Corticobasal Degeneration

Common Name(s)

Corticobasal Degeneration

Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. The cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. Signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. These symptoms develop and worsen over time. Currently the cause of corticobasal degeneration is not known.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corticobasal Degeneration" for support, advocacy or research.

CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

Last Updated: 30 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corticobasal Degeneration" for support, advocacy or research.

CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

http://www.curepsp.org/

Last Updated: 30 Apr 2014

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General Support Organizations

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General Resources

Support Groups

Listing of current online and face-to-face support groups

Updated 30 Apr 2014

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Newsletter

Quarterly publication (past and present)

Updated 30 Apr 2014

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CurePSP Webinars

Upcoming webinar listings and previously recorded webinars on various topics related to the diseases.

Updated 30 Apr 2014

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Blogs

CurePSP Forum

Bulletin board type service for patients and caregivers to share thoughts and information.

Updated 30 Apr 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Corticobasal Degeneration" returned 55 free, full-text research articles on human participants. First 3 results:

Validation of the new consensus criteria for the diagnosis of corticobasal degeneration.
 

Author(s): S K Alexander, T Rittman, J H Xuereb, T H Bak, J R Hodges, J B Rowe

Journal: J. Neurol. Neurosurg. Psychiatr.. 2014 Aug;85(8):925-9.

 

Corticobasal degeneration (CBD) is a complex neurodegenerative disorder. Accurate diagnosis is increasingly important, with the advent of clinical trials of drugs aimed at modifying the underlying tau pathology. CBD often presents with a 'corticobasal syndrome' including impairments ...

Last Updated: 10 Jul 2014

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Long-term exercise training for an individual with mixed corticobasal degeneration and progressive supranuclear palsy features: 10-year case report follow-up.
 

Author(s): Teresa M Steffen, Bradley F Boeve, Cheryl M Petersen, Leah Dvorak, Kejal Kantarci

Journal: Phys Ther. 2014 Feb;94(2):289-96.

 

This case report describes the effects of long-term (10-year) participation in a community exercise program for a client with mixed features of corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). The effects of exercise participation on both functional status ...

Last Updated: 3 Feb 2014

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Exome sequencing in familial corticobasal degeneration.
 

Author(s): Robert Fekete, Matthew Bainbridge, Jose Fidel Baizabal-Carvallo, Andreana Rivera, Bradley Miller, Peicheng Du, Vladyslav Kholodovych, Suzanne Powell, William Ondo

Journal: Parkinsonism Relat. Disord.. 2013 Nov;19(11):1049-52.

 

Corticobasal degeneration (CBD) is a neurodegenerative, sporadic disorder of unknown cause. Few familial cases have been described.

Last Updated: 11 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Corticobasal Degeneration" returned 1 free, full-text review articles on human participants. First 3 results:

Corticobasal degeneration: a report of three cases.
 

Author(s): K A Muhiddin, R J Hardie, V R Pearce, B J Kirby

Journal: J R Soc Med. 1994 Jun;87(6):359-60.

 

Last Updated: 1 Sep 1994

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy Volunteers
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy; Corticobasal Degeneration

 

Last Updated: 3 Sep 2014

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4 Repeat Tauopathy Neuroimaging Initiative
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy; Corticobasal Degeneration

 

Last Updated: 25 Jun 2014

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Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders, PD,Essential Tremor, (ET),Cortical Basal Degeneration, (CBD),Multiple Systems Atrophy (MSA), Magnetoencephalography
 

Status: Recruiting

Condition Summary: Essential Tremor; Multiple System Atrophy; Corticobasal Degeneration; Supranuclear Palsy, Progressive

 

Last Updated: 2 May 2014

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