Cold Agglutinin Disease

Common Name(s)

Cold Agglutinin Disease

Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia. In this condition, the immune system makes antibodies that attack the body's own red blood cells. This causes the blood cells to die prematurely (hemolysis). Symptoms may include pallor and fatigue; back and leg pain; headache; vomiting; diarrhea; and dark urine. CAD gets its name from the fact that the antibodies react at temperatures below 37ºC, so a cold environment may trigger the condition or make it worse. It can be primary (idiopathic) or secondary, due to an underlying condition such as an infection, another autoimmune disease, or certain cancers. Treatment often involves avoidance of cold temperatures.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cold Agglutinin Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cold Agglutinin Disease" returned 25 free, full-text research articles on human participants. First 3 results:

A man with "black fingers". Cold agglutinin disease (CAD).
 

Author(s): M A de Witte, R M Determann, S S Zeerleder

Journal: Neth J Med. 2014 Jan;72(1):35, 39-40.

 

Last Updated: 24 Jan 2014

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Blood clotting at room temperature in cold agglutinin disease.
 

Author(s): Martin Heni, Sebastian Jonas Saur

Journal: Blood. 2013 Jun;121(25):4975.

 

Last Updated: 14 Aug 2013

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Acronecrosis with cold agglutinin disease mimics diabetic gangrene.
 

Author(s): Hiroaki Iwasaki

Journal: Intern. Med.. 2013 ;52(7):837-8.

 

Last Updated: 2 Apr 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cold Agglutinin Disease" returned 2 free, full-text review articles on human participants. First 3 results:

Cold agglutinin disease.
 

Author(s): Paul L Swiecicki, Livia T Hegerova, Morie A Gertz

Journal: Blood. 2013 Aug;122(7):1114-21.

 

Cold agglutinin disease is a rare and poorly understood disorder affecting 15% of patients with autoimmune hemolytic anemia. We reviewed the clinical and pathologic features, prognosis, and management in the literature and describe our institutional experience to improve strategies ...

Last Updated: 16 Aug 2013

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Primary chronic cold agglutinin disease: an update on pathogenesis, clinical features and therapy.
 

Author(s): Sigbjørn Berentsen, Klaus Beiske, Geir E Tjønnfjord

Journal: Hematology. 2007 Oct;12(5):361-70.

 

Chronic cold agglutinin disease (CAD) is a subgroup of autoimmune hemolytic anemia. Primary CAD has traditionally been defined by the absence of any underlying or associated disease. The results of therapy with corticosteroids, alkylating agents and interferon-alpha have been poor. ...

Last Updated: 24 Sep 2007

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Short Course of Bortezomib in Anemic Patients With Refractory Cold Agglutinin Disease
 

Status: Recruiting

Condition Summary: Refractory Cold Agglutinin Disease

 

Last Updated: 30 Jan 2014

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