Craniopharyngioma

Common Name(s)

Craniopharyngioma

A craniopharyngioma is a slow-growing benign tumor that develops near the pituitary gland (a small endocrine gland at the base of the brain) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves).  This tumor most commonly affects children between 5 and 10 years of age; however, adults can sometimes be affected.  Craniopharyngiomas are thought to arise from remnants of the craniopharyngeal duct and/or Rathke cleft or from metaplasia (abnormal transformation of cells) of squamous epithelial cell remnants of the stomadeum. Craniopharyngioma is treated with surgery alone or by surgery followed by radiation.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Craniopharyngioma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Craniopharyngioma" returned 158 free, full-text research articles on human participants. First 3 results:

Identification of targets for rational pharmacological therapy in childhood craniopharyngioma.
 

Author(s): Jacob M Gump, Andrew M Donson, Diane K Birks, Vladimir M Amani, Karun K Rao, Andrea M Griesinger, B K Kleinschmidt-DeMasters, James M Johnston, Richard C E Anderson, Amy Rosenfeld, Michael Handler, Lia Gore, Nicholas Foreman, Todd C Hankinson

Journal:

 

Pediatric adamantinomatous craniopharyngioma (ACP) is a histologically benign but clinically aggressive brain tumor that arises from the sellar/suprasellar region. Despite a high survival rate with current surgical and radiation therapy (75-95 % at 10 years), ACP is associated with ...

Last Updated: 20 May 2015

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Survival, hypothalamic obesity, and neuropsychological/psychosocial status after childhood-onset craniopharyngioma: newly reported long-term outcomes.
 

Author(s): Anthe S Sterkenburg, Anika Hoffmann, Ursel Gebhardt, Monika Warmuth-Metz, Anna M M Daubenbüchel, Hermann L Müller

Journal: Neuro-oncology. 2015 Jul;17(7):1029-38.

 

Quality of life (QoL) and long-term prognosis are frequently, and often severely, impaired in craniopharyngioma (CP) patients. Knowledge of risk factors for long-term outcome is important for optimization of treatment.

Last Updated: 20 Jun 2015

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An infrasellar craniopharyngioma involving the sphenoid sinus and clivus.
 

Author(s): Zhong Zhang, Ming-Yang Li, Yan-Wei Liu, Yong-Zhi Wang

Journal: Chin. Med. J.. 2015 Mar;128(6):844-5.

 

Last Updated: 11 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Craniopharyngioma" returned 17 free, full-text review articles on human participants. First 3 results:

ENDOCRINE TUMORS: BRAF V600E mutations in papillary craniopharyngioma.
 

Author(s): Priscilla K Brastianos, Sandro Santagata

Journal: Eur. J. Endocrinol.. 2016 Apr;174(4):R139-44.

 

Papillary craniopharyngioma (PCP) is an intracranial tumor that results in high levels of morbidity. We recently demonstrated that the vast majority of these tumors harbor the oncogenic BRAF V600E mutation. The pathologic diagnosis of PCP can now be confirmed using mutation specific ...

Last Updated: 23 Feb 2016

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60 YEARS OF NEUROENDOCRINOLOGY: Biology of human craniopharyngioma: lessons from mouse models.
 

Author(s): Juan Pedro Martinez-Barbera

Journal: J. Endocrinol.. 2015 Aug;226(2):T161-72.

 

Adamantinomatous craniopharyngiomas (ACP) are clinically relevant tumours that are associated with high morbidity, poor quality of life and occasional mortality. Human and mouse studies have provided important insights into the biology of these aggressive tumours, and we are starting ...

Last Updated: 25 Jul 2015

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Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma.
 

Author(s): Juan Pedro Martinez-Barbera

Journal: Neuropathol. Appl. Neurobiol.. 2015 Oct;41(6):721-32.

 

Adamantinomatous craniopharyngiomas (ACPs) are the most common pituitary tumours in children. Although histologically benign, these are clinically aggressive tumours, difficult to manage and associated with poor quality of life for the patients. Several human and mouse studies have ...

Last Updated: 19 Sep 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prospective Study of Children and Adolescents With Craniopharyngioma
 

Status: Recruiting

Condition Summary: Craniopharyngioma; Obesity

 

Last Updated: 16 Apr 2015

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Last Updated: 4 Aug 2016

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