Connective Tissue Disorders

Common Name(s)

Connective Tissue Disorders

Connective tissue is the "cellular glue" inside your body that supports many of its various parts in order to give tissues their shape and keep them strong. Two examples of connective tissue are fat and cartilage. There are more than 200 known connective tissue disorders. Each conncetive tissue disorder may affect different parts of the body such as joints, muscles, and skin. Organs such as the eyes, heart, lungs, or kidneys may also be affected. Some of these disorders may result from an infection, such as cellulits. Scarring is considered a connective tissue disorder and is most commonly caused by injuries or surgery. Other connective tissue disorders result from a mutation or error in a person’s DNA or genes and may run be inherited or run in families. Some examples of genetic connective tissue disorders are osteogenesis imperfecta, Marfan syndrome, Ehlers-Danlos syndrom and pseudoxanthoma elasticum (PXE) . And for others such as scleroderma, the cause is unknown. Treatment options for connective tissue disorders vary due to different parts of the body being affected. Talk with you doctor about developing the best care plan if you or a family member has been diagnosed with a connective tissue disorder.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Connective Tissue Disorders" for support, advocacy or research.

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Connective Tissue Disorders" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Connective Tissue Disorders" returned 38 free, full-text research articles on human participants. First 3 results:

Heritable disorders of connective tissue: introduction to mini-review cluster.
 

Author(s): Jouni Uitto

Journal: Matrix Biol.. 2014 Jan;33():8-9.

 

Last Updated: 24 Feb 2014

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Mutations in B3GALT6, which encodes a glycosaminoglycan linker region enzyme, cause a spectrum of skeletal and connective tissue disorders.
 

Author(s): Masahiro Nakajima, Shuji Mizumoto, Noriko Miyake, Ryo Kogawa, Aritoshi Iida, Hironori Ito, Hiroshi Kitoh, Aya Hirayama, Hiroshi Mitsubuchi, Osamu Miyazaki, Rika Kosaki, Reiko Horikawa, Angeline Lai, Roberto Mendoza-Londono, Lucie Dupuis, David Chitayat, Andrew Howard, Gabriela F Leal, Denise Cavalcanti, Yoshinori Tsurusaki, Hirotomo Saitsu, Shigehiko Watanabe, Ekkehart Lausch, Sheila Unger, Luisa Bonafé, Hirofumi Ohashi, Andrea Superti-Furga, Naomichi Matsumoto, Kazuyuki Sugahara, Gen Nishimura, Shiro Ikegawa

Journal: Am. J. Hum. Genet.. 2013 Jun;92(6):927-34.

 

Proteoglycans (PGs) are a major component of the extracellular matrix in many tissues and function as structural and regulatory molecules. PGs are composed of core proteins and glycosaminoglycan (GAG) side chains. The biosynthesis of GAGs starts with the linker region that consists ...

Last Updated: 19 Nov 2013

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High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders.
 

Author(s): J Pablo Abonia, Ting Wen, Emily M Stucke, Tommie Grotjan, Molly S Griffith, Katherine A Kemme, Margaret H Collins, Philip E Putnam, James P Franciosi, Karl F von Tiehl, Brad T Tinkle, Keith A Marsolo, Lisa J Martin, Stephanie M Ware, Marc E Rothenberg

Journal: J. Allergy Clin. Immunol.. 2013 Aug;132(2):378-86.

 

Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease mediated by immune hypersensitization to multiple foods and strongly associated with atopy and esophageal remodeling.

Last Updated: 2 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Connective Tissue Disorders" returned 12 free, full-text review articles on human participants. First 3 results:

Connective tissue disorders and cardiovascular complications: the indomitable role of transforming growth factor-beta signaling.
 

Author(s): Jason B Wheeler, John S Ikonomidis, Jeffrey A Jones

Journal: Adv. Exp. Med. Biol.. 2014 ;802():107-27.

 

Marfan Syndrome (MFS) and Loeys-Dietz Syndrome (LDS) represent heritable connective tissue disorders that cosegregate with a similar pattern of cardiovascular defects (thoracic aortic aneurysm, mitral valve prolapse/regurgitation, and aortic root dilatation with regurgitation). This ...

Last Updated: 20 Jan 2014

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Next generation diagnostics of heritable connective tissue disorders.
 

Author(s): Amr Salam, Michael A Simpson, Kristina L Stone, Takuya Takeichi, Arti Nanda, Masashi Akiyama, John A McGrath

Journal: Matrix Biol.. 2014 Jan;33():35-40.

 

Finding pathogenic mutations in monogenic diseases represents one of the significant milestones of late 20th century molecular genetics. Mutation data can improve genetic counseling, assist disease modeling and provide a basis for translational research and therapeutics. The logistics ...

Last Updated: 24 Feb 2014

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Ectopic mineralization disorders of the extracellular matrix of connective tissue: molecular genetics and pathomechanisms of aberrant calcification.
 

Author(s): Qiaoli Li, Qiujie Jiang, Jouni Uitto

Journal: Matrix Biol.. 2014 Jan;33():23-8.

 

Ectopic mineralization of connective tissues is a complex process leading to deposition of calcium phosphate complexes in the extracellular matrix, particularly affecting the skin and the arterial blood vessels and common in age-associated disorders. A number of initiating and contributing ...

Last Updated: 24 Feb 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation and Treatment of Patients With Connective Tissue Disease
 

Status: Recruiting

Condition Summary: Connective Tissue Disorders

 

Last Updated: 3 Mar 2015

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Testing Effectiveness of Losartan in Patients With EoE With or Without a CTD
 

Status: Recruiting

Condition Summary: Eosinophilic Esophagitis; Connective Tissue Disorders

 

Last Updated: 5 Jan 2015

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Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD
 

Status: Recruiting

Condition Summary: Interstitial Lung Disease; Scleroderma; Idiopathic Inflammatory Myositis; Mixed Connective Tissue Disease

 

Last Updated: 6 May 2015

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