Common Variable Immunodeficiency

Common Name(s)

Common Variable Immunodeficiency

Common variable immunodeficiency (CVID) is a group of disorders in which the immune system cannot make antibodies in response to foreign substances that cause infection. The main feature that separates CVID from other immunodeficiencies is low levels of two specific antibodies, immunoglobulin A (IgA) and immunoglobulin G (IgG). People with CVID get more frequent infections, particularly in the sinuses, lungs, and digestive tract. Symptoms most commonly begin in early adulthood, but have been found in children as young as age two. While in most cases the cause of CVID is unknown, the condition has been associated with mutations in at least 10 genes. About 10% of affected people have mutations in the TNFRSF13B gene. The main treatment for CVID is Ig replacement therapy, which stops the cycle of recurrent infections.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Common Variable Immunodeficiency" for support, advocacy or research.

Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

Last Updated: 27 Aug 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Common Variable Immunodeficiency" for support, advocacy or research.

Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

http://www.primaryimmune.org

Last Updated: 27 Aug 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Common Variable Immunodeficiency" returned 327 free, full-text research articles on human participants. First 3 results:

Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders.
 

Author(s): Pauline A van Schouwenburg, Emma E Davenport, Anne-Kathrin Kienzler, Ishita Marwah, Benjamin Wright, Mary Lucas, Tomas Malinauskas, Hilary C Martin, , Helen E Lockstone, Jean-Baptiste Cazier, Helen M Chapel, Julian C Knight, Smita Y Patel

Journal: Clin. Immunol.. 2015 Oct;160(2):301-14.

 

Common Variable Immunodeficiency Disorders (CVIDs) are the most prevalent cause of primary antibody failure. CVIDs are highly variable and a genetic causes have been identified in <5% of patients. Here, we performed whole genome sequencing (WGS) of 34 CVID patients (94% sporadic) ...

Last Updated: 24 Sep 2015

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Clinical and immunological features of common variable immunodeficiency in China.
 

Author(s): Lian-Jun Lin, Yu-Chuan Wang, Xin-Min Liu

Journal: Chin. Med. J.. 2015 Feb;128(3):310-5.

 

Common variable immunodeficiency (CVID) is one of the most common symptomatic primary immunodeficiency syndromes. The purpose of this article was to broaden our knowledge about CVID for better diagnosis and treatment.

Last Updated: 31 Jan 2015

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Multiple malignancies in a female patient with common variable immunodeficiency syndrome.
 

Author(s): Milena Todorovic, Bela Balint, Bosko Andjelic, Biljana Mihaljevic

Journal: Singapore Med J. 2014 Oct;55(10):e162-4.

 

We herein present the case of a 55-year-old woman with a previous history of malignancies--uterine adenocarcinoma, basal cell carcinoma (which occurred twice consecutively), recurrent respiratory infections due to common variable immunodeficiency (CVID), and systemic granulomatous ...

Last Updated: 29 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Common Variable Immunodeficiency" returned 23 free, full-text review articles on human participants. First 3 results:

Common Variable Immunodeficiency or Late-Onset Combined Immunodeficiency: A New Hypomorphic JAK3 Patient and Review of the Literature.
 

Author(s): H Abolhassani, T Cheraghi, N Rezaei, A Aghamohammadi, Hammarström L

Journal: J Investig Allergol Clin Immunol. 2015 ;25(3):218-20.

 

Last Updated: 17 Jul 2015

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Lymphoproliferative disease and cancer among patients with common variable immunodeficiency.
 

Author(s): S Gangemi, A Allegra, C Musolino

Journal: Leuk. Res.. 2015 Apr;39(4):389-96.

 

Innate immune deficiencies are a heterogeneous group of genetically inherited diseases affecting the innate and adaptive immune systems that confer susceptibility to infection, autoimmunity, and cancer. This review discusses the latest insights into the links between common variable ...

Last Updated: 23 Mar 2015

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The many faces of common variable immunodeficiency.
 

Author(s): Charlotte Cunningham-Rundles

Journal: Hematology Am Soc Hematol Educ Program. 2012 ;2012():301-5.

 

Common variable immunodeficiency (CVID) is a rare immune deficiency characterized by low levels of serum IgG, IgA, and/or IgM, with a loss of Ab production. The diagnosis is most commonly made in adults between the ages of 20 and 40 years, but both children and much older adults can ...

Last Updated: 12 Dec 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lymphocyte Immunophenotyping in Common Variable Immunodeficiency
 

Status: Recruiting

Condition Summary: Common Variable Immunodeficiency; Granulomatous Disease; Bronchiectasis; Immunoglobulin Treatment

 

Last Updated: 7 Sep 2010

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Pharmacokinetics (PK) and Safety of Subgam®VF in Primary Immunodeficiency Diseases
 

Status: Recruiting

Condition Summary: Primary Immune Deficiency Disorders; Common Variable Immunodeficiency; X-linked Agammaglobulinaemia; Hyperimmunoglobulin M Syndrome

 

Last Updated: 28 Jan 2016

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