Cryptococcosis

Common Name(s)

Cryptococcosis

Cryptococcosis is a fungal infection caused specifically by the fungus cryptococcus neofromans, which is usually found in soil and bird droppings or less commonly, the fungus cryptococcus gatti, found in sub-tropical regions. An individual usually contracts this infection through the air by breathing in the spores. Cryptococcocsis is most commonly associated with HIV and with people with weakened immune systems such as Hodgkin’s disease, individuals taking high doses of corticosteroid medications or undergoing chemotherapy. However, cryptococcocsis may affect individuals with normal immune systems as well. In some cases, there are no symptoms at all, however because the fungus is typically inhaled, the lungs are most commonly infected. It is more likely to spread beyond the lungs to the brain (and cause meningitis) in individuals with weakened immune systems. Symptoms may include blurred vision, chest pain, fatigue, dry coughs, fever, headache, nausea, sweating, and skin rashes. Other symptoms include mental confusion or unintentional weight loss. Cryptococcosis can be diagnosed through blood tests, CT scans, biopsies, and samples of cerebrospinal fluid (CSF). Cryptococcocis is treated with medications including Amphotericin B, flucytosine, and fluconazole. Cryptococcosis is one of the leading causes of death in individuals living with HIV/AIDS in sub-Saharan Africa. Many efforts are being made to combat this infection. Talk with your doctor about current treatment options if you or a family member has been diagnosed with cryptococcosis

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryptococcosis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cryptococcosis" returned 307 free, full-text research articles on human participants. First 3 results:

Cryptococcosis in Atlántico, Colombia: an approximation of the prevalence of this mycosis and the distribution of the etiological agent in the environment.
 

Author(s): María Clara Noguera, Patricia Escandón, Elizabeth Castañeda

Journal: Rev. Soc. Bras. Med. Trop.. ;48(5):580-6.

 

Cryptococcosis is an invasive disease acquired by inhalation of infectious propagules from the environment. Currently, compulsory notification of the spread of this disease is not required in Colombia. However, reporting of human immunodeficiency virus (HIV)/acquired immune deficiency ...

Last Updated: 31 Oct 2015

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Increasing trend of fluconazole-non-susceptible Cryptococcus neoformans in patients with invasive cryptococcosis: a 12-year longitudinal study.
 

Author(s): Yi-Chun Chen, Tzu-Yao Chang, Jien-Wei Liu, Fang-Ju Chen, Chun-Chih Chien, Chen-Hsiang Lee, Cheng-Hsien Lu

Journal:

 

This study aimed to investigate the rate of fluconazole-non-susceptible Cryptococcus neoformans in Southern Taiwan for the period 2001-2012 and analyze the risk factors for acquiring it among patients with invasive cryptococcosis.

Last Updated: 21 Jul 2015

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Pancytopenia and cutaneous cryptococcosis as an indicator disease of acquired immune deficiency syndrome.
 

Author(s): R Khuraijam, P Lungran, K Yoihenba, R S Laishram, P Pukhrambam

Journal: Indian J Med Microbiol. ;33(3):439-42.

 

We present a case of pancytopenia and cutaneous cryptococcosis in a young girl with no complaints of fever, headache and vomiting. Fine-needle aspiration cytology and further investigation for pancytopenia revealed presence of Cryptococcus in skin and bone marrow aspirates. Fungal ...

Last Updated: 13 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cryptococcosis" returned 25 free, full-text review articles on human participants. First 3 results:

Pleural effusion as the initial clinical presentation in disseminated cryptococcosis and fungaemia: an unusual manifestation and a literature review.
 

Author(s): Mayun Chen, Xiaomi Wang, Xianjuan Yu, Caijun Dai, Dunshun Chen, Chang Yu, Xiaomei Xu, Dan Yao, Li Yang, Yuping Li, Liangxing Wang, Xiaoying Huang

Journal:

 

Cryptococcus neoformans infection usually presents as chronic meningitis and is increasingly being recognized in immunocompromised patients. Presentation with pleural effusion is rare in cryptococcal disease; in fact, only 4 cases of pleural effusion as the initial clinical presentation ...

Last Updated: 23 Sep 2015

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Evaluation of a new cryptococcal antigen lateral flow immunoassay in serum, cerebrospinal fluid and urine for the diagnosis of cryptococcosis: a meta-analysis and systematic review.
 

Author(s): Hua-Rong Huang, Li-Chao Fan, Bhavana Rajbanshi, Jin-Fu Xu

Journal:

 

A new lateral flow immunoassay (LFA) for the detection of cryptococcal antigen was developed.

Last Updated: 15 May 2015

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Epidemiology of Cryptococcus and cryptococcosis in China.
 

Author(s): Wei Fang, Zhenzong Fa, Wanqing Liao

Journal: Fungal Genet. Biol.. 2015 May;78():7-15.

 

Cryptococcosis is a significant invasive fungal infection with noteworthy morbidity and mortality, primarily caused by Cryptococcus neoformans and Cryptococcus gattii. In China, C. neoformans var. grubii (especially molecular type VNI) is the most common variety in the environment ...

Last Updated: 8 Jun 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation and Follow-up of Patients With Cryptococcosis
 

Status: Recruiting

Condition Summary: Cryptococcosis

 

Last Updated: 27 Apr 2016

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Vicente Ferrer HIV Cohort Study
 

Status: Recruiting

Condition Summary: HIV; Tuberculosis; Cryptococcosis; Opportunistic Infections; Noncommunicable Diseases

 

Last Updated: 9 Apr 2016

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Efficacy, Safety and Pharmacokinetics of SPK-843 in the Treatment of Pulmonary Mycosis
 

Status: Recruiting

Condition Summary: Cryptococcosis or Aspergillosis Infections

 

Last Updated: 6 Jun 2011

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