Cleft Palate

Common Name(s)

Cleft Palate, Cleft palate, isolated

Cleft palate as an isolated malformation behaves as an entity distinct from cleft lip with or without cleft palate (see {119530}). Dominantly inherited cleft soft palate in 4 generations has been reported ({6:Jenkins and Stady, 1980}); see {119570}.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cleft Palate" for support, advocacy or research.

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Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

Last Updated: 15 Apr 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cleft Palate" for support, advocacy or research.

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Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

http://www.oklahomafamilynetwork.org

Last Updated: 15 Apr 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cleft Palate" returned 501 free, full-text research articles on human participants. First 3 results:

Amelogenin gene influence on enamel defects of cleft lip and palate patients.
 

Author(s): Fernanda Veronese Oliveira, Thiago José Dionísio, Lucimara Teixeira Neves, Maria Aparecida Andrade Moreira Machado, Carlos Ferreira Santos, Thais Marchini Oliveira

Journal: Braz Oral Res. ;28(1):.

 

The aim of this study was to investigate the occurrence of mutations in the amelogenin gene (AMELX) in patients with cleft lip and palate (CLP) and enamel defects (ED). A total of 165 patients were divided into four groups: with CLP and ED (n=46), with CLP and without ED (n = 34), ...

Last Updated: 29 Aug 2014

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Prevalence, pattern and perceptions of cleft lip and cleft palate among children born in two hospitals in Kisoro District, Uganda.
 

Author(s): Teopista Kesande, Louis Mugambe Muwazi, Aisha Bataringaya, Charles Mugisha Rwenyonyi

Journal:

 

Cleft lip with or without cleft palate is one of the most common congenital anomalies that affect the oro-facial region. The aim of the study was to determine the period prevalence, pattern and perceptions of cleft lip and cleft palate in children born between 2005 and 2010 in two ...

Last Updated: 21 Aug 2014

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Association between polymorphism of TGFA Taq I and cleft lip and/or palate: a meta-analysis.
 

Author(s): Cuijuan Feng, Enjiao Zhang, Weiyi Duan, Zhongfei Xu, Yang Zhang, Li Lu

Journal:

 

Cleft lip and palate (CL/P) is one of the most common malformations in humans. Transforming growth factor alpha (TGFA) is a well characterized mammalian growth factor which might contribute to the development of CL/P. This meta-analysis aimed to summarize the association between the ...

Last Updated: 22 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cleft Palate" returned 29 free, full-text review articles on human participants. First 3 results:

Genetics of cleft lip and cleft palate.
 

Author(s): Elizabeth J Leslie, Mary L Marazita

Journal: Am J Med Genet C Semin Med Genet. 2013 Nov;163C(4):246-58.

 

Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with these birth defects and their family members: from subclinical phenotypes to associated syndromic ...

Last Updated: 29 Oct 2013

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Indices to assess malocclusions in patients with cleft lip and palate.
 

Author(s): Mostafa Altalibi, Humam Saltaji, Ryan Edwards, Paul W Major, Carlos Flores-Mir

Journal: Eur J Orthod. 2013 Dec;35(6):772-82.

 

Several indices are now available to assess the severity of the malocclusion in cleft lip and/or palate (CLP) patients; and although it has been quite some time since the introduction of these indices, there is no consensus as to which index should be used for CLP populations.

Last Updated: 26 Nov 2013

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MOMENT--Management of Otitis Media with Effusion in Cleft Palate: protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey.
 

Author(s): Nicola L Harman, Iain A Bruce, Peter Callery, Stephanie Tierney, Mohammad Owaise Sharif, Kevin O'Brien, Paula R Williamson

Journal:

 

Cleft palate (CP) has an incidence of approximately 1 in 700. Children with CP are also susceptible to otitis media with effusion (OME), with approximately 90% experiencing nontrivial OME. There are several approaches to the management of OME in children with CP. The Management of ...

Last Updated: 22 Jul 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Timing of Primary Surgery for Cleft Palate
 

Status: Recruiting

Condition Summary: Cleft Palate

 

Last Updated: 15 Aug 2013

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An Investigation for the Optimal Timing of a Cleft Palate Repair
 

Status: Recruiting

Condition Summary: Cleft Palate

 

Last Updated: 23 Oct 2008

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Preoperative Antibiotics Study
 

Status: Recruiting

Condition Summary: Cleft Palates

 

Last Updated: 29 Jul 2013

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