Common Variable Immunodeficiency

Common Name(s)

Common Variable Immunodeficiency

Common variable immunodeficiency (CVID) is a group of disorders in which the immune system cannot make antibodies in response to foreign substances that cause infection. The main feature that separates CVID from other immunodeficiencies is low levels of two specific antibodies, immunoglobulin A (IgA) and immunoglobulin G (IgG). People with CVID get more frequent infections, particularly in the sinuses, lungs, and digestive tract. Symptoms most commonly begin in early adulthood, but have been found in children as young as age two. While in most cases the cause of CVID is unknown, the condition has been associated with mutations in at least 10 genes. About 10% of affected people have mutations in the TNFRSF13B gene. The main treatment for CVID is Ig replacement therapy, which stops the cycle of recurrent infections.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Common Variable Immunodeficiency" for support, advocacy or research.

Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

Last Updated: 27 Aug 2015

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Common Variable Immunodeficiency" for support, advocacy or research.

Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

http://www.primaryimmune.org

Last Updated: 27 Aug 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Common Variable Immunodeficiency" returned 344 free, full-text research articles on human participants. First 3 results:

Burden of Skin Disease in Selective IgA Deficiency and Common Variable Immunodeficiency.
 

Author(s): G Gualdi, V Lougaris, M Baronio, M Vitali, G Tampella, D Moratto, P Tanghetti, P Monari, P Calzavara-Pinton, A Plebani

Journal: J Investig Allergol Clin Immunol. 2015 ;25(5):369-71.

 

Last Updated: 5 Jan 2016

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Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency.
 

Author(s): Manfred Fliegauf, Vanessa L Bryant, Natalie Frede, Charlotte Slade, See-Tarn Woon, Klaus Lehnert, Sandra Winzer, Alla Bulashevska, Thomas Scerri, Euphemia Leung, Anthony Jordan, Baerbel Keller, Esther de Vries, Hongzhi Cao, Fang Yang, Alejandro A Schäffer, Klaus Warnatz, Peter Browett, Jo Douglass, Rohan V Ameratunga, Jos W M van der Meer, Bodo Grimbacher

Journal: Am. J. Hum. Genet.. 2015 Sep;97(3):389-403.

 

Common variable immunodeficiency (CVID), characterized by recurrent infections, is the most prevalent symptomatic antibody deficiency. In ∼90% of CVID-affected individuals, no genetic cause of the disease has been identified. In a Dutch-Australian CVID-affected family, we identified ...

Last Updated: 5 Sep 2015

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[Common variable immunodeficiency: Clinical and immunological characterization of patients and homogeneous subgroup definition by means of B lymphocyte subpopulation typing].
 

Author(s): Alejandra Catalina Vélez, Diana María Castaño, Rubén Darío Gómez, Julio César Orrego, Marcela Moncada, José Luis Franco

Journal: Biomedica. ;35(1):101-16.

 

Common variable immunodeficiency is a heterogeneous syndrome characterized by recurrent infections, hypogammaglobulinemia and defective production of specific antibodies. Abnormalities in peripheral blood lymphocyte subpopulations, in particular of B lymphocytes, allow the classification ...

Last Updated: 7 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Common Variable Immunodeficiency" returned 23 free, full-text review articles on human participants. First 3 results:

Common Variable Immunodeficiency or Late-Onset Combined Immunodeficiency: A New Hypomorphic JAK3 Patient and Review of the Literature.
 

Author(s): H Abolhassani, T Cheraghi, N Rezaei, A Aghamohammadi, Hammarström L

Journal: J Investig Allergol Clin Immunol. 2015 ;25(3):218-20.

 

Last Updated: 17 Jul 2015

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Lymphoproliferative disease and cancer among patients with common variable immunodeficiency.
 

Author(s): S Gangemi, A Allegra, C Musolino

Journal: Leuk. Res.. 2015 Apr;39(4):389-96.

 

Innate immune deficiencies are a heterogeneous group of genetically inherited diseases affecting the innate and adaptive immune systems that confer susceptibility to infection, autoimmunity, and cancer. This review discusses the latest insights into the links between common variable ...

Last Updated: 23 Mar 2015

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The many faces of common variable immunodeficiency.
 

Author(s): Charlotte Cunningham-Rundles

Journal: Hematology Am Soc Hematol Educ Program. 2012 ;2012():301-5.

 

Common variable immunodeficiency (CVID) is a rare immune deficiency characterized by low levels of serum IgG, IgA, and/or IgM, with a loss of Ab production. The diagnosis is most commonly made in adults between the ages of 20 and 40 years, but both children and much older adults can ...

Last Updated: 12 Dec 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lymphocyte Immunophenotyping in Common Variable Immunodeficiency
 

Status: Recruiting

Condition Summary: Common Variable Immunodeficiency; Granulomatous Disease; Bronchiectasis; Immunoglobulin Treatment

 

Last Updated: 7 Sep 2010

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Pharmacokinetics (PK) and Safety of Subgam®VF in Primary Immunodeficiency Diseases
 

Status: Recruiting

Condition Summary: Primary Immune Deficiency Disorders; Common Variable Immunodeficiency; X-linked Agammaglobulinaemia; Hyperimmunoglobulin M Syndrome

 

Last Updated: 23 May 2016

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Improving the Diagnosis of Common Variable Immune Deficiency
 

Status: Not yet recruiting

Condition Summary: Common Variable Immune Deficiency (CVID)

 

Last Updated: 10 Feb 2016

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