Cleft Palate

Common Name(s)

Cleft Palate, Cleft palate, isolated

Cleft palate as an isolated malformation behaves as an entity distinct from cleft lip with or without cleft palate (see {119530}). Dominantly inherited cleft soft palate in 4 generations has been reported ({6:Jenkins and Stady, 1980}); see {119570}.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cleft Palate" for support, advocacy or research.

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Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

Last Updated: 15 Apr 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cleft Palate" for support, advocacy or research.

Logo
Oklahoma Family Network

To Provide emotional, informational and navigational support to those who have special health care needs or a disability, their families and the professionals who serve them. OFN promotes family/professional partnerships and family-centered care, assuring services are offered as recipients prefer..

http://www.oklahomafamilynetwork.org

Last Updated: 15 Apr 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cleft Palate" returned 633 free, full-text research articles on human participants. First 3 results:

The Nasolabial Angle Among Patients with Total Cleft Lip and Palate.
 

Author(s): Anna M Paradowska-Stolarz, Beata Kawala

Journal: Adv Clin Exp Med. ;24(3):481-5.

 

Nasolabial angle is the angle that is measured between points columella, subnasale and labiale superius. The reference values vary from 90 to 120 degrees (the mean value is 109.8 degrees). In some disorders, nasolabial angle might change. This influences the facial profile. One of ...

Last Updated: 15 Oct 2015

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A 5.8 Mb interstitial deletion on chromosome Xq21.1 in a boy with intellectual disability, cleft palate, hearing impairment and combined growth hormone deficiency.
 

Author(s): M Giordano, C Gertosio, S Pagani, C Meazza, I Fusco, E Bozzola, M Bozzola

Journal:

 

Deletions of the long arm of chromosome X in males are a rare cause of X-linked intellectual disability. Here we describe a patient with an interstitial deletion of the Xq21.1 chromosome.

Last Updated: 1 Sep 2015

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A Case-control Study of Environmental Risk Factors for Nonsyndromic Cleft of the Lip and/or Palate in Xuzhou, China.
 

Author(s): Li Fang Xu, Xiao Long Zhou, Qi Wang, Ji Long Zhou, Ya Peng Liu, Qiang Ju, Hui Wang, Jin Peng Zhang, Qing Rong Wu, Yi Qun Li, Yu Juan Xia, Xiu Peng, Mei Rong Zhang, Hong Min Yu, Li Chun Xu

Journal: Biomed. Environ. Sci.. 2015 Jul;28(7):535-8.

 

In this study, we sought to determine the association between environmental factors and nonsyndromic cleft of the lip and/or palate (NSCLP) to understand the etiology of the disease. A total of 200 NSCLP cases and 327 controls were recruited at the Maternal and Child Health Hospital ...

Last Updated: 7 Aug 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cleft Palate" returned 31 free, full-text review articles on human participants. First 3 results:

Grommets for otitis media with effusion in children with cleft palate: a systematic review.
 

Author(s): Chin-Lung Kuo, Yuan-Heng Tsao, Hao-Min Cheng, Chiang-Feng Lien, Chyong-Hsin Hsu, Chii-Yuan Huang, An-Suey Shiao

Journal: Pediatrics. 2014 Nov;134(5):983-94.

 

No consensus has yet been reached with regard to the link between otitis media with effusion (OME), hearing loss, and language development in children with cleft palate. The objective of this study was to address the effectiveness of ventilation tube insertion (VTI) for OME in children ...

Last Updated: 3 Nov 2014

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How various surgical protocols of the unilateral cleft lip and palate influence the facial growth and possible orthodontic problems? Which is the best timing of lip, palate and alveolus repair? literature review.
 

Author(s): Giampietro Farronato, Laima Kairyte, Lucia Giannini, Guido Galbiati, Cinzia Maspero

Journal: Stomatologija. 2014 ;16(2):53-60.

 

OBJECTIVES. Cleft lip palate is congenital growth disease with unknown etiology, probably linked to both genetically and external causes. The aim of this work consists in presenting the effects of these diseases on cranio facial growth and the surgical protocols described in literature. ...

Last Updated: 11 Sep 2014

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Genetics of cleft lip and cleft palate.
 

Author(s): Elizabeth J Leslie, Mary L Marazita

Journal: Am J Med Genet C Semin Med Genet. 2013 Nov;163C(4):246-58.

 

Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with these birth defects and their family members: from subclinical phenotypes to associated syndromic ...

Last Updated: 29 Oct 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Timing of Primary Surgery for Cleft Palate
 

Status: Recruiting

Condition Summary: Cleft Palate

 

Last Updated: 26 May 2015

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An Investigation for the Optimal Timing of a Cleft Palate Repair
 

Status: Recruiting

Condition Summary: Cleft Palate

 

Last Updated: 23 Oct 2008

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Improving Outcomes in Cleft Palate Surgery
 

Status: Recruiting

Condition Summary: Cleft Palate

 

Last Updated: 20 Oct 2015

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