Craniopharyngioma

Common Name(s)

Craniopharyngioma

A craniopharyngioma is a slow-growing benign tumor that develops near the pituitary gland (a small endocrine gland at the base of the brain) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves).  This tumor most commonly affects children between 5 and 10 years of age; however, adults can sometimes be affected.  Craniopharyngiomas are thought to arise from remnants of the craniopharyngeal duct and/or Rathke cleft or from metaplasia (abnormal transformation of cells) of squamous epithelial cell remnants of the stomadeum. Craniopharyngioma is treated with surgery alone or by surgery followed by radiation.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Craniopharyngioma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Craniopharyngioma" returned 175 free, full-text research articles on human participants. First 3 results:

MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.
 

Author(s): Scott Haston, Sara Pozzi, Gabriela Carreno, Saba Manshaei, Leonidas Panousopoulos, Jose Mario Gonzalez-Meljem, John R Apps, Alex Virasami, Selvam Thavaraj, Alice Gutteridge, Tim Forshew, Richard Marais, Sebastian Brandner, Thomas S Jacques, Cynthia L Andoniadou, Juan Pedro Martinez-Barbera

Journal: Development. 2017 06;144(12):2141-2152.

 

Despite the importance of the RAS-RAF-MAPK pathway in normal physiology and disease of numerous organs, its role during pituitary development and tumourigenesis remains largely unknown. Here, we show that the over-activation of the MAPK pathway, through conditional expression of the ...

Last Updated: 31 Dec 1969

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Interleukin‑6 induces an epithelial‑mesenchymal transition phenotype in human adamantinomatous craniopharyngioma cells and promotes tumor cell migration.
 

Author(s): Jie Zhou, Chao Zhang, Jun Pan, Ligang Chen, Song-Tao Qi

Journal: Mol Med Rep. 2017 Jun;15(6):4123-4131.

 

Total resection of adamantinomatous craniopharyngioma (ACP) is complex and often leads to postoperative recurrence. This is due to the tendency of the tumor to invade the surrounding brain tissue and the generation of a local inflammatory state between the tumor cells and parenchyma. ...

Last Updated: 31 Dec 1969

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The purine receptor P2X7R regulates the release of pro-inflammatory cytokines in human craniopharyngioma.
 

Author(s): Jing Nie, Guang-Long Huang, Sheng-Ze Deng, Yun Bao, Ya-Wei Liu, Zhan-Peng Feng, Chao-Hu Wang, Ming Chen, Song-Tao Qi, Jun Pan

Journal: Endocr. Relat. Cancer. 2017 Jun;24(6):287-296.

 

Craniopharyngiomas (CPs) are usually benign, non-metastasizing embryonic malformations originating from the sellar area. They are, however, locally invasive and generate adherent interfaces with the surrounding brain parenchyma. Previous studies have shown the tumor microenvironment ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Craniopharyngioma" returned 21 free, full-text review articles on human participants. First 3 results:

Genetically engineered mouse models of craniopharyngioma: an opportunity for therapy development and understanding of tumor biology.
 

Author(s): John Richard Apps, Juan Pedro Martinez-Barbera

Journal: Brain Pathol.. 2017 May;27(3):364-369.

 

Adamantinomatous craniopharyngioma (ACP) is the commonest tumor of the sellar region in childhood. Two genetically engineered mouse models have been developed and are giving valuable insights into ACP biology. These models have identified novel pathways activated in tumors, revealed ...

Last Updated: 31 Dec 1969

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Concise Review: Paracrine Role of Stem Cells in Pituitary Tumors: A Focus on Adamantinomatous Craniopharyngioma.
 

Author(s): Juan Pedro Martinez-Barbera, Cynthia L Andoniadou

Journal: Stem Cells. 2016 Feb;34(2):268-76.

 

The existence of tissue-specific progenitor/stem cells in the adult pituitary gland of the mouse has been demonstrated recently using genetic tracing experiments. These cells have the capacity to differentiate into all of the different cell lineages of the anterior pituitary and self-propagate ...

Last Updated: 31 Dec 1969

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Craniopharyngioma and hypothalamic injury: latest insights into consequent eating disorders and obesity.
 

Author(s): Hermann L Müller

Journal: Curr Opin Endocrinol Diabetes Obes. 2016 Feb;23(1):81-9.

 

Hypothalamic alterations, pathological or treatment induced, have major impact on prognosis in craniopharyngioma patients mainly because of consequent hypothalamic obesity. Recent insight in molecular genetics, treatment strategies, risk factors and outcomes associated with hypothalamic ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Examination of Sleep and Family Functioning in Pediatric Craniopharyngioma Patients
 

Status: Recruiting

Condition Summary: Craniopharyngioma

 

Last Updated: 13 Feb 2018

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Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma
 

Status: Recruiting

Condition Summary: BRAF V600E Mutation Present; Papillary Craniopharyngioma

 

Last Updated: 4 Apr 2018

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