Clostridium Difficile

Common Name(s)

Clostridium Difficile

Clostridium difficile colitis, also known as c. diff, is a type of bacterial infection that may affect the colon. The colon is the last portion of the gastrointestinal tract, which helps digest food and form stool. Clostridium difficile colitis can cause bloating, severe diarrhea, and abdominal pain. It is commonly related to overuse of antibiotics in older or hospitalized people. Physicians can diagnose clostridium difficile colitis by testing the stool for the bacteria or the toxins that it creates. Clostridium difficile colitis is treated with specific antibiotics to kill the bacteria, and other antibiotics are often stopped. Other newer treatments include probiotics and fecal transplants.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clostridium Difficile" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clostridium Difficile" returned 1598 free, full-text research articles on human participants. First 3 results:

Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection.
 

Author(s): Mark H Wilcox, Dale N Gerding, Ian R Poxton, Ciaran Kelly, Richard Nathan, Thomas Birch, Oliver A Cornely, Galia Rahav, Emilio Bouza, Christine Lee, Grant Jenkin, Werner Jensen, You-Sun Kim, Junichi Yoshida, Lori Gabryelski, Alison Pedley, Karen Eves, Robert Tipping, Dalya Guris, Nicholas Kartsonis, Mary-Beth Dorr,

Journal: N. Engl. J. Med.. 2017 01;376(4):305-317.

 

Background Clostridium difficile is the most common cause of infectious diarrhea in hospitalized patients. Recurrences are common after antibiotic therapy. Actoxumab and bezlotoxumab are human monoclonal antibodies against C. difficile toxins A and B, respectively. Methods We conducted ...

Last Updated: 25 Jan 2017

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Fecal Calprotectin Level Reflects the Severity of Clostridium difficile Infection.
 

Author(s): Jieun Kim, Heejung Kim, Hyun Ju Oh, Hyung Sun Kim, Youn Jee Hwang, Dongeun Yong, Seok Hoon Jeong, Kyungwon Lee

Journal: Ann Lab Med. 2017 Jan;37(1):53-57.

 

Clostridium difficile is a significant nosocomial and community-acquired pathogen, and is the leading cause of antibiotic-induced diarrhea associated with high morbidity and mortality. Given that the treatment outcome depends on the severity of C. difficile infection (CDI), we aimed ...

Last Updated: 11 Nov 2016

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Heat shock increases conjugation efficiency in Clostridium difficile.
 

Author(s): Joseph A Kirk, Robert P Fagan

Journal: Anaerobe. 2016 Dec;42():1-5.

 

Clostridium difficile infection has increased in incidence and severity over the past decade, and poses a unique threat to human health. However, genetic manipulation of C. difficile remains in its infancy and the bacterium remains relatively poorly characterised. Low-efficiency conjugation ...

Last Updated: 24 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clostridium Difficile" returned 194 free, full-text review articles on human participants. First 3 results:

Ridinilazole: a novel therapy for Clostridium difficile infection.
 

Author(s): Richard J Vickers, Glenn Tillotson, Ellie J C Goldstein, Diane M Citron, Kevin W Garey, Mark H Wilcox

Journal: Int. J. Antimicrob. Agents. 2016 Aug;48(2):137-43.

 

Clostridium difficile infection (CDI) is the leading cause of infectious healthcare-associated diarrhoea. Recurrent CDI increases disease morbidity and mortality, posing a high burden to patients and a growing economic burden to the healthcare system. Thus, there exists a significant ...

Last Updated: 1 Aug 2016

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Impact of microbial derived secondary bile acids on colonization resistance against Clostridium difficile in the gastrointestinal tract.
 

Author(s): Jenessa A Winston, Casey M Theriot

Journal: Anaerobe. 2016 Oct;41():44-50.

 

Clostridium difficile is an anaerobic, Gram positive, spore-forming bacillus that is the leading cause of nosocomial gastroenteritis. Clostridium difficile infection (CDI) is associated with increasing morbidity and mortality, consequently posing an urgent threat to public health. ...

Last Updated: 22 May 2016

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The role of Clostridium difficile in the paediatric and neonatal gut - a narrative review.
 

Author(s): E A Lees, F Miyajima, M Pirmohamed, E D Carrol

Journal: Eur. J. Clin. Microbiol. Infect. Dis.. 2016 Jul;35(7):1047-57.

 

Clostridium difficile is an important nosocomial pathogen in adults. Its significance in children is less well defined, but cases of C. difficile infection (CDI) appear to be increasingly prevalent in paediatric patients. This review aims to summarize reported Clostridium difficile ...

Last Updated: 11 Jun 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 5 Sep 2015

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IMT for Primary Clostridium Difficile Infection
 

Status: Recruiting

Condition Summary: Clostridium Difficile Infection

 

Last Updated: 4 Feb 2015

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Last Updated: 2 Aug 2016

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