Clostridium Difficile

Common Name(s)

Clostridium Difficile

Clostridium difficile colitis, also known as c. diff, is a type of bacterial infection that may affect the colon. The colon is the last portion of the gastrointestinal tract, which helps digest food and form stool. Clostridium difficile colitis can cause bloating, severe diarrhea, and abdominal pain. It is commonly related to overuse of antibiotics in older or hospitalized people. Physicians can diagnose clostridium difficile colitis by testing the stool for the bacteria or the toxins that it creates. Clostridium difficile colitis is treated with specific antibiotics to kill the bacteria, and other antibiotics are often stopped. Other newer treatments include probiotics and fecal transplants.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clostridium Difficile" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clostridium Difficile" returned 1502 free, full-text research articles on human participants. First 3 results:

Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function.
 

Author(s): Jhansi L Leslie, Sha Huang, Judith S Opp, Melinda S Nagy, Masayuki Kobayashi, Vincent B Young, Jason R Spence

Journal: Infect. Immun.. 2015 Jan;83(1):138-45.

 

Clostridium difficile is the leading cause of infectious nosocomial diarrhea. The pathogenesis of C. difficile infection (CDI) results from the interactions between the pathogen, intestinal epithelium, host immune system, and gastrointestinal microbiota. Previous studies of the host-pathogen ...

Last Updated: 17 Dec 2014

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A search for Clostridium difficile ribotypes 027 and 078 in Brazil.
 

Author(s): Alexandre de Almeida Monteiro, Renata Neto Pires, Søren Persson, Edison Moraes Rodrigues Filho, Alessandro Comarú Pasqualotto

Journal: Braz J Infect Dis. ;18(6):672-4.

 

Toxigenic strains of Clostridium difficile may be disseminating. Here we prospectively screened patients with nosocomial diarrhoea in two hospitals in Brazil. To identify C. difficile polymerase chain reaction ribotypes 027/078 strains, we used high resolution melting and multiplex ...

Last Updated: 9 Dec 2014

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Evaluation of three enzyme immunoassays and a nucleic acid amplification test for the diagnosis of Clostridium difficile-associated diarrhea at a university hospital in Brazil.
 

Author(s): Rodrigo Otávio Silveira Silva, Eduardo Garcia Vilela, Monique Silva Neves, Francisco Carlos Faria Lobato

Journal: Rev. Soc. Bras. Med. Trop.. 2014 Jul;47(4):447-50.

 

Despite the known importance of Clostridium difficile as a nosocomial pathogen, few studies regarding Clostridium difficile infection (CDI) in Brazil have been conducted. To date, the diagnostic tests that are available on the Brazilian market for the diagnosis of CDI have not been ...

Last Updated: 18 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clostridium Difficile" returned 170 free, full-text review articles on human participants. First 3 results:

Role of microbiota and innate immunity in recurrent Clostridium difficile infection.
 

Author(s): Stefano Bibbò, Loris Riccardo Lopetuso, Gianluca Ianiro, Teresa Di Rienzo, Antonio Gasbarrini, Giovanni Cammarota

Journal: J Immunol Res. 2014 ;2014():462740.

 

Recurrent Clostridium difficile infection represents a burdensome clinical issue whose epidemiology is increasing worldwide. The pathogenesis is not yet completely known. Recent observations suggest that the alteration of the intestinal microbiota and impaired innate immunity may ...

Last Updated: 4 Jul 2014

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Recurrent Clostridium difficile infections: the importance of the intestinal microbiota.
 

Author(s): Marie Céline Zanella Terrier, Martine Louis Simonet, Philippe Bichard, Jean Louis Frossard

Journal: World J. Gastroenterol.. 2014 Jun;20(23):7416-23.

 

Clostridium difficile infections (CDI) are a leading cause of antibiotic-associated and nosocomial diarrhea. Despite effective antibiotic treatments, recurrent infections are common. With the recent emergence of hypervirulent isolates of C. difficile, CDI is a growing epidemic with ...

Last Updated: 26 Jun 2014

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Risk factors for recurrence, complications and mortality in Clostridium difficile infection: a systematic review.
 

Author(s): Claire Nour Abou Chakra, Jacques Pepin, Stephanie Sirard, Louis Valiquette

Journal:

 

Clostridium difficile infection (CDI) can lead to complications, recurrence, and death. Numerous studies have assessed risk factors for these unfavourable outcomes, but systematic reviews or meta-analyses published so far were limited in scope or in quality.

Last Updated: 6 Jun 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of CB-183,315 in Patients With Clostridium Difficile Associated Diarrhea
 

Status: Recruiting

Condition Summary: Clostridium Difficile Infection

 

Last Updated: 10 Apr 2015

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Study of a Candidate Clostridium Difficile Toxoid Vaccine in Subjects at Risk for C. Difficile Infection
 

Status: Recruiting

Condition Summary: Clostridium Difficile Infection

 

Last Updated: 17 Mar 2015

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The Risk for Clostridium Difficile Colitis During Hospitalization in Asymptomatic Carriers
 

Status: Not yet recruiting

Condition Summary: Clostridium Difficile; Colitis

 

Last Updated: 13 Feb 2014

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