Clostridium Difficile

Common Name(s)

Clostridium Difficile

Clostridium difficile colitis, also known as c. diff, is a type of bacterial infection that may affect the colon. The colon is the last portion of the gastrointestinal tract, which helps digest food and form stool. Clostridium difficile colitis can cause bloating, severe diarrhea, and abdominal pain. It is commonly related to overuse of antibiotics in older or hospitalized people. Physicians can diagnose clostridium difficile colitis by testing the stool for the bacteria or the toxins that it creates. Clostridium difficile colitis is treated with specific antibiotics to kill the bacteria, and other antibiotics are often stopped. Other newer treatments include probiotics and fecal transplants.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clostridium Difficile" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clostridium Difficile" returned 1343 free, full-text research articles on human participants. First 3 results:

CAGS and ACS evidence based reviews in surgery. Is a diverting loop ileostomy and colonic lavage an alternative to colectomy for the treatment of severe Clostridium difficile-associated disease?
 

Author(s): Carl J Brown, Marylise Boutros, Andrew Morris, Celia M Divino,

Journal: Can J Surg. 2014 Jun;57(3):214-6.

 

The term “evidence-based medicine” was first coined by Sackett and colleagues as “the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients.”1 The key to practising evidencebased medicine is applying the ...

Last Updated: 29 May 2014

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Increased incidence of Clostridium difficile PCR ribotype 027 in Hesse, Germany, 2011 to 2013.
 

Author(s): M Arvand, D Vollandt, G Bettge-Weller, C Harmanus, E J Kuijper,

Journal:

 

After the first outbreak of Clostridium difficile PCR ribotype (RT) 027 in Germany in 2007, no further outbreaks were reported until the recent re-emergence of RT 027 in Hesse, a federal state with 6 million inhabitants located in south-west Germany. We undertook a survey to determine ...

Last Updated: 21 Mar 2014

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Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence.
 

Author(s): Carsten Schwan, Anna S Kruppke, Thilo Nölke, Lucas Schumacher, Friedrich Koch-Nolte, Mikhail Kudryashev, Henning Stahlberg, Klaus Aktories

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Feb;111(6):2313-8.

 

Clostridium difficile causes antibiotic-associated diarrhea and pseudomembranous colitis by the actions of Rho-glucosylating toxins A and B. Recently identified hypervirulent strains, which are associated with increased morbidity and mortality, additionally produce the actin-ADP-ribosylating ...

Last Updated: 12 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clostridium Difficile" returned 143 free, full-text review articles on human participants. First 3 results:

Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile infection among hospitalized patients: systematic review and meta-analysis.
 

Author(s): Reena Pattani, Valerie A Palda, Stephen W Hwang, Prakeshkumar S Shah

Journal:

 

Antibiotic-associated diarrhea (AAD) and Clostridium difficile infection (CDI) are associated with high morbidity, mortality, and health care costs. Probiotics may mitigate the existing disease burden. We performed a systematic review and meta-analysis to evaluate the efficacy of ...

Last Updated: 18 Dec 2013

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Clostridium difficile and inflammatory bowel disease: role in pathogenesis and implications in treatment.
 

Author(s): Orna Nitzan, Mazen Elias, Bibiana Chazan, Raul Raz, Walid Saliba

Journal: World J. Gastroenterol.. 2013 Nov;19(43):7577-85.

 

Clostridium difficile (C. difficile) is the leading cause of antibiotic associated colitis and nosocomial diarrhea. Patients with inflammatory bowel disease (IBD) are at increased risk of developing C. difficile infection (CDI), have worse outcomes of CDI-including higher rates of ...

Last Updated: 27 Nov 2013

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Faecal microbiota transplantation for the treatment of recurrent Clostridium difficile infection: current promise and future needs.
 

Author(s): Mark J Koenigsknecht, Vincent B Young

Journal: Curr. Opin. Gastroenterol.. 2013 Nov;29(6):628-32.

 

The use of faecal microbiota transplantation (FMT) as treatment for recurrent Clostridium difficile infection (CDI) has increased rapidly over the past few years. In this review, we highlight clinical studies of FMT for treatment of recurrent CDI and discuss the safety, standardization ...

Last Updated: 9 Oct 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fecal Microbiota Transplantation in Recurrent or Refractory Clostridium Difficile Colitis
 

Status: Not yet recruiting

Condition Summary: Clostridium Difficile; Clostridium Difficile Infection

 

Last Updated: 10 Oct 2013

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Last Updated: 11 Aug 2014

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Oral Vancomycin Followed by Fecal Transplant Versus Tapering Oral Vancomycin
 

Status: Recruiting

Condition Summary: Recurrent Clostridium Difficile Infection; Laboratory Confirmed Clostridium Difficile Infection

 

Last Updated: 14 Jan 2013

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