Coats Disease

Common Name(s)

Coats Disease

Coats disease is an eye disorder characterized by abnormal development of the blood vessels in the retina (retinal telangiectasia). Most affected people begin showing symptoms of the condition in childhood. Early signs and symptoms vary but may include vision loss, crossed eyes (strabismus), and a white mass in the pupil behind the lens of the eye (leukocoria). Overtime, coats disease may also lead to retinal detachment, glaucoma, and clouding of the lens of the eye (cataracts) as the disease progresses. In most cases, only one eye is affected (unilateral). The exact underlying cause is not known but some cases may be due to somatic mutations in the NDP gene. Treatment depends on the symptoms present and may include cryotherapy, laser therapy, and/or surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Coats Disease" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

Last Updated: 1 Nov 2014

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The Jack McGovern Coats Disease Foundation

JMCDF was founded in 2006 by the parents of Jack McGovern as a promise to their son that they would never rest until there was a cure for Coats’ Disease.To this end the foundation was started to raise funds in support of ongoing research designed not only to support ongoing research to restore Jack’s vision, but also to offer all children like Jack hope as they wage a lifelong battle against Coats’ Disease and blindness.

Last Updated: 15 Mar 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Coats Disease" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

http://www.dcoutreach.com

Last Updated: 1 Nov 2014

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The Jack McGovern Coats Disease Foundation

JMCDF was founded in 2006 by the parents of Jack McGovern as a promise to their son that they would never rest until there was a cure for Coats’ Disease.To this end the foundation was started to raise funds in support of ongoing research designed not only to support ongoing research to restore Jack’s vision, but also to offer all children like Jack hope as they wage a lifelong battle against Coats’ Disease and blindness.

http://www.coatsdiseasefoundation.org

Last Updated: 15 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Coats Disease" returned 47 free, full-text research articles on human participants. First 3 results:

Vitrectomy for full-thickness macular hole in adult-onset Coats' disease.
 

Author(s): Vinod Kumar, Pradeep Kumar, Gaurav Garg, Saurabh Damodaran

Journal: Indian J Ophthalmol. 2017 Nov;65(11):1246-1248.

 

The occurrence of full thickness macular hole in Coats' disease is extremely rare. The purpose of this case report is to report pars plana vitrectomy for the treatment of full thickness macular hole in a patient with adult onset Coats disease. A young male presented with decreased ...

Last Updated: 31 Dec 1969

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Vitrectomy for epiretinal membrane in adult-onset Coats' disease.
 

Author(s): Pradeep Kumar, Vinod Kumar

Journal: Indian J Ophthalmol. 2017 Oct;65(10):1046-1048.

 

Coats' disease is characterized by retinal vascular telangiectasia and subretinal and intraretinal exudation. A relatively benign form of the disease that occurs in adults is referred to as adult-onset Coats' disease. Involvement of macula in the form of macular edema and exudation ...

Last Updated: 31 Dec 1969

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Cyclophotocoagulation-induced sympathetic ophthalmia in a Coats' disease patient supported by histopathology and immunohistochemistry.
 

Author(s): Pritam Bawankar, Dipankar Das, Shahinur Tayab, Ganesh Chandra Kuri, Jnanankar Medhi, Manabjyoti Barman, Ronel Soibam, Harsha Bhattacharjee, Panna Deka, Diva Kant Misra, Shriya Dhar

Journal: Indian J Ophthalmol. 2017 Aug;65(8):744-746.

 

We describe a case of a 13-year-old male patient of Coats' disease who developed sympathetic ophthalmia (SO) following contact diode laser cyclophotocoagulation. There was no history of invasive surgery or any perforating injuries preceding cyclodestructive therapy. The eye had neovascular ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Coats Disease" returned 4 free, full-text review articles on human participants. First 3 results:

Coats' disease in Tanzania: first case report and literature review.
 

Author(s): Belson Rugwizangoga, Theresia Mwabili, Trishia Scanlan, Peter Meyer, James Kitinya

Journal: Afr Health Sci. 2014 Sep;14(3):763-8.

 

Coats' disease is an exudative retinal detachment with vascular telangiectasis occurring mostly in male children, the age group most affected by retinoblastoma.

Last Updated: 31 Dec 1969

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Diagnosis and treatment of coats' disease: a review of the literature.
 

Author(s): Samim Ghorbanian, Adil Jaulim, Irini P Chatziralli

Journal: Ophthalmologica. 2012 ;227(4):175-82.

 

Coats' disease is an idiopathic, ophthalmic condition characterized by retinal telangiectasis, intraretinal and subretinal exudation, which can lead to retinal detachment. It is mostly unilateral, progressive and affects mainly males during childhood, although adult cases have also ...

Last Updated: 31 Dec 1969

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[Coats disease].
 

Author(s): P Gastaud

Journal: J Fr Ophtalmol. 2001 Nov;24(9):976-83.

 

In spite of an unclear definition of Coats disease, this angiomatosis can be defined by the presence of retinal telangiectasis of nondetectable etiology, complicated by severe exudative phenomena. The diagnosis of this serious affection remains difficult because of its numerous clinical ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 10 Apr 2018

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DiRectional AthErectomy + Drug CoAted BaLloon to Treat Long, CalcifIed FemoropopliTeal ArterY Lesions
 

Status: Recruiting

Condition Summary: Peripheral Vascular Disease

 

Last Updated: 26 Jul 2016

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Last Updated: 24 Jan 2018

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