Congenital Heart Defects

Common Name(s)

Congenital Heart Defects, Congenital Heart Disease

Congenital Heart Disease (or Congenital Heart Defects) is one of the most common abnormalities found in newborn babies. Congenital Heart Disease, or CHD, is a problem with the structure of the heart that is present at birth and may present in a wide range - from very mild to critically life threatening in the first days of life. The defects generally cause disruptions in the normal blood flow or rhythm of the heart. Defects can be associated with the chambers or valves of the heart or the arteries or veins near the heart. Critical Congenital Heart Disease (CCHD) defines more severe forms of CHD that can lead to death soon after the baby is born. CCHD happens when a baby’s heart does not develop normally before birth. Although it is rare, affecting only 2-3 of every 10,000 babies born, CCHD can quickly lead to serious illness and even death in the first few days of life. Some babies with CCHD are discovered early in pregnancy by prenatal ultrasound, but many babies with CCHD are diagnosed after they are born. Unfortunately, many of these babies can appear perfectly normal until they become critically ill.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Congenital Heart Defects" for support, advocacy or research.

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Congenital Heart Information Network

C.H.I.N. is a national organization that provides reliable information, advocacy, support services, financial assistance and resources to families of children with congenital heart defects and acquired heart disease, and adults with congenital heart defects.

Last Updated: 6 Apr 2015

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Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

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Mended Hearts, Inc.

Our mission is dedicated to “Inspiring hope and improving the quality of life for heart patients and their families through ongoing peer-to-peer support”.

Last Updated: 11 Mar 2013

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Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

Last Updated: 15 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Congenital Heart Defects" for support, advocacy or research.

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Congenital Heart Information Network

C.H.I.N. is a national organization that provides reliable information, advocacy, support services, financial assistance and resources to families of children with congenital heart defects and acquired heart disease, and adults with congenital heart defects.

http://tchin.org

Last Updated: 6 Apr 2015

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Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

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Mended Hearts, Inc.

Our mission is dedicated to “Inspiring hope and improving the quality of life for heart patients and their families through ongoing peer-to-peer support”.

http://www.mendedhearts.org

Last Updated: 11 Mar 2013

View Details
Saving Little Hearts

Saving Little Hearts is dedicated to helping children with congenital heart defects and their families by providing emotional assistance and educational information primarily through the distribution of Care Packages.

http://www.savinglittlehearts.com

Last Updated: 15 Mar 2013

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General Support Organizations

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General Resources

 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Congenital Heart Defects" returned 236 free, full-text research articles on human participants. First 3 results:

Birth prevalence of congenital heart defects in Norway 1994-2009--a nationwide study.
 

Author(s): Elisabeth Leirgul, Tatiana Fomina, Kristoffer Brodwall, Gottfried Greve, Henrik Holmstrøm, Stein Emil Vollset, Grethe S Tell, Nina Øyen

Journal: Am. Heart J.. 2014 Dec;168(6):956-64.

 

The reasons for decreasing birth prevalence of congenital heart defects (CHDs) in several European countries and Canada are not fully understood. We present CHD prevalence among live births, stillbirths, and terminated pregnancies in an entire nation over a period of 16 years.

Last Updated: 3 Dec 2014

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Maternal socioeconomic status and the risk of congenital heart defects in offspring: a meta-analysis of 33 studies.
 

Author(s): Di Yu, Yu Feng, Lei Yang, Min Da, Changfeng Fan, Song Wang, Xuming Mo

Journal:

 

We conducted this meta-analysis to address the open question of a possible association between maternal socioeconomic status and congenital heart defects (CHDs).

Last Updated: 28 Oct 2014

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Maternal parity and the risk of congenital heart defects in offspring: a dose-response meta-analysis of epidemiological observational studies.
 

Author(s): Yu Feng, Di Yu, Tao Chen, Jin Liu, Xing Tong, Lei Yang, Min Da, Shutong Shen, Changfeng Fan, Song Wang, Xuming Mo

Journal:

 

Epidemiological studies have reported conflicting results regarding maternal parity and the risk of congenital heart defects (CHDs). However, a meta-analysis of the association between maternal parity and CHDs in offspring has not been conducted.

Last Updated: 9 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Congenital Heart Defects" returned 33 free, full-text review articles on human participants. First 3 results:

Folate deficiency and folic acid supplementation: the prevention of neural-tube defects and congenital heart defects.
 

Author(s): Andrew E Czeizel, Istvan Dudás, Attila Vereczkey, Ferenc Bánhidy

Journal:

 

Diet, particularly vitamin deficiency, is associated with the risk of birth defects. The aim of this review paper is to show the characteristics of common and severe neural-tube defects together with congenital heart defects (CHD) as vitamin deficiencies play a role in their origin. ...

Last Updated: 28 Nov 2013

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Physical activity in adolescents and adults with congenital heart defects: individualized exercise prescription.
 

Author(s): Werner Budts, Mats Börjesson, Massimo Chessa, Frank van Buuren, Pedro Trigo Trindade, Domenico Corrado, Hein Heidbuchel, Gary Webb, Johan Holm, Michael Papadakis

Journal: Eur. Heart J.. 2013 Dec;34(47):3669-74.

 

Last Updated: 16 Dec 2013

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Congenital heart defects and extracardiac malformations.
 

Author(s): Rosana Cardoso M Rosa, Rafael Fabiano M Rosa, Paulo Ricardo G Zen, Giorgio Adriano Paskulin

Journal: Rev Paul Pediatr. 2013 Jun;31(2):243-51.

 

To review the association between congenital heart defects and extracardiac malformations.

Last Updated: 5 Jul 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Molecular Basis of Congenital Heart Defects
 

Status: Recruiting

Condition Summary: Congenital Heart Defects

 

Last Updated: 5 Nov 2010

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Molecular Genetics of Heterotaxy and Related Congenital Heart Defects
 

Status: Recruiting

Condition Summary: Heterotaxy Syndrome; Congenital Heart Defects

 

Last Updated: 30 Apr 2015

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Interval Training in Adults With Congenital Heart Disease a Randomized Trial
 

Status: Recruiting

Condition Summary: Congenital Heart Defects

 

Last Updated: 2 May 2013

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