Corneal Dystrophy

Common Name(s)

Corneal Dystrophy

Corneal dystrophy is a condition in which the cornea, the clear covering of the eye, becomes less clear because of a buildup of cloudy material. There are over 20 kinds of corneal dystrophy, but they all share certain traits. Corneal dystrophies are usually inherited, affect both eyes equally, are not caused by injury, get gradually worse with time, and are not related to any other kind of disease. Symptoms can range from no vision impairment to severe vision impairment. Some forms of corneal dystrophy can also cause pain. The early stages of corneal dystrophy can be treated with special eyedrops, but once there is severe vision impairment, surgery and corneal transplant may be necessary.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corneal Dystrophy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Corneal Dystrophy" returned 299 free, full-text research articles on human participants. First 3 results:

Vps35-deficiency impairs SLC4A11 trafficking and promotes corneal dystrophy.
 

Author(s): Wei Liu, Fu-Lei Tang, Sen Lin, Kai Zhao, Lin Mei, Jian Ye, Wen-Cheng Xiong

Journal:

 

Vps35 (vacuolar protein sorting 35) is a major component of retromer that selectively promotes endosome-to-Golgi retrieval of transmembrane proteins. Dysfunction of retromer is a risk factor for the pathogenesis of Parkinson's disease (PD) and Alzheimer's disease (AD). However, Vps35/retromer's ...

Last Updated: 21 Sep 2017

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Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy.
 

Author(s): V Vinod Mootha, Brock Hansen, Ziye Rong, Pradeep P Mammen, Zhengyang Zhou, Chao Xing, Xin Gong

Journal: Invest. Ophthalmol. Vis. Sci.. 2017 Sep;58(11):4579-4585.

 

The most common cause of Fuchs' endothelial corneal dystrophy (FECD) is an intronic CTG repeat expansion in TCF4. Expanded CUG repeat RNA colocalize with splicing factor, muscleblind-like 1 (MBNL1), in nuclear foci in endothelium as a molecular hallmark. Myotonic dystrophy type 1 ...

Last Updated: 8 Sep 2017

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TGC repeat expansion in the TCF4 gene increases the risk of Fuchs' endothelial corneal dystrophy in Australian cases.
 

Author(s): Abraham Kuot, Alex W Hewitt, Grant R Snibson, Emmanuelle Souzeau, Richard Mills, Jamie E Craig, Kathryn P Burdon, Shiwani Sharma

Journal:

 

Fuchs' endothelial corneal dystrophy (FECD) is a progressive, vision impairing disease. Common single nucleotide polymorphisms (SNPs) and a trinucleotide repeat polymorphism, thymine-guanine-cytosine (TGC), in the TCF4 gene have been associated with the risk of FECD in some populations. ...

Last Updated: 23 Aug 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Corneal Dystrophy" returned 5 free, full-text review articles on human participants. First 3 results:

Transcript profile of cellular senescence-related genes in Fuchs endothelial corneal dystrophy.
 

Author(s): Mario Matthaei, Angela Y Zhu, Laura Kallay, Charles G Eberhart, Claus Cursiefen, Albert S Jun

Journal: Exp. Eye Res.. 2014 Dec;129():13-7.

 

Fuchs endothelial corneal dystrophy (FECD) is a genetically heterogeneous disease. Hypothesizing that cellular senescence may be relevant in FECD pathogenesis, genetically undifferentiated late-onset FECD endothelial samples were analyzed to identify common changes of specific senescence-related ...

Last Updated: 8 Dec 2014

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Oxidative stress in the pathogenesis of keratoconus and Fuchs endothelial corneal dystrophy.
 

Author(s): Katarzyna A Wojcik, Anna Kaminska, Janusz Blasiak, Jerzy Szaflik, Jacek P Szaflik

Journal:

 

Due to its localization and function, the cornea is regularly exposed to sunlight and atmospheric oxygen, mainly dioxygen, which produce reactive oxygen species (ROS). Therefore, corneal cells are particularly susceptible to oxidative stress. The accumulation of ROS in the cornea ...

Last Updated: 25 Sep 2013

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Fuchs endothelial corneal dystrophy.
 

Author(s): Hussain Elhalis, Behrooz Azizi, Ula V Jurkunas

Journal: Ocul Surf. 2010 Oct;8(4):173-84.

 

Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive loss of corneal endothelial cells, thickening of Descement's membrane and deposition of extracellular matrix in the form of guttae. When the number of endothelial cells becomes critically low, the cornea swells ...

Last Updated: 22 Oct 2010

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Descemet Membrane Endothelial Keratoplasty (DMEK)
 

Status: Recruiting

Condition Summary: Corneal Dystrophies, Hereditary

 

Last Updated: 2 Jun 2015

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Descemet Stripping (Automated) Endothelial Keratoplasty (DSEK or DSAEK)
 

Status: Recruiting

Condition Summary: Corneal Dystrophies, Hereditary

 

Last Updated: 2 Jun 2015

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Autologous Adipose-Derived Adult Stem Cell Transplantation for Corneal Diseases
 

Status: Recruiting

Condition Summary: Hereditary Corneal Dystrophy; Keratoconus

 

Last Updated: 11 Oct 2016

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