Common Variable Immunodeficiency

Common Name(s)

Common Variable Immunodeficiency

Common variable immunodeficiency (CVID) is a group of disorders in which the immune system cannot make antibodies in response to foreign substances that cause infection. The main feature that separates CVID from other immunodeficiencies is low levels of two specific antibodies, immunoglobulin A (IgA) and immunoglobulin G (IgG). People with CVID get more frequent infections, particularly in the sinuses, lungs, and digestive tract. Symptoms most commonly begin in early adulthood, but have been found in children as young as age two. While in most cases the cause of CVID is unknown, the condition has been associated with mutations in at least 10 genes. About 10% of affected people have mutations in the TNFRSF13B gene. The main treatment for CVID is Ig replacement therapy, which stops the cycle of recurrent infections.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Common Variable Immunodeficiency" for support, advocacy or research.

Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

Last Updated: 27 Aug 2015

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Common Variable Immunodeficiency" for support, advocacy or research.

Immune Deficiency Foundation

The Immune Deficiency Foundation is the national patient organization dedicated to improving the diagnosis, treatment and quality of life of persons with primary immunodeficiency diseases through advocacy, education and research.

http://www.primaryimmune.org

Last Updated: 27 Aug 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Common Variable Immunodeficiency" returned 352 free, full-text research articles on human participants. First 3 results:

Diffuse Nodular Lymphoid Hyperplasia of the Intestine Caused by Common Variable Immunodeficiency and Refractory Giardiasis.
 

Author(s): Jung Hye Choi, Dong Soo Han, Jieun Kim, Kijong Yi, Young-Ha Oh, Yongsoo Kim

Journal: Intern. Med.. 2017 ;56(3):283-287.

 

Diffuse nodular lymphoid hyperplasia of the gastrointestinal tract is a rare disease characterized by numerous small polypoid nodules in the small intestine, large intestine, or both. It is associated with immunodeficiency and infection, such as Giardia lamblia and Helicobacter pylori. ...

Last Updated: 3 Feb 2017

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Important Factors Influencing Severity of Common Variable Immunodeficiency.
 

Author(s): Mahisa Mokhtari, Alireza Shakeri, Babak Mirminachi, Hassan Abolhassani, Reza Yazdani, Bodo Grimbacher, Asghar Aghamohammadi

Journal: Arch Iran Med. 2016 Aug;19(8):544-50.

 

Common variable immunodeficiency (CVID) is a primary immune deficiency with heterogeneous complications. The purpose of this study is to determine disease severity in a cohort of CVID patients based on the suggested scoring system and investigate predisposing factors which would be ...

Last Updated: 22 Aug 2016

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Asthma and Allergic Diseases in a Selected Group of Patients With Common Variable Immunodeficiency.
 

Author(s): R Yazdani, A Heydari, G Azizi, H Abolhassani, A Aghamohammadi

Journal: J Investig Allergol Clin Immunol. 2016 ;26(3):209-11.

 

Last Updated: 22 Jun 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Common Variable Immunodeficiency" returned 27 free, full-text review articles on human participants. First 3 results:

NFKB2 mutation in common variable immunodeficiency and isolated adrenocorticotropic hormone deficiency: A case report and review of literature.
 

Author(s): Chuan Shi, Fen Wang, Anli Tong, Xiao-Qian Zhang, Hong-Mei Song, Zheng-Yin Liu, Wei Lyu, Yue-Hua Liu, Wei-Bo Xia

Journal: Medicine (Baltimore). 2016 Oct;95(40):e5081.

 

Common variable immunodeficiency (CVID) with central adrenal insufficiency is a recently defined clinical syndrome caused by mutations in the nuclear factor kappa-B subunit 2 (NFKB2) gene. We present the first case of NFKB2 mutation in Asian population.

Last Updated: 17 Oct 2016

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T-Cell Abnormalities in Common Variable Immunodeficiency.
 

Author(s): G Azizi, N Rezaei, F Kiaee, N Tavakolinia, R Yazdani, A Mirshafiey, A Aghamohammadi

Journal: J Investig Allergol Clin Immunol. 2016 ;26(4):233-43.

 

Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-cell differentiation to plasma and memory B cells. Moreover, numerous T-cell abnormalities have been reported and include decreased T-cell count and proliferative ...

Last Updated: 1 Aug 2016

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T-cell abnormalities in common variable immunodeficiency: the hidden defect.
 

Author(s): Gabriel K Wong, Aarnoud P Huissoon

Journal: J. Clin. Pathol.. 2016 Aug;69(8):672-6.

 

This review discusses how the T-cell compartment in common variable immunodeficiency is marked by the premature arrest in thymic output, leading to T-cell exhaustion and immune dysregulation. Although B cells have been the main focus of the disorder, ample experimental data suggest ...

Last Updated: 21 Jul 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Improving the Diagnosis of Common Variable Immune Deficiency
 

Status: Not yet recruiting

Condition Summary: Common Variable Immune Deficiency (CVID)

 

Last Updated: 10 Feb 2016

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Last Updated: 24 Jan 2017

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