Common Variable Immunodeficiency

Common Name(s)

Common Variable Immunodeficiency

Common variable immunodeficiency (CVID) is a group of disorders in which the immune system cannot make antibodies in response to foreign substances that cause infection. The main feature that separates CVID from other immunodeficiencies is low levels of two specific antibodies, immunoglobulin A (IgA) and immunoglobulin G (IgG). People with CVID get more frequent infections, particularly in the sinuses, lungs, and digestive tract. Symptoms most commonly begin in early adulthood, but have been found in children as young as age two. While in most cases the cause of CVID is unknown, the condition has been associated with mutations in at least 10 genes. About 10% of affected people have mutations in the TNFRSF13B gene. The main treatment for CVID is Ig replacement therapy, which stops the cycle of recurrent infections.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Common Variable Immunodeficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Common Variable Immunodeficiency" returned 294 free, full-text research articles on human participants. First 3 results:

Modulation of adaptive immune response following intravenous immunoglobulin therapy in common variable immunodeficiency.
 

Author(s): Marzia Dolcino, Antonio Puccetti, Andrea Ottria, Alessandro Barbieri, Giuseppe Patuzzo, Claudio Lunardi

Journal: Isr. Med. Assoc. J.. 2014 Oct;16(10):648-50.

 

Last Updated: 2 Dec 2014

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Alteration in humoral immunity is common among family members of patients with common variable immunodeficiency.
 

Author(s): E Karakoc-Aydiner, A O Ozen, S Baris, H Ercan, C Ozdemir, I B Barlan

Journal: J Investig Allergol Clin Immunol. 2014 ;24(5):346-51.

 

The prevalence of primary immunodeficiency (PID) in the relatives of patients with common variable immunodeficiency (CVID) and IgA deficiency is high. Allergic disorders have been recorded in patients with humoral immunodeficiency. We aimed to determine the frequency of humoral immunodeficiency ...

Last Updated: 27 Oct 2014

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Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders.
 

Author(s): Matthieu Perreau, Selena Vigano, Florence Bellanger, CĂ©line Pellaton, Guillaume Buss, Denis Comte, Thierry Roger, Christine Lacabaratz, Pierre-Alexandre Bart, Yves Levy, Giuseppe Pantaleo

Journal: J. Exp. Med.. 2014 Sep;211(10):2033-45.

 

In the present study, we have investigated the functional profile of CD4 T cells from patients with common variable immunodeficiency (CVID), including production of cytokines and proliferation in response to bacteria and virus-derived antigens. We show that the functional impairment ...

Last Updated: 23 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Common Variable Immunodeficiency" returned 18 free, full-text review articles on human participants. First 3 results:

The many faces of common variable immunodeficiency.
 

Author(s): Charlotte Cunningham-Rundles

Journal: Hematology Am Soc Hematol Educ Program. 2012 ;2012():301-5.

 

Common variable immunodeficiency (CVID) is a rare immune deficiency characterized by low levels of serum IgG, IgA, and/or IgM, with a loss of Ab production. The diagnosis is most commonly made in adults between the ages of 20 and 40 years, but both children and much older adults can ...

Last Updated: 12 Dec 2012

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Chipping away at a mountain: genomic studies in common variable immunodeficiency.
 

Author(s): Michael D Keller, Soma Jyonouchi

Journal: Autoimmun Rev. 2013 Apr;12(6):687-9.

 

Common variable immunodeficiency (CVID) represents one of the most frequently diagnosed disorders of the immune system. Though several causative and associated genes have been identified, the origins of most cases remain unknown. Diagnostic delay is common due to the gradual evolution ...

Last Updated: 6 May 2013

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[Common variable immunodeficiency: an update on etiology, pathophysiology, and classification].
 

Author(s): Tomohiro Morio

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2012 ;35(1):14-22.

 

Common variable immunodeficiency is one of the most common primary immunodeficiency that is categorized into primary antibody deficiency. The responsible genes identified so far include ICOS, TACI, CD19, CD20, CD21, CD81 and BAFF-R; and most of the CVID-causing genes are yet to be ...

Last Updated: 29 Feb 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lymphocyte Immunophenotyping in Common Variable Immunodeficiency
 

Status: Recruiting

Condition Summary: Common Variable Immunodeficiency; Granulomatous Disease; Bronchiectasis; Immunoglobulin Treatment

 

Last Updated: 7 Sep 2010

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The Rifaximin Study in CVID
 

Status: Recruiting

Condition Summary: Common Variable Immunodeficiency (CVID)

 

Last Updated: 4 Nov 2014

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