Corneal Dystrophy

Common Name(s)

Corneal Dystrophy

Corneal dystrophy is a condition in which the cornea, the clear covering of the eye, becomes less clear because of a buildup of cloudy material. There are over 20 kinds of corneal dystrophy, but they all share certain traits. Corneal dystrophies are usually inherited, affect both eyes equally, are not caused by injury, get gradually worse with time, and are not related to any other kind of disease. Symptoms can range from no vision impairment to severe vision impairment. Some forms of corneal dystrophy can also cause pain. The early stages of corneal dystrophy can be treated with special eyedrops, but once there is severe vision impairment, surgery and corneal transplant may be necessary.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corneal Dystrophy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Corneal Dystrophy" returned 274 free, full-text research articles on human participants. First 3 results:

New histopathologic and ultrastructural findings in Reis-Bücklers corneal dystrophy caused by the Arg124Leu mutation of TGFBI gene.
 

Author(s): Wen-Ya Qiu, Li-Bin Zheng, Fei Pan, Bei-Bei Wang, Yu-Feng Yao

Journal:

 

Reis-Bücklers corneal dystrophy (RBCD) was consistently reported as a corneal dystrophy only affected Bowman's layer and superficial corneal stroma, and superficial keratectomy was a recommendation surgery for treatment in literatures. The study reported new histopathological and ...

Last Updated: 3 Sep 2016

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pH Induced Conformational Transitions in the Transforming Growth Factor β-Induced Protein (TGFβIp) Associated Corneal Dystrophy Mutants.
 

Author(s): Elavazhagan Murugan, Anandalakshmi Venkatraman, Zhou Lei, Victoria Mouvet, Rayne Rui Yi Lim, Nandhakumar Muruganantham, Eunice Goh, Gary Swee Lim Peh, Roger W Beuerman, Shyam S Chaurasia, Lakshminarayanan Rajamani, Jodhbir S Mehta

Journal:

 

Most stromal corneal dystrophies are associated with aggregation and deposition of the mutated transforming growth factor-β induced protein (TGFβIp). The 4(th)_FAS1 domain of TGFβIp harbors ~80% of the mutations that forms amyloidogenic and non-amyloidogenic aggregates. To understand ...

Last Updated: 31 Mar 2016

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The Ultrastructures and Mechanical Properties of the Descement's Membrane in Fuchs Endothelial Corneal Dystrophy.
 

Author(s): Dan Xia, Shuai Zhang, Esben Nielsen, Anders Ramløv Ivarsen, Chunyong Liang, Qiang Li, Karen Thomsen, Jesper Østergaard Hjortdal, Mingdong Dong

Journal:

 

Fuchs endothelial corneal dystrophy (FECD), is the most common corneal endothelial dystrophy, and contributes up to 50% of all corneal transplantations performed in developed countries. FECD develops in Descemet's membrane (DM) and possibly alters the mechanical properties and internal ...

Last Updated: 16 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Corneal Dystrophy" returned 5 free, full-text review articles on human participants. First 3 results:

Transcript profile of cellular senescence-related genes in Fuchs endothelial corneal dystrophy.
 

Author(s): Mario Matthaei, Angela Y Zhu, Laura Kallay, Charles G Eberhart, Claus Cursiefen, Albert S Jun

Journal: Exp. Eye Res.. 2014 Dec;129():13-7.

 

Fuchs endothelial corneal dystrophy (FECD) is a genetically heterogeneous disease. Hypothesizing that cellular senescence may be relevant in FECD pathogenesis, genetically undifferentiated late-onset FECD endothelial samples were analyzed to identify common changes of specific senescence-related ...

Last Updated: 8 Dec 2014

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Oxidative stress in the pathogenesis of keratoconus and Fuchs endothelial corneal dystrophy.
 

Author(s): Katarzyna A Wojcik, Anna Kaminska, Janusz Blasiak, Jerzy Szaflik, Jacek P Szaflik

Journal:

 

Due to its localization and function, the cornea is regularly exposed to sunlight and atmospheric oxygen, mainly dioxygen, which produce reactive oxygen species (ROS). Therefore, corneal cells are particularly susceptible to oxidative stress. The accumulation of ROS in the cornea ...

Last Updated: 25 Sep 2013

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Fuchs endothelial corneal dystrophy.
 

Author(s): Hussain Elhalis, Behrooz Azizi, Ula V Jurkunas

Journal: Ocul Surf. 2010 Oct;8(4):173-84.

 

Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive loss of corneal endothelial cells, thickening of Descement's membrane and deposition of extracellular matrix in the form of guttae. When the number of endothelial cells becomes critically low, the cornea swells ...

Last Updated: 22 Oct 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Descemet Membrane Endothelial Keratoplasty (DMEK)
 

Status: Recruiting

Condition Summary: Corneal Dystrophies, Hereditary

 

Last Updated: 2 Jun 2015

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Descemet Stripping (Automated) Endothelial Keratoplasty (DSEK or DSAEK)
 

Status: Recruiting

Condition Summary: Corneal Dystrophies, Hereditary

 

Last Updated: 2 Jun 2015

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Autologous Adipose-Derived Adult Stem Cell Transplantation for Corneal Diseases
 

Status: Recruiting

Condition Summary: Hereditary Corneal Dystrophy; Keratoconus

 

Last Updated: 11 Oct 2016

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