Congenital Heart Block

Common Name(s)

Congenital Heart Block

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Congenital Heart Block" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Congenital Heart Block" returned 114 free, full-text research articles on human participants. First 3 results:

Exome Sequencing Identifies Compound Heterozygous Mutations in SCN5A Associated with Congenital Complete Heart Block in the Thai Population.
 

Author(s): Chuphong Thongnak, Pornprot Limprasert, Duangkamol Tangviriyapaiboon, Suchaya Silvilairat, Apichaya Puangpetch, Ekawat Pasomsub, Chonlaphat Sukasem, Wasun Chantratita

Journal: Dis. Markers. 2016 ;2016():3684965.

 

Background. Congenital heart block is characterized by blockage of electrical impulses from the atrioventricular node (AV node) to the ventricles. This blockage can be caused by ion channel impairment that is the result of genetic variation. This study aimed to investigate the possible ...

Last Updated: 26 Dec 2016

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Isolated congenital complete heart block in a five-year-old seronegative girl born to a woman seropositive for human immunodeficiency virus: a case report.
 

Author(s): Pedro Pallangyo, Isaac Mawenya, Paulina Nicholaus, Henry Mayala, Amida Kalombola, Godwin Sharau, Naiz Majani, Mohamed Janabi

Journal:

 

Congenital complete heart block is a life-threatening condition which is highly associated with autoimmune and connective tissue disorders. Presence of maternal autoantibodies for associated conditions increases the risk of delivering a child with congenital complete heart block, ...

Last Updated: 19 Oct 2016

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Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation.
 

Author(s): Rajib Chowdhury, Hassan Ashraf, Michelle Melanson, Yohei Tanada, Minh Nguyen, Michael Silberbach, Hiroko Wakimoto, D Woodrow Benson, Robert H Anderson, Hideko Kasahara

Journal: Circ Arrhythm Electrophysiol. 2015 Oct;8(5):1255-64.

 

Heterozygous human NKX2-5 homeodomain (DNA-binding domain) missense mutations are highly penetrant for varied congenital heart defects, including progressive atrioventricular (AV) block requiring pacemaker implantation. We recently replicated this genetic defect in a murine knockin ...

Last Updated: 21 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Congenital Heart Block" returned 10 free, full-text review articles on human participants. First 3 results:

Prevention and treatment in utero of autoimmune-associated congenital heart block.
 

Author(s): Amit Saxena, Peter M Izmirly, Barbara Mendez, Jill P Buyon, Deborah M Friedman

Journal: Cardiol Rev. ;22(6):263-7.

 

Transplacental transfer of maternal anti-Ro and/or anti-La autoantibodies can result in fetal cardiac disease, including congenital heart block and cardiomyopathy, called cardiac neonatal lupus (NL). Thousands of women are faced with the risk of cardiac NL in their offspring, which ...

Last Updated: 7 Oct 2014

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Neonatal congenital heart block.
 

Author(s): Ayse Yildirim, F Sedef Tunaoolu, Aysu Turkmen Karaaoac

Journal: Indian Pediatr. 2013 May;50(5):483-8.

 

Congenital Heart Block (CHB) is the most serious complication of neonatal lupus erythematosus. Transplasental transfer of maternal anti SSA/Ro or antiSSB/La antibodies around 12th week of gestation is associated with development of CHB. This may lead to inflammation, fibrosis and ...

Last Updated: 19 Jun 2013

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Congenital heart block: evidence for a pathogenic role of maternal autoantibodies.
 

Author(s): Aurélie Ambrosi, Marie Wahren-Herlenius

Journal:

 

During pregnancy in autoimmune conditions, maternal autoantibodies are transported across the placenta and may affect the developing fetus. Congenital heart block (CHB) is known to associate with the presence of anti-Ro/SSA and anti-La/SSB antibodies in the mother and is characterized ...

Last Updated: 18 Sep 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Preventive Approach to Congenital Heart Block With Hydroxychloroquine
 

Status: Recruiting

Condition Summary: Congenital Heart Block; Neonatal Lupus; Autoantibody-Associated Heart Block

 

Last Updated: 21 Sep 2016

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Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms
 

Status: Recruiting

Condition Summary: Congenital Complete Heart Block; Cardiac Conduction Defect Progressive

 

Last Updated: 24 Aug 2016

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The Research Registry for Neonatal Lupus
 

Status: Recruiting

Condition Summary: Neonatal Lupus; Systemic Lupus Erythematosus; Sjogren's Syndrome; Congenital Heart Block

 

Last Updated: 17 Oct 2016

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