Cold Agglutinin Disease

Common Name(s)

Cold Agglutinin Disease

Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia. In this condition, the immune system makes antibodies that attack the body's own red blood cells. This causes the blood cells to die prematurely (hemolysis). Symptoms may include pallor and fatigue; back and leg pain; headache; vomiting; diarrhea; and dark urine. CAD gets its name from the fact that the antibodies react at temperatures below 37ºC, so a cold environment may trigger the condition or make it worse. It can be primary (idiopathic) or secondary, due to an underlying condition such as an infection, another autoimmune disease, or certain cancers. Treatment often involves avoidance of cold temperatures.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cold Agglutinin Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cold Agglutinin Disease" returned 30 free, full-text research articles on human participants. First 3 results:

Postoperative Recurrence of Invasive Thymoma with Cold Agglutinin Disease and Autoimmune Hemolytic Anemia.
 

Author(s): Taro Yoneda, Hayato Koba, Kota Tanimura, Naohiko Ogawa, Satoshi Watanabe, Johsuke Hara, Miki Abo, Takashi Sone, Hideharu Kimura, Kazuo Kasahara

Journal: Intern. Med.. ;55(18):2685-9.

 

A 50-year-old man presented to our hospital in 1995. Invasive thymoma was diagnosed and extended thymectomy and left upper lobe partial resection were performed. In 2013, he complained of dyspnea. Chest computed tomography showed postoperative recurrence of invasive thymoma. Several ...

Last Updated: 16 Sep 2016

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Cold agglutinin disease-associated digital gangrene treated with plasmapheresis.
 

Author(s): Yuta Koike, Yuichiro Akiyama, Atsushi Utani

Journal: Indian J Dermatol Venereol Leprol. ;80(6):575-6.

 

Last Updated: 10 Nov 2014

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A man with "black fingers". Cold agglutinin disease (CAD).
 

Author(s): M A de Witte, R M Determann, S S Zeerleder

Journal: Neth J Med. 2014 Jan;72(1):35, 39-40.

 

Last Updated: 24 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cold Agglutinin Disease" returned 2 free, full-text review articles on human participants. First 3 results:

Cold agglutinin disease.
 

Author(s): Paul L Swiecicki, Livia T Hegerova, Morie A Gertz

Journal: Blood. 2013 Aug;122(7):1114-21.

 

Cold agglutinin disease is a rare and poorly understood disorder affecting 15% of patients with autoimmune hemolytic anemia. We reviewed the clinical and pathologic features, prognosis, and management in the literature and describe our institutional experience to improve strategies ...

Last Updated: 16 Aug 2013

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Primary chronic cold agglutinin disease: an update on pathogenesis, clinical features and therapy.
 

Author(s): Sigbjørn Berentsen, Klaus Beiske, Geir E Tjønnfjord

Journal: Hematology. 2007 Oct;12(5):361-70.

 

Chronic cold agglutinin disease (CAD) is a subgroup of autoimmune hemolytic anemia. Primary CAD has traditionally been defined by the absence of any underlying or associated disease. The results of therapy with corticosteroids, alkylating agents and interferon-alpha have been poor. ...

Last Updated: 24 Sep 2007

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety, Tolerability and Activity of TNT009 in Healthy Volunteers and Patients With Complement Mediated Disorders
 

Status: Recruiting

Condition Summary: Bullous Pemphigoid (BP); Cold Agglutinin Disease; Warm Autoimmune Hemolytic Anemia; End-stage Renal Disease (ESRD)

 

Last Updated: 10 Feb 2017

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