Connective Tissue Disorders

Common Name(s)

Connective Tissue Disorders

Connective tissue is the "cellular glue" inside your body that supports many of its various parts in order to give tissues their shape and keep them strong. Two examples of connective tissue are fat and cartilage. There are more than 200 known connective tissue disorders. Each conncetive tissue disorder may affect different parts of the body such as joints, muscles, and skin. Organs such as the eyes, heart, lungs, or kidneys may also be affected. Some of these disorders may result from an infection, such as cellulits. Scarring is considered a connective tissue disorder and is most commonly caused by injuries or surgery. Other connective tissue disorders result from a mutation or error in a person’s DNA or genes and may run be inherited or run in families. Some examples of genetic connective tissue disorders are osteogenesis imperfecta, Marfan syndrome, Ehlers-Danlos syndrom and pseudoxanthoma elasticum (PXE) . And for others such as scleroderma, the cause is unknown. Treatment options for connective tissue disorders vary due to different parts of the body being affected. Talk with you doctor about developing the best care plan if you or a family member has been diagnosed with a connective tissue disorder.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Connective Tissue Disorders" for support, advocacy or research.

EDSers United

Mission is to develop the Treatment and Research Center for Rare Genetic Conditions. This center will specialize in Ehlers-Danlos Syndrome and will adopt other rare diseases as it grows and advances throughout the years. EDSers United was initially launched in 2010 to generate global awareness and to provide overall support to those affected by Ehlers-Danlos Syndrome. We have always focused on steps to one day be a part of finding a cure for all the types of EDS that currently exist. We are a team of EDSers, Caregivers & Health Care Providers dedicated to establishing a center of excellence.

Last Updated: 25 Feb 2016

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Connective Tissue Disorders" for support, advocacy or research.

EDSers United

Mission is to develop the Treatment and Research Center for Rare Genetic Conditions. This center will specialize in Ehlers-Danlos Syndrome and will adopt other rare diseases as it grows and advances throughout the years. EDSers United was initially launched in 2010 to generate global awareness and to provide overall support to those affected by Ehlers-Danlos Syndrome. We have always focused on steps to one day be a part of finding a cure for all the types of EDS that currently exist. We are a team of EDSers, Caregivers & Health Care Providers dedicated to establishing a center of excellence.

https://www.edsers.org

Last Updated: 25 Feb 2016

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Connective Tissue Disorders" returned 44 free, full-text research articles on human participants. First 3 results:

Effects of rituximab in connective tissue disorders related interstitial lung disease.
 

Author(s): Gemma Lepri, Jerome Avouac, Paolo Airò, Francisco Anguita Santos, Silvia Bellando-Randone, Jelena Blagojevic, Francisco Garcia Hernàndez, Jose Antonio Gonzalez Nieto, Serena Guiducci, Suzana Jordan, Vidya Limaye, Britta Maurer, Albert Selva-O'Callaghan, Valeria Riccieri, Oliver Distler, Marco Matucci-Cerinic, Yannick Allanore

Journal: Clin. Exp. Rheumatol.. ;34 Suppl 100(5):181-185.

 

Interstitial lung disease (ILD) is a key prognostic factor in connective tissue disorders (CTDs). The aim of our study was to assess the changes in pulmonary functional tests (PFTs) in various CTDs, including anti-synthetase syndrome (SYN), systemic sclerosis (SSc) and mixed connective ...

Last Updated: 17 Oct 2016

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Response to Letters Regarding Article "Segmental Aortic Stiffness in Children and Young Adults With Connective Tissue Disorders: Relationships With Age, Aortic Size, Rate of Dilation, and Surgical Root Replacement".
 

Author(s): Ashwin Prakash, Himanshu Adlakha, Nicole Rabideau, Cara J Hass, Shaine A Morris, Tal Geva, Kimberlee Gauvreau, Michael N Singh, Ronald V Lacro

Journal: Circulation. 2016 Feb;133(7):e405.

 

Last Updated: 17 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Connective Tissue Disorders" returned 12 free, full-text review articles on human participants. First 3 results:

Esophageal disorders in mixed connective tissue diseases.
 

Author(s): A E Nica, L M Alexa, A O Ionescu, O Andronic, D N Păduraru

Journal: J Med Life. ;9(2):141-3.

 

Extra Musculoskeletal manifestations are a distinct clinical entity that refers to a combination of clinical features, which are found in multiple rheumatic diseases. Besides the standard manifestations, other organs can be damaged such as the vascular system, skin, gastrointestinal ...

Last Updated: 25 Jul 2016

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Connective tissue disorders and cardiovascular complications: the indomitable role of transforming growth factor-beta signaling.
 

Author(s): Jason B Wheeler, John S Ikonomidis, Jeffrey A Jones

Journal: Adv. Exp. Med. Biol.. 2014 ;802():107-27.

 

Marfan Syndrome (MFS) and Loeys-Dietz Syndrome (LDS) represent heritable connective tissue disorders that cosegregate with a similar pattern of cardiovascular defects (thoracic aortic aneurysm, mitral valve prolapse/regurgitation, and aortic root dilatation with regurgitation). This ...

Last Updated: 20 Jan 2014

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Next generation diagnostics of heritable connective tissue disorders.
 

Author(s): Amr Salam, Michael A Simpson, Kristina L Stone, Takuya Takeichi, Arti Nanda, Masashi Akiyama, John A McGrath

Journal: Matrix Biol.. 2014 Jan;33():35-40.

 

Finding pathogenic mutations in monogenic diseases represents one of the significant milestones of late 20th century molecular genetics. Mutation data can improve genetic counseling, assist disease modeling and provide a basis for translational research and therapeutics. The logistics ...

Last Updated: 24 Feb 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Evaluation and Treatment of Patients With Connective Tissue Disease
 

Status: Recruiting

Condition Summary: Connective Tissue Disorders

 

Last Updated: 20 Apr 2017

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Undifferentiated Connective Tissue Disease Registry
 

Status: Recruiting

Condition Summary: Undifferentiated Connective Tissue Disease

 

Last Updated: 13 Mar 2017

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Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CATALYST
 

Status: Recruiting

Condition Summary: Connective Tissue Disease-Associated Pulmonary Arterial Hypertension

 

Last Updated: 15 May 2017

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