Acute Mountain Sickness

Common Name(s)

Acute Mountain Sickness

Acute mountain sickness is an illness caused by reduced air pressure and lower oxygen levels at high altitudes (usually above 8,000 feet or 2,400 meters). People at higher risk for acute mountain sickness are those who live at or near sea level and travel to a high altitude, or people who have had the illness before. The faster one climbs to a higher altitude, the more likely acute mountain sickness will occur. Signs and symptoms depend on the speed of ascension and the level of exertion, and can range from mild to life-threatening. Mild to moderate symptoms include difficulty sleeping, dizziness or light-headedness, fatigue, headache, loss of appetite, nausea or vomiting, rapid pulse, and shortness of breath with exertion. Symptoms of more severe acute mountain sickness include blue color to the skin, chest tightness or congestion, confusion, cough, coughing up blood, decreased consciousness, gray or pale complexion, cannot walk in a straight line or walk at all, shortness of breath at rest, and death due to lung problems or brain swelling.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Mountain Sickness" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Mountain Sickness" returned 95 free, full-text research articles on human participants. First 3 results:

Obesity is a risk factor for acute mountain sickness: a prospective study in Tibet railway construction workers on Tibetan plateau.
 

Author(s): B Yang, Z-J Sun, F Cao, H Zhao, C-W Li, J Zhang

Journal: Eur Rev Med Pharmacol Sci. 2015 Jan;19(1):119-22.

 

Although few retrospective studies of high altitude have reported that obesity might be associated with the development of acute mountain sickness (AMS), this association has not been fully studied prospectively. The aim of this study was to investigate the effect of obesity on subjects ...

Last Updated: 31 Jan 2015

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Variants of the low oxygen sensors EGLN1 and HIF-1AN associated with acute mountain sickness.
 

Author(s): Enhao Zhang, Jihang Zhang, Jun Jin, Jun Qin, Huijie Li, Lan Huang

Journal:

 

Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-α inhibitor (HIF-1AN), play pivotal roles in the regulation of HIF-1α, and high altitude adaption may be involved in the pathology of acute mountain sickness (AMS). Here, we aimed to analyze single ...

Last Updated: 29 Nov 2014

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Age as a risk factor for acute mountain sickness upon rapid ascent to 3,700 m among young adult Chinese men.
 

Author(s): Xu-Gang Tang, Ji-hang Zhang, Jun Qin, Xu-bin Gao, Qian-ning Li, Jie Yu, Xiao-han Ding, Lan Huang

Journal:

 

The aim of this study was to explore the relationship between age and acute mountain sickness (AMS) when subjects are exposed suddenly to high altitude.

Last Updated: 14 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Mountain Sickness" returned 10 free, full-text review articles on human participants. First 3 results:

Non-high altitude methods for rapid screening of susceptibility to acute mountain sickness.
 

Author(s): Han Song, Tao Ke, Wen-Jing Luo, Jing-Yuan Chen

Journal:

 

Acute mountain sickness (AMS) refers to the cerebral abnormalities typically triggered by exposure to hypobaric hypoxia at high altitude. Although AMS is not often life threatening, it can seriously impact health quality and decrease productivity. Thus, detection of potential susceptibility ...

Last Updated: 15 Nov 2013

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Identifying the lowest effective dose of acetazolamide for the prophylaxis of acute mountain sickness: systematic review and meta-analysis.
 

Author(s): Emma V Low, Anthony J Avery, Vaibhav Gupta, Angela Schedlbauer, Michael P W Grocott

Journal:

 

To assess the efficacy of three different daily doses of acetazolamide in the prevention of acute mountain sickness and to determine the lowest effective dose.

Last Updated: 19 Oct 2012

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Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological.
 

Author(s): Damian Miles Bailey, Peter Bärtsch, Michael Knauth, Ralf W Baumgartner

Journal: Cell. Mol. Life Sci.. 2009 Nov;66(22):3583-94.

 

Acute mountain sickness (AMS) is a neurological disorder that typically affects mountaineers who ascend to high altitude. The symptoms have traditionally been ascribed to intracranial hypertension caused by extracellular vasogenic edematous brain swelling subsequent to mechanical ...

Last Updated: 21 Jan 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Comparison of Metoclopramide and Ibuprofen for the Treatment of Acute Mountain Sickness
 

Status: Recruiting

Condition Summary: Acute Mountain Sickness; High Altitude Headache

 

Last Updated: 22 Apr 2015

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Training in Hypoxia to Prevent Acute Mountain Sickness
 

Status: Recruiting

Condition Summary: Acute Mountain Sickness; Healthy

 

Last Updated: 24 Jun 2010

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Hemodynamic Changes in Altitude Adaptation
 

Status: Recruiting

Condition Summary: Acute Mountain Sickness; High Altitude Pulmonary Edema; High Altitude Cerebral Edema

 

Last Updated: 2 Oct 2012

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