Acute lymphoblastic leukemia

Common Name(s)

Acute lymphoblastic leukemia, Acute lymphocytic leukemia

Acute lymphoblastic leukemia (ALL) is a quickly progressing (acute) cancer of the white blood cells. These white blood cells, also called lymphocytes, are produced in the bone marrow (inner part of the bones) and are part of our body’s immune system which fights infections. The bone marrow also makes red blood cells (which carry oxygen to all the cells of our body) and platelets (which help our blood clot). ALL occurs when cancerous, immature white blood cells are overproduced in the bone marrow, which limits the production of other blood cells, such as red blood cells and platelets. ALL is most common among children ages 2 through 5 and the elderly. The symptoms that result are fever, shortness of breath, coughing, chest pain, vomiting, increased bleeding, bleeding from the gums, and an increased risk of infections like pneumonia.

Diagnosis of ALL includes examining family history, a physical exam, blood counts, and a blood smear. A bone marrow biopsy may also be used to make a concrete diagnosis. Treatments have improved over the years, and about 80% of children diagnosed with ALL are cured. However, the prognosis for older individuals suffering from ALL are less positive. There are many treatment options such as chemotherapy, radiation therapy, biological therapy, and immunotherapy. These may be used alone or in combination with each other. While treatment and survival has improved, early detection is key. It is important to talk to your doctor as soon as possible if you think you or your child may have ALL.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute lymphoblastic leukemia" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute lymphoblastic leukemia" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute lymphoblastic leukemia" returned 2419 free, full-text research articles on human participants. First 3 results:

Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition.
 

Author(s): Julie Irving, Elizabeth Matheson, Lynne Minto, Helen Blair, Marian Case, Christina Halsey, Isabella Swidenbank, Frida Ponthan, Renate Kirschner-Schwabe, Stefanie Groeneveld-Krentz, Jana Hof, James Allan, Christine Harrison, Josef Vormoor, Arend von Stackelberg, Cornelia Eckert

Journal: Blood. 2014 Nov;124(23):3420-30.

 

For most children who relapse with acute lymphoblastic leukemia (ALL), the prognosis is poor, and there is a need for novel therapies to improve outcome. We screened samples from children with B-lineage ALL entered into the ALL-REZ BFM 2002 clinical trial (www.clinicaltrials.gov, ...

Last Updated: 28 Nov 2014

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[Increased B-lymphocyte prognitor cells in a boy with acute lymphoblastic leukemia after chemotherapy].
 

Author(s): Qi-Dong Ye, Xiang Wang, Yan Miao, Ci Pan, Jing-Yan Tang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 Sep;16(9):955-6.

 

Last Updated: 18 Sep 2014

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Piperlongumine inhibits the proliferation and survival of B-cell acute lymphoblastic leukemia cell lines irrespective of glucocorticoid resistance.
 

Author(s): Seong-Su Han, Sangwoo Han, Natalie L Kamberos

Journal: Biochem. Biophys. Res. Commun.. 2014 Sep;452(3):669-75.

 

Piperlongumine (PL), a pepper plant alkaloid from Piper longum, has anti-inflammatory and anti-cancer properties. PL selectively kills both solid and hematologic cancer cells, but not normal counterparts. Here we evaluated the effect of PL on the proliferation and survival of B-cell ...

Last Updated: 29 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute lymphoblastic leukemia" returned 147 free, full-text review articles on human participants. First 3 results:

Development of asparaginase Erwinia chrysanthemi for the treatment of acute lymphoblastic leukemia.
 

Author(s): Wanda L Salzer, Barbara L Asselin, Paul V Plourde, Tim Corn, Stephen P Hunger

Journal: Ann. N. Y. Acad. Sci.. 2014 Nov;1329():81-92.

 

Since it was identified in 1963 as the antileukemic agent in guinea pig serum, L-asparaginase (ASNase) has become an integral component of chemotherapy protocols to treat patients with acute lymphoblastic leukemia (ALL). Escherichia coli and Erwinia chrysanthemi provide the sources ...

Last Updated: 17 Nov 2014

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The biology of relapsed acute lymphoblastic leukemia: opportunities for therapeutic interventions.
 

Author(s): Teena Bhatla, Courtney L Jones, Julia A Meyer, Nicholas A Vitanza, Elizabeth A Raetz, William L Carroll

Journal: J. Pediatr. Hematol. Oncol.. 2014 Aug;36(6):413-8.

 

Although great strides have been made in the improvement of outcome for newly diagnosed pediatric acute lymphoblastic leukemia because of refinements in risk stratification and selective intensification of therapy, the prognosis for relapsed leukemia has lagged behind significantly. ...

Last Updated: 23 Jul 2014

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Mercaptopurine/Methotrexate maintenance therapy of childhood acute lymphoblastic leukemia: clinical facts and fiction.
 

Author(s): Kjeld Schmiegelow, Stine N Nielsen, Thomas L Frandsen, Jacob Nersting

Journal: J. Pediatr. Hematol. Oncol.. 2014 Oct;36(7):503-17.

 

The antileukemic mechanisms of 6-mercaptopurine (6MP) and methotrexate (MTX) maintenance therapy are poorly understood, but the benefits of several years of myelosuppressive maintenance therapy for acute lymphoblastic leukemia are well proven. Currently, there is no international ...

Last Updated: 24 Sep 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults
 

Status: Recruiting

Condition Summary: Acute Lymphoblastic Leukemia; Lymphoblastic Lymphoma; B-cell Adult Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia

 

Last Updated: 15 Dec 2014

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Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: B-cell Adult Acute Lymphoblastic Leukemia; B-cell Childhood Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Childhood Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia

 

Last Updated: 9 Sep 2014

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Risk-Adapted Chemotherapy in Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: B-cell Childhood Acute Lymphoblastic Leukemia; Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia

 

Last Updated: 17 Feb 2014

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