Craniopharyngioma

Common Name(s)

Craniopharyngioma

A craniopharyngioma is a slow-growing benign tumor that develops near the pituitary gland (a small endocrine gland at the base of the brain) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves).  This tumor most commonly affects children between 5 and 10 years of age; however, adults can sometimes be affected.  Craniopharyngiomas are thought to arise from remnants of the craniopharyngeal duct and/or Rathke cleft or from metaplasia (abnormal transformation of cells) of squamous epithelial cell remnants of the stomadeum. Craniopharyngioma is treated with surgery alone or by surgery followed by radiation.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Craniopharyngioma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Craniopharyngioma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Craniopharyngioma" returned 174 free, full-text research articles on human participants. First 3 results:

MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.
 

Author(s): Scott Haston, Sara Pozzi, Gabriela Carreno, Saba Manshaei, Leonidas Panousopoulos, Jose Mario Gonzalez-Meljem, John R Apps, Alex Virasami, Selvam Thavaraj, Alice Gutteridge, Tim Forshew, Richard Marais, Sebastian Brandner, Thomas S Jacques, Cynthia L Andoniadou, Juan Pedro Martinez-Barbera

Journal: Development. 2017 06;144(12):2141-2152.

 

Despite the importance of the RAS-RAF-MAPK pathway in normal physiology and disease of numerous organs, its role during pituitary development and tumourigenesis remains largely unknown. Here, we show that the over-activation of the MAPK pathway, through conditional expression of the ...

Last Updated: 31 Dec 1969

Go To URL
Craniopharyngioma presenting with severe hyponatremia, hyponatremia-induced myopathy, and panhypopituitarism: a case report.
 

Author(s): M D S A Dilrukshi, G V N Sandakumari, P K Abeysundara, T Chang

Journal:

 

Craniopharyngiomas are rare intracranial tumors commonly presenting with neurological symptoms. Reports of severe hyponatremia as a presenting manifestation of a craniopharyngioma and hyponatremia-induced myopathy are rare. We report the case of a patient with craniopharyngioma presenting ...

Last Updated: 31 Dec 1969

Go To URL
[Influence of preventive use of vasopressin tannate on diabetes insipidus and serum sodium at the early postoperation of craniopharyngioma].
 

Author(s): Tao Xiong, Siyi Wanggou, Xuejun Li, Qing Liu, Xingjun Jiang, Zefeng Peng, Xianrui Yuan

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Oct;41(10):1058-1063.

 

To explore the influence of preventive use of vasopressin tannate on diabetes insipidus and serum sodium at the early postoperation of craniopharyngioma.
 Methods: The data of 83 patients, who underwent unilateral sub-frontal approach resection of craniopharyngioma between 2010 ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Craniopharyngioma" returned 22 free, full-text review articles on human participants. First 3 results:

Genetically engineered mouse models of craniopharyngioma: an opportunity for therapy development and understanding of tumor biology.
 

Author(s): John Richard Apps, Juan Pedro Martinez-Barbera

Journal: Brain Pathol.. 2017 May;27(3):364-369.

 

Adamantinomatous craniopharyngioma (ACP) is the commonest tumor of the sellar region in childhood. Two genetically engineered mouse models have been developed and are giving valuable insights into ACP biology. These models have identified novel pathways activated in tumors, revealed ...

Last Updated: 31 Dec 1969

Go To URL
Concise Review: Paracrine Role of Stem Cells in Pituitary Tumors: A Focus on Adamantinomatous Craniopharyngioma.
 

Author(s): Juan Pedro Martinez-Barbera, Cynthia L Andoniadou

Journal: Stem Cells. 2016 Feb;34(2):268-76.

 

The existence of tissue-specific progenitor/stem cells in the adult pituitary gland of the mouse has been demonstrated recently using genetic tracing experiments. These cells have the capacity to differentiate into all of the different cell lineages of the anterior pituitary and self-propagate ...

Last Updated: 31 Dec 1969

Go To URL
Craniopharyngioma and hypothalamic injury: latest insights into consequent eating disorders and obesity.
 

Author(s): Hermann L Müller

Journal: Curr Opin Endocrinol Diabetes Obes. 2016 Feb;23(1):81-9.

 

Hypothalamic alterations, pathological or treatment induced, have major impact on prognosis in craniopharyngioma patients mainly because of consequent hypothalamic obesity. Recent insight in molecular genetics, treatment strategies, risk factors and outcomes associated with hypothalamic ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Examination of Sleep and Family Functioning in Pediatric Craniopharyngioma Patients
 

Status: Recruiting

Condition Summary: Craniopharyngioma

 

Last Updated: 13 Feb 2018

Go to URL

Last Updated: 10 Jul 2017

Go to URL