Clostridium Difficile

Common Name(s)

Clostridium Difficile

Clostridium difficile colitis, also known as c. diff, is a type of bacterial infection that may affect the colon. The colon is the last portion of the gastrointestinal tract, which helps digest food and form stool. Clostridium difficile colitis can cause bloating, severe diarrhea, and abdominal pain. It is commonly related to overuse of antibiotics in older or hospitalized people. Physicians can diagnose clostridium difficile colitis by testing the stool for the bacteria or the toxins that it creates. Clostridium difficile colitis is treated with specific antibiotics to kill the bacteria, and other antibiotics are often stopped. Other newer treatments include probiotics and fecal transplants.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clostridium Difficile" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clostridium Difficile" returned 1938 free, full-text research articles on human participants. First 3 results:

Hospital readmission with Clostridium difficile infection as a secondary diagnosis is associated with worsened outcomes and greater revenue loss relative to principal diagnosis: A retrospective cohort study.
 

Author(s): Marya D Zilberberg, Brian H Nathanson, Stephen Marcella, John Jay Hawkshead, Andrew F Shorr

Journal: Medicine (Baltimore). 2018 Sep;97(36):e12212.

 

Recurrent Clostridium difficile infection (rCDI) requiring rehospitalization contributes to poor outcomes, which may differ between patients hospitalized with versus for it.We performed a multicenter retrospective cohort study of rehospitalized adults surviving initial CDI hospitalization. ...

Last Updated: 31 Dec 1969

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Epidemiological and genomic characterization of community-acquired Clostridium difficile infections.
 

Author(s): Christina S Thornton, Joseph E Rubin, Alexander L Greninger, Gisele Peirano, Charles Y Chiu, Dylan R Pillai

Journal:

 

Clostridium difficile infection (CDI) is a major cause of morbidity and mortality in North America and Europe. The aim of this study was to identify epidemiologically-confirmed cases of community-acquired (CA)-CDI in a large North American urban center and analyze isolates using multiple ...

Last Updated: 31 Dec 1969

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The use of faecal microbiota transplant as treatment for recurrent or refractory infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines.
 

Author(s): Benjamin H Mullish, Mohammed Nabil Quraishi, Jonathan P Segal, Victoria L McCune, Melissa Baxter, Gemma L Marsden, David J Moore, Alaric Colville, Neeraj Bhala, Tariq H Iqbal, Christopher Settle, Graziella Kontkowski, Ailsa L Hart, Peter M Hawkey, Simon D Goldenberg, Horace R T Williams

Journal: Gut. 2018 11;67(11):1920-1941.

 

Interest in the therapeutic potential of faecal microbiota transplant (FMT) has been increasing globally in recent years, particularly as a result of randomised studies in which it has been used as an intervention. The main focus of these studies has been the treatment of recurrent ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clostridium Difficile" returned 265 free, full-text review articles on human participants. First 3 results:

Outcomes of intrahospital antimicrobial stewardship programs related to prevention of Clostridium difficile infection outbreaks.
 

Author(s): Biljana Mijović, Milena Dubravac Tanasković, Maja Račić, Janja Bojanić, Slobodan Stanić, Dušica Banković Lazarević

Journal: Med Glas (Zenica). 2018 Aug;15(2):122-131.

 

Aim To synthesize evidence about the influence of individual antimicrobial stewardship programs (ASP) related to the prevention of Clostridium difficile (C. difficile) infection on primary and secondary outcomes. Methods Relevant databases such as Medline, PUBMED, COCHRANE library ...

Last Updated: 31 Dec 1969

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Primary prevention of Clostridium difficile infections with a specific probiotic combining Lactobacillus acidophilus, L. casei, and L. rhamnosus strains: assessing the evidence.
 

Author(s): L V McFarland, N Ship, J Auclair, M Millette

Journal: J. Hosp. Infect.. 2018 Aug;99(4):443-452.

 

Clostridium difficile infection (CDI) has become the leading healthcare-associated infection and cause of outbreaks around the world. Although various innovative treatments have been developed, preventive strategies using multi-faceted infection control programmes have not been successful ...

Last Updated: 31 Dec 1969

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Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms.
 

Author(s): Saeed S Banawas

Journal:

 

is the most prevalent causative pathogen of healthcare-associated diarrhea. Notably, over the past 10 years, the number of outbreaks has increased with the rate of morbidity and mortality. The occurrence and spread of strains that are resistant to multiple antimicrobial drugs complicate ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Prevention of Clostridium Difficile Infections Using Lactobacillus Plantarum 299v Strain
 

Status: Not yet recruiting

Condition Summary: Clostridium Difficile

 

Last Updated: 8 Dec 2017

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Last Updated: 22 Feb 2017

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Last Updated: 7 Aug 2018

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