Clostridium Difficile

Common Name(s)

Clostridium Difficile

Clostridium difficile colitis, also known as c. diff, is a type of bacterial infection that may affect the colon. The colon is the last portion of the gastrointestinal tract, which helps digest food and form stool. Clostridium difficile colitis can cause bloating, severe diarrhea, and abdominal pain. It is commonly related to overuse of antibiotics in older or hospitalized people. Physicians can diagnose clostridium difficile colitis by testing the stool for the bacteria or the toxins that it creates. Clostridium difficile colitis is treated with specific antibiotics to kill the bacteria, and other antibiotics are often stopped. Other newer treatments include probiotics and fecal transplants.

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clostridium Difficile" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clostridium Difficile" returned 1675 free, full-text research articles on human participants. First 3 results:

Risk of surgical site infection, acute kidney injury, and Clostridium difficile infection following antibiotic prophylaxis with vancomycin plus a beta-lactam versus either drug alone: A national propensity-score-adjusted retrospective cohort study.
 

Author(s): Westyn Branch-Elliman, John E Ripollone, William J O'Brien, Kamal M F Itani, Marin L Schweizer, Eli Perencevich, Judith Strymish, Kalpana Gupta

Journal:

 

The optimal regimen for perioperative antimicrobial prophylaxis is controversial. Use of combination prophylaxis with a beta-lactam plus vancomycin is increasing; however, the relative risks and benefits associated with this strategy are unknown. Thus, we sought to compare postoperative ...

Last Updated: 10 Jul 2017

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Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferiority study.
 

Author(s): Richard J Vickers, Glenn S Tillotson, Richard Nathan, Sabine Hazan, John Pullman, Christopher Lucasti, Kenneth Deck, Bruce Yacyshyn, Benedict Maliakkal, Yves Pesant, Bina Tejura, David Roblin, Dale N Gerding, Mark H Wilcox,

Journal: Lancet Infect Dis. 2017 Jul;17(7):735-744.

 

Clostridium difficile infection is the most common health-care-associated infection in the USA. We assessed the safety and efficacy of ridinilazole versus vancomycin for treatment of C difficile infection.

Last Updated: 2 May 2017

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Bezlotoxumab and Recurrent Clostridium difficile Infection.
 

Author(s): Mark Wilcox, Mary-Beth Dorr, Alison Pedley

Journal: N. Engl. J. Med.. 2017 04;376(16):1594-6.

 

Last Updated: 19 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clostridium Difficile" returned 209 free, full-text review articles on human participants. First 3 results:

Infection prevention and control of Clostridium difficile: a global review of guidelines, strategies, and recommendations.
 

Author(s): Evelyn Balsells, Teodora Filipescu, Moe H Kyaw, Camilla Wiuff, Harry Campbell, Harish Nair

Journal: J Glob Health. 2016 Dec;6(2):020410.

 

Clostridium difficile is the leading cause of health care-associated infections. Given the high incidence of C. difficile infection (CDI) and the lack of primary prevention through immunization, health care professionals should be aware of the most current guidance, as well as strengths ...

Last Updated: 28 Dec 2016

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Clostridium difficile: A healthcare-associated infection of unknown significance in adults in sub-Saharan Africa.
 

Author(s): Alexander J Keeley, Nicholas J Beeching, Katharine E Stott, Paul Roberts, Alastair J Watson, Michael Bj Beadsworth

Journal: Malawi Med J. 2016 Jun;28(2):66-69.

 

Clostridium difficile infection (CDI) causes a high burden of disease in high-resource healthcare systems, with significant morbidity, mortality, and financial implications. CDI is a healthcare-associated infection for which the primary risk factor is antibiotic usage, and it is the ...

Last Updated: 29 Nov 2016

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Fecal Microbiota-based Therapeutics for Recurrent Clostridium difficile Infection, Ulcerative Colitis and Obesity.
 

Author(s): Christian Carlucci, Elaine O Petrof, Emma Allen-Vercoe

Journal: EBioMedicine. 2016 Nov;13():37-45.

 

The human gut microbiome is a complex ecosystem of fundamental importance to human health. Our increased understanding of gut microbial composition and functional interactions in health and disease states has spurred research efforts examining the gut microbiome as a valuable target ...

Last Updated: 10 Oct 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 22 Feb 2017

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IMT for Primary Clostridium Difficile Infection
 

Status: Recruiting

Condition Summary: Clostridium Difficile Infection

 

Last Updated: 4 Feb 2015

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Last Updated: 2 Aug 2016

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