Crohn Disease

Common Name(s)

Crohn Disease, Crohn's disease

Crohn's disease is a type of inflammatory bowel disease (IBD), the general name for conditions that cause inflammation in the intestines. Common signs and symptoms include abdominal pain and diarrhea. Bleeding from the rectum, weight loss, joint pain, skin problems and fever may also occur. Other problems can include intestinal blockage and malnutrition. Crohn's disease can occur in people of all age groups but is most often diagnosed in young adults. The exact cause is unknown, but is thought to involve both genetic and environmental factors. It appears to run in some families. Treatment is aimed at relieving symptoms and reducing inflammation, but some people require surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Crohn Disease" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

Last Updated: 8 Apr 2014

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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

Last Updated: 29 Apr 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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Pull-thru Network, Inc.

The Pull-thru Network is a volunteer-based organization dedicated to providing education, information, support and advocacy for those individuals, and the families of those individuals, who are affected by any congenital anorectal, colorectal or urogenital disorder and any of the variety of related diagnoses.

Last Updated: 8 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Crohn Disease" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

View Details
Crohn's & Colitis Foundation of America, Inc.

CCFA's mission is to cure Crohn's disease and ulcerative colitis and to improve the quality of life of children and adults affected by these diseases.

http://www.ccfa.org

Last Updated: 8 Apr 2014

View Details
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Digestive Disease National Coalition

The Digestive Disease National Coalition (DDNC) has provided national leadership on behalf of patient organizations, professional societies, and industry interested in the full spectrum of digestive disorders.

http://ddnc.org/

Last Updated: 29 Apr 2014

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
Pull-thru Network, Inc.

The Pull-thru Network is a volunteer-based organization dedicated to providing education, information, support and advocacy for those individuals, and the families of those individuals, who are affected by any congenital anorectal, colorectal or urogenital disorder and any of the variety of related diagnoses.

http://www.PullthruNetwork.org

Last Updated: 8 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Crohn Disease" returned 143 free, full-text research articles on human participants. First 3 results:

Lymphomatoid granulomatosis associated with azathioprine therapy in Crohn disease.
 

Author(s): William Connors, Cameron Griffiths, Jay Patel, Paul J Belletrutti

Journal:

 

Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus-associated lymphoproliferative disorder. It most often occurs in patients with immunodeficiency and the clinical course ranges from indolent behavior to that of an aggressive malignancy. Pulmonary, central nervous system ...

Last Updated: 22 Jul 2014

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Gender-related differences in clinical course of crohn?s disease in an Asian population: a retrospective cohort review.
 

Author(s): Siu-tong Law, Kin Kong Li

Journal: Arq Gastroenterol. ;51(2):90-6.

 

Data from Asian populations about gender-related differences in Crohn's disease are few. Objectives This study was to analyze the clinical characteristics between women and men affected by Crohn's disease.

Last Updated: 9 Jul 2014

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Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.
 

Author(s): Yael Haberman, Timothy L Tickle, Phillip J Dexheimer, Mi-Ok Kim, Dora Tang, Rebekah Karns, Robert N Baldassano, Joshua D Noe, Joel Rosh, James Markowitz, Melvin B Heyman, Anne M Griffiths, Wallace V Crandall, David R Mack, Susan S Baker, Curtis Huttenhower, David J Keljo, Jeffrey S Hyams, Subra Kugathasan, Thomas D Walters, Bruce Aronow, Ramnik J Xavier, Dirk Gevers, Lee A Denson

Journal: J. Clin. Invest.. 2014 Aug;124(8):3617-33.

 

Interactions between the host and gut microbial community likely contribute to Crohn disease (CD) pathogenesis; however, direct evidence for these interactions at the onset of disease is lacking. Here, we characterized the global pattern of ileal gene expression and the ileal microbial ...

Last Updated: 2 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Crohn Disease" returned 8 free, full-text review articles on human participants. First 3 results:

Indications of capsule endoscopy in Crohn´s disease.
 

Author(s): Marisol Luján-Sanchis, Laura Sanchis-Artero, Patricia Suárez-Callol, Enrique Medina-Chuliá

Journal: Rev Esp Enferm Dig. 2014 Jan;106(1):37-44.

 

Capsule endoscopy currently plays a relevant role for Crohn´s disease. This manuscript will discuss the current indications and practical uses of capsule endoscopy in this disease. It is a non-invasive technique that represents a significant advance in the endoscopic diagnosis of ...

Last Updated: 2 Apr 2014

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The endoplasmic reticulum stress response chaperone: Gp96, a host receptor for Crohn disease-associated adherent-invasive Escherichia coli.
 

Author(s): Nathalie Rolhion, Paul Hofman, Arlette Darfeuille-Michaud

Journal: Gut Microbes. ;2(2):115-9.

 

Ileal lesions of Crohn disease (CD) patients are abnormally colonized by adherent-invasive Escherichia coli (AIEC) producing outer membrane vesicles (OMVs) that contribute to the bacterial invasion process. In addition, endoplasmic stress was recently reported to have a key role in ...

Last Updated: 22 Jun 2011

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Crohn disease: a current perspective on genetics, autophagy and immunity.
 

Author(s): Thaddeus S Stappenbeck, John D Rioux, Atsushi Mizoguchi, Tatsuya Saitoh, Alan Huett, Arlette Darfeuille-Michaud, Tom Wileman, Noboru Mizushima, Simon Carding, Shizuo Akira, Miles Parkes, Ramnik J Xavier

Journal: Autophagy. 2011 Apr;7(4):355-74.

 

Crohn disease (CD) is a chronic and debilitating inflammatory condition of the gastrointestinal tract. Prevalence in Western populations is 100-150/100,000 and somewhat higher in Ashkenazi Jews. Peak incidence is in early adult life, although any age can be affected and a majority ...

Last Updated: 30 Jun 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

High-dose Cyclophosphamide for Severe Refractory Crohn Disease
 

Status: Recruiting

Condition Summary: Crohn's Disease; Crohn Disease

 

Last Updated: 1 Mar 2015

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Induction of Clinical Response Using Rifaximin in Crohn's Disease
 

Status: Recruiting

Condition Summary: Crohn's Disease

 

Last Updated: 13 Jun 2012

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Last Updated: 25 Jun 2015

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