical pulmonary carcinoid caused by hypercorticism. Complete tumor resection is the standard curative treatment for primary typical pulmonary ...

Last Updated: 23 Aug 2017

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Diagnosis and Differential Diagnosis of Cushing's Syndrome.
 

Author(s): D Lynn Loriaux

Journal: N. Engl. J. Med.. 2017 07;377(2):e3.

 

Last Updated: 12 Jul 2017

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Urinary steroid metabolites in a case of florid Ectopic Cushing's syndrome and clinical correlations.
 

Author(s): Angelos Kyriacou, Karolina M Stepien, Basil Issa

Journal: Hormones (Athens). 2016 10;15(4):540-547.

 

A 51-year old woman was admitted with multiple cerebral, pulmonary and intra-abdominal abscesses. The combination of apparent immunosuppression, obesity, diabetes mellitus, hypertension, hypokalaemia, osteoporotic fractures and bilateral shoulder avascular necrosis led to a clinical ...

Last Updated: 21 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cushing's Syndrome" returned 92 free, full-text review articles on human participants. First 3 results:

DIAGNOSIS OF ENDOCRINE DISEASE: Differentiation of pathologic/neoplastic hypercortisolism (Cushing's syndrome) from physiologic/non-neoplastic hypercortisolism (formerly known as pseudo-Cushing's syndrome).
 

Author(s): James W Findling, Hershel Raff

Journal: Eur. J. Endocrinol.. 2017 May;176(5):R205-R216.

 

Endogenous hypercortisolism (Cushing's syndrome) usually implies the presence of a pathologic condition caused by either an ACTH-secreting neoplasm or autonomous cortisol secretion from a benign or malignant adrenal neoplasm. However, sustained or intermittent hypercortisolism may ...

Last Updated: 9 Feb 2017

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Adrenalectomy for Cushing's syndrome: do's and don'ts.
 

Author(s): D N Paduraru, A Nica, M Carsote, A Valea

Journal: J Med Life. ;9(4):334-341.

 

Aim. To present specific aspects of adrenalectomy for Cushing's syndrome (CS) by introducing well established aspects ("do's") and less known aspects ("don'ts"). Material and Method. This is a narrative review. Results. The "do's" for laparoscopic adrenalectomy (LA) are the following: ...

Last Updated: 8 Dec 2016

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Updates on the role of adrenal steroidogenesis inhibitors in Cushing's syndrome: a focus on novel therapies.
 

Author(s): Maria Fleseriu, Frederic Castinetti

Journal: Pituitary. 2016 Dec;19(6):643-653.

 

Endogenous Cushing's syndrome (CS) is a rare disease that results from exposure to high levels of cortisol; Cushing's disease (CD) is the most frequent form of CS. Patients with CS suffer from a variety of comorbidities that increase the risk of mortality. Surgical resection of the ...

Last Updated: 7 Sep 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of ATR-101 for the Treatment of Endogenous Cushing's Syndrome
 

Status: Recruiting

Condition Summary: Cushing Syndrome

 

Last Updated: 11 Aug 2017

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A Study to Assess the Safety and Efficacy of Levoketoconazole in the Treatment of Endogenous Cushing's Syndrome.
 

Status: Not yet recruiting

Condition Summary: Endogenous Cushing's Syndrome

 

Last Updated: 11 Sep 2017

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Study to Evaluate CORT125134 in Patients With Cushing's Syndrome
 

Status: Recruiting

Condition Summary: Cushing's Syndrome

 

Last Updated: 15 Jun 2017

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