Acute Megakaryoblastic Leukemia

Common Name(s)

Acute Megakaryoblastic Leukemia

Acute megakaryoblastic leukemia is also known as acute magakaryocytic leukemia. It is a type of cancer affecting the blood. Although the precise cause of this disorder is not fully understood, exposure to radiation or certain chemicals is considered risk factors for this condition. Acute megakaryoblastic leukemia may cause various symptoms such as bruises, excessive bleeding, fatigue and fever. A physician can often diagnose this condition with a physical exam and blood tests, although certain imaging studies such as an x-ray or CT scan might be necessary. Treatment for cancers of the blood, including acute megakaryoblastic leukemia, is rapidly progressing with advances in medical research. Currently, chemotherapy and bone marrow transplant are two possible treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Megakaryoblastic Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Megakaryoblastic Leukemia" returned 43 free, full-text research articles on human participants. First 3 results:

Acute megakaryoblastic leukemia M7 presenting with extreme myelofibrosis.
 

Author(s): Aniket Kumbhojkar, Rajesh Kulkarni, Akash Chheda, Prakash Gambhir, Aarti Kinikar, Sandhya Khadse

Journal: Indian J Pathol Microbiol. ;57(3):512-4.

 

Last Updated: 14 Aug 2014

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LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia.
 

Author(s): Stephan Emmrich, Alexandra Streltsov, Franziska Schmidt, Veera Raghavan Thangapandi, Dirk Reinhardt, Jan-Henning Klusmann

Journal:

 

Long non-coding RNAs (lncRNAs) are recognized as pivotal players during developmental ontogenesis and pathogenesis of cancer. The intronic microRNA (miRNA) clusters miR-99a ~ 125b-2 and miR-100 ~ 125b-1 promote progression of acute megakaryoblastic leukemia (AMKL), an aggressive ...

Last Updated: 1 Aug 2014

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Detection of RBM15-MKL1 fusion was useful for diagnosis and monitoring of minimal residual disease in infant acute megakaryoblastic leukemia.
 

Author(s): Akiko Takeda, Akira Shimada, Kazuko Hamamoto, Syuuji Yoshino, Tomoko Nagai, Yousuke Fujii, Mutsuko Yamada, Yoshimi Nakamura, Toshiyuki Watanabe, Yuki Watanabe, Yuko Yamamoto, Kanae Sakakibara, Megumi Oda, Tsuneo Morishima

Journal: Acta Med. Okayama. 2014 ;68(2):119-23.

 

Acute megakaryocytic leukemia (AMKL) with t(1;22)(p13;q13) is a distinct category of myeloid leukemia by WHO classification and mainly reported in infants and young children. Accurate diagnosis of this type of AMKL can be difficult, because a subset of patients have a bone marrow ...

Last Updated: 18 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Megakaryoblastic Leukemia" returned 1 free, full-text review articles on human participants. First 3 results:

Phenotypes of blasts in acute erythroblastic and megakaryoblastic leukemia--review.
 

Author(s): J Breton-Gorius

Journal: Keio J Med. 1987 Jan;36(1):23-45.

 

Last Updated: 15 Sep 1987

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Studying Genes in Samples From Younger Patients With Acute Megakaryoblastic Leukemia
 

Status: Recruiting

Condition Summary: Childhood Acute Megakaryocytic Leukemia (M7); Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies

 

Last Updated: 5 May 2015

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Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia
 

Status: Recruiting

Condition Summary: Adult Acute Megakaryoblastic Leukemia; Adult Acute Monoblastic Leukemia; Adult Acute Monocytic Leukemia; Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With Maturation; Adult Acute Myeloid Leukemia With Minimal Differentiation; Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1; Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL; Adult Acute Myeloid Leukemia Without Maturation; Adult Acute Myelomonocytic Leukemia; Adult Erythroleukemia; Adult Pure Erythroid Leukemia; Childhood Acute Erythroid Leukemia; Childhood Acute Megakaryoblastic Leukemia; Childhood Acute Monoblastic Leukemia; Childhood Acute Monocytic Leukemia; Childhood Acute Myeloid Leukemia With Maturation; Childhood Acute Myeloid Leukemia Without Maturation; Childhood Acute Myelomonocytic Leukemia; Untreated Adult Acute Myeloid Leukemia; Untreated Childhood Myeloid Neoplasm

 

Last Updated: 30 Jul 2015

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Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia
 

Status: Recruiting

Condition Summary: Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Childhood Acute Erythroleukemia (M6); Childhood Acute Megakaryocytic Leukemia (M7); Childhood Acute Monoblastic Leukemia (M5a); Childhood Acute Monocytic Leukemia (M5b); Childhood Acute Myeloblastic Leukemia With Maturation (M2); Childhood Acute Myeloblastic Leukemia Without Maturation (M1); Childhood Acute Myeloid Leukemia in Remission; Childhood Acute Myelomonocytic Leukemia (M4); Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies

 

Last Updated: 25 Mar 2015

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