Corticobasal degeneration

Common Name(s)

Corticobasal degeneration, CBD

Corticobasal degeneration is characterized by the break down (degeneration) of parts of the brain, including the cerebral cortex and basal ganglia. The cerebral cortex is responsible for most of the brain's processing of information, and the basal ganglia are deep brain structures that help start and control movement. Signs and symptoms of corticobasal degeneration include poor coordination, loss of movement, rigidity, poor balance, unnatural posturing of the muscles, intellectual (cognitive) impairment, speech impairment, muscular jerks, and difficulty swallowing. These symptoms develop and worsen over time. Currently the cause of corticobasal degeneration is not known.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corticobasal degeneration" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

Last Updated: 8 Jul 2015

View Details
CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

Last Updated: 30 Apr 2014

View Details
The PSP Association

The PSP Association offers support and information to people living with PSP and CBD, while supporting research into treatments and ultimately a cure for these conditions.

Last Updated: 5 Jun 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corticobasal degeneration" for support, advocacy or research.

Logo
Association for Frontotemporal Degeneration

The Association for Frontotemporal Degeneration (AFTD) is a nationwide non-profit organization whose mission is to promote and fund research into finding the cause and cure for the frontotemporal dementias; to provide information, education, and support to persons diagnosed with frontotemporal dementias (FTD) and their families and caregivers; and to educate physicians and allied health professionals about FTD.

http://www.theaftd.org

Last Updated: 8 Jul 2015

View Details
CurePSP: Foundation for PSP|CBD and Related Brain Diseases, Inc.

CurePSP strives to increase awareness of PSP (progressive supranuclear palsy) and CBD (corticobasal degeneration) and other Atypical Parkinsonian disorders; fund research toward treatment, cure and prevention; educate healthcare professionals; and provide support, education and hope for affected persons and their families.

http://www.curepsp.org/

Last Updated: 30 Apr 2014

View Details
The PSP Association

The PSP Association offers support and information to people living with PSP and CBD, while supporting research into treatments and ultimately a cure for these conditions.

http://www.pspassociation.org.uk/

Last Updated: 5 Jun 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

Support Groups

Listing of current online and face-to-face support groups

Updated 30 Apr 2014

Go To URL
Newsletter

Quarterly publication (past and present)

Updated 30 Apr 2014

Go To URL
CurePSP Webinars

Upcoming webinar listings and previously recorded webinars on various topics related to the diseases.

Updated 30 Apr 2014

Go To URL
 
 
Top

Blogs

CurePSP Forum

Bulletin board type service for patients and caregivers to share thoughts and information.

Updated 30 Apr 2014

Go To URL
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Corticobasal degeneration" returned 69 free, full-text research articles on human participants. First 3 results:

Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy.
 

Author(s): Naomi Kouri, Owen A Ross, Beth Dombroski, Curtis S Younkin, Daniel J Serie, Alexandra Soto-Ortolaza, Matthew Baker, Ni Cole A Finch, Hyejin Yoon, Jungsu Kim, Shinsuke Fujioka, Catriona A McLean, Bernardino Ghetti, Salvatore Spina, Laura B Cantwell, Martin R Farlow, Jordan Grafman, Edward D Huey, Mi Ryung Han, Sherry Beecher, Evan T Geller, Hans A Kretzschmar, Sigrun Roeber, Marla Gearing, Jorge L Juncos, Jean Paul G Vonsattel, Vivianna M Van Deerlin, Murray Grossman, Howard I Hurtig, Rachel G Gross, Steven E Arnold, John Q Trojanowski, Virginia M Lee, Gregor K Wenning, Charles L White, Günter U Höglinger, Ulrich Müller, Bernie Devlin, Lawrence I Golbe, Julia Crook, Joseph E Parisi, Bradley F Boeve, Keith A Josephs, Zbigniew K Wszolek, Ryan J Uitti, Neill R Graff-Radford, Irene Litvan, Steven G Younkin, Li-San Wang, Nilüfer Ertekin-Taner, Rosa Rademakers, Hakon Hakonarsen, Gerard D Schellenberg, Dennis W Dickson

Journal:

 

Corticobasal degeneration (CBD) is a neurodegenerative disorder affecting movement and cognition, definitively diagnosed only at autopsy. Here, we conduct a genome-wide association study (GWAS) in CBD cases (n=152) and 3,311 controls, and 67 CBD cases and 439 controls in a replication ...

Last Updated: 16 Jun 2015

Go To URL
Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains.
 

Author(s): Susana Boluda, Michiyo Iba, Bin Zhang, Kevin M Raible, Virginia M-Y Lee, John Q Trojanowski

Journal: Acta Neuropathol.. 2015 Feb;129(2):221-37.

 

Filamentous tau pathologies are hallmark lesions of several neurodegenerative tauopathies including Alzheimer's disease (AD) and corticobasal degeneration (CBD) which show cell type-specific and topographically distinct tau inclusions. Growing evidence supports templated transmission ...

Last Updated: 24 Jan 2015

Go To URL
Ultrastructural differences in pretangles between Alzheimer disease and corticobasal degeneration revealed by comparative light and electron microscopy.
 

Author(s): Shinsui Tatsumi, Toshiki Uchihara, Ikuko Aiba, Yasushi Iwasaki, Maya Mimuro, Ryosuke Takahashi, Mari Yoshida

Journal:

 

Pretangles are defined under the light microscope as diffuse and granular tau immunoreactivity in neurons in tissue from patients with Alzheimer disease (AD) or corticobasal degeneration (CBD) and are considered to be a premature stage before neurofibrillary tangle formation. However, ...

Last Updated: 18 Dec 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Corticobasal degeneration" returned 3 free, full-text review articles on human participants. First 3 results:

Key emerging issues in progressive supranuclear palsy and corticobasal degeneration.
 

Author(s): Keith A Josephs

Journal: J. Neurol.. 2015 Mar;262(3):783-8.

 

It has been approximately 50 years since neurologists were introduced to the entities, "progressive supranuclear palsy" and "corticobasal degeneration". Since the two seminal publications, there have been significant advancements in our understanding of these two neurodegenerative ...

Last Updated: 18 Mar 2015

Go To URL
Dystonia in corticobasal degeneration: a review of the literature on 404 pathologically proven cases.
 

Author(s): Maria Stamelou, Araceli Alonso-Canovas, Kailash P Bhatia

Journal: Mov. Disord.. 2012 May;27(6):696-702.

 

Dystonia is considered one of the classical features of corticobasal degeneration and is reported in up to 83% in clinical, not pathologically confirmed, series. Here, we aimed to establish the frequency and the clinical characteristics of dystonia in CBD by reviewing the literature ...

Last Updated: 31 May 2012

Go To URL
Corticobasal degeneration: a report of three cases.
 

Author(s): K A Muhiddin, R J Hardie, V R Pearce, B J Kirby

Journal: J R Soc Med. 1994 Jun;87(6):359-60.

 

Last Updated: 1 Sep 1994

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

4 Repeat Tauopathy Neuroimaging Initiative
 

Status: Recruiting

Condition Summary: Progressive Supranuclear Palsy; Corticobasal Degeneration

 

Last Updated: 1 Dec 2015

Go to URL
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)
 

Status: Recruiting

Condition Summary: FTLD; Progressive Supranuclear Palsy (PSP); Frontotemporal Dementia (FTD); Corticobasal Degeneration (CBD); PPA Syndrome; Behavioral Variant Frontotemporal Dementia (bvFTD); Semantic Variant Primary Progressive Aphasia (svPPA); Nonfluent Variant Primary Progressive Aphasia (nfvPPA); FTD With Amyotrophic Lateral Sclerosis (FTD/ALS); Amyotrophic Lateral Sclerosis (ALS); Oligosymptomatic PSP (oPSP); Corticobasal Syndrome (CBS)

 

Last Updated: 5 Feb 2016

Go to URL
Safety Study of TPI-287 to Treat CBS and PSP
 

Status: Recruiting

Condition Summary: Primary Four Repeat Tauopathies (4RT); Corticobasal Syndrome (CBS); Progressive Supranuclear Palsy (PSP); Corticobasal Degeneration (CBD)

 

Last Updated: 26 Jan 2016

Go to URL