Congenital Diaphragmatic Hernia

Common Name(s)

Congenital Diaphragmatic Hernia

Congenital diaphragmatic hernia (CDH) refers to a group of congenital defects in the structural integrity of the diaphragm which are often associated with lethal pulmonary hypoplasia and pulmonary hypertension. Prevalence in newborns ranges from 1 in 2,500 to 1 in 4,000, and there is a 30 to 60% mortality rate ({22:Langham et al., 1996}; {14:Harrison et al., 1994}; {25:Nobuhara et al., 1996}). Most cases of congenital diaphragmatic hernia are sporadic. Genetic Heterogeneity of Diaphragmatic Hernia One form of congenital diaphragmatic hernia, DIH1, has been mapped to chromosome 15q26, and another, DIH2 ({222400}), to chromosome 8p23.1. See also DIH3 ({610187}), which is associated with mutation in the ZFPM2 gene ({603693}). There is evidence for further genetic heterogeneity. Also see {306950} for a possible X-linked form. Congenital diaphragmatic hernia can also present with other congenital anomalies. Fryns syndrome ({229850}) may be the most common autosomal recessive syndrome with DIH as a cardinal feature ({31:Slavotinek et al., 2005)}. See {15:Holder et al. (2007)} for a review of genetic factors in congenital diaphragmatic hernia. {28:Pober (2008)} reviewed genetic aspects of congenital diaphragmatic hernia, with emphasis on various syndromes in which CDH occurs along with other manifestations.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Congenital Diaphragmatic Hernia" for support, advocacy or research.

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Breath of Hope

Breath of Hope exists to raise awareness of congenital diaphragmatic hernia by working with parents, family members, and medical professionals to educate and support all who are affected by or want to learn more about CDH.

Last Updated: 15 Feb 2013

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Breath of Hope, Incorporated

Breath of Hope exists to raise awareness of congenital diaphragmatic hernia by working with parents, family members, and medical professionals to educate and support all who are affected by or want to learn more about CDH.

Last Updated: 19 Aug 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Congenital Diaphragmatic Hernia" for support, advocacy or research.

Logo
Breath of Hope

Breath of Hope exists to raise awareness of congenital diaphragmatic hernia by working with parents, family members, and medical professionals to educate and support all who are affected by or want to learn more about CDH.

http://www.breathofhopeinc.com

Last Updated: 15 Feb 2013

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Breath of Hope, Incorporated

Breath of Hope exists to raise awareness of congenital diaphragmatic hernia by working with parents, family members, and medical professionals to educate and support all who are affected by or want to learn more about CDH.

http://www.breathofhopeinc.com

Last Updated: 19 Aug 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Congenital Diaphragmatic Hernia" returned 252 free, full-text research articles on human participants. First 3 results:

Left congenital diaphragmatic hernia -- case report.
 

Author(s): L Topor, T Pătrăncuş, R Caragaţa, A Moga

Journal: Chirurgia (Bucur). ;110(1):84-7.

 

Congenital diaphragmatic hernia (CDH) occurs when the abdominal contents protrude into the thoracic cavity through an anatomical defect in the diaphragm. The incidence of CDH is 1 in 2500 births, with left congenital diaphragmatic hernias(LCDH) being more common than right-side hernias ...

Last Updated: 24 Mar 2015

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Persistence of pulmonary hypertension by echocardiography predicts short-term outcomes in congenital diaphragmatic hernia.
 

Author(s): Leslie A Lusk, Katherine C Wai, Anita J Moon-Grady, Martina A Steurer, Roberta L Keller

Journal: J. Pediatr.. 2015 Feb;166(2):251-6.e1.

 

To describe the natural history of pulmonary hypertension (PH) and the risk of death and pulmonary morbidity associated with the persistence of PH through the neonatal hospitalization for these infants.

Last Updated: 27 Jan 2015

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Possibilities and limits in the treatment of congenital diaphragmatic hernia.
 

Author(s): R Georgescu, L Chiuţu, R Nemeş, I Georgescu, A Stoica, E Georgescu

Journal: J Med Life. 2014 Sep;7(3):433-9.

 

to establish a therapeutic strategy that will improve the prognosis and increase the survival rate in congenital diaphragmatic hernia.

Last Updated: 21 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Congenital Diaphragmatic Hernia" returned 27 free, full-text review articles on human participants. First 3 results:

[Research advances in persistent pulmonary hypertension of the newborn secondary to congenital diaphragmatic hernia].
 

Author(s): Bin Xiao, Min Liu, Chang Xu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Sep;17(9):1013-9.

 

Persistent pulmonary hypertension of the newborn (PPHN) secondary to congenital diaphragmatic hernia (CDH) is one of the main reasons for high mortality of the newborn and a factor that leads to respiratory and circulatory failure in newborns with CDH. PPHN secondary to CDH is severe ...

Last Updated: 28 Sep 2015

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Prenatal diagnosis and array comparative genomic hybridization characterization of trisomy 21 in a fetus associated with right congenital diaphragmatic hernia and a review of the literature of chromosomal abnormalities associated with congenital diaphragmatic hernia.
 

Author(s): Chih-Ping Chen, Yeou-Lih Wang, Schu-Rern Chern, Yu-Peng Liu, Cheng-Ran Peng, Yu-Ling Kuo, Peih-Shan Wu, Wen-Lin Chen, Wayseen Wang

Journal: Taiwan J Obstet Gynecol. 2015 Feb;54(1):66-70.

 

Rapid genome-wide aneuploidy diagnosis using uncultured amniocytes and array comparative genomic hybridization (aCGH) is useful in pregnancy with abnormal ultrasound findings. The purpose of this report is to report a case of right congenital diaphragmatic hernia (CDH) associated ...

Last Updated: 14 Feb 2015

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Genetic causes of congenital diaphragmatic hernia.
 

Author(s): Julia Wynn, Lan Yu, Wendy K Chung

Journal: Semin Fetal Neonatal Med. 2014 Dec;19(6):324-30.

 

Congenital diaphragmatic hernia (CDH) is a moderately prevalent birth defect that, despite advances in neonatal care, is still a significant cause of infant death, and surviving patients have significant morbidity. The goal of ongoing research to elucidate the genetic causes of CDH ...

Last Updated: 8 Dec 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fetal Endotracheal Occlusion (FETO) in Severe and Extremely Severe Congenital Diaphragmatic Hernia
 

Status: Recruiting

Condition Summary: Congenital Diaphragmatic Hernia

 

Last Updated: 11 Jan 2016

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Early FETO for Severe Congenital Diaphragmatic Hernia
 

Status: Not yet recruiting

Condition Summary: Congenital Diaphragmatic Hernia

 

Last Updated: 16 Dec 2013

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Fetoscopic Endoluminal Tracheal Occlusion in Severe Left Congenital Diaphragmatic Hernia
 

Status: Recruiting

Condition Summary: Congenital Diaphragmatic Hernia; Pulmonary Hypoplasia

 

Last Updated: 11 Sep 2015

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