Acute Megakaryoblastic Leukemia

Common Name(s)

Acute Megakaryoblastic Leukemia

Acute megakaryoblastic leukemia is also known as acute magakaryocytic leukemia. It is a type of cancer affecting the blood. Although the precise cause of this disorder is not fully understood, exposure to radiation or certain chemicals is considered risk factors for this condition. Acute megakaryoblastic leukemia may cause various symptoms such as bruises, excessive bleeding, fatigue and fever. A physician can often diagnose this condition with a physical exam and blood tests, although certain imaging studies such as an x-ray or CT scan might be necessary. Treatment for cancers of the blood, including acute megakaryoblastic leukemia, is rapidly progressing with advances in medical research. Currently, chemotherapy and bone marrow transplant are two possible treatment options.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute Megakaryoblastic Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute Megakaryoblastic Leukemia" returned 69 free, full-text research articles on human participants. First 3 results:

New hPSC-based human models to study pediatric Acute Megakaryoblastic Leukemia harboring the fusion oncogene RBM15-MKL1.
 

Author(s): Verónica Ayllón, Marina Vogel-González, Federico González-Pozas, Joan Domingo-Reinés, Rosa Montes, Lucía Morales-Cacho, Verónica Ramos-Mejía

Journal: Stem Cell Res. 2017 Mar;19():1-5.

 

Pediatric Acute Megakaryoblastic Leukemia not associated to Down Syndrome (non-DS AMKL) is a rare disease with a dismal prognosis. Around 15% of patients carry the chromosomal translocation t(1;22) that originates the fusion oncogene RBM15-MKL1, which is linked to an earlier disease ...

Last Updated: 17 Apr 2017

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Acute Megakaryoblastic Leukemia with Myelodysplasia-related Changes Associated with ATM Gene Deletion.
 

Author(s): Hiroshi Ureshino, Momoka Tanabe, Kazuya Kurogi, Masaharu Miyahara, Shinya Kimura

Journal: Intern. Med.. 2016 ;55(12):1625-9.

 

Ataxia telangiectasia mutated (ATM) is a tumor suppressor gene, and its somatic inactivation plays a role in the pathogenesis of lymphoid malignancies. However, the role of ATM in patients with myeloid malignancies is still unknown. We herein report a case of acute megakaryoblastic ...

Last Updated: 15 Jun 2016

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Clinical Courses of Two Pediatric Patients with Acute Megakaryoblastic Leukemia Harboring the CBFA2T3-GLIS2 Fusion Gene.
 

Author(s): Mayu Ishibashi, Tomoko Yokosuka, Masakatsu D Yanagimachi, Fuminori Iwasaki, Shin-Ichi Tsujimoto, Koji Sasaki, Masanobu Takeuchi, Reo Tanoshima, Hiromi Kato, Ryosuke Kajiwara, Fumiko Tanaka, Hiroaki Goto, Shumpei Yokota

Journal: Turk J Haematol. 2016 Dec;33(4):331-334.

 

Acute megakaryoblastic leukemia (AMKL) in children without Down syndrome (DS) has an extremely poor outcome with 3-year survival of less than 40%, whereas AMKL in children with DS has an excellent survival rate. Recently, a novel recurrent translocation involving CBFA2T3 and GLIS2 ...

Last Updated: 20 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute Megakaryoblastic Leukemia" returned 3 free, full-text review articles on human participants. First 3 results:

The biology of pediatric acute megakaryoblastic leukemia.
 

Author(s): Tanja A Gruber, James R Downing

Journal: Blood. 2015 Aug;126(8):943-9.

 

Acute megakaryoblastic leukemia (AMKL) comprises between 4% and 15% of newly diagnosed pediatric acute myeloid leukemia patients. AMKL in children with Down syndrome (DS) is characterized by a founding GATA1 mutation that cooperates with trisomy 21, followed by the acquisition of ...

Last Updated: 21 Aug 2015

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Acute megakaryoblastic leukemia associated with mosaic Down's syndrome.
 

Author(s): J H Simon, C K Tebbi, A I Freeman, M L Brecher, D M Green, A A Sandberg

Journal: Cancer. 1987 Nov;60(10):2515-20.

 

There have been several reports of the association between Down's Syndrome and acute megakaryoblastic (M7) leukemia (AMKL). The diagnosis of this rare form of leukemia has been better delineated by the use of the platelet peroxidase reaction and the antifactor VIII antibody immunoperoxidase ...

Last Updated: 4 Dec 1987

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Phenotypes of blasts in acute erythroblastic and megakaryoblastic leukemia--review.
 

Author(s): J Breton-Gorius

Journal: Keio J Med. 1987 Jan;36(1):23-45.

 

Last Updated: 15 Sep 1987

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Alisertib in Treating Patients With Myelofibrosis or Relapsed or Refractory Acute Megakaryoblastic Leukemia
 

Status: Recruiting

Condition Summary: Acute Megakaryoblastic Leukemia; Myelofibrosis; Primary Myelofibrosis

 

Last Updated: 13 Apr 2017

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Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid Leukemia
 

Status: Recruiting

Condition Summary: Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Childhood Acute Erythroleukemia (M6); Childhood Acute Megakaryocytic Leukemia (M7); Childhood Acute Monoblastic Leukemia (M5a); Childhood Acute Monocytic Leukemia (M5b); Childhood Acute Myeloblastic Leukemia With Maturation (M2); Childhood Acute Myeloblastic Leukemia Without Maturation (M1); Childhood Acute Myeloid Leukemia in Remission; Childhood Acute Myelomonocytic Leukemia (M4); Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies

 

Last Updated: 18 Apr 2017

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Donor Umbilical Cord Blood Transplant With or Without Ex-vivo Expanded Cord Blood Progenitor Cells in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, or Myelodysplastic Syndromes
 

Status: Recruiting

Condition Summary: Acute Biphenotypic Leukemia; Acute Erythroid Leukemia; Acute Lymphoblastic Leukemia in Remission; Acute Megakaryoblastic Leukemia; Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Acute Myeloid Leukemia in Remission; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Mixed Phenotype Acute Leukemia; Myelodysplastic Syndrome; Myelodysplastic Syndrome With Excess Blasts; Pancytopenia; Refractory Anemia; Secondary Acute Myeloid Leukemia

 

Last Updated: 18 Apr 2017

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