Acute Megakaryoblastic Leukemia

Common Name(s)

Acute Megakaryoblastic Leukemia

Acute megakaryoblastic leukemia is also known as acute magakaryocytic leukemia. It is a type of cancer affecting the blood. Although the precise cause of this disorder is not fully understood, exposure to radiation or certain chemicals is considered risk factors for this condition. Acute megakaryoblastic leukemia may cause various symptoms such as bruises, excessive bleeding, fatigue and fever. A physician can often diagnose this condition with a physical exam and blood tests, although certain imaging studies such as an x-ray or CT scan might be necessary. Treatment for cancers of the blood, including acute megakaryoblastic leukemia, is rapidly progressing with advances in medical research. Currently, chemotherapy and bone marrow transplant are two possible treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Megakaryoblastic Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Megakaryoblastic Leukemia" returned 66 free, full-text research articles on human participants. First 3 results:

Re: Lee H, et al. An unusual case of myeloperoxidase-positive acute megakaryoblastic leukemia. Ann Lab Med 2015;35:466-8.
 

Author(s): John M Bennett, Denise A Wells

Journal: Ann Lab Med. 2015 Sep;35(5):542-3.

 

Last Updated: 24 Jul 2015

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Improved outcome of pediatric patients with acute megakaryoblastic leukemia in the AML-BFM 04 trial.
 

Author(s): Jana Schweitzer, Martin Zimmermann, Mareike Rasche, Christine von Neuhoff, Ursula Creutzig, Michael Dworzak, Dirk Reinhardt, Jan-Henning Klusmann

Journal: Ann. Hematol.. 2015 Aug;94(8):1327-36.

 

Despite recent advances in the treatment of children with acute megakaryoblastic leukemia (AMKL) using intensified treatment protocols, clear prognostic indicators, and treatment recommendations for this acute myeloid leukemia (AML) subgroup are yet to be defined. Here, we report ...

Last Updated: 3 Jul 2015

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MiR-125b and miR-99a encoded on chromosome 21 co-regulate vincristine resistance in childhood acute megakaryoblastic leukemia.
 

Author(s): Ravinder Kandi, Usha Gutti, Raja Gopal Venakata Saladi, Ravi Kumar Gutti

Journal: Hematol Oncol Stem Cell Ther. 2015 Jun;8(2):95-7.

 

Last Updated: 22 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Megakaryoblastic Leukemia" returned 3 free, full-text review articles on human participants. First 3 results:

The biology of pediatric acute megakaryoblastic leukemia.
 

Author(s): Tanja A Gruber, James R Downing

Journal: Blood. 2015 Aug;126(8):943-9.

 

Acute megakaryoblastic leukemia (AMKL) comprises between 4% and 15% of newly diagnosed pediatric acute myeloid leukemia patients. AMKL in children with Down syndrome (DS) is characterized by a founding GATA1 mutation that cooperates with trisomy 21, followed by the acquisition of ...

Last Updated: 21 Aug 2015

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Acute megakaryoblastic leukemia associated with mosaic Down's syndrome.
 

Author(s): J H Simon, C K Tebbi, A I Freeman, M L Brecher, D M Green, A A Sandberg

Journal: Cancer. 1987 Nov;60(10):2515-20.

 

There have been several reports of the association between Down's Syndrome and acute megakaryoblastic (M7) leukemia (AMKL). The diagnosis of this rare form of leukemia has been better delineated by the use of the platelet peroxidase reaction and the antifactor VIII antibody immunoperoxidase ...

Last Updated: 4 Dec 1987

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Phenotypes of blasts in acute erythroblastic and megakaryoblastic leukemia--review.
 

Author(s): J Breton-Gorius

Journal: Keio J Med. 1987 Jan;36(1):23-45.

 

Last Updated: 15 Sep 1987

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Alisertib in Treating Patients With Myelofibrosis or Relapsed or Refractory Acute Megakaryoblastic Leukemia
 

Status: Recruiting

Condition Summary: Acute Megakaryoblastic Leukemia; Myelofibrosis; Primary Myelofibrosis

 

Last Updated: 26 May 2016

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Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia
 

Status: Recruiting

Condition Summary: Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Childhood Acute Erythroleukemia (M6); Childhood Acute Megakaryocytic Leukemia (M7); Childhood Acute Monoblastic Leukemia (M5a); Childhood Acute Monocytic Leukemia (M5b); Childhood Acute Myeloblastic Leukemia With Maturation (M2); Childhood Acute Myeloblastic Leukemia Without Maturation (M1); Childhood Acute Myeloid Leukemia in Remission; Childhood Acute Myelomonocytic Leukemia (M4); Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies

 

Last Updated: 29 Aug 2015

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Caspofungin Acetate or Fluconazole in Preventing Invasive Fungal Infections in Patients With Acute Myeloid Leukemia Who Are Undergoing Chemotherapy
 

Status: Recruiting

Condition Summary: Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Childhood Acute Erythroleukemia (M6); Childhood Acute Megakaryocytic Leukemia (M7); Childhood Acute Minimally Differentiated Myeloid Leukemia (M0); Childhood Acute Monoblastic Leukemia (M5a); Childhood Acute Monocytic Leukemia (M5b); Childhood Acute Myeloblastic Leukemia With Maturation (M2); Childhood Acute Myeloblastic Leukemia Without Maturation (M1); Childhood Acute Myeloid Leukemia in Remission; Childhood Acute Myelomonocytic Leukemia (M4); Fungal Infection; Neutropenia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies

 

Last Updated: 23 Aug 2016

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