Craniopharyngioma

Common Name(s)

Craniopharyngioma

A craniopharyngioma is a slow-growing benign tumor that develops near the pituitary gland (a small endocrine gland at the base of the brain) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves).  This tumor most commonly affects children between 5 and 10 years of age; however, adults can sometimes be affected.  Craniopharyngiomas are thought to arise from remnants of the craniopharyngeal duct and/or Rathke cleft or from metaplasia (abnormal transformation of cells) of squamous epithelial cell remnants of the stomadeum. Craniopharyngioma is treated with surgery alone or by surgery followed by radiation.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Craniopharyngioma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Craniopharyngioma" returned 160 free, full-text research articles on human participants. First 3 results:

History before diagnosis in childhood craniopharyngioma: associations with initial presentation and long-term prognosis.
 

Author(s): Anika Hoffmann, Svenja Boekhoff, Ursel Gebhardt, Anthe S Sterkenburg, Anna M M Daubenbüchel, Maria Eveslage, Hermann L Müller

Journal: Eur. J. Endocrinol.. 2015 Dec;173(6):853-62.

 

Childhood craniopharyngiomas (CP) are often diagnosed after a long duration of history (DOH). Tumor size, hypothalamic involvement (HI), and obesity are associated with reduced overall survival (OS) and functional capacity (FC). The effect of DOH and specific symptoms in history on ...

Last Updated: 3 Nov 2015

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Nonalcoholic fatty liver disease and fatigue in long-term survivors of childhood-onset craniopharyngioma.
 

Author(s): Anika Hoffmann, Klaus Bootsveld, Ursel Gebhardt, Anna M M Daubenbüchel, Anthe S Sterkenburg, Hermann L Müller

Journal: Eur. J. Endocrinol.. 2015 Sep;173(3):389-97.

 

Hypothalamic obesity in childhood craniopharyngioma (CP) patients carries a high risk for development of metabolic syndrome. In metabolic syndrome, the development of nonalcoholic fatty liver disease (NAFLD) is known. The aim of this study is to detect the risk for NAFLD in childhood-onset CP.

Last Updated: 5 Aug 2015

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Identification of targets for rational pharmacological therapy in childhood craniopharyngioma.
 

Author(s): Jacob M Gump, Andrew M Donson, Diane K Birks, Vladimir M Amani, Karun K Rao, Andrea M Griesinger, B K Kleinschmidt-DeMasters, James M Johnston, Richard C E Anderson, Amy Rosenfeld, Michael Handler, Lia Gore, Nicholas Foreman, Todd C Hankinson

Journal:

 

Pediatric adamantinomatous craniopharyngioma (ACP) is a histologically benign but clinically aggressive brain tumor that arises from the sellar/suprasellar region. Despite a high survival rate with current surgical and radiation therapy (75-95 % at 10 years), ACP is associated with ...

Last Updated: 20 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Craniopharyngioma" returned 19 free, full-text review articles on human participants. First 3 results:

Concise Review: Paracrine Role of Stem Cells in Pituitary Tumors: A Focus on Adamantinomatous Craniopharyngioma.
 

Author(s): Juan Pedro Martinez-Barbera, Cynthia L Andoniadou

Journal: Stem Cells. 2016 Feb;34(2):268-76.

 

The existence of tissue-specific progenitor/stem cells in the adult pituitary gland of the mouse has been demonstrated recently using genetic tracing experiments. These cells have the capacity to differentiate into all of the different cell lineages of the anterior pituitary and self-propagate ...

Last Updated: 15 Feb 2016

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Craniopharyngioma and hypothalamic injury: latest insights into consequent eating disorders and obesity.
 

Author(s): Hermann L Müller

Journal: Curr Opin Endocrinol Diabetes Obes. 2016 Feb;23(1):81-9.

 

Hypothalamic alterations, pathological or treatment induced, have major impact on prognosis in craniopharyngioma patients mainly because of consequent hypothalamic obesity. Recent insight in molecular genetics, treatment strategies, risk factors and outcomes associated with hypothalamic ...

Last Updated: 25 Dec 2015

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ENDOCRINE TUMORS: BRAF V600E mutations in papillary craniopharyngioma.
 

Author(s): Priscilla K Brastianos, Sandro Santagata

Journal: Eur. J. Endocrinol.. 2016 Apr;174(4):R139-44.

 

Papillary craniopharyngioma (PCP) is an intracranial tumor that results in high levels of morbidity. We recently demonstrated that the vast majority of these tumors harbor the oncogenic BRAF V600E mutation. The pathologic diagnosis of PCP can now be confirmed using mutation specific ...

Last Updated: 23 Feb 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 26 Oct 2016

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Prospective Study of Children and Adolescents With Craniopharyngioma
 

Status: Recruiting

Condition Summary: Craniopharyngioma; Obesity

 

Last Updated: 15 Sep 2016

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