Common Variable Immunodeficiency

Common Name(s)

Common Variable Immunodeficiency

Common variable immunodeficiency (CVID) is a group of disorders in which the immune system cannot make antibodies in response to foreign substances that cause infection. The main feature that separates CVID from other immunodeficiencies is low levels of two specific antibodies, immunoglobulin A (IgA) and immunoglobulin G (IgG). People with CVID get more frequent infections, particularly in the sinuses, lungs, and digestive tract. Symptoms most commonly begin in early adulthood, but have been found in children as young as age two. While in most cases the cause of CVID is unknown, the condition has been associated with mutations in at least 10 genes. About 10% of affected people have mutations in the TNFRSF13B gene. The main treatment for CVID is Ig replacement therapy, which stops the cycle of recurrent infections.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Common Variable Immunodeficiency" for support, advocacy or research.

Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

Last Updated: 27 Aug 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Common Variable Immunodeficiency" for support, advocacy or research.

Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

http://www.primaryimmune.org

Last Updated: 27 Aug 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Common Variable Immunodeficiency" returned 355 free, full-text research articles on human participants. First 3 results:

Asthma and Allergic Diseases in a Selected Group of Patients With Common Variable Immunodeficiency.
 

Author(s): R Yazdani, A Heydari, G Azizi, H Abolhassani, A Aghamohammadi

Journal: J Investig Allergol Clin Immunol. 2016 ;26(3):209-11.

 

Last Updated: 22 Jun 2016

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Common Variable Immunodeficiency and Circulating TFH.
 

Author(s): Ana Coraglia, Nora Galassi, Diego S Fernández Romero, M Cecilia Juri, Marta Felippo, Alejandro Malbrán, María M E de Bracco

Journal: J Immunol Res. 2016 ;2016():4951587.

 

CD4+ T follicular helper cells (TFH) were assessed in adult patients with common variable immune deficiency (CVID) classified according to the presence of granulomatous disease (GD), autoimmunity (AI), or both GD and AI (Group I) or the absence of AI and GD (Group II). TFH lymphocytes ...

Last Updated: 12 Apr 2016

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IL-10-Producing Regulatory B Cells Are Decreased in Patients with Common Variable Immunodeficiency.
 

Author(s): Nathalia Silveira Barsotti, Rafael Ribeiro Almeida, Priscilla Ramos Costa, Myrthes Toledo Barros, Jorge Kalil, Cristina Maria Kokron

Journal:

 

Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency in adults. CVID patients often present changes in the frequency and function of B lymphocytes, reduced number of Treg cells, chronic immune activation, recurrent infections, high incidence ...

Last Updated: 19 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Common Variable Immunodeficiency" returned 25 free, full-text review articles on human participants. First 3 results:

T-Cell Abnormalities in Common Variable Immunodeficiency.
 

Author(s): G Azizi, N Rezaei, F Kiaee, N Tavakolinia, R Yazdani, A Mirshafiey, A Aghamohammadi

Journal: J Investig Allergol Clin Immunol. 2016 ;26(4):233-43.

 

Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-cell differentiation to plasma and memory B cells. Moreover, numerous T-cell abnormalities have been reported and include decreased T-cell count and proliferative ...

Last Updated: 1 Aug 2016

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International Consensus Document (ICON): Common Variable Immunodeficiency Disorders.
 

Author(s): Francisco A Bonilla, Isil Barlan, Helen Chapel, Beatriz T Costa-Carvalho, Charlotte Cunningham-Rundles, M Teresa de la Morena, Francisco J Espinosa-Rosales, Lennart Hammarström, Shigeaki Nonoyama, Isabella Quinti, John M Routes, Mimi L K Tang, Klaus Warnatz

Journal: J Allergy Clin Immunol Pract. ;4(1):38-59.

 

Last Updated: 16 Jan 2016

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Common Variable Immunodeficiency or Late-Onset Combined Immunodeficiency: A New Hypomorphic JAK3 Patient and Review of the Literature.
 

Author(s): H Abolhassani, T Cheraghi, N Rezaei, A Aghamohammadi, Hammarström L

Journal: J Investig Allergol Clin Immunol. 2015 ;25(3):218-20.

 

Last Updated: 17 Jul 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Improving the Diagnosis of Common Variable Immune Deficiency
 

Status: Not yet recruiting

Condition Summary: Common Variable Immune Deficiency (CVID)

 

Last Updated: 10 Feb 2016

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Last Updated: 3 Dec 2016

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