Common Variable Immunodeficiency

Common Name(s)

Common Variable Immunodeficiency

Common variable immunodeficiency (CVID) is a group of disorders in which the immune system cannot make antibodies in response to foreign substances that cause infection. The main feature that separates CVID from other immunodeficiencies is low levels of two specific antibodies, immunoglobulin A (IgA) and immunoglobulin G (IgG). People with CVID get more frequent infections, particularly in the sinuses, lungs, and digestive tract. Symptoms most commonly begin in early adulthood, but have been found in children as young as age two. While in most cases the cause of CVID is unknown, the condition has been associated with mutations in at least 10 genes. About 10% of affected people have mutations in the TNFRSF13B gene. The main treatment for CVID is Ig replacement therapy, which stops the cycle of recurrent infections.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Common Variable Immunodeficiency" for support, advocacy or research.

Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

Last Updated: 27 Aug 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Common Variable Immunodeficiency" for support, advocacy or research.

Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

http://www.primaryimmune.org

Last Updated: 27 Aug 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Common Variable Immunodeficiency" returned 353 free, full-text research articles on human participants. First 3 results:

Asthma and Allergic Diseases in a Selected Group of Patients With Common Variable Immunodeficiency.
 

Author(s): R Yazdani, A Heydari, G Azizi, H Abolhassani, A Aghamohammadi

Journal: J Investig Allergol Clin Immunol. 2016 ;26(3):209-11.

 

Last Updated: 22 Jun 2016

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IL-10-Producing Regulatory B Cells Are Decreased in Patients with Common Variable Immunodeficiency.
 

Author(s): Nathalia Silveira Barsotti, Rafael Ribeiro Almeida, Priscilla Ramos Costa, Myrthes Toledo Barros, Jorge Kalil, Cristina Maria Kokron

Journal:

 

Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency in adults. CVID patients often present changes in the frequency and function of B lymphocytes, reduced number of Treg cells, chronic immune activation, recurrent infections, high incidence ...

Last Updated: 19 Mar 2016

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Fusarium ramigenum, a novel human opportunist in a patient with common variable immunodeficiency and cellular immune defects: case report.
 

Author(s): Ruxandra V Moroti, Valeriu Gheorghita, Abdullah M S Al-Hatmi, G Sybren de Hoog, Jacques F Meis, Mihai G Netea

Journal:

 

Fusarium species are ubiquitous environmental fungi that occasionally provoke serious invasive infections in immunocompromised hosts. Among Fusarium species, Fusarium ramigenum, belonging to the Fusarium fujikuroi species complex, has thus far never been found to cause human infections. ...

Last Updated: 15 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Common Variable Immunodeficiency" returned 24 free, full-text review articles on human participants. First 3 results:

T-Cell Abnormalities in Common Variable Immunodeficiency.
 

Author(s): G Azizi, N Rezaei, F Kiaee, N Tavakolinia, R Yazdani, A Mirshafiey, A Aghamohammadi

Journal: J Investig Allergol Clin Immunol. 2016 ;26(4):233-43.

 

Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-cell differentiation to plasma and memory B cells. Moreover, numerous T-cell abnormalities have been reported and include decreased T-cell count and proliferative ...

Last Updated: 1 Aug 2016

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Common Variable Immunodeficiency or Late-Onset Combined Immunodeficiency: A New Hypomorphic JAK3 Patient and Review of the Literature.
 

Author(s): H Abolhassani, T Cheraghi, N Rezaei, A Aghamohammadi, Hammarström L

Journal: J Investig Allergol Clin Immunol. 2015 ;25(3):218-20.

 

Last Updated: 17 Jul 2015

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Lymphoproliferative disease and cancer among patients with common variable immunodeficiency.
 

Author(s): S Gangemi, A Allegra, C Musolino

Journal: Leuk. Res.. 2015 Apr;39(4):389-96.

 

Innate immune deficiencies are a heterogeneous group of genetically inherited diseases affecting the innate and adaptive immune systems that confer susceptibility to infection, autoimmunity, and cancer. This review discusses the latest insights into the links between common variable ...

Last Updated: 23 Mar 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lymphocyte Immunophenotyping in Common Variable Immunodeficiency
 

Status: Recruiting

Condition Summary: Common Variable Immunodeficiency; Granulomatous Disease; Bronchiectasis; Immunoglobulin Treatment

 

Last Updated: 7 Sep 2010

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Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation Disorders
 

Status: Recruiting

Condition Summary: Lymphohistiocytosis, Hemophagocytic; Common Variable Immunodeficiency; Severe Combined Immunodeficiency

 

Last Updated: 24 Sep 2016

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Pharmacokinetics (PK) and Safety of Subgam®VF in Primary Immunodeficiency Diseases
 

Status: Recruiting

Condition Summary: Primary Immune Deficiency Disorders; Common Variable Immunodeficiency; X-linked Agammaglobulinaemia; Hyperimmunoglobulin M Syndrome

 

Last Updated: 29 Jul 2016

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