Common Variable Immunodeficiency

Common Name(s)

Common Variable Immunodeficiency

Common variable immunodeficiency (CVID) is a group of disorders in which the immune system cannot make antibodies in response to foreign substances that cause infection. The main feature that separates CVID from other immunodeficiencies is low levels of two specific antibodies, immunoglobulin A (IgA) and immunoglobulin G (IgG). People with CVID get more frequent infections, particularly in the sinuses, lungs, and digestive tract. Symptoms most commonly begin in early adulthood, but have been found in children as young as age two. While in most cases the cause of CVID is unknown, the condition has been associated with mutations in at least 10 genes. About 10% of affected people have mutations in the TNFRSF13B gene. The main treatment for CVID is Ig replacement therapy, which stops the cycle of recurrent infections.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Common Variable Immunodeficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Common Variable Immunodeficiency" returned 296 free, full-text research articles on human participants. First 3 results:

Modulation of adaptive immune response following intravenous immunoglobulin therapy in common variable immunodeficiency.
 

Author(s): Marzia Dolcino, Antonio Puccetti, Andrea Ottria, Alessandro Barbieri, Giuseppe Patuzzo, Claudio Lunardi

Journal: Isr. Med. Assoc. J.. 2014 Oct;16(10):648-50.

 

Last Updated: 2 Dec 2014

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Alteration in humoral immunity is common among family members of patients with common variable immunodeficiency.
 

Author(s): E Karakoc-Aydiner, A O Ozen, S Baris, H Ercan, C Ozdemir, I B Barlan

Journal: J Investig Allergol Clin Immunol. 2014 ;24(5):346-51.

 

The prevalence of primary immunodeficiency (PID) in the relatives of patients with common variable immunodeficiency (CVID) and IgA deficiency is high. Allergic disorders have been recorded in patients with humoral immunodeficiency. We aimed to determine the frequency of humoral immunodeficiency ...

Last Updated: 27 Oct 2014

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Liver transplantation in patients with common variable immunodeficiency: a report of two cases.
 

Author(s): Roberto Montalti, Federico Mocchegiani, Paolo Vincenzi, Gianluca Svegliati Baroni, Daniele Nicolini, Marco Vivarelli

Journal:

 

Common variable immunodeficiency (CVID) is the most common primary immunodeficiency disease and is a heterogeneous group of antibody deficiency syndromes characterized by hypogammaglobulinemia, recurrent bacterial infections, and frequent autoimmune manifestations. Liver transplantation ...

Last Updated: 23 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Common Variable Immunodeficiency" returned 19 free, full-text review articles on human participants. First 3 results:

Lymphoproliferative disease and cancer among patients with common variable immunodeficiency.
 

Author(s): S Gangemi, A Allegra, C Musolino

Journal: Leuk. Res.. 2015 Apr;39(4):389-96.

 

Innate immune deficiencies are a heterogeneous group of genetically inherited diseases affecting the innate and adaptive immune systems that confer susceptibility to infection, autoimmunity, and cancer. This review discusses the latest insights into the links between common variable ...

Last Updated: 23 Mar 2015

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The many faces of common variable immunodeficiency.
 

Author(s): Charlotte Cunningham-Rundles

Journal: Hematology Am Soc Hematol Educ Program. 2012 ;2012():301-5.

 

Common variable immunodeficiency (CVID) is a rare immune deficiency characterized by low levels of serum IgG, IgA, and/or IgM, with a loss of Ab production. The diagnosis is most commonly made in adults between the ages of 20 and 40 years, but both children and much older adults can ...

Last Updated: 12 Dec 2012

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Chipping away at a mountain: genomic studies in common variable immunodeficiency.
 

Author(s): Michael D Keller, Soma Jyonouchi

Journal: Autoimmun Rev. 2013 Apr;12(6):687-9.

 

Common variable immunodeficiency (CVID) represents one of the most frequently diagnosed disorders of the immune system. Though several causative and associated genes have been identified, the origins of most cases remain unknown. Diagnostic delay is common due to the gradual evolution ...

Last Updated: 6 May 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lymphocyte Immunophenotyping in Common Variable Immunodeficiency
 

Status: Recruiting

Condition Summary: Common Variable Immunodeficiency; Granulomatous Disease; Bronchiectasis; Immunoglobulin Treatment

 

Last Updated: 7 Sep 2010

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Bioequivalence Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Gammaplex® 10 and Gammaplex® 5% in Primary Immunodeficiency Diseases
 

Status: Recruiting

Condition Summary: Primary Immune Deficiency Disorders; Common Variable Immunodeficiency; X-linked Agammaglobulinaemia; Hyper-IgM Syndrome

 

Last Updated: 26 Mar 2015

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