Creutzfeldt-Jakob Disease

Common Name(s)

Creutzfeldt-Jakob Disease, CJD

Creutzfeldt-Jakob disease (CJD) is a rare, degenerative, invariably fatal brain disorder. It affects about one person in every one million people per year worldwide. CJD usually appears in later life and runs a rapid course. Typically, onset of symptoms occurs about age 60, and about 90 percent of patients die within 1 year. In the early stages of disease, patients may have failing memory, behavioral changes, lack of coordination and visual disturbances. As the illness progresses, mental deterioration becomes pronounced and involuntary movements, blindness, weakness of extremities, and coma may occur.

CJD belongs to a family of human and animal diseases known as the transmissible spongiform encephalopathies (TSEs). Spongiform refers to the characteristic appearance of infected brains, which become filled with holes until they resemble sponges under a microscope. CJD is the most common of the known human TSEs. Other human TSEs include kuru, fatal familial insomnia (FFI), and Gerstmann-Straussler-Scheinker disease (GSS).

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Creutzfeldt-Jakob Disease" for support, advocacy or research.

Logo
The CJD Foundation

The Creutzfeldt-Jakob Disease Foundation consists of members who are concerned about the complexity of issues surrounding this fatal brain disease. Our mission is to support families and loved ones touched by CJD.

Last Updated: 11 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Creutzfeldt-Jakob Disease" for support, advocacy or research.

Logo
The CJD Foundation

The Creutzfeldt-Jakob Disease Foundation consists of members who are concerned about the complexity of issues surrounding this fatal brain disease. Our mission is to support families and loved ones touched by CJD.

http://www.cjdfoundation.org

Last Updated: 11 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Creutzfeldt-Jakob Disease" returned 493 free, full-text research articles on human participants. First 3 results:

Postmortem findings in a case of variant Creutzfeldt-Jakob disease treated with intraventricular pentosan polysulfate.
 

Author(s): P K Newman, N V Todd, D Scoones, S Mead, R S G Knight, R G Will, J W Ironside

Journal: J. Neurol. Neurosurg. Psychiatr.. 2014 Aug;85(8):921-4.

 

A small number of patients with variant Creutzfeldt-Jakob disease (vCJD) have been treated with intraventicular pentosan polysulfate (iPPS) and extended survival has been reported in some cases. To date, there have been no reports on the findings of postmortem examination of the brain ...

Last Updated: 10 Jul 2014

Go To URL
Detection of infectivity in blood of persons with variant and sporadic Creutzfeldt-Jakob disease.
 

Author(s): Jean Yves Douet, Saima Zafar, Armand Perret-Liaudet, Caroline Lacroux, Séverine Lugan, Naima Aron, Herve Cassard, Claudia Ponto, Fabien Corbière, Juan Maria Torres, Inga Zerr, Olivier Andreoletti

Journal: Emerging Infect. Dis.. 2014 Jan;20(1):114-7.

 

We report the presence of infectivity in erythrocytes, leukocytes, and plasma of 1 person with variant Creutzfeldt-Jakob disease and in the plasma of 2 in 4 persons whose tests were positive for sporadic Creutzfeldt-Jakob disease. The measured infectivity levels were comparable to ...

Last Updated: 31 Dec 2013

Go To URL
Increased interleukin-17 in the cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease: a case-control study of rapidly progressive dementia.
 

Author(s): Koji Fujita, Naoko Matsui, Yukitoshi Takahashi, Yasushi Iwasaki, Mari Yoshida, Tatsuhiko Yuasa, Yuishin Izumi, Ryuji Kaji

Journal:

 

Inflammatory responses in the cerebrospinal fluid (CSF) of patients with sporadic Creutzfeldt-Jakob disease (sCJD) remain elusive.

Last Updated: 9 Dec 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Creutzfeldt-Jakob Disease" returned 41 free, full-text review articles on human participants. First 3 results:

Creutzfeldt-Jakob disease: a case report and differential diagnoses.
 

Author(s): Gotaro Kojima, Brent K Tatsuno, Michiko Inaba, Stephanie Velligas, Kamal Masaki, Kore K Liow

Journal: Hawaii J Med Public Health. 2013 Apr;72(4):136-9.

 

Sporadic Creutzfeldt-Jakob disease is a rare neurodegenerative disorder of unknown etiology that causes rapidly progressive dementia. This disease is uniformly fatal and most patients die within 12 months. Clinical findings include myoclonus, visual disturbances, and cerebellar and ...

Last Updated: 24 Jun 2013

Go To URL
Sensitivity to biases of case-control studies on medical procedures, particularly surgery and blood transfusion, and risk of Creutzfeldt-Jakob disease.
 

Author(s): Jesús de Pedro Cuesta, María Ruiz Tovar, Hester Ward, Miguel Calero, Andrew Smith, Concepción Alonso Verduras, Maurizio Pocchiari, Marc L Turner, Frode Forland, Daniel Palm, Robert G Will

Journal: Neuroepidemiology. 2012 ;39(1):1-18.

 

Evidence of risk of Creutzfeldt-Jakob disease (CJD) associated with medical procedures, including surgery and blood transfusion, is limited by susceptibility to bias in epidemiological studies.

Last Updated: 26 Jul 2012

Go To URL
Health professions and risk of sporadic Creutzfeldt-Jakob disease, 1965 to 2010.
 

Author(s): E Alcalde-Cabero, J Almazan-Isla, J P Brandel, M Breithaupt, J Catarino, S Collins, J Hayback, R Hoftberger, E Kahana, G G Kovacs, A Ladogana, E Mitrova, A Molesworth, Y Nakamura, M Pocchiari, M Popovic, M Ruiz-Tovar, Al Taratuto, C van Duijn, M Yamada, R G Will, I Zerr, J de Pedro Cuesta

Journal:

 

In 2009, a pathologist with sporadic Creutzfeldt-Jakob Disease (sCJD) was reported to the Spanish registry. This case prompted a request for information on health-related occupation in sCJD cases from countries participating in the European Creutzfeldt Jakob Disease Surveillance network ...

Last Updated: 20 Apr 2012

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Notification of Donors With Positive Microbiology Markers
 

Status: Not yet recruiting

Condition Summary: Human Immunodeficiency Virus; Hepatitis B; Hepatitis C; Human T-lymphotropic Virus I & II; Creutzfeldt-Jakob Syndrome; HIV Infections

 

Last Updated: 12 Feb 2010

Go to URL