Cleft lip/palate

Common Name(s)

Cleft lip/palate, Cleft lip and palate

Cleft lip and palate are common birth defects that affect the development of the lip or roof of the mouth (palate). Cleft lip occurs when the lip does not completely form and leaves a cleft or split in the upper lip on either side of the nose (unilateral cleft lip) or both sides (bilateral cleft lip). Cleft palate is when the palate does not completely close leaving a gap in the roof of the mouth inside. It is possible to have either cleft palate or cleft lip alone, or both cleft lip and palate. Cleft lip and palate are noted at birth and can sometimes be seen on ultrasound during pregnancy. Clefts occur very early in pregnancy, typically before most women even know they are pregnant (between 4-6 weeks).

The cause of both types of clefting is considered multifactorial meaning that risk factors include both genetic and environmental influences. These risk factors may include but are not limited to family history, race (most common in Indian and Asian backgrounds), gender (cleft lip more common in boys, cleft palate more common in girls), certain medications during pregnancy, chemical or drug exposures during pregnancy, viruses and genetic factors as well. Risks to have a child with a cleft lip and/or palate increase when other family members have been born with clefts. In families with no family history who have had a child born with a cleft lip or palate have a 2-6% risk for a second child to be born with a cleft. Even within families, the type and severity of clefts can vary greatly.

Babies born with clefts may have difficulty feeding, more frequent ear infections, sometimes hearing loss and dental problems. Surgery to correct a cleft lip is usually done by 12 months and 18 months for a cleft palate closure. Although many children born with clefts require dental and orthodontic care or other surgeries later, they typically lead a normal life after treatment.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cleft lip/palate" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cleft lip/palate" returned 35 free, full-text research articles on human participants. First 3 results:

3D analysis of effects of primary surgeries in cleft lip/palate children during the first two years of life.
 

Author(s): Karine Laskos Sakoda, Paula Karine Jorge, Cleide Felício Carvalho Carrara, Maria Aparecida de Andrade Moreira Machado, Fabrício Pinelli Valarelli, Arnaldo Pinzan, Thais Marchini Oliveira

Journal:

 

This study aimed at monitoring the maxillary growth of children with cleft lip/palate in the first two years of life, and to evaluate the effects of primary surgeries on dental arch dimensions. The sample consisted of the three-dimensional digital models of 25 subjects with unilateral ...

Last Updated: 7 Jun 2017

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[Cleft lip/palate and flour fortification with folic acid in Chile].
 

Author(s): Angélica Paulos, Paulina Pino, Gabriel Cavada, Carolina Lagos, Valentina Broussain, Andrea Hasbún

Journal: Rev Med Chil. 2016 Aug;144(8):1012-1019.

 

The effect of food fortification with folic acid on the incidence of lip-palate fissures (FLP) is under discussion.

Last Updated: 1 Dec 2016

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Time trend of incidence rates of cleft lip/palate in Taiwan from 1994 to 2013.
 

Author(s): Wei-Jung Chang, Lai-Chu See, Lun-Jou Lo

Journal: Biomed J. 2016 Apr;39(2):150-4.

 

This study was to estimate the incidence rate of cleft lip and/or cleft palate (CL/P) in Taiwan from 1994 to 2013, and to assess the time trend over these years.

Last Updated: 4 Jul 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cleft lip/palate" returned 1 free, full-text review articles on human participants. First 3 results:

Complications following orthognathic surgery for patients with cleft lip/palate: A systematic review.
 

Author(s): Kazuaki Yamaguchi, Daniel Lonic, Lun-Jou Lo

Journal: J. Formos. Med. Assoc.. 2016 Apr;115(4):269-77.

 

The purpose of this systematic review is to update the available data for complications following orthognathic surgery in cleft lip and/or palate patients.

Last Updated: 9 Apr 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate
 

Status: Recruiting

Condition Summary: Cleft Lip and Palate

 

Last Updated: 27 May 2016

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Evaluation of Arch Dimensions of Children With Surgically Repaired Unilateral Cleft Lip and Palate
 

Status: Not yet recruiting

Condition Summary: Surgically Repaired Unilateral Cleft Lip and Palate

 

Last Updated: 17 Jul 2017

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