Cryoglobulinemia

Common Name(s)

Cryoglobulinemia

Cryoglobulinemia is a condition that can affect blood vessels throughout the body. This condition is caused by the presence of abnormal proteins in the blood called cryoglobulins. These abnormal proteins become solid in cold temperatures and block blood flow. Symptoms may include difficulty breathing, tiredness, glomerulonephritis, joint and muscle pain, purpura, Raynaud's phenomenon, skin ulcers, and skin death.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryoglobulinemia" for support, advocacy or research.

Alliance for Cryoglobulinemia

Alliance for Cryoglobulinemia is an inclusive network of patients, caregivers, family, medical professionals and other supporters dedicated to improving quality of life for people with cryoglobulinemia. Our goal is to create a platform that links all efforts of campaigns, research, support and other resources related to cryoglobulinemia. We utilize medical advisors, community networking, crowd-funding, peer to peer support, social media and campaign strategies to advocate awareness, patient support, education and research.

Last Updated: 24 Apr 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryoglobulinemia" for support, advocacy or research.

Alliance for Cryoglobulinemia

Alliance for Cryoglobulinemia is an inclusive network of patients, caregivers, family, medical professionals and other supporters dedicated to improving quality of life for people with cryoglobulinemia. Our goal is to create a platform that links all efforts of campaigns, research, support and other resources related to cryoglobulinemia. We utilize medical advisors, community networking, crowd-funding, peer to peer support, social media and campaign strategies to advocate awareness, patient support, education and research.

http://allianceforcryo.org/

Last Updated: 24 Apr 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cryoglobulinemia" returned 138 free, full-text research articles on human participants. First 3 results:

Clinical features of 30 patients with cryoglobulinemia.
 

Author(s): Xiao-Hu Shi, Jie Ma, Chao Li, Yu-Bing Wen, Hang Li, Ming-Xi Li, Xue-Wang Li, Xue-Mei Li

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2014 Dec;36(6):639-44.

 

To summarize the clinical features of cryoglobulinemia.

Last Updated: 5 Jan 2015

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Cryofibrinogenemia associated with cryoglobulinemia--a severe case with amputation of four extremities.
 

Author(s): Thomas Winkens, Alexander Pfeil, Bernhard Theis, Christian Jung

Journal: Jpn. J. Clin. Oncol.. 2014 Oct;44(10):1013-4.

 

Last Updated: 2 Dec 2014

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Serum levels of immunoglobulin free light chains in patients with chronic hepatitis C presenting cryoglobulinemia.
 

Author(s): Isabela S Oliveira, Milena S Cabral, Larissa S Jesus, Raymundo ParanĂ¡, Ajax M Atta, Maria Luiza B Sousa Atta

Journal: Braz J Infect Dis. ;18(6):638-42.

 

Hepatitis C virus (HCV) infects B-lymphocytes, provokes cellular dysfunction and causes lymphoproliferative diseases such as cryoglobulinemia and non-Hodgkin's B-cell lymphoma. In the present study, we investigated the serum levels of kappa and lambda free light chains (FLC) of immunoglobulins ...

Last Updated: 3 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cryoglobulinemia" returned 14 free, full-text review articles on human participants. First 3 results:

Thyroid involvement in hepatitis C - associated mixed cryoglobulinemia.
 

Author(s): Poupak Fallahi, Silvia Martina Ferrari, Dilia Giuggioli, Andreina Manfredi, Caterina Mancusi, Silvia Fabiani, Marco Centanni, Santino Marchi, Clodoveo Ferri, Alessandro Antonelli

Journal: Hormones (Athens). ;13(1):16-23.

 

The prevalence and clinical features of thyroid involvement in patients with hepatitis C virus-associated mixed cryoglobulinemia (MC+HCV) have been reviewed.

Last Updated: 11 Apr 2014

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Hepatitis C virus-related mixed cryoglobulinemia: is genetics to blame?
 

Author(s): Laura Gragnani, Elisa Fognani, Alessia Piluso, Anna Linda Zignego

Journal: World J. Gastroenterol.. 2013 Dec;19(47):8910-5.

 

Mixed cryoglobulinemia (MC) is the extrahepatic manifestation most strictly correlated with hepatitis C virus (HCV) infection; it is a benign autoimmune and lymphoproliferative disorder that evolves to lymphoma in 5%-10% of cases. MC is reputed to be a multistep and multifactorial ...

Last Updated: 31 Dec 2013

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Molecular signatures of hepatitis C virus (HCV)-induced type II mixed cryoglobulinemia (MCII).
 

Author(s): Giuseppe Sautto, Nicasio Mancini, Massimo Clementi, Roberto Burioni

Journal:

 

The role of hepatitis C virus (HCV) infection in the induction of type II mixed cryoglobulinemia (MCII) and the possible establishment of related lymphoproliferative disorders, such as B-cell non-Hodgkin lymphoma (B-NHL), is well ascertained. However, the molecular pathways involved ...

Last Updated: 3 Dec 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.