Congenital Heart Block

Common Name(s)

Congenital Heart Block

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Congenital Heart Block" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Congenital Heart Block" returned 118 free, full-text research articles on human participants. First 3 results:

Reactivity to the p305 Epitope of the α1G T-Type Calcium Channel and Autoimmune-Associated Congenital Heart Block.
 

Author(s): Androo J Markham, Sara E Rasmussen, Jane E Salmon, Wilnelly Martinez-Ortiz, Timothy J Cardozo, Robert M Clancy, Jill P Buyon

Journal:

 

Only 2% of mothers positive for anti-SSA/Ro (Ro) antibodies have children with congenital heart block (CHB). This study aimed to determine whether reactivity with p305, an epitope within the α1G T-type calcium channel, confers added risk over anti-Ro antibodies.

Last Updated: 21 May 2015

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Towards computational modelling of the human foetal electrocardiogram: normal sinus rhythm and congenital heart block.
 

Author(s): Eleftheria Pervolaraki, Sam Hodgson, Arun V Holden, Alan P Benson

Journal: Europace. 2014 May;16(5):758-65.

 

We aim to engineer a computational model of propagation during normal sinus rhythm in the foetal human heart, by modifying models for adult cardiac tissue to match foetal electrocardiogram (fECG) characteristics. The model will be partially validated by fECG data, and applied to explore ...

Last Updated: 6 May 2014

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Prenatal anti-Ro antibody exposure, congenital complete atrioventricular heart block, and high-dose steroid therapy: impact on neurocognitive outcome in school-age children.
 

Author(s): E N Kelly, R Sananes, C Chiu-Man, E D Silverman, E Jaeggi

Journal: Arthritis Rheumatol. 2014 Aug;66(8):2290-6.

 

To determine the impact of prenatal exposure to maternal anti-Ro antibodies, slow fetal heart rate, and/or prolonged dexamethasone therapy for immune-mediated congenital atrioventricular heart block (CAVB) on the cognitive and academic performance of these children at school age.

Last Updated: 29 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Congenital Heart Block" returned 11 free, full-text review articles on human participants. First 3 results:

Prevention and treatment in utero of autoimmune-associated congenital heart block.
 

Author(s): Amit Saxena, Peter M Izmirly, Barbara Mendez, Jill P Buyon, Deborah M Friedman

Journal: Cardiol Rev. ;22(6):263-7.

 

Transplacental transfer of maternal anti-Ro and/or anti-La autoantibodies can result in fetal cardiac disease, including congenital heart block and cardiomyopathy, called cardiac neonatal lupus (NL). Thousands of women are faced with the risk of cardiac NL in their offspring, which ...

Last Updated: 7 Oct 2014

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Neonatal congenital heart block.
 

Author(s): Ayse Yildirim, F Sedef Tunaoolu, Aysu Turkmen Karaaoac

Journal: Indian Pediatr. 2013 May;50(5):483-8.

 

Congenital Heart Block (CHB) is the most serious complication of neonatal lupus erythematosus. Transplasental transfer of maternal anti SSA/Ro or antiSSB/La antibodies around 12th week of gestation is associated with development of CHB. This may lead to inflammation, fibrosis and ...

Last Updated: 19 Jun 2013

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Congenital heart block: evidence for a pathogenic role of maternal autoantibodies.
 

Author(s): Aurélie Ambrosi, Marie Wahren-Herlenius

Journal:

 

During pregnancy in autoimmune conditions, maternal autoantibodies are transported across the placenta and may affect the developing fetus. Congenital heart block (CHB) is known to associate with the presence of anti-Ro/SSA and anti-La/SSB antibodies in the mother and is characterized ...

Last Updated: 18 Sep 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Preventive Approach to Congenital Heart Block With Hydroxychloroquine
 

Status: Recruiting

Condition Summary: Congenital Heart Block; Neonatal Lupus; Autoantibody-Associated Heart Block

 

Last Updated: 10 Mar 2016

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The Research Registry for Neonatal Lupus
 

Status: Recruiting

Condition Summary: Neonatal Lupus; Systemic Lupus Erythematosus; Sjogren's Syndrome; Congenital Heart Block

 

Last Updated: 12 Apr 2016

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Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms
 

Status: Recruiting

Condition Summary: Congenital Complete Heart Block; Cardiac Conduction Defect Progressive

 

Last Updated: 24 Aug 2016

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