Cleft Lip/Palate

Common Name(s)

Cleft Lip/Palate

Cleft lip and palate are common birth defects that affect the development of an infant’s mouth or lip. Cleft lip is when the lip does not completely form, leaving a gap in the middle of the upper lip on either side of the nose. Cleft palate is when there is a hole in the roof of the infant’s mouth. It is possible to have either of these conditions or a combination of both. Prenatal ultrasounds sometimes detect the presence of the cleft before birth. The cause is usually unknown and cannot be prevented, but sometimes exposure to certain viruses or drugs taken during pregnancy may cause cleft lip and/or palate. Cleft lip is more common in boys, while cleft palate is more common in girls. Children with cleft lip and/or palate often have trouble talking or feeding. They can also have more frequent ear infections, hearing loss, and teeth problems. Surgery to close the opening is usually possible, and is typically done before 12 months for cleft lip or 18 months for cleft palate. Although many children with the condition require dental-orthodontic care and sometimes other surgeries, they can typically lead a normal life with treatment.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cleft Lip/Palate" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cleft Lip/Palate" returned 22 free, full-text research articles on human participants. First 3 results:

A genome-wide study of de novo deletions identifies a candidate locus for non-syndromic isolated cleft lip/palate risk.
 

Author(s): Samuel G Younkin, Robert B Scharpf, Holger Schwender, Margaret M Parker, Alan F Scott, Mary L Marazita, Terri H Beaty, Ingo Ruczinski

Journal:

 

Copy number variants (CNVs) may play an important part in the development of common birth defects such as oral clefts, and individual patients with multiple birth defects (including clefts) have been shown to carry small and large chromosomal deletions. In this paper we investigate ...

Last Updated: 20 Feb 2014

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Registries of cleft lip/palate cases between 2004 and 2010 in Denizli, Turkey.
 

Author(s): A G Tomatir, I Acikbas, B Akdag, A Köksal

Journal:

 

Oral clefts are one of the most common birth defects in humans. However, few population-based studies of these defects have been carried out in Turkey. Our objective was to determine the registries of cases of cleft lip and palate. All cases of cleft lip and palate referred to central ...

Last Updated: 13 Nov 2013

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[Ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome, report of a case with variable expressivity].
 

Author(s): Luis Enrique Meza Escobar, Carolina Isaza, Harry Pachajoa

Journal: Arch Argent Pediatr. 2012 Oct;110(5):e95-8.

 

The ectrodactyly-ectodermal dysplasia-cleft lip/palate syndrome is a rare entity associated with mutations in the genes that express the protein p63. We present a case of a patient with right foot ectrodactyly associated with cleft lip and palate, without other evident anomalies. ...

Last Updated: 16 Oct 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cleft Lip/Palate" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients
 

Status: Recruiting

Condition Summary: Cleft Lip and Palate

 

Last Updated: 30 Aug 2013

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One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy
 

Status: Recruiting

Condition Summary: Cleft Lip and Palate; Le Fort

 

Last Updated: 3 Jun 2013

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