Colorectal Cancer

Common Name(s)

Colorectal Cancer, Cancer, Colorectal

Colorectal cancer is cancer of the colon or rectum. The colon and the rectum are part of the large intestine, which is part of the digestive system. Colorectal cancer occurs when tumors form in the lining of the large intestine, also called the large bowel. Symptoms include diarrhea or constipation, blood in your stool, frequent gas pains or cramps, weight loss, fatigue, and nausea. Screening tests are important as these symptoms may not be present at first. Tests include colonoscopy and tests for blood in the stool.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Colorectal Cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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C3: Colorectal Cancer Coalition

Fight Colorectal Cancer ( formerly C3: Colorectal Cancer Coalition ) is a national, nonpartisan organization whose mission is to win the fight against colorectal cancer through research, empowerment and access. FightCRC pushes for research to improve screening, diagnosis, and treatment of colorectal cancer; for policy decisions that make the most effective colon and rectal cancer prevention and treatment available to all; and for increased awareness that colorectal cancer is preventable, treatable, and beatable.

Last Updated: 16 Oct 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Colon Cancer Alliance

Our mission is to knock colon cancer out of the top three cancer killers. We are doing this by championing prevention, funding cutting-edge research and providing the highest quality patient support services.

Last Updated: 12 Oct 2013

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Colorectal Cancer Association of Canada

Our mandate is threefold: 1) To raise awareness of colorectal cancer, to educate the public about this disease, and how to prevent and treat it; 2) To provide support for colorectal cancer patients and their families; and 3) To advocate on their behalf for equal and timely access to effective medicines and treatments.

Last Updated: 9 Jul 2013

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Fight Colorectal Cancer

Fight Colorectal Cancer is a national, nonpartisan organization whose mission is to win the fight against colorectal cancer through research, empowerment and access. FightCRC pushes for research to improve screening, diagnosis, and treatment of colorectal cancer; for policy decisions that make the most effective colon and rectal cancer prevention and treatment available to all; and for increased awareness that colorectal cancer is preventable, treatable, and beatable.

Last Updated: 8 Apr 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Colorectal Cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

View Details
C3: Colorectal Cancer Coalition

Fight Colorectal Cancer ( formerly C3: Colorectal Cancer Coalition ) is a national, nonpartisan organization whose mission is to win the fight against colorectal cancer through research, empowerment and access. FightCRC pushes for research to improve screening, diagnosis, and treatment of colorectal cancer; for policy decisions that make the most effective colon and rectal cancer prevention and treatment available to all; and for increased awareness that colorectal cancer is preventable, treatable, and beatable.

http://www.fightcolorectalcancer.org

Last Updated: 16 Oct 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

View Details
Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Colon Cancer Alliance

Our mission is to knock colon cancer out of the top three cancer killers. We are doing this by championing prevention, funding cutting-edge research and providing the highest quality patient support services.

http://www.ccalliance.org

Last Updated: 12 Oct 2013

View Details
Colorectal Cancer Association of Canada

Our mandate is threefold: 1) To raise awareness of colorectal cancer, to educate the public about this disease, and how to prevent and treat it; 2) To provide support for colorectal cancer patients and their families; and 3) To advocate on their behalf for equal and timely access to effective medicines and treatments.

http://www.colorectal-cancer.ca

Last Updated: 9 Jul 2013

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Fight Colorectal Cancer

Fight Colorectal Cancer is a national, nonpartisan organization whose mission is to win the fight against colorectal cancer through research, empowerment and access. FightCRC pushes for research to improve screening, diagnosis, and treatment of colorectal cancer; for policy decisions that make the most effective colon and rectal cancer prevention and treatment available to all; and for increased awareness that colorectal cancer is preventable, treatable, and beatable.

http://fightcolorectalcancer.org

Last Updated: 8 Apr 2014

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

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General Support Organizations

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General Resources

Research

We work with the gastrointestinal research community to identify emerging areas of study that should be explored. Once they are identified, Fight Colorectal Cancer helps build bridges between basic scientists, clinical researchers and patient advocates. Grant applications are peer-reviewed in collaboration with the American Association for Cancer Research, and target promising research for patients with metastatic colorectal cancer.

Updated 16 Oct 2012

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One Million Strong

Inspired by more than one million colorectal cancer survivors in the United States, Fight Colorectal Cancer has launched a national awareness campaign called One Million Strong to raise awareness and take action! We want to unify survivors and those

Updated 7 Mar 2013

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Blogs

Policy News

Blogs related to industry related items in the news.

Updated 16 Oct 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Colorectal Cancer" returned 11101 free, full-text research articles on human participants. First 3 results:

The lncRNA H19 Promotes Cell Proliferation by Competitively Binding to miR-200a and Derepressing β-Catenin Expression in Colorectal Cancer.
 

Author(s): Weiwei Yang, Ning Ning, Xiaoming Jin

Journal: Biomed Res Int. 2017 ;2017():2767484.

 

H19, a paternally imprinted noncoding RNA, has been found to be overexpressed in various cancers, including colorectal cancer (CRC), and may function as an oncogene. However, the mechanism by which H19 regulates CRC progression remains poorly understood. In this study, we aimed to ...

Last Updated: 6 Feb 2017

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Microbiota Composition, HSP70 and Caspase-3 Expression as Marker for Colorectal Cancer Patients in Aceh, Indonesia.
 

Author(s): Fauzi Yusuf, Syafruddin Ilyas, Harun Al Rasyid Damanik, Fatchiyah Fatchiyah

Journal: Acta Med Indones. 2016 Oct;48(4):289-299.

 

to investigate the relationship between microbiota composition with HSP70 and Caspase-3 expressions in colon tissue as an initial study to develop the candidate for early detection of colorectal cancer for Indonesian patients.

Last Updated: 1 Feb 2017

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Role of CDH13 promoter methylation in the carcinogenesis, progression, and prognosis of colorectal cancer: A systematic meta-analysis under PRISMA guidelines.
 

Author(s): Meng Ye, Tao Huang, Jinyun Li, Chongchang Zhou, Ping Yang, Chao Ni, Si Chen

Journal: Medicine (Baltimore). 2017 Jan;96(4):e5956.

 

H-cadherin (CDH13) is commonly downregulated through promoter methylation in various cancers. However, the role of CDH13 promoter methylation status in patients with colorectal cancer (CRC) remains to be clarified.

Last Updated: 25 Jan 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Colorectal Cancer" returned 1244 free, full-text review articles on human participants. First 3 results:

ECCO Essential Requirements for Quality Cancer Care: Colorectal Cancer. A critical review.
 

Author(s): Geerard Beets, David Sebag-Montefiore, Elisabeth Andritsch, Dirk Arnold, Marc Beishon, Mirjam Crul, Jan Willem Dekker, Roberto Delgado-Bolton, Jean-François Fléjou, Wolfgang Grisold, Geoffrey Henning, Andrea Laghi, Jozsef Lovey, Anastassia Negrouk, Philippe Pereira, Pierre Roca, Tiina Saarto, Thomas Seufferlein, Claire Taylor, Giampaolo Ugolini, Cornelis van de Velde, Bert van Herck, Wendy Yared, Alberto Costa, Peter Naredi

Journal: Crit. Rev. Oncol. Hematol.. 2017 Feb;110():81-93.

 

ECCO essential requirements for quality cancer care (ERQCC) are checklists and explanations of organisation and actions that are necessary to give high-quality care to patients who have a specific tumour type. They are written by European experts representing all disciplines involved ...

Last Updated: 22 Jan 2017

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The efficacy and safety of panitumumab plus irrinotecan-based chemotherapy in the treatment of metastatic colorectal cancer: A meta-analysis.
 

Author(s): Qiang Chen, Minjing Cheng, Zhuo Wang, Shipeng Zhao

Journal: Medicine (Baltimore). 2016 Dec;95(50):e5284.

 

Panitumumab, a fully human monoclonal antibody targeting epidermal growth factor receptor, is used in combination with chemotherapy for patients with metastatic colorectal cancer (mCRC). However, the effects of panitumumab in combination with irrinotecan-based chemotherapy remain ...

Last Updated: 15 Dec 2016

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Biomarkers Discovery for Colorectal Cancer: A Review on Tumor Endothelial Markers as Perspective Candidates.
 

Author(s): Łukasz Pietrzyk

Journal: Dis. Markers. 2016 ;2016():4912405.

 

Colorectal cancer (CRC) is the third most common cancer in the world. The early detection of CRC, during the promotion/progression stages, is an enormous challenge for a successful outcome and remains a fundamental problem in clinical approach. Despite the continuous advancement in ...

Last Updated: 14 Dec 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Role of the MET Oncogene in Human Colorectal Cancer - A Translational Study
 

Status: Recruiting

Condition Summary: Colorectal Cancer

 

Last Updated: 19 Aug 2016

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LEAC-102 for Advanced Colorectal Cancer
 

Status: Not yet recruiting

Condition Summary: Advanced Colorectal Cancer

 

Last Updated: 28 Dec 2016

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Last Updated: 1 Feb 2017

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