Cloacal Exstrophy

Common Name(s)

Cloacal Exstrophy

Cloacal exstrophy is a rare genetic condition. This condition results from a mutation or error in a person’s DNA or genes that causes severe birth defects where much of the abdominal organs, like the bladder and intestines, are exposed. It can also cause the male and female genitalia, the penis or clitoris respectively, to split, and the anus can be sealed. Cloacal exstrophy occurs 1 in 400,000 live births and can usually be diagnosed before birth during an ultrasound. Although there is currently no cure for cloacal exstrophy, there are various resources available to patients to help manage the condition and treat birth defects, including surgical repair, which may also require several additional reconstructive surgeries over many years. Doctors seek help from various therapists and community services to provide support and care for families affected by cloacal exstrophy.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cloacal Exstrophy" for support, advocacy or research.

Pull-thru Network, Inc.

The Pull-thru Network is a volunteer-based organization dedicated to providing education, information, support and advocacy for those individuals, and the families of those individuals, who are affected by any congenital anorectal, colorectal or urogenital disorder and any of the variety of related diagnoses.

Last Updated: 8 Nov 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cloacal Exstrophy" for support, advocacy or research.

Pull-thru Network, Inc.

The Pull-thru Network is a volunteer-based organization dedicated to providing education, information, support and advocacy for those individuals, and the families of those individuals, who are affected by any congenital anorectal, colorectal or urogenital disorder and any of the variety of related diagnoses.

http://www.PullthruNetwork.org

Last Updated: 8 Nov 2012

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cloacal Exstrophy" returned 13 free, full-text research articles on human participants. First 3 results:

Cloacal exstrophy: a complex disease.
 

Author(s): Antonio Macedo, Atila Rondon, Ricardo Frank, Herick Bacelar, Bruno Leslie, Sergio Ottoni, Gilmar Garrone, Riberto Liguori, Valdemar Ortiz

Journal: Int Braz J Urol. ;39(6):897; discussion 898.

 

Cloacal exstrophy is a rare occurrence with an incidence of 1:200,000 to 1:400,000 live births. It represents one of the most challenging reconstructive endeavors faced by pediatric surgeons and urologists. Aside from the genitourinary defects, there are other associated anomalies ...

Last Updated: 24 Jan 2014

Go To URL
Cloacal exstrophy with vesicoureteric junction obstruction: rare association.
 

Author(s): Amit Singh, Minu Bajpai, Abid Ali

Journal: Afr J Paediatr Surg. ;10(3):282-4.

 

Cloacal exstrophy is an extremely rare congenital abnormality resulting in an exstrophy of the urinary, intestinal and genital organs and associated with anomalies of other organ systems. We report a complicated case of cloacal exstrophy associated with right vesicoureteric junction obstruction.

Last Updated: 6 Nov 2013

Go To URL
Y chromosome aberration in a patient with cloacal-bladder exstrophy-epispadias complex: an unusual finding.
 

Author(s): Mirian Yumie Nishi, Thais Cotrim Martins, Elaine Maria Frade Costa, Berenice Bilharinho Mendonca, Amilcar Martins Giron, Sorahia Domenice

Journal: Arq Bras Endocrinol Metabol. 2013 Mar;57(2):148-52.

 

Chromosome aberrations or genetic syndromes associated with cloacal-bladder exstrophy complex have rarely been reported. The aim of this report is to describe a 14 year-old female Brazilian patient with a complex urogenital malformation, short stature, lack of secondary se-xual characteristics ...

Last Updated: 25 Mar 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cloacal Exstrophy" returned 1 free, full-text review articles on human participants. First 3 results:

Cloacal exstrophy: a case report and literature review.
 

Author(s): Vitalij Varygin, Šarūnas Bernotas, Pranas Gurskas, Valerijus Karmanovas, Sigitas Strupas, Olga Zimanaitė, Gilvydas Verkauskas

Journal: Medicina (Kaunas). 2011 ;47(12):682-5.

 

Cloacal exstrophy is an extremely rare congenital malformation resulting in an exstrophy of the urinary, intestinal, and genital organs and associated with anomalies of other organ systems. We present a complicated case of cloacal exstrophy and the recent progress in the management ...

Last Updated: 28 Feb 2012

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.