Corticobasal degeneration

Common Name(s)

Corticobasal degeneration, CBD

Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. The cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. Signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. These symptoms develop and worsen over time. Currently the cause of corticobasal degeneration is not known.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corticobasal degeneration" for support, advocacy or research.

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Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 8 Jul 2015

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CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

Last Updated: 30 Apr 2014

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The PSP Association

The PSP Association offers support and information to people living with PSP and CBD, while supporting research into treatments and ultimately a cure for these conditions.

Last Updated: 5 Jun 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corticobasal degeneration" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 8 Jul 2015

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CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

http://www.curepsp.org/

Last Updated: 30 Apr 2014

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The PSP Association

The PSP Association offers support and information to people living with PSP and CBD, while supporting research into treatments and ultimately a cure for these conditions.

http://www.pspassociation.org.uk/

Last Updated: 5 Jun 2015

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General Support Organizations

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General Resources

Support Groups

Listing of current online and face-to-face support groups

Updated 30 Apr 2014

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Newsletter

Quarterly publication (past and present)

Updated 30 Apr 2014

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CurePSP Webinars

Upcoming webinar listings and previously recorded webinars on various topics related to the diseases.

Updated 30 Apr 2014

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Blogs

CurePSP Forum

Bulletin board type service for patients and caregivers to share thoughts and information.

Updated 30 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Corticobasal degeneration" returned 75 free, full-text research articles on human participants. First 3 results:

Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy.
 

Author(s): Antonio Piras, Ludovic Collin, Fiona Grüninger, Caroline Graff, Annica Rönnbäck

Journal:

 

The accumulation of insoluble proteins within neurons and glia cells is a pathological hallmark of several neurodegenerative diseases. Abnormal aggregation of the microtubule-associated protein tau characterizes the neuropathology of tauopathies, such as Alzheimer disease (AD), corticobasal ...

Last Updated: 3 Mar 2016

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Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration.
 

Author(s): Erik G Gentry, Benjamin W Henderson, Andrew E Arrant, Marla Gearing, Yangbo Feng, Nicole C Riddle, Jeremy H Herskowitz

Journal: J. Neurosci.. 2016 Jan;36(4):1316-23.

 

Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neurodegenerative four-repeat tauopathies with no cure. Mitigating pathogenic tau levels is a rational strategy for tauopathy treatment, but therapeutic targets with clinically available drugs are lacking. ...

Last Updated: 28 Jan 2016

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Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy.
 

Author(s): Naomi Kouri, Owen A Ross, Beth Dombroski, Curtis S Younkin, Daniel J Serie, Alexandra Soto-Ortolaza, Matthew Baker, Ni Cole A Finch, Hyejin Yoon, Jungsu Kim, Shinsuke Fujioka, Catriona A McLean, Bernardino Ghetti, Salvatore Spina, Laura B Cantwell, Martin R Farlow, Jordan Grafman, Edward D Huey, Mi Ryung Han, Sherry Beecher, Evan T Geller, Hans A Kretzschmar, Sigrun Roeber, Marla Gearing, Jorge L Juncos, Jean Paul G Vonsattel, Vivianna M Van Deerlin, Murray Grossman, Howard I Hurtig, Rachel G Gross, Steven E Arnold, John Q Trojanowski, Virginia M Lee, Gregor K Wenning, Charles L White, Günter U Höglinger, Ulrich Müller, Bernie Devlin, Lawrence I Golbe, Julia Crook, Joseph E Parisi, Bradley F Boeve, Keith A Josephs, Zbigniew K Wszolek, Ryan J Uitti, Neill R Graff-Radford, Irene Litvan, Steven G Younkin, Li-San Wang, Nilüfer Ertekin-Taner, Rosa Rademakers, Hakon Hakonarsen, Gerard D Schellenberg, Dennis W Dickson

Journal:

 

Corticobasal degeneration (CBD) is a neurodegenerative disorder affecting movement and cognition, definitively diagnosed only at autopsy. Here, we conduct a genome-wide association study (GWAS) in CBD cases (n=152) and 3,311 controls, and 67 CBD cases and 439 controls in a replication ...

Last Updated: 16 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Corticobasal degeneration" returned 4 free, full-text review articles on human participants. First 3 results:

Key emerging issues in progressive supranuclear palsy and corticobasal degeneration.
 

Author(s): Keith A Josephs

Journal: J. Neurol.. 2015 Mar;262(3):783-8.

 

It has been approximately 50 years since neurologists were introduced to the entities, "progressive supranuclear palsy" and "corticobasal degeneration". Since the two seminal publications, there have been significant advancements in our understanding of these two neurodegenerative ...

Last Updated: 18 Mar 2015

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Dystonia in corticobasal degeneration: a review of the literature on 404 pathologically proven cases.
 

Author(s): Maria Stamelou, Araceli Alonso-Canovas, Kailash P Bhatia

Journal: Mov. Disord.. 2012 May;27(6):696-702.

 

Dystonia is considered one of the classical features of corticobasal degeneration and is reported in up to 83% in clinical, not pathologically confirmed, series. Here, we aimed to establish the frequency and the clinical characteristics of dystonia in CBD by reviewing the literature ...

Last Updated: 31 May 2012

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[Corticobasal degeneration: clinical and neuropsychological profile].
 

Author(s): Olivier Felician, Lejla Koric, Nicolas Rochefort

Journal: Psychol Neuropsychiatr Vieil. 2009 Jun;7(2):91-100.

 

Corticobasal degeneration (CBD) is a rare neurodegenerative disorder, primarily defined on clinical and pathological grounds. CBD may present with a large set of cognitive and motor symptoms in relation with asymmetrically distributed lesions in the fronto-parietal cortex and basal ...

Last Updated: 28 May 2009

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy (PSP); Corticobasal Degeneration; Multiple System Atrophy (MSA)

 

Last Updated: 17 May 2016

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4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2
 

Status: Recruiting

Condition Summary: Corticobasal Degeneration (CBD); Corticobasal Syndrome (CBS); Cortical-basal Ganglionic Degeneration (CBGD); Progressive Supranuclear Palsy (PSP); Nonfluent Variant Primary Progressive Aphasia (nfvPPA); Oligosymptomatic/Variant Progressive Supranuclear Palsy (o/vPSP)

 

Last Updated: 15 Nov 2016

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Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)
 

Status: Recruiting

Condition Summary: FTLD; Progressive Supranuclear Palsy (PSP); Frontotemporal Dementia (FTD); Corticobasal Degeneration (CBD); PPA Syndrome; Behavioral Variant Frontotemporal Dementia (bvFTD); Semantic Variant Primary Progressive Aphasia (svPPA); Nonfluent Variant Primary Progressive Aphasia (nfvPPA); FTD With Amyotrophic Lateral Sclerosis (FTD/ALS); Amyotrophic Lateral Sclerosis (ALS); Oligosymptomatic PSP (oPSP); Corticobasal Syndrome (CBS)

 

Last Updated: 2 Dec 2016

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