Coats Disease

Common Name(s)

Coats Disease

Coats disease is an eye disorder characterized by abnormal development of the blood vessels in the retina (retinal telangiectasia). Most affected people begin showing symptoms of the condition in childhood. Early signs and symptoms vary but may include vision loss, crossed eyes (strabismus), and a white mass in the pupil behind the lens of the eye (leukocoria). Overtime, coats disease may also lead to retinal detachment, glaucoma, and clouding of the lens of the eye (cataracts) as the disease progresses. In most cases, only one eye is affected (unilateral). The exact underlying cause is not known but some cases may be due to somatic mutations in the NDP gene. Treatment depends on the symptoms present and may include cryotherapy, laser therapy, and/or surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Coats Disease" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

Last Updated: 1 Nov 2014

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The Jack McGovern Coats Disease Foundation

JMCDF was founded in 2006 by the parents of Jack McGovern as a promise to their son that they would never rest until there was a cure for Coats’ Disease.To this end the foundation was started to raise funds in support of ongoing research designed not only to support ongoing research to restore Jack’s vision, but also to offer all children like Jack hope as they wage a lifelong battle against Coats’ Disease and blindness.

Last Updated: 15 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Coats Disease" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

http://www.dcoutreach.com

Last Updated: 1 Nov 2014

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The Jack McGovern Coats Disease Foundation

JMCDF was founded in 2006 by the parents of Jack McGovern as a promise to their son that they would never rest until there was a cure for Coats’ Disease.To this end the foundation was started to raise funds in support of ongoing research designed not only to support ongoing research to restore Jack’s vision, but also to offer all children like Jack hope as they wage a lifelong battle against Coats’ Disease and blindness.

http://www.coatsdiseasefoundation.org

Last Updated: 15 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Coats Disease" returned 37 free, full-text research articles on human participants. First 3 results:

Risk of Tractional Retinal Detachment Following Intravitreal Bevacizumab Along with Subretinal Fluid Drainage and Cryotherapy for Stage 3B Coats' Disease.
 

Author(s): Vishalakshi Bhat, Palmeera D'Souza, Parag K Shah, V Narendran

Journal: Middle East Afr J Ophthalmol. ;23(2):208-11.

 

To review the surgical outcomes of intravitreal bevacizumab (IVB) along with subretinal fluid drainage with cryotherapy in patients with stage 3B Coats' disease.

Last Updated: 10 May 2016

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Successful use of intravitreal ranibizumab injection and combined treatment in the management of Coats' disease.
 

Author(s): Qiong Yang, Wenbin Wei, Xuehui Shi, Lihong Yang

Journal: Acta Ophthalmol. 2016 Jun;94(4):401-6.

 

To observe the efficacy of intravitreal ranibizumab (IVR) combined with another ablative therapy, such as laser photocoagulation, for Coats' disease.

Last Updated: 24 May 2016

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Coats' disease and retrobulbar haemodynamics.
 

Author(s): Qi Zhao, Xiao-Yan Peng, Wen-Li Yang, Dong-Jun Li, Qi-Sheng You, Jost B Jonas

Journal: Acta Ophthalmol. 2016 Jun;94(4):397-400.

 

To study the retrobulbar haemodynamics in patients with Coats' disease.

Last Updated: 24 May 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Coats Disease" returned 3 free, full-text review articles on human participants. First 3 results:

Coats' disease in Tanzania: first case report and literature review.
 

Author(s): Belson Rugwizangoga, Theresia Mwabili, Trishia Scanlan, Peter Meyer, James Kitinya

Journal: Afr Health Sci. 2014 Sep;14(3):763-8.

 

Coats' disease is an exudative retinal detachment with vascular telangiectasis occurring mostly in male children, the age group most affected by retinoblastoma.

Last Updated: 29 Oct 2014

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[Coats disease].
 

Author(s): P Gastaud

Journal: J Fr Ophtalmol. 2001 Nov;24(9):976-83.

 

In spite of an unclear definition of Coats disease, this angiomatosis can be defined by the presence of retinal telangiectasis of nondetectable etiology, complicated by severe exudative phenomena. The diagnosis of this serious affection remains difficult because of its numerous clinical ...

Last Updated: 26 Mar 2002

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Advanced Coats' disease.
 

Author(s): B G Haik

Journal: Trans Am Ophthalmol Soc. 1991 ;89():371-476.

 

Advanced Coats' disease and retinoblastoma can both present with the triad of a retinal detachment, the appearance of a subretinal mass, and dilated retinal vessels. Thus, even the most experienced observer may not be able to differentiate these entities on ophthalmoscopic findings ...

Last Updated: 20 May 1992

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 31 May 2017

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DiRectional AthErectomy + Drug CoAted BaLloon to Treat Long, CalcifIed FemoropopliTeal ArterY Lesions
 

Status: Recruiting

Condition Summary: Peripheral Vascular Disease

 

Last Updated: 26 Jul 2016

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