Common Variable Immunodeficiency

Common Name(s)

Common Variable Immunodeficiency

Common variable immunodeficiency is a group of disorders in which the immune system cannot make antibodies in response to foreign substances that may cause infection.  The main features that separate CVID from other immunodeficiencies are low levels of two specific antibodies, immunoglobulin A (IgA) and immunoglobulin G (IgG).  Individuals with this condition develop more frequent infections, particularly in the sinuses, lungs, and digestive tract.   CVID symptoms most commonly begin in early adulthood, but have been found in children as young as two years.  Though some cases of CVID are caused by known genetic factors, the cause of most cases is unknown.    CVID can sometimes be treated by "replacing" antibodies into the body; this treatment is called "immunoglobulin therapy". 
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Common Variable Immunodeficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Common Variable Immunodeficiency" returned 284 free, full-text research articles on human participants. First 3 results:

Chronic tubulo-interstitial nephritis in common variable immunodeficiency: a rare association.
 

Author(s): Sumantra Sarkar, Rakesh Mondal, Madhumita Nandi, Parasar Ghosh

Journal: Saudi J Kidney Dis Transpl. 2014 Mar;25(2):394-7.

 

Common variable immunodeficiency (CVID) is characterized by reduced serum immunoglobulin levels and repeated serious bacterial infections involving different organ systems. Chronic kidney disease (CKD) is an uncommon association with CVID. Chronic tubulo-interstitial nephritis in ...

Last Updated: 14 Mar 2014

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Celiac disease and common variable immunodeficiency: a familial inheritance?
 

Author(s): Raffaele Licinio, Mariabeatrice Principi, Annacinzia Amoruso, Domenico Piscitelli, Enzo Ierardi, Alfredo Di Leo

Journal: J Gastrointestin Liver Dis. 2013 Dec;22(4):473.

 

Last Updated: 26 Dec 2013

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Granulomatous-lymphocytic interstitial lung disease in a patient with common variable immunodeficiency.
 

Author(s): Keishi Sugino, Toshimasa Uekusa, Sakae Homma

Journal: Intern. Med.. 2013 ;52(23):2683-4.

 

Last Updated: 2 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Common Variable Immunodeficiency" returned 17 free, full-text review articles on human participants. First 3 results:

The many faces of common variable immunodeficiency.
 

Author(s): Charlotte Cunningham-Rundles

Journal: Hematology Am Soc Hematol Educ Program. 2012 ;2012():301-5.

 

Common variable immunodeficiency (CVID) is a rare immune deficiency characterized by low levels of serum IgG, IgA, and/or IgM, with a loss of Ab production. The diagnosis is most commonly made in adults between the ages of 20 and 40 years, but both children and much older adults can ...

Last Updated: 12 Dec 2012

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Chipping away at a mountain: genomic studies in common variable immunodeficiency.
 

Author(s): Michael D Keller, Soma Jyonouchi

Journal: Autoimmun Rev. 2013 Apr;12(6):687-9.

 

Common variable immunodeficiency (CVID) represents one of the most frequently diagnosed disorders of the immune system. Though several causative and associated genes have been identified, the origins of most cases remain unknown. Diagnostic delay is common due to the gradual evolution ...

Last Updated: 6 May 2013

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[Common variable immunodeficiency: an update on etiology, pathophysiology, and classification].
 

Author(s): Tomohiro Morio

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2012 ;35(1):14-22.

 

Common variable immunodeficiency is one of the most common primary immunodeficiency that is categorized into primary antibody deficiency. The responsible genes identified so far include ICOS, TACI, CD19, CD20, CD21, CD81 and BAFF-R; and most of the CVID-causing genes are yet to be ...

Last Updated: 29 Feb 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lymphocyte Immunophenotyping in Common Variable Immunodeficiency
 

Status: Recruiting

Condition Summary: Common Variable Immunodeficiency; Granulomatous Disease; Bronchiectasis; Immunoglobulin Treatment

 

Last Updated: 7 Sep 2010

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Immune Regulation in Patients With Common Variable Immunodeficiency and Related Syndromes
 

Status: Recruiting

Condition Summary: Agammaglobulinemia; Common Variable Immunodeficiency; Immunologic Deficiency Syndrome

 

Last Updated: 14 Mar 2014

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