Clostridium Difficile

Common Name(s)

Clostridium Difficile

Clostridium difficile colitis, also known as c. diff, is a type of bacterial infection that may affect the colon. The colon is the last portion of the gastrointestinal tract, which helps digest food and form stool. Clostridium difficile colitis can cause bloating, severe diarrhea, and abdominal pain. It is commonly related to overuse of antibiotics in older or hospitalized people. Physicians can diagnose clostridium difficile colitis by testing the stool for the bacteria or the toxins that it creates. Clostridium difficile colitis is treated with specific antibiotics to kill the bacteria, and other antibiotics are often stopped. Other newer treatments include probiotics and fecal transplants.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clostridium Difficile" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clostridium Difficile" returned 1528 free, full-text research articles on human participants. First 3 results:

Vitamin D deficiency is associated with community-acquired clostridium difficile infection: a case-control study.
 

Author(s): Tanya Sahay, Ashwin N Ananthakrishnan

Journal:

 

Clostridium difficile infection (CDI) is increasingly recognized as an important community acquired pathogen causing disease (CA-CDI). Vitamin D [25(OH)D] has immune modulatory effects and plays an important role in intestinal immunity. The role of vitamin D in CA-CDI has not been ...

Last Updated: 8 Dec 2014

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Whole genome sequencing reveals potential spread of Clostridium difficile between humans and farm animals in the Netherlands, 2002 to 2011.
 

Author(s): C W Knetsch, T R Connor, A Mutreja, S M van Dorp, I M Sanders, H P Browne, D Harris, L Lipman, E C Keessen, J Corver, E J Kuijper, T D Lawley

Journal:

 

Farm animals are a potential reservoir for human Clostridium difficile infection (CDI), particularly PCR ribotype 078 which is frequently found in animals and humans. Here, whole genome single-nucleotide polymorphism (SNP) analysis was used to study the evolutionary relatedness of ...

Last Updated: 21 Nov 2014

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Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function.
 

Author(s): Jhansi L Leslie, Sha Huang, Judith S Opp, Melinda S Nagy, Masayuki Kobayashi, Vincent B Young, Jason R Spence

Journal: Infect. Immun.. 2015 Jan;83(1):138-45.

 

Clostridium difficile is the leading cause of infectious nosocomial diarrhea. The pathogenesis of C. difficile infection (CDI) results from the interactions between the pathogen, intestinal epithelium, host immune system, and gastrointestinal microbiota. Previous studies of the host-pathogen ...

Last Updated: 17 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clostridium Difficile" returned 176 free, full-text review articles on human participants. First 3 results:

Molecular epidemiology of Clostridium difficile for clinical practice.
 

Author(s): Sarah Tschudin-Sutter

Journal:

 

During the last decade, the world has witnessed numerous outbreaks of Clostridium difficile infections (CDI) in healthcare settings. Increasing incidence rates of CDI have been mainly attributed to the successful global spread of a more virulent strain of C. difficile - namely PCR-ribotype ...

Last Updated: 11 Sep 2014

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Proton pump inhibitors and risk for Clostridium difficile associated diarrhea.
 

Author(s): Sasmita Biswal

Journal: Biomed J. ;37(4):178-83.

 

Increased incidence of Clostridium difficile infection (CDI) among in-patients is associated with significant increased mortality, morbidity, and stay in the hospitals. This has occurred despite heightened awareness of the risks of broad-spectrum antibiotics, overall reduction in ...

Last Updated: 13 Aug 2014

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Role of microbiota and innate immunity in recurrent Clostridium difficile infection.
 

Author(s): Stefano Bibbò, Loris Riccardo Lopetuso, Gianluca Ianiro, Teresa Di Rienzo, Antonio Gasbarrini, Giovanni Cammarota

Journal: J Immunol Res. 2014 ;2014():462740.

 

Recurrent Clostridium difficile infection represents a burdensome clinical issue whose epidemiology is increasing worldwide. The pathogenesis is not yet completely known. Recent observations suggest that the alteration of the intestinal microbiota and impaired innate immunity may ...

Last Updated: 4 Jul 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of CB-183,315 in Patients With Clostridium Difficile Associated Diarrhea
 

Status: Recruiting

Condition Summary: Clostridium Difficile Infection

 

Last Updated: 10 Apr 2015

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Study of a Candidate Clostridium Difficile Toxoid Vaccine in Subjects at Risk for C. Difficile Infection
 

Status: Recruiting

Condition Summary: Clostridium Difficile Infection

 

Last Updated: 14 May 2015

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The Risk for Clostridium Difficile Colitis During Hospitalization in Asymptomatic Carriers
 

Status: Not yet recruiting

Condition Summary: Clostridium Difficile; Colitis

 

Last Updated: 13 Feb 2014

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