Cryoglobulinemia

Common Name(s)

Cryoglobulinemia

Cryoglobulinemia is a condition that can affect blood vessels throughout the body. This condition is caused by the presence of abnormal proteins in the blood called cryoglobulins. These abnormal proteins become solid in cold temperatures and block blood flow. Symptoms may include difficulty breathing, tiredness, glomerulonephritis, joint and muscle pain, purpura, Raynaud's phenomenon, skin ulcers, and skin death.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryoglobulinemia" for support, advocacy or research.

Alliance for Cryoglobulinemia

Alliance for Cryoglobulinemia is an inclusive network of patients, caregivers, family, medical professionals and other supporters dedicated to improving quality of life for people with cryoglobulinemia. Our goal is to create a platform that links all efforts of campaigns, research, support and other resources related to cryoglobulinemia. We utilize medical advisors, community networking, crowd-funding, peer to peer support, social media and campaign strategies to advocate awareness, patient support, education and research.

Last Updated: 24 Apr 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryoglobulinemia" for support, advocacy or research.

Alliance for Cryoglobulinemia

Alliance for Cryoglobulinemia is an inclusive network of patients, caregivers, family, medical professionals and other supporters dedicated to improving quality of life for people with cryoglobulinemia. Our goal is to create a platform that links all efforts of campaigns, research, support and other resources related to cryoglobulinemia. We utilize medical advisors, community networking, crowd-funding, peer to peer support, social media and campaign strategies to advocate awareness, patient support, education and research.

http://allianceforcryo.org/

Last Updated: 24 Apr 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cryoglobulinemia" returned 196 free, full-text research articles on human participants. First 3 results:

Successful Treatment of Pyoderma Gangrenosum with Cryoglobulinemia and Hepatitis C.
 

Author(s): Mohsen Pourmorteza, Fady Tawadros, Gilbert Bader, Mohamed Al-Tarawneh, Emilie Cook, Wael Shams, Mark Young

Journal:

 

Pyoderma gangrenosum is a rare, ulcerative cutaneous condition that was first described by Brocq in 1916. This diagnosis is quite challenging as the histopathological findings are nonspecific. Pyoderma gangrenosum is usually associated with inflammatory bowel disease, leukemia, and ...

Last Updated: 27 Jun 2016

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Purtscher-like Retinopathy as a Rare Presentation of Cryoglobulinemia.
 

Author(s): Ahmed Chebil, Rym Mammouri, Mohamed Ben Abdallah, Leila El Matri

Journal: Middle East Afr J Ophthalmol. ;23(2):219-21.

 

Purtscher's retinopathy is a rare condition that is noted in cases related to various types of trauma. The characteristic finding in the fundus is the presence of multiple Purtscher flecken. Purtscher-like retinopathy has a similar presentation in the fundus but is not associated ...

Last Updated: 10 May 2016

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Cryoglobulinemia presenting with crystals in peripheral blood.
 

Author(s): Nelson C N Chan, Sequence S H Tang

Journal: Blood. 2015 Dec;126(24):2642.

 

Last Updated: 10 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cryoglobulinemia" returned 20 free, full-text review articles on human participants. First 3 results:

[Renal damage caused by Rhupus syndrome associated with anti-neutrophil cytoplasmic antibodies vasculitis and cryoglobulinemia].
 

Author(s): Xin-ju Zhao, Tao Wei, Bao Dong, Yuan Jia, Mei Wang

Journal: Beijing Da Xue Xue Bao. 2015 Oct;47(5):870-4.

 

We analyzed the clinicopathological characteristics of one patient with Rhupus syndrome associated nephropathy in Peking University People's Hospital, and reviewed the related literature. The patient was a middle aged female. She developed rheumatoid arthritis first, and then manifested ...

Last Updated: 17 Oct 2015

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Thyroid involvement in hepatitis C - associated mixed cryoglobulinemia.
 

Author(s): Poupak Fallahi, Silvia Martina Ferrari, Dilia Giuggioli, Andreina Manfredi, Caterina Mancusi, Silvia Fabiani, Marco Centanni, Santino Marchi, Clodoveo Ferri, Alessandro Antonelli

Journal: Hormones (Athens). ;13(1):16-23.

 

The prevalence and clinical features of thyroid involvement in patients with hepatitis C virus-associated mixed cryoglobulinemia (MC+HCV) have been reviewed.

Last Updated: 11 Apr 2014

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Hepatitis C virus-related mixed cryoglobulinemia: is genetics to blame?
 

Author(s): Laura Gragnani, Elisa Fognani, Alessia Piluso, Anna Linda Zignego

Journal: World J. Gastroenterol.. 2013 Dec;19(47):8910-5.

 

Mixed cryoglobulinemia (MC) is the extrahepatic manifestation most strictly correlated with hepatitis C virus (HCV) infection; it is a benign autoimmune and lymphoproliferative disorder that evolves to lymphoma in 5%-10% of cases. MC is reputed to be a multistep and multifactorial ...

Last Updated: 31 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy of All-Oral Anti-Viral Therapy for Symptomatic Hepatitis C Virus Infection-Related Cryoglobulinemia
 

Status: Recruiting

Condition Summary: Hepatitis C; Cryoglobulinemia

 

Last Updated: 29 Mar 2017

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Rituximab Plus Corticosteroids in Non-infectious Active Mixed Cryoglobulinemia Vasculitis
 

Status: Recruiting

Condition Summary: Cryoglobulinemia; Systemic Vasculitis

 

Last Updated: 24 Oct 2016

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Direct Antiviral Agents for Hepatitis C Virus-associated Cryoglobulinaemia Vasculitis
 

Status: Recruiting

Condition Summary: Vasculitis; Cryoglobulinemia; Hepatitis C

 

Last Updated: 28 Sep 2016

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