Acute lymphoblastic leukemia

Common Name(s)

Acute lymphoblastic leukemia, Acute lymphocytic leukemia

Acute lymphoblastic leukemia (ALL) is a quickly progressing (acute) cancer of the white blood cells. These white blood cells, also called lymphocytes, are produced in the bone marrow (inner part of the bones) and are part of our body’s immune system which fights infections. The bone marrow also makes red blood cells (which carry oxygen to all the cells of our body) and platelets (which help our blood clot). ALL occurs when cancerous, immature white blood cells are overproduced in the bone marrow, which limits the production of other blood cells, such as red blood cells and platelets. ALL is most common among children ages 2 through 5 and the elderly. The symptoms that result are fever, shortness of breath, coughing, chest pain, vomiting, increased bleeding, bleeding from the gums, and an increased risk of infections like pneumonia.

Diagnosis of ALL includes examining family history, a physical exam, blood counts, and a blood smear. A bone marrow biopsy may also be used to make a concrete diagnosis. Treatments have improved over the years, and about 80% of children diagnosed with ALL are cured. However, the prognosis for older individuals suffering from ALL are less positive. There are many treatment options such as chemotherapy, radiation therapy, biological therapy, and immunotherapy. These may be used alone or in combination with each other. While treatment and survival has improved, early detection is key. It is important to talk to your doctor as soon as possible if you think you or your child may have ALL.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute lymphoblastic leukemia" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute lymphoblastic leukemia" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute lymphoblastic leukemia" returned 2374 free, full-text research articles on human participants. First 3 results:

[Correlations between 6-mercaptopurine treatment-related adverse reactions in children with acute lymphoblastic leukemia and polymorphisms of thiopurine methyltransferase gene].
 

Author(s): Cai Xie, Li-Jie Yue, Hui Ding, Yan-Fei Ren, Chun-Lan Yang, Miao-Miao Zheng

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 May;16(5):499-503.

 

To explore 6-mercaptopurine (6-MP) treatment-related adverse reactions in children with acute lymphoblastic leukemia (ALL), and to assess the association between the polymorphisms of thiopurine methyltransferase (TPMT) gene and these 6-MP related toxicities.

Last Updated: 26 May 2014

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[A comparison of minimal residual disease in children with acute lymphoblastic leukemia of different genetic abnormalities].
 

Author(s): Shan-Ya-Mei Huang, Yue-Ping Jia, Gui-Lan Liu, Le-Ping Zhang, Ai-Dong Lu, Bin Wang

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2014 May;16(5):494-8.

 

To study the changes of minimal residual disease (MRD) in children with B cell acute lymphoblastic leukemia (B-ALL) of different genetic abnormalities.

Last Updated: 26 May 2014

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Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia.
 

Author(s): Behzad Kharabi Masouleh, Huimin Geng, Christian Hurtz, Lai N Chan, Aaron C Logan, Mi Sook Chang, Chuanxin Huang, Srividya Swaminathan, Haibo Sun, Elisabeth Paietta, Ari M Melnick, Phillip Koeffler, Markus Müschen

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 May;111(21):E2219-28.

 

The unfolded protein response (UPR) pathway, a stress-induced signaling cascade emanating from the endoplasmic reticulum (ER), regulates the expression and activity of molecules including BiP (HSPA5), IRE1 (ERN1), Blimp-1 (PRDM1), and X-box binding protein 1 (XBP1). These molecules ...

Last Updated: 10 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute lymphoblastic leukemia" returned 143 free, full-text review articles on human participants. First 3 results:

Mercaptopurine/Methotrexate maintenance therapy of childhood acute lymphoblastic leukemia: clinical facts and fiction.
 

Author(s): Kjeld Schmiegelow, Stine N Nielsen, Thomas L Frandsen, Jacob Nersting

Journal: J. Pediatr. Hematol. Oncol.. 2014 Oct;36(7):503-17.

 

The antileukemic mechanisms of 6-mercaptopurine (6MP) and methotrexate (MTX) maintenance therapy are poorly understood, but the benefits of several years of myelosuppressive maintenance therapy for acute lymphoblastic leukemia are well proven. Currently, there is no international ...

Last Updated: 24 Sep 2014

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Oral manifestations resulting from chemotherapy in children with acute lymphoblastic leukemia.
 

Author(s): Everton Freitas de Morais, Jadson Alexandre da Silva Lira, Rômulo Augusto de Paiva Macedo, Klaus Steyllon dos Santos, Cassandra Teixeira Valle Elias, Maria de Lourdes Silva de Arruda Morais

Journal: Braz J Otorhinolaryngol. ;80(1):78-85.

 

Acute lymphocytic leukemia is a type of cancer most common in children and it is characterized by excessive and disordered immature leukocytes in the bone marrow.

Last Updated: 14 Mar 2014

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Genomic characterization of childhood acute lymphoblastic leukemia.
 

Author(s): Charles G Mullighan

Journal: Semin. Hematol.. 2013 Oct;50(4):314-24.

 

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and a leading case of childhood cancer death. The last decade has witnessed a transformation in our understanding of the genetic basis of ALL due to detailed integrative genomic profiling of large cohorts of ...

Last Updated: 19 Nov 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults
 

Status: Not yet recruiting

Condition Summary: Acute Lymphoblastic Leukemia; Lymphoblastic Lymphoma; B-cell Adult Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia

 

Last Updated: 27 Aug 2014

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Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: B-cell Adult Acute Lymphoblastic Leukemia; B-cell Childhood Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Childhood Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia

 

Last Updated: 9 Sep 2014

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Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: Childhood Acute Lymphoblastic Leukemia; Philadelphia Chromosome, Ph^1^, Absent; B-cell Childhood Acute Lymphoblastic Leukemia

 

Last Updated: 20 Nov 2013

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