Clostridium Difficile

Common Name(s)

Clostridium Difficile

Clostridium difficile colitis, also known as c. diff, is a type of bacterial infection that may affect the colon. The colon is the last portion of the gastrointestinal tract, which helps digest food and form stool. Clostridium difficile colitis can cause bloating, severe diarrhea, and abdominal pain. It is commonly related to overuse of antibiotics in older or hospitalized people. Physicians can diagnose clostridium difficile colitis by testing the stool for the bacteria or the toxins that it creates. Clostridium difficile colitis is treated with specific antibiotics to kill the bacteria, and other antibiotics are often stopped. Other newer treatments include probiotics and fecal transplants.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clostridium Difficile" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clostridium Difficile" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clostridium Difficile" returned 1441 free, full-text research articles on human participants. First 3 results:

Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function.
 

Author(s): Jhansi L Leslie, Sha Huang, Judith S Opp, Melinda S Nagy, Masayuki Kobayashi, Vincent B Young, Jason R Spence

Journal: Infect. Immun.. 2015 Jan;83(1):138-45.

 

Clostridium difficile is the leading cause of infectious nosocomial diarrhea. The pathogenesis of C. difficile infection (CDI) results from the interactions between the pathogen, intestinal epithelium, host immune system, and gastrointestinal microbiota. Previous studies of the host-pathogen ...

Last Updated: 17 Dec 2014

Go To URL
Severe community onset healthcare-associated Clostridium difficile infection complicated by carbapenemase producing Klebsiella pneumoniae bloodstream infection.
 

Author(s): Simone Giuliano, Maurizio Guastalegname, Miryam Jenco, Andrea Morelli, Marco Falcone, Mario Venditti

Journal:

 

Clostridium difficile infection (CDI) and Klebsiella pneumoniae carbapenemase producing-Klebsiella pneumoniae (KPC-Kp) bloodstream infection (BSI) are emerging health-care associated (HCA) diseases of public health concern, in terms of morbidity, mortality, and insufficient response ...

Last Updated: 9 Sep 2014

Go To URL
Incidence of diarrhea by Clostridium difficile in hematologic patients and hematopoietic stem cell transplantation patients: risk factors for severe forms and death.
 

Author(s): Fernanda Spadão, Juliana Gerhardt, Thais Guimarães, Frederico Dulley, João Nóbrega de Almeida Junior, Marjorie Vieira Batista, Maria Aparecida Shikanai-Yasuda, Anna Sara Levin, Silvia Figueiredo Costa

Journal: Rev. Inst. Med. Trop. Sao Paulo. ;56(4):325-31.

 

We describe the rate of incidence of Clostridium difficile-associated diarrhea (CDAD) in hematologic and patients undergone stem cell transplant (HSCT) at HC-FMUSP, from January 2007 to June 2011, using two denominators 1,000 patient and 1,000 days of neutropenia and the risk factors ...

Last Updated: 31 Jul 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clostridium Difficile" returned 153 free, full-text review articles on human participants. First 3 results:

Role of microbiota and innate immunity in recurrent Clostridium difficile infection.
 

Author(s): Stefano Bibbò, Loris Riccardo Lopetuso, Gianluca Ianiro, Teresa Di Rienzo, Antonio Gasbarrini, Giovanni Cammarota

Journal: J Immunol Res. 2014 ;2014():462740.

 

Recurrent Clostridium difficile infection represents a burdensome clinical issue whose epidemiology is increasing worldwide. The pathogenesis is not yet completely known. Recent observations suggest that the alteration of the intestinal microbiota and impaired innate immunity may ...

Last Updated: 4 Jul 2014

Go To URL
Clostridium difficile infection: a worldwide disease.
 

Author(s): Kristin E Burke, J Thomas Lamont

Journal: Gut Liver. 2014 Jan;8(1):1-6.

 

Clostridium difficile, an anaerobic toxigenic bacterium, causes a severe infectious colitis that leads to significant morbidity and mortality worldwide. Both enhanced bacterial toxins and diminished host immune response contribute to symptomatic disease. C. difficile has been a well-established ...

Last Updated: 11 Feb 2014

Go To URL
Clostridium difficile infection: molecular pathogenesis and novel therapeutics.
 

Author(s): Ardeshir Rineh, Michael J Kelso, Fatma Vatansever, George P Tegos, Michael R Hamblin

Journal: Expert Rev Anti Infect Ther. 2014 Jan;12(1):131-50.

 

The Gram-positive anaerobic bacterium Clostridium difficile produces toxins A and B, which can cause a spectrum of diseases from pseudomembranous colitis to C. difficile-associated diarrhea. A limited number of C. difficile strains also produce a binary toxin that exhibits ADP ribosyltransferase ...

Last Updated: 13 Jan 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of CB-183,315 in Patients With Clostridium Difficile Associated Diarrhea
 

Status: Recruiting

Condition Summary: Clostridium Difficile Infection

 

Last Updated: 12 Feb 2015

Go to URL
Study of a Candidate Clostridium Difficile Toxoid Vaccine in Subjects at Risk for C. Difficile Infection
 

Status: Recruiting

Condition Summary: Clostridium Difficile Infection

 

Last Updated: 11 Apr 2014

Go to URL
The Risk for Clostridium Difficile Colitis During Hospitalization in Asymptomatic Carriers
 

Status: Not yet recruiting

Condition Summary: Clostridium Difficile; Colitis

 

Last Updated: 13 Feb 2014

Go to URL