Corneal Dystrophy

Common Name(s)

Corneal Dystrophy

Corneal dystrophy is a condition in which the cornea, the clear covering of the eye, becomes less clear because of a buildup of cloudy material. There are over 20 kinds of corneal dystrophy, but they all share certain traits. Corneal dystrophies are usually inherited, affect both eyes equally, are not caused by injury, get gradually worse with time, and are not related to any other kind of disease. Symptoms can range from no vision impairment to severe vision impairment. Some forms of corneal dystrophy can also cause pain. The early stages of corneal dystrophy can be treated with special eyedrops, but once there is severe vision impairment, surgery and corneal transplant may be necessary.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corneal Dystrophy" for support, advocacy or research.

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corneal Dystrophy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Corneal Dystrophy" returned 269 free, full-text research articles on human participants. First 3 results:

Objective assessment of the corneal endothelium in Fuchs' endothelial dystrophy.
 

Author(s): Jay W McLaren, Lori A Bachman, Katrina M Kane, Sanjay V Patel

Journal:

 

To develop a standardized method of endothelial cell density (ECD) assessment in Fuchs' endothelial dystrophy that maximizes the sample area and uses the clearest endothelial cells in confocal images.

Last Updated: 27 Feb 2014

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Polymorphism of the transferrin gene in eye diseases: keratoconus and Fuchs endothelial corneal dystrophy.
 

Author(s): Katarzyna A Wójcik, Ewelina Synowiec, Manuel P Jiménez-García, Anna Kaminska, Piotr Polakowski, Janusz Blasiak, Jerzy Szaflik, Jacek P Szaflik

Journal: Biomed Res Int. 2013 ;2013():247438.

 

Oxidative stress may play a role in the pathogenesis of keratoconus (KC) and Fuchs endothelial corneal dystrophy (FECD). Iron may promote the stress by the Fenton reaction, so its homeostasis should be strictly controlled. Transferrin is essential for iron homeostasis because it transports ...

Last Updated: 18 Dec 2013

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Genetic screen of African Americans with Fuchs endothelial corneal dystrophy.
 

Author(s): Mollie A Minear, Yi-Ju Li, Jacqueline Rimmler, Elmer Balajonda, Shera Watson, R Rand Allingham, Michael A Hauser, Gordon K Klintworth, Natalie A Afshari, Simon G Gregory

Journal:

 

Fuchs endothelial corneal dystrophy (FECD) is a genetically heterogeneous disorder that has been primarily studied in patients of European or Asian ancestry. Given the sparse literature on African Americans with FECD, we sought to characterize the genetic variation in three known ...

Last Updated: 18 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Corneal Dystrophy" returned 3 free, full-text review articles on human participants. First 3 results:

Oxidative stress in the pathogenesis of keratoconus and Fuchs endothelial corneal dystrophy.
 

Author(s): Katarzyna A Wojcik, Anna Kaminska, Janusz Blasiak, Jerzy Szaflik, Jacek P Szaflik

Journal:

 

Due to its localization and function, the cornea is regularly exposed to sunlight and atmospheric oxygen, mainly dioxygen, which produce reactive oxygen species (ROS). Therefore, corneal cells are particularly susceptible to oxidative stress. The accumulation of ROS in the cornea ...

Last Updated: 25 Sep 2013

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Fuchs endothelial corneal dystrophy.
 

Author(s): Hussain Elhalis, Behrooz Azizi, Ula V Jurkunas

Journal: Ocul Surf. 2010 Oct;8(4):173-84.

 

Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive loss of corneal endothelial cells, thickening of Descement's membrane and deposition of extracellular matrix in the form of guttae. When the number of endothelial cells becomes critically low, the cornea swells ...

Last Updated: 22 Oct 2010

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Macular corneal dystrophy. Studies of sulfated glycosaminoglycans in corneal explant and confluent stromal cell cultures.
 

Author(s): G K Klintworth, C F Smith

Journal: Am. J. Pathol.. 1977 Oct;89(1):167-82.

 

The inherited disorder macular corneal dystrophy (MCD), a localized corneal mucopolysaccharidosis, is currently thought to result from an inability to catabolize corneal keratan sulfate (keratan sulfate 1). As studies on isolated cells have provided insight into metabolic abnormalities ...

Last Updated: 30 Nov 1977

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Studies in Families With Corneal Dystrophy or Other Inherited Corneal Diseases
 

Status: Recruiting

Condition Summary: Corneal Dystrophies, Hereditary; Corneal Disease

 

Last Updated: 20 Aug 2014

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DSAEK- Postoperative Positioning and Transplant Dislocation
 

Status: Recruiting

Condition Summary: Corneal Transplantation; Descemet Stripping Automated Endothelial Keratoplasty; Fuchs' Endothelial Dystrophy; Corneal Dystrophies, Hereditary

 

Last Updated: 20 Sep 2010

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Descemet Membrane Endothelial Keratoplasty (DMEK)
 

Status: Recruiting

Condition Summary: Corneal Dystrophies, Hereditary

 

Last Updated: 30 Oct 2012

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