Coats Disease

Common Name(s)

Coats Disease

Coats disease is an eye disorder characterized by abnormal development of the blood vessels of the retina (retinal telangiectasia). Signs and symptoms differ depending on the extent and size of blood vessels involved; some individuals are asymptomatic while others are severly affected. Symptoms typically begin at an early age (most commonly between ages 6 to 8) and may include vision loss; crossed eyes (strabismus); a white mass in the pupil behind the lens of the eye (leukokoria); and/or retinal detachment. In most cases, only one eye is affected (unilateral) but in rare cases both eyes are affected (bilateral). The cause is not exactly known but some cases may be due to somatic mutations in the NDP gene. Treatment depends on the symptoms present and may include cryotherapy, laser therapy, photocoagulation and/or surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Coats Disease" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

Last Updated: 2 Oct 2014

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The Jack McGovern Coats Disease Foundation

JMCDF was founded in 2006 by the parents of Jack McGovern as a promise to their son that they would never rest until there was a cure for Coats’ Disease.To this end the foundation was started to raise funds in support of ongoing research designed not only to support ongoing research to restore Jack’s vision, but also to offer all children like Jack hope as they wage a lifelong battle against Coats’ Disease and blindness.

Last Updated: 15 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Coats Disease" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

http://www.dcoutreach.com

Last Updated: 2 Oct 2014

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The Jack McGovern Coats Disease Foundation

JMCDF was founded in 2006 by the parents of Jack McGovern as a promise to their son that they would never rest until there was a cure for Coats’ Disease.To this end the foundation was started to raise funds in support of ongoing research designed not only to support ongoing research to restore Jack’s vision, but also to offer all children like Jack hope as they wage a lifelong battle against Coats’ Disease and blindness.

http://www.coatsdiseasefoundation.org

Last Updated: 15 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Coats Disease" returned 26 free, full-text research articles on human participants. First 3 results:

Combined treatment for Coats' disease: retinal laser photocoagulation combined with intravitreal bevacizumab injection was effective in two cases.
 

Author(s): Aya Kodama, Koji Sugioka, Shunji Kusaka, Chota Matsumoto, Yoshikazu Shimomura

Journal:

 

The exact pathogenetic mechanisms of Coats' disease remain unknown. In this report, we show two cases of Coats' disease that achieved a favorable prognosis with the combined treatment of intravitreal bevacizumab (IVB) injection prior to photocoagulation, although both initially resisted ...

Last Updated: 31 Mar 2014

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Successful use of intravitreal bevacizumab and pascal laser photocoagulation in the management of adult Coats' disease.
 

Author(s): Naz Raoof, Fahd Quhill

Journal: Middle East Afr J Ophthalmol. ;20(3):256-8.

 

Traditional methods of managing exudative retinal detachment secondary to Coats' disease have been associated with varying degrees of success. We describe a case of a 34 year-old male who presented with a sub-total exudative retinal detachment of the right eye that encroached upon ...

Last Updated: 9 Sep 2013

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Functional characterization of human CTC1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease Coats plus.
 

Author(s): Peili Gu, Sandy Chang

Journal: Aging Cell. 2013 Dec;12(6):1100-9.

 

Coats plus is a rare recessive disorder characterized by intracranial calcifications, hematological abnormalities, and retinal vascular defects. This disease results from mutations in CTC1, a member of the CTC1-STN1-TEN1 (CST) complex critical for telomere replication. Telomeres are ...

Last Updated: 22 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Coats Disease" returned 3 free, full-text review articles on human participants. First 3 results:

Diagnosis and treatment of coats' disease: a review of the literature.
 

Author(s): Samim Ghorbanian, Adil Jaulim, Irini P Chatziralli

Journal: Ophthalmologica. 2012 ;227(4):175-82.

 

Coats' disease is an idiopathic, ophthalmic condition characterized by retinal telangiectasis, intraretinal and subretinal exudation, which can lead to retinal detachment. It is mostly unilateral, progressive and affects mainly males during childhood, although adult cases have also ...

Last Updated: 27 Apr 2012

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[Coats disease].
 

Author(s): P Gastaud

Journal: J Fr Ophtalmol. 2001 Nov;24(9):976-83.

 

In spite of an unclear definition of Coats disease, this angiomatosis can be defined by the presence of retinal telangiectasis of nondetectable etiology, complicated by severe exudative phenomena. The diagnosis of this serious affection remains difficult because of its numerous clinical ...

Last Updated: 26 Mar 2002

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Advanced Coats' disease.
 

Author(s): B G Haik

Journal: Trans Am Ophthalmol Soc. 1991 ;89():371-476.

 

Advanced Coats' disease and retinoblastoma can both present with the triad of a retinal detachment, the appearance of a subretinal mass, and dilated retinal vessels. Thus, even the most experienced observer may not be able to differentiate these entities on ophthalmoscopic findings ...

Last Updated: 20 May 1992

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 30 Jan 2014

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Stenting With or Without Coating Compared With Angioplasty in Non-benestent Disease
 

Status: Not yet recruiting

Condition Summary: Coronary Artery Disease

 

Last Updated: 17 Aug 2010

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First-in-man Evaluation of a Novel, Microcrystalline Paclitaxel Coated Balloon for Treatment of Femoropopliteal Artery Restenosis (PAX-r)
 

Status: Not yet recruiting

Condition Summary: Femoropopliteal Artery Restenosis; Vascular Disease

 

Last Updated: 21 May 2014

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