Cryptococcosis

Common Name(s)

Cryptococcosis

Cryptococcosis is a fungal infection caused specifically by the fungus cryptococcus neofromans, which is usually found in soil and bird droppings or less commonly, the fungus cryptococcus gatti, found in sub-tropical regions. An individual usually contracts this infection through the air by breathing in the spores. Cryptococcocsis is most commonly associated with HIV and with people with weakened immune systems such as Hodgkin’s disease, individuals taking high doses of corticosteroid medications or undergoing chemotherapy. However, cryptococcocsis may affect individuals with normal immune systems as well. In some cases, there are no symptoms at all, however because the fungus is typically inhaled, the lungs are most commonly infected. It is more likely to spread beyond the lungs to the brain (and cause meningitis) in individuals with weakened immune systems. Symptoms may include blurred vision, chest pain, fatigue, dry coughs, fever, headache, nausea, sweating, and skin rashes. Other symptoms include mental confusion or unintentional weight loss. Cryptococcosis can be diagnosed through blood tests, CT scans, biopsies, and samples of cerebrospinal fluid (CSF). Cryptococcocis is treated with medications including Amphotericin B, flucytosine, and fluconazole. Cryptococcosis is one of the leading causes of death in individuals living with HIV/AIDS in sub-Saharan Africa. Many efforts are being made to combat this infection. Talk with your doctor about current treatment options if you or a family member has been diagnosed with cryptococcosis

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryptococcosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cryptococcosis" returned 319 free, full-text research articles on human participants. First 3 results:

The Role of Cryptococcus in the Immune System of Pulmonary Cryptococcosis Patients.
 

Author(s): Jinlin Wang, Yunxiang Zeng, Weizhan Luo, Xiaohong Xie, Shiyue Li

Journal:

 

To investigate the role of Cryptococcus in the immune system of immunocompetent patients with pulmonary cryptococcosis (PC) by analysing the dynamic changes of patients' immune status before and after antifungal therapy.

Last Updated: 5 Dec 2015

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Performance of the Cryptococcal Antigen Lateral Flow Assay in Non-HIV-Related Cryptococcosis.
 

Author(s): Anupop Jitmuang, Anil A Panackal, Peter R Williamson, John E Bennett, John P Dekker, Adrian M Zelazny

Journal: J. Clin. Microbiol.. 2016 Feb;54(2):460-3.

 

The cryptococcal antigen lateral flow assay (CrAg LFA) was evaluated for the diagnosis of cryptococcosis in HIV-negative patients. The sensitivity was excellent, suggesting that this assay can replace conventional testing based on latex agglutination (LA). CrAg LFA and LA titers were ...

Last Updated: 29 Jan 2016

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Clinical study of 23 pediatric patients with cryptococcosis.
 

Author(s): F-L Luo, Y-H Tao, Y-M Wang, H Li

Journal: Eur Rev Med Pharmacol Sci. 2015 Oct;19(20):3801-10.

 

Cryptococcus neoformans is a common opportunistic infection in adults with acquired immunodeficiency syndrome. However, limited data exist for pediatric patients. The aim of this study was to describe the clinical characteristics of cryptococcosis in pediatric patients.

Last Updated: 4 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cryptococcosis" returned 28 free, full-text review articles on human participants. First 3 results:

Common invasive fungal diseases: an overview of invasive candidiasis, aspergillosis, cryptococcosis, and Pneumocystis pneumonia.
 

Author(s): Yvonne Schmiedel, Stephan Zimmerli

Journal:

 

Every year, Candida, Aspergillus, Cryptococcus and Pneumocystis infect an estimated two million individuals worldwide. Most are immunocompromised or critically ill. Candida is the most common fungal pathogen of the critically ill and of recipients of transplanted abdominal organs. ...

Last Updated: 23 Feb 2016

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Pleural effusion as the initial clinical presentation in disseminated cryptococcosis and fungaemia: an unusual manifestation and a literature review.
 

Author(s): Mayun Chen, Xiaomi Wang, Xianjuan Yu, Caijun Dai, Dunshun Chen, Chang Yu, Xiaomei Xu, Dan Yao, Li Yang, Yuping Li, Liangxing Wang, Xiaoying Huang

Journal:

 

Cryptococcus neoformans infection usually presents as chronic meningitis and is increasingly being recognized in immunocompromised patients. Presentation with pleural effusion is rare in cryptococcal disease; in fact, only 4 cases of pleural effusion as the initial clinical presentation ...

Last Updated: 23 Sep 2015

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Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis.
 

Author(s): Ana Caroline Colombo, Marcio L Rodrigues

Journal: An. Acad. Bras. Cienc.. 2015 Aug;87(2 Suppl):1293-309.

 

Brain infection by the fungus Cryptococcus neoformans results in an estimated 500,000 human deaths per annum. Colonization of the central nervous system (CNS) by C. neoformans causes different clinical syndromes that involve interaction of a number of fungal components with distinct ...

Last Updated: 24 Sep 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation and Follow-up of Patients With Cryptococcosis
 

Status: Recruiting

Condition Summary: Cryptococcosis

 

Last Updated: 31 Aug 2016

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Vicente Ferrer HIV Cohort Study
 

Status: Recruiting

Condition Summary: HIV; Tuberculosis; Cryptococcosis; Opportunistic Infections; Noncommunicable Diseases

 

Last Updated: 30 Nov 2016

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Vietnam Cryptococcal Retention in Care Study
 

Status: Not yet recruiting

Condition Summary: Meningitis, Cryptococcal; Central Nervous System Fungal Infections; Central Nervous System Infections; Meningitis, Fungal

 

Last Updated: 6 Jan 2015

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