Coats Disease

Common Name(s)

Coats Disease

Coats disease is an eye disorder characterized by abnormal development of the blood vessels in the retina (retinal telangiectasia). Most affected people begin showing symptoms of the condition in childhood. Early signs and symptoms vary but may include vision loss, crossed eyes (strabismus), and a white mass in the pupil behind the lens of the eye (leukocoria). Overtime, coats disease may also lead to retinal detachment, glaucoma, and clouding of the lens of the eye (cataracts) as the disease progresses. In most cases, only one eye is affected (unilateral). The exact underlying cause is not known but some cases may be due to somatic mutations in the NDP gene. Treatment depends on the symptoms present and may include cryotherapy, laser therapy, and/or surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Coats Disease" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

Last Updated: 1 Nov 2014

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The Jack McGovern Coats Disease Foundation

JMCDF was founded in 2006 by the parents of Jack McGovern as a promise to their son that they would never rest until there was a cure for Coats’ Disease.To this end the foundation was started to raise funds in support of ongoing research designed not only to support ongoing research to restore Jack’s vision, but also to offer all children like Jack hope as they wage a lifelong battle against Coats’ Disease and blindness.

Last Updated: 15 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Coats Disease" for support, advocacy or research.

Dyskeratosis Congenita Outreach, Inc.

Our mission is to provide information and support services to families affected by Dyskeratosis Congenita, a Telomere Biology Disorder worldwide, to encourage the medical community's research in finding causes and effective treatments, and to facilitate improved diagnosis by educating medical providers.

http://www.dcoutreach.com

Last Updated: 1 Nov 2014

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The Jack McGovern Coats Disease Foundation

JMCDF was founded in 2006 by the parents of Jack McGovern as a promise to their son that they would never rest until there was a cure for Coats’ Disease.To this end the foundation was started to raise funds in support of ongoing research designed not only to support ongoing research to restore Jack’s vision, but also to offer all children like Jack hope as they wage a lifelong battle against Coats’ Disease and blindness.

http://www.coatsdiseasefoundation.org

Last Updated: 15 Mar 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Coats Disease" returned 36 free, full-text research articles on human participants. First 3 results:

A Case of Congenital Simple Hamartoma of the Retinal Pigment Epithelium and Coats' Disease in the Same Eye.
 

Author(s): Won Jae Heo, Dong Ho Park, Jae Pil Shin

Journal: Korean J Ophthalmol. 2015 Aug;29(4):282-3.

 

Last Updated: 4 Aug 2015

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Coats disease.
 

Author(s): Samar Younes, Hicham Tahri

Journal:

 

Last Updated: 26 Jun 2015

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Case of adult-onset Coats' disease with epiretinal membrane treated with 25-gauge pars plana vitrectomy.
 

Author(s): Akiko Mino, Yoshinori Mitamura, Takashi Katome, Kentaro Semba, Mariko Egawa, Takeshi Naito

Journal: J. Med. Invest.. 2015 ;62(1-2):85-8.

 

We describe a case of untreated adult-onset Coats' disease with a proliferative epiretinal membrane (ERM) treated successfully with 25-gauge pars plana vitrectomy (25GPPV). A 26-year-old man presented with a 3-week history of decreased vision in his left eye. At the initial examination, ...

Last Updated: 30 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Coats Disease" returned 4 free, full-text review articles on human participants. First 3 results:

Coats' disease in Tanzania: first case report and literature review.
 

Author(s): Belson Rugwizangoga, Theresia Mwabili, Trishia Scanlan, Peter Meyer, James Kitinya

Journal: Afr Health Sci. 2014 Sep;14(3):763-8.

 

Coats' disease is an exudative retinal detachment with vascular telangiectasis occurring mostly in male children, the age group most affected by retinoblastoma.

Last Updated: 29 Oct 2014

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Diagnosis and treatment of coats' disease: a review of the literature.
 

Author(s): Samim Ghorbanian, Adil Jaulim, Irini P Chatziralli

Journal: Ophthalmologica. 2012 ;227(4):175-82.

 

Coats' disease is an idiopathic, ophthalmic condition characterized by retinal telangiectasis, intraretinal and subretinal exudation, which can lead to retinal detachment. It is mostly unilateral, progressive and affects mainly males during childhood, although adult cases have also ...

Last Updated: 27 Apr 2012

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[Coats disease].
 

Author(s): P Gastaud

Journal: J Fr Ophtalmol. 2001 Nov;24(9):976-83.

 

In spite of an unclear definition of Coats disease, this angiomatosis can be defined by the presence of retinal telangiectasis of nondetectable etiology, complicated by severe exudative phenomena. The diagnosis of this serious affection remains difficult because of its numerous clinical ...

Last Updated: 26 Mar 2002

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 17 Nov 2015

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DiRectional AthErectomy + Drug CoAted BaLloon to Treat Long, CalcifIed FemoropopliTeal ArterY Lesions
 

Status: Recruiting

Condition Summary: Peripheral Vascular Disease

 

Last Updated: 26 Jul 2016

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First-in-man Study of Titanium-Nitride Coated Woven-nitinol Peripheral Arterial Stent
 

Status: Recruiting

Condition Summary: Peripheral Arterial Disease

 

Last Updated: 19 Feb 2016

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