Clostridium Difficile

Common Name(s)

Clostridium Difficile

Clostridium difficile colitis, also known as c. diff, is a type of bacterial infection that may affect the colon. The colon is the last portion of the gastrointestinal tract, which helps digest food and form stool. Clostridium difficile colitis can cause bloating, severe diarrhea, and abdominal pain. It is commonly related to overuse of antibiotics in older or hospitalized people. Physicians can diagnose clostridium difficile colitis by testing the stool for the bacteria or the toxins that it creates. Clostridium difficile colitis is treated with specific antibiotics to kill the bacteria, and other antibiotics are often stopped. Other newer treatments include probiotics and fecal transplants.

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Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clostridium Difficile" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clostridium Difficile" returned 1380 free, full-text research articles on human participants. First 3 results:

Incidence of diarrhea by Clostridium difficile in hematologic patients and hematopoietic stem cell transplantation patients: risk factors for severe forms and death.
 

Author(s): Fernanda Spadão, Juliana Gerhardt, Thais Guimarães, Frederico Dulley, João Nóbrega de Almeida Junior, Marjorie Vieira Batista, Maria Aparecida Shikanai-Yasuda, Anna Sara Levin, Silvia Figueiredo Costa

Journal: Rev. Inst. Med. Trop. Sao Paulo. ;56(4):325-31.

 

We describe the rate of incidence of Clostridium difficile-associated diarrhea (CDAD) in hematologic and patients undergone stem cell transplant (HSCT) at HC-FMUSP, from January 2007 to June 2011, using two denominators 1,000 patient and 1,000 days of neutropenia and the risk factors ...

Last Updated: 31 Jul 2014

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International Clostridium difficile animal strain collection and large diversity of animal associated strains.
 

Author(s): Sandra Janezic, Valerija Zidaric, Bart Pardon, Alexander Indra, Branko Kokotovic, Jose Luis Blanco, Christian Seyboldt, Cristina Rodriguez Diaz, Ian R Poxton, Vincent Perreten, Ilenia Drigo, Alena Jiraskova, Matjaz Ocepek, J Scott Weese, J Glenn Songer, Mark H Wilcox, Maja Rupnik

Journal:

 

Clostridium difficile is an important cause of intestinal infections in some animal species and animals might be a reservoir for community associated human infections. Here we describe a collection of animal associated C. difficile strains from 12 countries based on inclusion criteria ...

Last Updated: 17 Jul 2014

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CAGS and ACS evidence based reviews in surgery. Is a diverting loop ileostomy and colonic lavage an alternative to colectomy for the treatment of severe Clostridium difficile-associated disease?
 

Author(s): Carl J Brown, Marylise Boutros, Andrew Morris, Celia M Divino,

Journal: Can J Surg. 2014 Jun;57(3):214-6.

 

The term “evidence-based medicine” was first coined by Sackett and colleagues as “the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients.”1 The key to practising evidencebased medicine is applying the ...

Last Updated: 29 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clostridium Difficile" returned 148 free, full-text review articles on human participants. First 3 results:

Clostridium difficile infection: a worldwide disease.
 

Author(s): Kristin E Burke, J Thomas Lamont

Journal: Gut Liver. 2014 Jan;8(1):1-6.

 

Clostridium difficile, an anaerobic toxigenic bacterium, causes a severe infectious colitis that leads to significant morbidity and mortality worldwide. Both enhanced bacterial toxins and diminished host immune response contribute to symptomatic disease. C. difficile has been a well-established ...

Last Updated: 11 Feb 2014

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Parameters for the mathematical modelling of Clostridium difficile acquisition and transmission: a systematic review.
 

Author(s): Eroboghene H Otete, Anand S Ahankari, Helen Jones, Kirsty J Bolton, Caroline W Jordan, Tim C Boswell, Mark H Wilcox, Neil M Ferguson, Charles R Beck, Richard L Puleston

Journal:

 

Mathematical modelling of Clostridium difficile infection dynamics could contribute to the optimisation of strategies for its prevention and control. The objective of this systematic review was to summarise the available literature specifically identifying the quantitative parameters ...

Last Updated: 30 Dec 2013

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Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile infection among hospitalized patients: systematic review and meta-analysis.
 

Author(s): Reena Pattani, Valerie A Palda, Stephen W Hwang, Prakeshkumar S Shah

Journal:

 

Antibiotic-associated diarrhea (AAD) and Clostridium difficile infection (CDI) are associated with high morbidity, mortality, and health care costs. Probiotics may mitigate the existing disease burden. We performed a systematic review and meta-analysis to evaluate the efficacy of ...

Last Updated: 18 Dec 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Risk for Clostridium Difficile Colitis During Hospitalization in Asymptomatic Carriers
 

Status: Not yet recruiting

Condition Summary: Clostridium Difficile; Colitis

 

Last Updated: 13 Feb 2014

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Study of CB-183,315 in Patients With Clostridium Difficile Associated Diarrhea
 

Status: Recruiting

Condition Summary: Clostridium Difficile Infection

 

Last Updated: 13 Nov 2014

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A Study of CB-183,315 in Patients With Clostridium Difficile Associated Diarrhea
 

Status: Recruiting

Condition Summary: Clostridium Difficile Infection

 

Last Updated: 13 Nov 2014

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