Congenital Heart Block

Common Name(s)

Congenital Heart Block

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Congenital Heart Block" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Congenital Heart Block" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Congenital Heart Block" returned 88 free, full-text research articles on human participants. First 3 results:

Congenital heart block maternal sera autoantibodies target an extracellular epitope on the α1G T-type calcium channel in human fetal hearts.
 

Author(s): Linn S Strandberg, Xuezhi Cui, Arianna Rath, Jie Liu, Earl D Silverman, Xiaoru Liu, Vinayakumar Siragam, Cameron Ackerley, Brenda Bin Su, Jane Yuqing Yan, Marco Capecchi, Luca Biavati, Alice Accorroni, William Yuen, Filippo Quattrone, Kalvin Lung, Edgar T Jaeggi, Peter H Backx, Charles M Deber, Robert M Hamilton

Journal:

 

Congenital heart block (CHB) is a transplacentally acquired autoimmune disease associated with anti-Ro/SSA and anti-La/SSB maternal autoantibodies and is characterized primarily by atrioventricular (AV) block of the fetal heart. This study aims to investigate whether the T-type calcium ...

Last Updated: 16 Sep 2013

Go To URL
A novel role of endothelin-1 in linking Toll-like receptor 7-mediated inflammation to fibrosis in congenital heart block.
 

Author(s): David Alvarez, Paraskevi Briassouli, Robert M Clancy, Jiri Zavadil, Joanne H Reed, Rosanna G Abellar, Marc Halushka, Karen Fox-Talbot, Franck J Barrat, Jill P Buyon

Journal: J. Biol. Chem.. 2011 Sep;286(35):30444-54.

 

Autoimmune associated congenital heart block (CHB) may result from pathogenic cross-talk between inflammatory and profibrosing pathways. Incubation of macrophages with immune complexes (IC) composed of Ro60, a target of the pathologic maternal autoantibodies necessary for CHB, hY3 ...

Last Updated: 29 Aug 2011

Go To URL
Association of the idiotype:antiidiotype antibody ratio with the efficacy of intravenous immunoglobulin treatment for the prevention of recurrent autoimmune-associated congenital heart block.
 

Author(s): John G Routsias, Nikolaos C Kyriakidis, Deborah M Friedman, Carolina Llanos, Robert Clancy, Haralampos M Moutsopoulos, Jill Buyon, Athanasios G Tzioufas

Journal: Arthritis Rheum.. 2011 Sep;63(9):2783-9.

 

Congenital heart block (CHB), a manifestation of neonatal lupus, is associated with maternal anti-Ro/SSA and anti-La/SSB autoantibodies and recurs in ∼18% of subsequent pregnancies. This study was undertaken to investigate the effect of the idiotype:antiidiotype (Id:anti-Id) antibody ...

Last Updated: 7 Sep 2011

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Congenital Heart Block" returned 8 free, full-text review articles on human participants. First 3 results:

Neonatal congenital heart block.
 

Author(s): Ayse Yildirim, F Sedef Tunaoolu, Aysu Turkmen Karaaoac

Journal: Indian Pediatr. 2013 May;50(5):483-8.

 

Congenital Heart Block (CHB) is the most serious complication of neonatal lupus erythematosus. Transplasental transfer of maternal anti SSA/Ro or antiSSB/La antibodies around 12th week of gestation is associated with development of CHB. This may lead to inflammation, fibrosis and ...

Last Updated: 19 Jun 2013

Go To URL
Congenital heart block: evidence for a pathogenic role of maternal autoantibodies.
 

Author(s): Aurélie Ambrosi, Marie Wahren-Herlenius

Journal:

 

During pregnancy in autoimmune conditions, maternal autoantibodies are transported across the placenta and may affect the developing fetus. Congenital heart block (CHB) is known to associate with the presence of anti-Ro/SSA and anti-La/SSB antibodies in the mother and is characterized ...

Last Updated: 18 Sep 2012

Go To URL
Cardiac manifestations of neonatal lupus: a review of autoantibody-associated congenital heart block and its impact in an adult population.
 

Author(s): Christine Capone, Jill P Buyon, Deborah M Friedman, William H Frishman

Journal: Cardiol Rev. ;20(2):72-6.

 

Within the last decade the prevalence of adult patients living with congenital heart disease equals that seen in children. This expanding population poses a challenge to clinical cardiologists who will be caring for patients with the clinical manifestations of this condition. Neonatal ...

Last Updated: 8 Feb 2012

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Preventive Approach to Congenital Heart Block With Hydroxychloroquine
 

Status: Recruiting

Condition Summary: Congenital Heart Block; Neonatal Lupus; Autoantibody-Associated Heart Block

 

Last Updated: 7 Jun 2013

Go to URL
The Research Registry for Neonatal Lupus
 

Status: Recruiting

Condition Summary: Neonatal Lupus; Systemic Lupus Erythematosus; Sjogren's Syndrome; Congenital Heart Block

 

Last Updated: 9 Apr 2013

Go to URL
Relationship Between Parameters of VOT Using NIRS and Clinical Outcomes in Pediatric Cardiac Surgery
 

Status: Recruiting

Condition Summary: Congenital Heart Disease

 

Last Updated: 10 Nov 2014

Go to URL