Clostridium Difficile

Common Name(s)

Clostridium Difficile

Clostridium difficile colitis, also known as c. diff, is a type of bacterial infection that may affect the colon. The colon is the last portion of the gastrointestinal tract, which helps digest food and form stool. Clostridium difficile colitis can cause bloating, severe diarrhea, and abdominal pain. It is commonly related to overuse of antibiotics in older or hospitalized people. Physicians can diagnose clostridium difficile colitis by testing the stool for the bacteria or the toxins that it creates. Clostridium difficile colitis is treated with specific antibiotics to kill the bacteria, and other antibiotics are often stopped. Other newer treatments include probiotics and fecal transplants.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clostridium Difficile" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clostridium Difficile" returned 1749 free, full-text research articles on human participants. First 3 results:

Analysis of Clostridium difficile infections in patients hospitalized at the nephrological ward in Poland.
 

Author(s): Agata Kujawa-Szewieczek, Marcin Adamczak, Katarzyna Kwiecień, Sylwia Dudzicz, Zofia Prażak, Andrzej Więcek

Journal:

 

Few studies have evaluated the incidence and risk factors of Clostridium difficile infection (CDI) in the adult Polish population, in particular in solid organ recipients hospitalized at the nephrological ward.

Last Updated: 16 May 2016

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Cost-Effectiveness Analysis of Six Strategies to Treat Recurrent Clostridium difficile Infection.
 

Author(s): Lauren Lapointe-Shaw, Kim L Tran, Peter C Coyte, Rebecca L Hancock-Howard, Jeff Powis, Susan M Poutanen, Susy Hota

Journal:

 

To assess the cost-effectiveness of six treatment strategies for patients diagnosed with recurrent Clostridium difficile infection (CDI) in Canada: 1. oral metronidazole; 2. oral vancomycin; 3.oral fidaxomicin; 4. fecal transplantation by enema; 5. fecal transplantation by nasogastric ...

Last Updated: 23 Feb 2016

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An Integrated Metabolomic and Microbiome Analysis Identified Specific Gut Microbiota Associated with Fecal Cholesterol and Coprostanol in Clostridium difficile Infection.
 

Author(s): Vijay C Antharam, Daniel C McEwen, Timothy J Garrett, Aaron T Dossey, Eric C Li, Andrew N Kozlov, Zhubene Mesbah, Gary P Wang

Journal:

 

Clostridium difficile infection (CDI) is characterized by dysbiosis of the intestinal microbiota and a profound derangement in the fecal metabolome. However, the contribution of specific gut microbes to fecal metabolites in C. difficile-associated gut microbiome remains poorly understood. ...

Last Updated: 13 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clostridium Difficile" returned 223 free, full-text review articles on human participants. First 3 results:

[Clostridium difficile associated diarrhea in children].
 

Author(s): Pilar Rodríguez, José Cofré

Journal: Rev Chilena Infectol. 2015 Oct;32(5):550-8.

 

Clostridium difficile is the most commonly isolated organism in antimicrobial and health care-associated diarrhea and is growing in relevance in community-acquired infections. It is a Gram-positive bacillus acquired via the fecal-oral route in the community and in hospital setting.

Last Updated: 4 Dec 2015

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Asymptomatic Clostridium difficile colonization: epidemiology and clinical implications.
 

Author(s): Luis Furuya-Kanamori, John Marquess, Laith Yakob, Thomas V Riley, David L Paterson, Niki F Foster, Charlotte A Huber, Archie C A Clements

Journal:

 

The epidemiology of Clostridium difficile infection (CDI) has changed over the past decades with the emergence of highly virulent strains. The role of asymptomatic C. difficile colonization as part of the clinical spectrum of CDI is complex because many risk factors are common to ...

Last Updated: 17 Nov 2015

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Interactions Between the Gastrointestinal Microbiome and Clostridium difficile.
 

Author(s): Casey M Theriot, Vincent B Young

Journal: Annu. Rev. Microbiol.. 2015 ;69():445-61.

 

Antibiotics have significant and long-lasting effects on the intestinal microbiota and consequently reduce colonization resistance against pathogens, including Clostridium difficile. By altering the community structure of the gut microbiome, antibiotics alter the intestinal metabolome, ...

Last Updated: 22 Oct 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of a Candidate Clostridium Difficile Toxoid Vaccine (Cdiffense) in Subjects at Risk for C. Difficile Infection
 

Status: Recruiting

Condition Summary: Clostridium Difficile Infection

 

Last Updated: 20 Jun 2016

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Vancomycin Prophylaxis in Recurrent Clostridium Difficile Infection
 

Status: Recruiting

Condition Summary: Clostridium Difficile Infection

 

Last Updated: 10 Sep 2014

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Fecal Microbiota Transplantation in Recurrent or Refractory Clostridium Difficile Colitis
 

Status: Not yet recruiting

Condition Summary: Clostridium Difficile; Clostridium Difficile Infection

 

Last Updated: 10 Oct 2013

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