Cryptococcosis

Common Name(s)

Cryptococcosis

Cryptococcosis is a fungal infection caused specifically by the fungus cryptococcus neofromans, which is usually found in soil and bird droppings or less commonly, the fungus cryptococcus gatti, found in sub-tropical regions. An individual usually contracts this infection through the air by breathing in the spores. Cryptococcocsis is most commonly associated with HIV and with people with weakened immune systems such as Hodgkin’s disease, individuals taking high doses of corticosteroid medications or undergoing chemotherapy. However, cryptococcocsis may affect individuals with normal immune systems as well. In some cases, there are no symptoms at all, however because the fungus is typically inhaled, the lungs are most commonly infected. It is more likely to spread beyond the lungs to the brain (and cause meningitis) in individuals with weakened immune systems. Symptoms may include blurred vision, chest pain, fatigue, dry coughs, fever, headache, nausea, sweating, and skin rashes. Other symptoms include mental confusion or unintentional weight loss. Cryptococcosis can be diagnosed through blood tests, CT scans, biopsies, and samples of cerebrospinal fluid (CSF). Cryptococcocis is treated with medications including Amphotericin B, flucytosine, and fluconazole. Cryptococcosis is one of the leading causes of death in individuals living with HIV/AIDS in sub-Saharan Africa. Many efforts are being made to combat this infection. Talk with your doctor about current treatment options if you or a family member has been diagnosed with cryptococcosis

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryptococcosis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cryptococcosis" returned 287 free, full-text research articles on human participants. First 3 results:

Progressive cutaneous Cryptococcosis complicated with meningitis in a myasthenia gravis patient on long-term immunosuppressive therapy - a case report.
 

Author(s): Nguyen Thi Cam Huong, Ahmed M A Altibi, Nguyen My Hoa, Le Anh Tuan, Samar Salman, Sara Morsy, Nguyen Thi Bich Lien, Nguyen Thanh Truong, Nguyen Thi Hoang Mai, Pham Thi Le Hoa, Nguyen Ba Thang, Van The Trung

Journal:

 

Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans and most remarkably manifests in HIV-infected individuals, especially in the settings of very low CD4 count. Development of cryptococcosis in HIV-uninfected individuals is exceedingly ...

Last Updated: 27 Apr 2017

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The epidemiology of cryptococcosis and the characterization of Cryptococcus neoformans isolated in a Brazilian University Hospital.
 

Author(s): Paula Augusta Dias Fogaça de Aguiar, Reginaldo Dos Santos Pedroso, Aércio Sebastião Borges, Tomaz de Aquino Moreira, Lúcio Borges de Araújo, Denise Von Dolinger de Brito Röder

Journal:

 

Cryptococcosis, a systemic disease caused by the fungus Cryptococcus neoformans/ Cryptococcus gattii is more severe in immunocompromised individuals. This study aimed to analyze the epidemiology of the disease, the molecular characteristics and the antifungal susceptibility of C. ...

Last Updated: 19 Apr 2017

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Disseminated cryptococcosis manifested as a single tumor in an immunocompetent patient, similar to the cutaneous primary forms.
 

Author(s): Danielle Mechereffe do Amaral, Ritha de Cássia Capelato Rocha, Luiz Euribel Prestes Carneiro, Dewton Moraes Vasconcelos, Marilda Aparecida Milanez Morgado de Abreu

Journal: An Bras Dermatol. ;91(5 suppl 1):29-31.

 

Cryptococcosis is a fungal infection caused by Cryptococcus neoformans that tends to affect immunocompromised individuals. The fungi are mostly acquired by inhalation, which leads to an initial pulmonary infection. Later, other organs - such as the central nervous system and the skin ...

Last Updated: 16 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cryptococcosis" returned 29 free, full-text review articles on human participants. First 3 results:

Integrated therapy for HIV and cryptococcosis.
 

Author(s): Sirawat Srichatrapimuk, Somnuek Sungkanuparph

Journal:

 

Cryptococcosis has been one of the most common opportunistic infections and causes of mortality among HIV-infected patients, especially in resource-limited countries. Cryptococcal meningitis is the most common form of cryptococcosis. Laboratory diagnosis of cryptococcosis includes ...

Last Updated: 1 Dec 2016

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Localized Cutaneous Cryptococcosis: Summary of Reported Cases in Japan.
 

Author(s): Hiromitsu Noguchi, Masataro Hiruma, Keishi Maruo, Masayoshi Jono, Keishi Miyata, Hideaki Tanaka, Koichi Tanabe, Yoshitsugu Miyazaki, Hironobu Ihn

Journal: Med Mycol J. 2016 ;57(3):E35-9.

 

A 68-year-old male plasterer with no history of trauma presented to our clinic in March 2012 with a 16×14-mm ulcer that developed following a crushed small papule on the right anterior chest. In April 2012, the patient was referred to another hospital, where cutaneous cryptococcosis ...

Last Updated: 1 Sep 2016

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Common invasive fungal diseases: an overview of invasive candidiasis, aspergillosis, cryptococcosis, and Pneumocystis pneumonia.
 

Author(s): Yvonne Schmiedel, Stephan Zimmerli

Journal:

 

Every year, Candida, Aspergillus, Cryptococcus and Pneumocystis infect an estimated two million individuals worldwide. Most are immunocompromised or critically ill. Candida is the most common fungal pathogen of the critically ill and of recipients of transplanted abdominal organs. ...

Last Updated: 23 Feb 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation and Follow-up of Patients With Cryptococcosis
 

Status: Recruiting

Condition Summary: Cryptococcosis

 

Last Updated: 13 Jul 2017

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Cryptococcal Antigen Screening Plus Sertraline
 

Status: Not yet recruiting

Condition Summary: Cryptococcosis; Cryptococcal Infections; AIDS-Related Opportunistic Infections

 

Last Updated: 9 May 2017

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Vicente Ferrer HIV Cohort Study
 

Status: Recruiting

Condition Summary: HIV; Tuberculosis; Cryptococcosis; Opportunistic Infections; Noncommunicable Diseases

 

Last Updated: 30 Dec 2016

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