Cryoglobulinemia

Common Name(s)

Cryoglobulinemia

Cryoglobulinemia is a condition that can affect blood vessels throughout the body. This condition is caused by the presence of abnormal proteins in the blood called cryoglobulins. These abnormal proteins become solid in cold temperatures and block blood flow. Symptoms may include difficulty breathing, tiredness, glomerulonephritis, joint and muscle pain, purpura, Raynaud's phenomenon, skin ulcers, and skin death.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryoglobulinemia" for support, advocacy or research.

Alliance for Cryoglobulinemia

Alliance for Cryoglobulinemia is an inclusive network of patients, caregivers, family, medical professionals and other supporters dedicated to improving quality of life for people with cryoglobulinemia. Our goal is to create a platform that links all efforts of campaigns, research, support and other resources related to cryoglobulinemia. We utilize medical advisors, community networking, crowd-funding, peer to peer support, social media and campaign strategies to advocate awareness, patient support, education and research.

Last Updated: 24 Apr 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryoglobulinemia" for support, advocacy or research.

Alliance for Cryoglobulinemia

Alliance for Cryoglobulinemia is an inclusive network of patients, caregivers, family, medical professionals and other supporters dedicated to improving quality of life for people with cryoglobulinemia. Our goal is to create a platform that links all efforts of campaigns, research, support and other resources related to cryoglobulinemia. We utilize medical advisors, community networking, crowd-funding, peer to peer support, social media and campaign strategies to advocate awareness, patient support, education and research.

http://allianceforcryo.org/

Last Updated: 24 Apr 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cryoglobulinemia" returned 201 free, full-text research articles on human participants. First 3 results:

Tubulointerstitial Nephritis Caused by Peritubular Capillaritis Accompanied by Cryoglobulinemia.
 

Author(s): Takamasa Iwakura, Akio Namikawa, Naoko Tsuji, Sayaka Ishigaki, Shinsuke Isobe, Masafumi Ono, Yukitoshi Sakao, Takayuki Tsuji, Naro Ohashi, Akihiko Kato, Mana Goto, Hideo Yasuda

Journal: Intern. Med.. 2015 ;54(22):2885-91.

 

A 73-year-old man with fever, renal insufficiency, and purpura was referred to our hospital to be evaluated for renal insufficiency. Renal biopsy revealed acute and chronic tubulointerstitial nephritis with no laboratory findings of sarcoidosis or connective tissue disease. Low C4 ...

Last Updated: 16 Nov 2015

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Pulmonary Extranodal Marginal Zone Lymphoma with Macroglobulinemia and Mixed Cryoglobulinemia Developed in a Patient with Chronic Hepatitis C.
 

Author(s): Chisun Min, Takakazu Higuchi, Ryosuke Koyamada, Norihiro Yamaguchi, Sadamu Okada

Journal: Intern. Med.. 2015 ;54(16):2061-4.

 

We report a 65-year-old woman with a chronic hepatitis C virus infection who developed pulmonary extranodal marginal zone lymphoma (EMZL) of mucosa-associated lymphoid tissues complicated with macroglobulinemia and mixed cryoglobulinemia. She was treated with immunochemotherapy which ...

Last Updated: 17 Aug 2015

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Early onset mixed cryoglobulinemia in hepatitis C.
 

Author(s): Kritika Krishnamurthy, Sudhesna Mohapatra, T K Mishra, Nikhil Jha

Journal: Indian J Pathol Microbiol. ;58(3):381-3.

 

Cryoglobulinemia is one of the most common forms of extrahepatic manifestation of chronic hepatitis infection. The phenomenon is generally seen after several years of chronicity predominantly in the female population resulting in arthralgias, purpuras, and other symptoms, due to vasculitis. ...

Last Updated: 15 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cryoglobulinemia" returned 18 free, full-text review articles on human participants. First 3 results:

[Renal damage caused by Rhupus syndrome associated with anti-neutrophil cytoplasmic antibodies vasculitis and cryoglobulinemia].
 

Author(s): Xin-ju Zhao, Tao Wei, Bao Dong, Yuan Jia, Mei Wang

Journal: Beijing Da Xue Xue Bao. 2015 Oct;47(5):870-4.

 

We analyzed the clinicopathological characteristics of one patient with Rhupus syndrome associated nephropathy in Peking University People's Hospital, and reviewed the related literature. The patient was a middle aged female. She developed rheumatoid arthritis first, and then manifested ...

Last Updated: 17 Oct 2015

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Thyroid involvement in hepatitis C - associated mixed cryoglobulinemia.
 

Author(s): Poupak Fallahi, Silvia Martina Ferrari, Dilia Giuggioli, Andreina Manfredi, Caterina Mancusi, Silvia Fabiani, Marco Centanni, Santino Marchi, Clodoveo Ferri, Alessandro Antonelli

Journal: Hormones (Athens). ;13(1):16-23.

 

The prevalence and clinical features of thyroid involvement in patients with hepatitis C virus-associated mixed cryoglobulinemia (MC+HCV) have been reviewed.

Last Updated: 11 Apr 2014

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Hepatitis C virus-related mixed cryoglobulinemia: is genetics to blame?
 

Author(s): Laura Gragnani, Elisa Fognani, Alessia Piluso, Anna Linda Zignego

Journal: World J. Gastroenterol.. 2013 Dec;19(47):8910-5.

 

Mixed cryoglobulinemia (MC) is the extrahepatic manifestation most strictly correlated with hepatitis C virus (HCV) infection; it is a benign autoimmune and lymphoproliferative disorder that evolves to lymphoma in 5%-10% of cases. MC is reputed to be a multistep and multifactorial ...

Last Updated: 31 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy of All-Oral Anti-Viral Therapy for Symptomatic Hepatitis C Virus Infection-Related Cryoglobulinemia
 

Status: Recruiting

Condition Summary: Hepatitis C; Cryoglobulinemia

 

Last Updated: 3 Jul 2016

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Direct Antiviral Agents for Hepatitis C Virus-associated Cryoglobulinaemia Vasculitis
 

Status: Recruiting

Condition Summary: Vasculitis; Cryoglobulinemia; Hepatitis C

 

Last Updated: 31 Jul 2016

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Rituximab Plus Corticosteroids in Non-infectious Active Mixed Cryoglobulinemia Vasculitis
 

Status: Recruiting

Condition Summary: Cryoglobulinemia; Systemic Vasculitis

 

Last Updated: 21 Apr 2016

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