Corneal Dystrophy

Common Name(s)

Corneal Dystrophy

Corneal dystrophy is a condition in which the cornea, the clear covering of the eye, becomes less clear because of a buildup of cloudy material. There are over 20 kinds of corneal dystrophy, but they all share certain traits. Corneal dystrophies are usually inherited, affect both eyes equally, are not caused by injury, get gradually worse with time, and are not related to any other kind of disease. Symptoms can range from no vision impairment to severe vision impairment. Some forms of corneal dystrophy can also cause pain. The early stages of corneal dystrophy can be treated with special eyedrops, but once there is severe vision impairment, surgery and corneal transplant may be necessary.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corneal Dystrophy" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corneal Dystrophy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Corneal Dystrophy" returned 265 free, full-text research articles on human participants. First 3 results:

Association of ZEB1 and TCF4 rs613872 changes with late onset Fuchs endothelial corneal dystrophy in patients from northern India.
 

Author(s): Ranjan Gupta, Babu Lal Kumawat, Preeti Paliwal, Radhika Tandon, Namrata Sharma, Seema Sen, Seema Kashyap, Tapas Chandra Nag, Rasik B Vajpayee, Arundhati Sharma

Journal:

 

Fuchs endothelial corneal dystrophy (FECD) results in loss of vision associated with progressive corneal edema and loss of corneal transparency. The aim of the study was to evaluate changes in ZEB1, COL8A2, SLC4A11, and TCF4 rs613872 and correlate them with clinical findings.

Last Updated: 1 Dec 2015

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Molecular analysis of the CHST6 gene in Korean patients with macular corneal dystrophy: Identification of three novel mutations.
 

Author(s): Shin Hae Park, Ye Jin Ahn, Hyojin Chae, Yonggoo Kim, Man Soo Kim, Myungshin Kim

Journal:

 

To identify the underlying genetic defect in Korean patients with macular corneal dystrophy (MCD).

Last Updated: 25 Nov 2015

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Histone methylation levels correlate with TGFBIp and extracellular matrix gene expression in normal and granular corneal dystrophy type 2 corneal fibroblasts.
 

Author(s): Yong-Sun Maeng, Ga-Hyun Lee, Seung-Il Choi, Kyu Seo Kim, Eung Kweon Kim

Journal:

 

TGFβ1-induced expression of transforming growth factor β-induced protein (TGFBIp) and extracellular matrix (ECM) genes plays a major role in the development of granular corneal dystrophy type 2 (GCD2: also called Avellino corneal dystrophy). Although some key transcription factors ...

Last Updated: 10 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Corneal Dystrophy" returned 5 free, full-text review articles on human participants. First 3 results:

Transcript profile of cellular senescence-related genes in Fuchs endothelial corneal dystrophy.
 

Author(s): Mario Matthaei, Angela Y Zhu, Laura Kallay, Charles G Eberhart, Claus Cursiefen, Albert S Jun

Journal: Exp. Eye Res.. 2014 Dec;129():13-7.

 

Fuchs endothelial corneal dystrophy (FECD) is a genetically heterogeneous disease. Hypothesizing that cellular senescence may be relevant in FECD pathogenesis, genetically undifferentiated late-onset FECD endothelial samples were analyzed to identify common changes of specific senescence-related ...

Last Updated: 8 Dec 2014

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Oxidative stress in the pathogenesis of keratoconus and Fuchs endothelial corneal dystrophy.
 

Author(s): Katarzyna A Wojcik, Anna Kaminska, Janusz Blasiak, Jerzy Szaflik, Jacek P Szaflik

Journal:

 

Due to its localization and function, the cornea is regularly exposed to sunlight and atmospheric oxygen, mainly dioxygen, which produce reactive oxygen species (ROS). Therefore, corneal cells are particularly susceptible to oxidative stress. The accumulation of ROS in the cornea ...

Last Updated: 25 Sep 2013

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Fuchs endothelial corneal dystrophy.
 

Author(s): Hussain Elhalis, Behrooz Azizi, Ula V Jurkunas

Journal: Ocul Surf. 2010 Oct;8(4):173-84.

 

Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive loss of corneal endothelial cells, thickening of Descement's membrane and deposition of extracellular matrix in the form of guttae. When the number of endothelial cells becomes critically low, the cornea swells ...

Last Updated: 22 Oct 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Studies in Families With Corneal Dystrophy or Other Inherited Corneal Diseases
 

Status: Recruiting

Condition Summary: Corneal Dystrophies, Hereditary; Corneal Disease

 

Last Updated: 11 May 2016

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Corneal Transplantation Guided by OCT RESCAN
 

Status: Not yet recruiting

Condition Summary: Cornea; Keratoconus; Bullous Keratopathy; Corneal Dystrophy

 

Last Updated: 8 Apr 2016

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DSAEK- Postoperative Positioning and Transplant Dislocation
 

Status: Recruiting

Condition Summary: Corneal Transplantation; Descemet Stripping Automated Endothelial Keratoplasty; Fuchs' Endothelial Dystrophy; Corneal Dystrophies, Hereditary

 

Last Updated: 20 Sep 2010

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