Acute lymphoblastic leukemia

Common Name(s)

Acute lymphoblastic leukemia, Acute lymphocytic leukemia

Acute lymphoblastic leukemia (ALL) is a quickly progressing (acute) cancer of the white blood cells. These white blood cells, also called lymphocytes, are produced in the bone marrow (inner part of the bones) and are part of our body’s immune system which fights infections. The bone marrow also makes red blood cells (which carry oxygen to all the cells of our body) and platelets (which help our blood clot). ALL occurs when cancerous, immature white blood cells are overproduced in the bone marrow, which limits the production of other blood cells, such as red blood cells and platelets. ALL is most common among children ages 2 through 5 and the elderly. The symptoms that result are fever, shortness of breath, coughing, chest pain, vomiting, increased bleeding, bleeding from the gums, and an increased risk of infections like pneumonia.

Diagnosis of ALL includes examining family history, a physical exam, blood counts, and a blood smear. A bone marrow biopsy may also be used to make a concrete diagnosis. Treatments have improved over the years, and about 80% of children diagnosed with ALL are cured. However, the prognosis for older individuals suffering from ALL are less positive. There are many treatment options such as chemotherapy, radiation therapy, biological therapy, and immunotherapy. These may be used alone or in combination with each other. While treatment and survival has improved, early detection is key. It is important to talk to your doctor as soon as possible if you think you or your child may have ALL.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute lymphoblastic leukemia" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acute lymphoblastic leukemia" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acute lymphoblastic leukemia" returned 3091 free, full-text research articles on human participants. First 3 results:

Rituximab in B-Lineage Adult Acute Lymphoblastic Leukemia.
 

Author(s): Sébastien Maury, Sylvie Chevret, Xavier Thomas, Dominik Heim, Thibaut Leguay, Françoise Huguet, Patrice Chevallier, Mathilde Hunault, Nicolas Boissel, Martine Escoffre-Barbe, Urs Hess, Norbert Vey, Jean-Michel Pignon, Thorsten Braun, Jean-Pierre Marolleau, Jean-Yves Cahn, Yves Chalandon, Véronique Lhéritier, Kheira Beldjord, Marie C Béné, Norbert Ifrah, Hervé Dombret,

Journal: N. Engl. J. Med.. 2016 Sep;375(11):1044-53.

 

Treatment with rituximab has improved the outcome for patients with non-Hodgkin's lymphoma. Patients with B-lineage acute lymphoblastic leukemia (ALL) may also have the CD20 antigen, which is targeted by rituximab. Although single-group studies suggest that adding rituximab to chemotherapy ...

Last Updated: 15 Sep 2016

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Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia.
 

Author(s): Hagop M Kantarjian, Daniel J DeAngelo, Matthias Stelljes, Giovanni Martinelli, Michaela Liedtke, Wendy Stock, Nicola Gökbuget, Susan O'Brien, Kongming Wang, Tao Wang, M Luisa Paccagnella, Barbara Sleight, Erik Vandendries, Anjali S Advani

Journal: N. Engl. J. Med.. 2016 Aug;375(8):740-53.

 

The prognosis for adults with relapsed acute lymphoblastic leukemia is poor. We sought to determine whether inotuzumab ozogamicin, an anti-CD22 antibody conjugated to calicheamicin, results in better outcomes in patients with relapsed or refractory acute lymphoblastic leukemia than ...

Last Updated: 25 Aug 2016

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Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemia Jurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways.
 

Author(s): Tingfang Yang, Shuluan Yao, Xianfeng Zhang, Yan Guo

Journal:

 

T-cell acute lymphoblastic leukemia (T-ALL) as a prevalent hematologic malignancy is one of the most common malignant tumors worldwide in children. Andrographolide (Andro), the major active component from Andrographis paniculata, has been shown to possess antitumor activities in several ...

Last Updated: 26 Apr 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acute lymphoblastic leukemia" returned 203 free, full-text review articles on human participants. First 3 results:

Advances in the Genetics and Therapy of Acute Lymphoblastic Leukemia.
 

Author(s): Sabina Chiaretti, Valentina Gianfelici, Susan M O'Brien, Charles G Mullighan

Journal: Am Soc Clin Oncol Educ Book. 2016 ;35():e314-22.

 

Acute lymphoblastic leukemia (ALL) remains an important cause of morbidity in children and adults. In this article, we highlight advances in the genetics and therapy of three key subtypes of ALL: T-cell ALL, BCR-ABL1 (Philadelphia [Ph] chromosone-positive), and Ph-like ALL. T-ALL ...

Last Updated: 2 Jun 2016

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Minimal Residual Disease Evaluation in Childhood Acute Lymphoblastic Leukemia: An Economic Analysis.
 

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Minimal residual disease (MRD) testing by higher performance techniques such as flow cytometry and polymerase chain reaction (PCR) can be used to detect the proportion of remaining leukemic cells in bone marrow or peripheral blood during and after the first phases of chemotherapy ...

Last Updated: 21 Apr 2016

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Minimal Residual Disease Evaluation in Childhood Acute Lymphoblastic Leukemia: A Clinical Evidence Review.
 

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Leukemia accounts for nearly a third of childhood cancers in Canada, with acute lymphoblastic leukemia (ALL) comprising nearly 80% of cases. Identification of prognostic factors that allow risk stratification and tailored treatment have improved overall survival. However, nearly a ...

Last Updated: 21 Apr 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

D-ALBA Frontline Sequential Dasatinib and Blinatumomab in Adult Philadelphia Positive Acute Lymphoblastic Leukemia
 

Status: Not yet recruiting

Condition Summary: Acute Lymphoblastic Leukemia

 

Last Updated: 21 Nov 2016

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Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents
 

Status: Not yet recruiting

Condition Summary: Acute Lymphoblastic Leukemia, Pediatric

 

Last Updated: 11 Jan 2017

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Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia
 

Status: Recruiting

Condition Summary: Acute Lymphoblastic Leukaemia

 

Last Updated: 15 Feb 2016

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