Acute lymphoblastic leukemia

Common Name(s)

Acute lymphoblastic leukemia, Acute lymphocytic leukemia

Acute lymphoblastic leukemia (ALL) is a quickly progressing (acute) cancer of the white blood cells. These white blood cells, also called lymphocytes, are produced in the bone marrow (inner part of the bones) and are part of our body’s immune system which fights infections. The bone marrow also makes red blood cells (which carry oxygen to all the cells of our body) and platelets (which help our blood clot). ALL occurs when cancerous, immature white blood cells are overproduced in the bone marrow, which limits the production of other blood cells, such as red blood cells and platelets. ALL is most common among children ages 2 through 5 and the elderly. The symptoms that result are fever, shortness of breath, coughing, chest pain, vomiting, increased bleeding, bleeding from the gums, and an increased risk of infections like pneumonia.

Diagnosis of ALL includes examining family history, a physical exam, blood counts, and a blood smear. A bone marrow biopsy may also be used to make a concrete diagnosis. Treatments have improved over the years, and about 80% of children diagnosed with ALL are cured. However, the prognosis for older individuals suffering from ALL are less positive. There are many treatment options such as chemotherapy, radiation therapy, biological therapy, and immunotherapy. These may be used alone or in combination with each other. While treatment and survival has improved, early detection is key. It is important to talk to your doctor as soon as possible if you think you or your child may have ALL.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute lymphoblastic leukemia" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute lymphoblastic leukemia" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute lymphoblastic leukemia" returned 3083 free, full-text research articles on human participants. First 3 results:

[Brain injury after induction chemotherapy in children with acute lymphoblastic leukemia].
 

Author(s): Dong-Fang Zou, Hong-Wu Zeng, Jie Yu, Hui-Rong Mai, Xiu-Li Yuan, Li-Hong Wang, Jian-Xiang Liao, Fei-Qiu Wen

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2016 Mar;18(3):254-8.

 

To investigate the changes in brain injury after the induction chemotherapy in children with acute lymphoblastic leukemia (ALL) by cranial MRI.

Last Updated: 15 Mar 2016

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Genome-Wide DNA Copy Number Analysis of Acute Lymphoblastic Leukemia Identifies New Genetic Markers Associated with Clinical Outcome.
 

Author(s): Maribel Forero-Castro, Cristina Robledo, Rocío Benito, María Abáigar, Ana África Martín, Maryam Arefi, José Luis Fuster, Natalia de Las Heras, Juan N Rodríguez, Jonathan Quintero, Susana Riesco, Lourdes Hermosín, Ignacio de la Fuente, Isabel Recio, Jordi Ribera, Jorge Labrador, José M Alonso, Carmen Olivier, Magdalena Sierra, Marta Megido, Luis A Corchete-Sánchez, Juana Ciudad Pizarro, Juan Luis García, José M Ribera, Jesús M Hernández-Rivas

Journal:

 

Identifying additional genetic alterations associated with poor prognosis in acute lymphoblastic leukemia (ALL) is still a challenge.

Last Updated: 13 Feb 2016

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[Detection of copy number variations in pediatric ETV6/RUNX1-positive acute lymphoblastic leukemia with multiplex ligation-dependent probe amplification].
 

Author(s): Li Zhang, Xiao-Ming Liu, Ye Guo, Wen-Yu Yang, Jia-Yuan Zhang, Fang Liu, Tian-Feng Liu, Shu-Chun Wang, Xiao-Juan Chen, Min Ruan, Ben-Quan Qi, Li-Xian Chang, Yao Zou, Yu-Mei Chen, Xiao-Fan Zhu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2016 Jan;18(1):34-8.

 

To investigate the application of multiplex ligation-dependent probe amplification (MLPA) in the detection of copy number variations (CNVs) in pediatric ETV6/RUNX1-positive acute lymphoblastic leukemia (ALL), to compare this method with conventional karyotype analysis and fluorescence ...

Last Updated: 19 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute lymphoblastic leukemia" returned 179 free, full-text review articles on human participants. First 3 results:

Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia.
 

Author(s): Alejandra Sanjuan-Pla, Clara Bueno, Cristina Prieto, Pamela Acha, Ronald W Stam, Rolf Marschalek, Pablo Menéndez

Journal: Blood. 2015 Dec;126(25):2676-85.

 

Infant B-cell acute lymphoblastic leukemia (B-ALL) accounts for 10% of childhood ALL. The genetic hallmark of most infant B-ALL is chromosomal rearrangements of the mixed-lineage leukemia (MLL) gene. Despite improvement in the clinical management and survival (∼85-90%) of childhood ...

Last Updated: 18 Dec 2015

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Monoclonal antibodies in acute lymphoblastic leukemia.
 

Author(s): Elias Jabbour, Susan O'Brien, Farhad Ravandi, Hagop Kantarjian

Journal: Blood. 2015 Jun;125(26):4010-6.

 

With modern intensive combination polychemotherapy, the complete response (CR) rate in adults with acute lymphoblastic leukemia (ALL) is 80% to 90%, and the cure rate is 40% to 50%. Hence, there is a need to develop effective salvage therapies and combine novel agents with standard ...

Last Updated: 26 Jun 2015

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CD19-targeted chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia.
 

Author(s): Shannon L Maude, David T Teachey, David L Porter, Stephan A Grupp

Journal: Blood. 2015 Jun;125(26):4017-23.

 

Relapsed and refractory acute lymphoblastic leukemia (ALL) remains difficult to treat, with minimal improvement in outcomes seen in more than 2 decades despite advances in upfront therapy and improved survival for de novo ALL. Adoptive transfer of T cells engineered to express a chimeric ...

Last Updated: 26 Jun 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults
 

Status: Recruiting

Condition Summary: Acute Lymphoblastic Leukemia; Lymphoblastic Lymphoma; B-cell Adult Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia

 

Last Updated: 6 Apr 2016

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Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
 

Status: Recruiting

Condition Summary: Adult B Acute Lymphoblastic Leukemia; Adult T Acute Lymphoblastic Leukemia; Childhood B Acute Lymphoblastic Leukemia; Childhood T Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia

 

Last Updated: 7 Apr 2016

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Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin Hydrochloride With Asparaginase in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma
 

Status: Not yet recruiting

Condition Summary: B Acute Lymphoblastic Leukemia; B Lymphoblastic Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent B Lymphoblastic Lymphoma; Recurrent T Lymphoblastic Leukemia/Lymphoma; Refractory B Lymphoblastic Lymphoma; Refractory T Lymphoblastic Lymphoma; T Acute Lymphoblastic Leukemia; T Lymphoblastic Lymphoma

 

Last Updated: 26 Apr 2016

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