Corneal Dystrophy

Common Name(s)

Corneal Dystrophy

Corneal dystrophy is a condition in which the cornea, the clear covering of the eye, becomes less clear because of a buildup of cloudy material. There are over 20 kinds of corneal dystrophy, but they all share certain traits. Corneal dystrophies are usually inherited, affect both eyes equally, are not caused by injury, get gradually worse with time, and are not related to any other kind of disease. Symptoms can range from no vision impairment to severe vision impairment. Some forms of corneal dystrophy can also cause pain. The early stages of corneal dystrophy can be treated with special eyedrops, but once there is severe vision impairment, surgery and corneal transplant may be necessary.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corneal Dystrophy" for support, advocacy or research.

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Corneal Dystrophy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Corneal Dystrophy" returned 235 free, full-text research articles on human participants. First 3 results:

RNA toxicity and missplicing in the common eye disease fuchs endothelial corneal dystrophy.
 

Author(s): Jintang Du, Ross A Aleff, Elisabetta Soragni, Krishna Kalari, Jinfu Nie, Xiaojia Tang, Jaime Davila, Jean-Pierre Kocher, Sanjay V Patel, Joel M Gottesfeld, Keith H Baratz, Eric D Wieben

Journal: J. Biol. Chem.. 2015 Mar;290(10):5979-90.

 

Fuchs endothelial corneal dystrophy (FECD) is an inherited degenerative disease that affects the internal endothelial cell monolayer of the cornea and can result in corneal edema and vision loss in severe cases. FECD affects ∼5% of middle-aged Caucasians in the United States and ...

Last Updated: 9 Mar 2015

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Association of common variants in TCF4 and PTPRG with Fuchs' corneal dystrophy: a systematic review and meta-analysis.
 

Author(s): Lawrence C M Lau, Li Ma, Alvin L Young, Shi Song Rong, Vishal Jhanji, Marten E Brelen, Chi Pui Pang, Li Jia Chen

Journal:

 

A meta-analysis of TCF4 and PTPRG gene variants in Fuchs' corneal dystrophy (FCD).

Last Updated: 10 Oct 2014

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Transethnic replication of association of CTG18.1 repeat expansion of TCF4 gene with Fuchs' corneal dystrophy in Chinese implies common causal variant.
 

Author(s): Chao Xing, Xin Gong, Imran Hussain, Chiea-Chuen Khor, Donald T H Tan, Tin Aung, Jodhbir S Mehta, Eranga N Vithana, V Vinod Mootha

Journal:

 

To test the association between the CTG18.1 trinucleotide repeat expansion of TCF4 gene and Fuchs' endothelial corneal dystrophy (FECD) in a Chinese population.

Last Updated: 8 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Corneal Dystrophy" returned 3 free, full-text review articles on human participants. First 3 results:

Oxidative stress in the pathogenesis of keratoconus and Fuchs endothelial corneal dystrophy.
 

Author(s): Katarzyna A Wojcik, Anna Kaminska, Janusz Blasiak, Jerzy Szaflik, Jacek P Szaflik

Journal:

 

Due to its localization and function, the cornea is regularly exposed to sunlight and atmospheric oxygen, mainly dioxygen, which produce reactive oxygen species (ROS). Therefore, corneal cells are particularly susceptible to oxidative stress. The accumulation of ROS in the cornea ...

Last Updated: 25 Sep 2013

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Fuchs endothelial corneal dystrophy.
 

Author(s): Hussain Elhalis, Behrooz Azizi, Ula V Jurkunas

Journal: Ocul Surf. 2010 Oct;8(4):173-84.

 

Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive loss of corneal endothelial cells, thickening of Descement's membrane and deposition of extracellular matrix in the form of guttae. When the number of endothelial cells becomes critically low, the cornea swells ...

Last Updated: 22 Oct 2010

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Macular corneal dystrophy. Studies of sulfated glycosaminoglycans in corneal explant and confluent stromal cell cultures.
 

Author(s): G K Klintworth, C F Smith

Journal: Am. J. Pathol.. 1977 Oct;89(1):167-82.

 

The inherited disorder macular corneal dystrophy (MCD), a localized corneal mucopolysaccharidosis, is currently thought to result from an inability to catabolize corneal keratan sulfate (keratan sulfate 1). As studies on isolated cells have provided insight into metabolic abnormalities ...

Last Updated: 30 Nov 1977

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Studies in Families With Corneal Dystrophy or Other Inherited Corneal Diseases
 

Status: Recruiting

Condition Summary: Corneal Dystrophies, Hereditary; Corneal Disease

 

Last Updated: 11 Nov 2014

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DSAEK- Postoperative Positioning and Transplant Dislocation
 

Status: Recruiting

Condition Summary: Corneal Transplantation; Descemet Stripping Automated Endothelial Keratoplasty; Fuchs' Endothelial Dystrophy; Corneal Dystrophies, Hereditary

 

Last Updated: 20 Sep 2010

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Descemet Membrane Endothelial Keratoplasty (DMEK)
 

Status: Recruiting

Condition Summary: Corneal Dystrophies, Hereditary

 

Last Updated: 2 Jun 2015

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