Colorectal Cancer

Common Name(s)

Colorectal Cancer, Cancer, Colorectal

Colorectal cancer is cancer of the colon or rectum. The colon and the rectum are part of the large intestine, which is part of the digestive system. Colorectal cancer occurs when tumors form in the lining of the large intestine, also called the large bowel. Symptoms include diarrhea or constipation, blood in your stool, frequent gas pains or cramps, weight loss, fatigue, and nausea. Screening tests are important as these symptoms may not be present at first. Tests include colonoscopy and tests for blood in the stool.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Colorectal Cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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C3: Colorectal Cancer Coalition

Fight Colorectal Cancer ( formerly C3: Colorectal Cancer Coalition ) is a national, nonpartisan organization whose mission is to win the fight against colorectal cancer through research, empowerment and access. FightCRC pushes for research to improve screening, diagnosis, and treatment of colorectal cancer; for policy decisions that make the most effective colon and rectal cancer prevention and treatment available to all; and for increased awareness that colorectal cancer is preventable, treatable, and beatable.

Last Updated: 16 Oct 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

Last Updated: 26 Dec 2012

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Colon Cancer Alliance

Our mission is to knock colon cancer out of the top three cancer killers. We are doing this by championing prevention, funding cutting-edge research and providing the highest quality patient support services.

Last Updated: 12 Oct 2013

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Colorectal Cancer Association of Canada

Our mandate is threefold: 1) To raise awareness of colorectal cancer, to educate the public about this disease, and how to prevent and treat it; 2) To provide support for colorectal cancer patients and their families; and 3) To advocate on their behalf for equal and timely access to effective medicines and treatments.

Last Updated: 9 Jul 2013

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Fight Colorectal Cancer

Fight Colorectal Cancer is a national, nonpartisan organization whose mission is to win the fight against colorectal cancer through research, empowerment and access. FightCRC pushes for research to improve screening, diagnosis, and treatment of colorectal cancer; for policy decisions that make the most effective colon and rectal cancer prevention and treatment available to all; and for increased awareness that colorectal cancer is preventable, treatable, and beatable.

Last Updated: 8 Apr 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Colorectal Cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

View Details
C3: Colorectal Cancer Coalition

Fight Colorectal Cancer ( formerly C3: Colorectal Cancer Coalition ) is a national, nonpartisan organization whose mission is to win the fight against colorectal cancer through research, empowerment and access. FightCRC pushes for research to improve screening, diagnosis, and treatment of colorectal cancer; for policy decisions that make the most effective colon and rectal cancer prevention and treatment available to all; and for increased awareness that colorectal cancer is preventable, treatable, and beatable.

http://www.fightcolorectalcancer.org

Last Updated: 16 Oct 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

View Details
Center for Jewish Genetics

The Center is dedicated to gathering and disseminating knowledge about Jewish genetic disorders and hereditary cancers. Its mission is to educate and serve health care professionals, clergy and the Jewish community.

http://www.jewishgenetics.org

Last Updated: 26 Dec 2012

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Colon Cancer Alliance

Our mission is to knock colon cancer out of the top three cancer killers. We are doing this by championing prevention, funding cutting-edge research and providing the highest quality patient support services.

http://www.ccalliance.org

Last Updated: 12 Oct 2013

View Details
Colorectal Cancer Association of Canada

Our mandate is threefold: 1) To raise awareness of colorectal cancer, to educate the public about this disease, and how to prevent and treat it; 2) To provide support for colorectal cancer patients and their families; and 3) To advocate on their behalf for equal and timely access to effective medicines and treatments.

http://www.colorectal-cancer.ca

Last Updated: 9 Jul 2013

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Fight Colorectal Cancer

Fight Colorectal Cancer is a national, nonpartisan organization whose mission is to win the fight against colorectal cancer through research, empowerment and access. FightCRC pushes for research to improve screening, diagnosis, and treatment of colorectal cancer; for policy decisions that make the most effective colon and rectal cancer prevention and treatment available to all; and for increased awareness that colorectal cancer is preventable, treatable, and beatable.

http://fightcolorectalcancer.org

Last Updated: 8 Apr 2014

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

View Details
Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

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General Support Organizations

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General Resources

Research

We work with the gastrointestinal research community to identify emerging areas of study that should be explored. Once they are identified, Fight Colorectal Cancer helps build bridges between basic scientists, clinical researchers and patient advocates. Grant applications are peer-reviewed in collaboration with the American Association for Cancer Research, and target promising research for patients with metastatic colorectal cancer.

Updated 16 Oct 2012

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One Million Strong

Inspired by more than one million colorectal cancer survivors in the United States, Fight Colorectal Cancer has launched a national awareness campaign called One Million Strong to raise awareness and take action! We want to unify survivors and those

Updated 7 Mar 2013

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Blogs

Policy News

Blogs related to industry related items in the news.

Updated 16 Oct 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Colorectal Cancer" returned 9160 free, full-text research articles on human participants. First 3 results:

Colorectal Cancer With Peritoneal Metastases: A Plea for Cooperation Between Medical and Surgical Oncologists.
 

Author(s): Jesus Esquivel

Journal: Oncology (Williston Park, N.Y.). 2015 Jul;29(7):521-2.

 

Last Updated: 16 Jul 2015

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[Role of CTHRC1 in proliferation, migration and invasion of human colorectal cancer cells].
 

Author(s): Li Yan, Geng-Tai Ye, Zhiyong Shen, Xianjun Zhu, Hao Liu, Guoxin Li

Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2015 May;35(5):767-71, 776.

 

To explore the expression of collagen triple helix repeat containing 1 (CTHRC1) in colorectal cancer and study its role in regulating the biological behaviors of colorectal cancer LoVo cells in vitro.

Last Updated: 28 May 2015

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[Compound K suppresses myeloid-derived suppressor cells in a mouse model bearing CT26 colorectal cancer xenograft].
 

Author(s): Rong Wang, Yalin Li, Wuzhou Wang, Meijuan Zhou, Zhaohui Cao

Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2015 May;35(5):748-52.

 

To investigate the effect of ginseng-derived compound K (C-K) on apoptosis, immunosuppressive activity, and pro-inflammatory cytokine production of myeloid-derived suppressor cells (MDSCs) from mice bearing colorectal cancer xenograft.

Last Updated: 28 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Colorectal Cancer" returned 1004 free, full-text review articles on human participants. First 3 results:

Colonic perforation with intraluminal stents and bevacizumab in advanced colorectal cancer: retrospective case series and literature review.
 

Author(s): Amal Imbulgoda, Anthony MacLean, John Heine, Sebastien Drolet, Michael M Vickers

Journal: Can J Surg. 2015 Jun;58(3):167-71.

 

Self-expanding metal stents (SEMS) are increasingly used in the treatment of malignant large bowel obstruction in the setting of inoperable colorectal cancer. Perforation is a well-known complication associated with these devices. The addition of the vascular endothelial growth factor ...

Last Updated: 27 May 2015

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Costs and effectiveness of genomic testing in the management of colorectal cancer.
 

Author(s): Daniel A Goldstein, Walid L Shaib, Christopher R Flowers

Journal: Oncology (Williston Park, N.Y.). 2015 Mar;29(3):175-83.

 

Numerous genomic tests are available for use in colorectal cancer, with a widely variable evidence base for their effectiveness and cost-effectiveness. In this review, we highlight many of these tests, with a focus on their proposed role, the evidence base to support that role, and ...

Last Updated: 18 Mar 2015

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The XPD Lys751Gln polymorphism has predictive value in colorectal cancer patients receiving oxaliplatin-based chemotherapy: a systemic review and meta-analysis.
 

Author(s): Ying-Ying Qian, Xin-You Liu, Dong Pei, Jia-Li Xu, Hua Shen, Xiao-Feng Chen, Yi-Qian Liu, Li-Zong Shen, Yong-Qian Shu

Journal: Asian Pac. J. Cancer Prev.. 2014 ;15(22):9699-706.

 

The predictive value of the xeroderma pigmentosum group D (XPD) Lys751Gln polymorphism regarding clinical outcomes of patients with colorectal cancer (CRC) receiving oxaliplatin-based chemotherapy has been evaluated in numerous published studies, but the results remain inconclusive. ...

Last Updated: 18 Dec 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of Famitinib in Patients With Advanced Colorectal Cancer
 

Status: Recruiting

Condition Summary: Colorectal Cancer; Colorectal Cancer Metastatic; Colorectal Cancer Recurrent

 

Last Updated: 4 Jan 2013

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A Phase 3 Study to Evaluate Xilonix as an Anticancer Therapy in Patients With Symptomatic Colorectal Cancer
 

Status: Recruiting

Condition Summary: Symptomatic Colorectal Cancer; Advanced Colorectal Cancer; Colorectal Cancer With Cachexia

 

Last Updated: 11 Jun 2015

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Safety Study of the Combination of Panitumumab, Irinotecan and Everolimus in the Treatment of Advanced Colorectal Cancer
 

Status: Recruiting

Condition Summary: Colorectal Cancer; Colorectal Carcinoma; Colorectal Tumors; Neoplasms, Colorectal

 

Last Updated: 3 Nov 2014

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