Cryptococcosis

Common Name(s)

Cryptococcosis

Cryptococcosis is a fungal infection caused specifically by the fungus cryptococcus neofromans, which is usually found in soil and bird droppings or less commonly, the fungus cryptococcus gatti, found in sub-tropical regions. An individual usually contracts this infection through the air by breathing in the spores. Cryptococcocsis is most commonly associated with HIV and with people with weakened immune systems such as Hodgkin’s disease, individuals taking high doses of corticosteroid medications or undergoing chemotherapy. However, cryptococcocsis may affect individuals with normal immune systems as well. In some cases, there are no symptoms at all, however because the fungus is typically inhaled, the lungs are most commonly infected. It is more likely to spread beyond the lungs to the brain (and cause meningitis) in individuals with weakened immune systems. Symptoms may include blurred vision, chest pain, fatigue, dry coughs, fever, headache, nausea, sweating, and skin rashes. Other symptoms include mental confusion or unintentional weight loss. Cryptococcosis can be diagnosed through blood tests, CT scans, biopsies, and samples of cerebrospinal fluid (CSF). Cryptococcocis is treated with medications including Amphotericin B, flucytosine, and fluconazole. Cryptococcosis is one of the leading causes of death in individuals living with HIV/AIDS in sub-Saharan Africa. Many efforts are being made to combat this infection. Talk with your doctor about current treatment options if you or a family member has been diagnosed with cryptococcosis

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryptococcosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cryptococcosis" returned 256 free, full-text research articles on human participants. First 3 results:

Cavitary pulmonary cryptococcosis with an Aspergillus fungus ball.
 

Author(s): Yasushi Makino, Osamu Nishiyama, Hiroyuki Sano, Takashi Iwanaga, Yuji Higashimoto, Hiroaki Kume, Yuji Tohda

Journal: Intern. Med.. 2014 ;53(23):2737-9.

 

We herein present the case of a 64-year-old immunocompetent man with a diagnosis of pulmonary cryptococcosis who presented with cavitary nodules, one of which contained a fungus ball, on chest CT. The coincidence of cavitary cryptococcosis and an Aspergillus fungus ball was histologically ...

Last Updated: 2 Dec 2014

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Pulmonary cryptococcosis with endobronchial lesions and meningitis.
 

Author(s): Kyuto Odashima, Noboru Takayanagi, Takashi Ishiguro, Yoshihiko Shimizu, Yutaka Sugita

Journal: Intern. Med.. 2014 ;53(23):2731-5.

 

A 58-year-old man presented with right chest pain, anorexia, general malaise, and fever. Chest computed tomography showed a mass lesion with right middle lobe atelectasis. The bronchoscopy showed polypoid lesions with a smooth surface in each right middle lobe bronchial lumen. The ...

Last Updated: 2 Dec 2014

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Disseminated cryptococcosis in bone marrow.
 

Author(s): Ludovic Suner, Stephanie Mathis

Journal: Blood. 2014 May;123(20):3070.

 

Last Updated: 19 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cryptococcosis" returned 20 free, full-text review articles on human participants. First 3 results:

Flucytosine and cryptococcosis: time to urgently address the worldwide accessibility of a 50-year-old antifungal.
 

Author(s): Angela Loyse, Françoise Dromer, Jeremy Day, Olivier Lortholary, Thomas S Harrison

Journal: J. Antimicrob. Chemother.. 2013 Nov;68(11):2435-44.

 

Current, widely accepted guidelines for the management of HIV-associated cryptococcal meningoencephalitis (CM) recommend amphotericin B combined with flucytosine (5-FC) for ≥2 weeks as the initial induction treatment of choice. However, access to flucytosine in Africa and Asia, ...

Last Updated: 17 Oct 2013

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Opportunistic yeast infections: candidiasis, cryptococcosis, trichosporonosis and geotrichosis.
 

Author(s): Denisse Vázquez-González, Ana María Perusquía-Ortiz, Max Hundeiker, Alexandro Bonifaz

Journal: J Dtsch Dermatol Ges. 2013 May;11(5):381-93; quiz 394.

 

Opportunistic yeast infections are diseases caused by fungi which normally are saprophytic and do not cause disease in humans or animals. The prevalence of these diseases has been increasing due to immunosuppressive, corticosteroid, and long-term antibiotic treatment following organ ...

Last Updated: 29 Apr 2013

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Cryptococcosis in sarcoidosis: cryptOsarc, a comparative study of 18 cases.
 

Author(s): C Bernard, D Maucort-Boulch, L Varron, C Charlier, K Sitbon, N Freymond, D Bouhour, A Hot, A C Masquelet, D Valeyre, N Costedoat-Chalumeau, M Etienne, I Gueit, S Jouneau, P Delaval, L Mouthon, J Pouget, J Serratrice, J-P Brion, F Vaylet, C Bremont, J M Chennebault, S Jaffuel, C Broussolle, O Lortholary, P Sève,

Journal: QJM. 2013 Jun;106(6):523-39.

 

To describe the main characteristics and the treatment of cryptococcosis in patients with sarcoidosis.

Last Updated: 30 May 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation and Follow-up of Patients With Cryptococcosis
 

Status: Recruiting

Condition Summary: Cryptococcosis

 

Last Updated: 3 Feb 2015

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Vicente Ferrer HIV Cohort Study
 

Status: Recruiting

Condition Summary: HIV; Tuberculosis; Cryptococcosis; Opportunistic Infections; Noncommunicable Diseases

 

Last Updated: 26 May 2015

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Efficacy, Safety and Pharmacokinetics of SPK-843 in the Treatment of Pulmonary Mycosis
 

Status: Recruiting

Condition Summary: Cryptococcosis or Aspergillosis Infections

 

Last Updated: 6 Jun 2011

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