Cryptococcosis

Common Name(s)

Cryptococcosis

Cryptococcosis is a fungal infection caused specifically by the fungus cryptococcus neofromans, which is usually found in soil and bird droppings or less commonly, the fungus cryptococcus gatti, found in sub-tropical regions. An individual usually contracts this infection through the air by breathing in the spores. Cryptococcocsis is most commonly associated with HIV and with people with weakened immune systems such as Hodgkin’s disease, individuals taking high doses of corticosteroid medications or undergoing chemotherapy. However, cryptococcocsis may affect individuals with normal immune systems as well. In some cases, there are no symptoms at all, however because the fungus is typically inhaled, the lungs are most commonly infected. It is more likely to spread beyond the lungs to the brain (and cause meningitis) in individuals with weakened immune systems. Symptoms may include blurred vision, chest pain, fatigue, dry coughs, fever, headache, nausea, sweating, and skin rashes. Other symptoms include mental confusion or unintentional weight loss. Cryptococcosis can be diagnosed through blood tests, CT scans, biopsies, and samples of cerebrospinal fluid (CSF). Cryptococcocis is treated with medications including Amphotericin B, flucytosine, and fluconazole. Cryptococcosis is one of the leading causes of death in individuals living with HIV/AIDS in sub-Saharan Africa. Many efforts are being made to combat this infection. Talk with your doctor about current treatment options if you or a family member has been diagnosed with cryptococcosis

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Condition Specific Organizations

Following organizations serve the condition "Cryptococcosis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cryptococcosis" returned 302 free, full-text research articles on human participants. First 3 results:

Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia.
 

Author(s): Diego H Cáceres, Alejandra Zuluaga, Ángela M Tabares, Tom Chiller, Ángel González, Beatriz L Gómez

Journal:

 

A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) ...

Last Updated: 31 Dec 1969

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Disseminated cryptococcosis with skin lesions: report of a case series.
 

Author(s): Marina Zoéga Hayashida, Camila Arai Seque, Victor Pavan Pasin, Milvia Maria Simões E Silva Enokihara, Adriana Maria Porro

Journal: An Bras Dermatol. 2017 ;92(5 Suppl 1):69-72.

 

Cryptococcosis is a common fungal infection in immunocompromised patients, caused by genus Cryptococcus, presenting with meningitis, pneumonia, and skin lesions. Cutaneous presentation can be varied, but specifically in solid organ transplant recipients (iatrogenically immunocompromised), ...

Last Updated: 31 Dec 1969

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Clinical features of pulmonary cryptococcosis among patients with different levels of peripheral blood CD4 T lymphocyte counts.
 

Author(s): Qian He, Yuan Ding, Wei Zhou, Hongxing Li, Ming Zhang, Yi Shi, Xin Su

Journal:

 

The clinical manifestation of pulmonary cryptococcosis varies notably between immunocompromised and immunocompetent patients. To better understand pulmonary cryptococcosis, we compared the clinical features of pulmonary cryptococcosis patients with or without decreased peripheral ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cryptococcosis" returned 36 free, full-text review articles on human participants. First 3 results:

Variability in innate host immune responses to cryptococcosis.
 

Author(s): Mariam Garelnabi, Robin C May

Journal: Mem. Inst. Oswaldo Cruz. 2018 ;113(7):e180060.

 

Cryptococcosis is an invasive fungal disease caused by Cryptococcus neoformans and the closely related species C. gattii. The severe form of the disease, cryptococcal meningitis (CM), is rapidly fatal without treatment. Although typically a disease of immunocompromised (especially ...

Last Updated: 31 Dec 1969

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The status of cryptococcosis in Latin America.
 

Author(s): Carolina Firacative, Jairo Lizarazo, María Teresa Illnait-Zaragozí, Elizabeth Castañeda,

Journal: Mem. Inst. Oswaldo Cruz. 2018 ;113(7):e170554.

 

Cryptococcosis is a life-threatening fungal infection caused by the encapsulated yeasts Cryptococcus neoformans and C. gattii, acquired from the environment. In Latin America, as occurring worldwide, C. neoformans causes more than 90% of the cases of cryptococcosis, affecting predominantly ...

Last Updated: 31 Dec 1969

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The war on cryptococcosis: A Review of the antifungal arsenal.
 

Author(s): Ahmad Mourad, John R Perfect

Journal: Mem. Inst. Oswaldo Cruz. 2018 ;113(7):e170391.

 

Cryptococcal meningitis is the most common central nervous system infection in the world today. It occurs primarily, but not exclusively, in immunocompromised individuals and despite substantial improvement in management of clinical events like AIDS, the numbers of cases of cryptococcosis ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation and Follow-up of Patients With Cryptococcosis
 

Status: Recruiting

Condition Summary: Cryptococcosis

 

Last Updated: 24 Apr 2018

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Vicente Ferrer HIV Cohort Study
 

Status: Recruiting

Condition Summary: HIV; Tuberculosis; Cryptococcosis; Opportunistic Infections; Noncommunicable Diseases

 

Last Updated: 18 Apr 2018

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Treatment With Tamoxifen in Cryptococcal Meningitis
 

Status: Recruiting

Condition Summary: Meningitis Streptococcal; Hiv; Meningitis; Meningoencephalitis

 

Last Updated: 9 Apr 2018

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