Corticobasal Degeneration

Common Name(s)

Corticobasal Degeneration

Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. The cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. Signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. These symptoms develop and worsen over time. Currently the cause of corticobasal degeneration is not known.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corticobasal Degeneration" for support, advocacy or research.

CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

Last Updated: 30 Apr 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corticobasal Degeneration" for support, advocacy or research.

CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

http://www.curepsp.org/

Last Updated: 30 Apr 2014

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

Support Groups

Listing of current online and face-to-face support groups

Updated 30 Apr 2014

Go To URL
Newsletter

Quarterly publication (past and present)

Updated 30 Apr 2014

Go To URL
CurePSP Webinars

Upcoming webinar listings and previously recorded webinars on various topics related to the diseases.

Updated 30 Apr 2014

Go To URL
 
 
Top

Blogs

CurePSP Forum

Bulletin board type service for patients and caregivers to share thoughts and information.

Updated 30 Apr 2014

Go To URL
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Corticobasal Degeneration" returned 53 free, full-text research articles on human participants. First 3 results:

Exome sequencing in familial corticobasal degeneration.
 

Author(s): Robert Fekete, Matthew Bainbridge, Jose Fidel Baizabal-Carvallo, Andreana Rivera, Bradley Miller, Peicheng Du, Vladyslav Kholodovych, Suzanne Powell, William Ondo

Journal: Parkinsonism Relat. Disord.. 2013 Nov;19(11):1049-52.

 

Corticobasal degeneration (CBD) is a neurodegenerative, sporadic disorder of unknown cause. Few familial cases have been described.

Last Updated: 11 Nov 2013

Go To URL
Corticobasal degeneration with olivopontocerebellar atrophy and TDP-43 pathology: an unusual clinicopathologic variant of CBD.
 

Author(s): Naomi Kouri, Kenichi Oshima, Makio Takahashi, Melissa E Murray, Zeshan Ahmed, Joseph E Parisi, Shu-Hui C Yen, Dennis W Dickson

Journal: Acta Neuropathol.. 2013 May;125(5):741-52.

 

Corticobasal degeneration (CBD) is a disorder affecting cognition and movement due to a progressive neurodegeneration associated with distinctive neuropathologic features, including abnormal phosphorylated tau protein in neurons and glia in cortex, basal ganglia, diencephalon, and ...

Last Updated: 22 Apr 2013

Go To URL
Criteria for the diagnosis of corticobasal degeneration.
 

Author(s): Melissa J Armstrong, Irene Litvan, Anthony E Lang, Thomas H Bak, Kailash P Bhatia, Barbara Borroni, Adam L Boxer, Dennis W Dickson, Murray Grossman, Mark Hallett, Keith A Josephs, Andrew Kertesz, Suzee E Lee, Bruce L Miller, Stephen G Reich, David E Riley, Eduardo Tolosa, Alexander I Tröster, Marie Vidailhet, William J Weiner

Journal: Neurology. 2013 Jan;80(5):496-503.

 

Current criteria for the clinical diagnosis of pathologically confirmed corticobasal degeneration (CBD) no longer reflect the expanding understanding of this disease and its clinicopathologic correlations. An international consortium of behavioral neurology, neuropsychology, and movement ...

Last Updated: 29 Jan 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Corticobasal Degeneration" returned 1 free, full-text review articles on human participants. First 3 results:

Corticobasal degeneration: a report of three cases.
 

Author(s): K A Muhiddin, R J Hardie, V R Pearce, B J Kirby

Journal: J R Soc Med. 1994 Jun;87(6):359-60.

 

Last Updated: 1 Sep 1994

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy Volunteers
 

Status: Not yet recruiting

Condition Summary: Progressive Supranuclear Palsy; Corticobasal Degeneration

 

Last Updated: 18 Jun 2014

Go to URL
4 Repeat Tauopathy Neuroimaging Initiative
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy; Corticobasal Degeneration

 

Last Updated: 25 Jun 2014

Go to URL
Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders, PD,Essential Tremor, (ET),Cortical Basal Degeneration, (CBD),Multiple Systems Atrophy (MSA), Magnetoencephalography
 

Status: Recruiting

Condition Summary: Essential Tremor; Multiple System Atrophy; Corticobasal Degeneration; Supranuclear Palsy, Progressive

 

Last Updated: 2 May 2014

Go to URL