Cleft Lip/Palate

Common Name(s)

Cleft Lip/Palate, Cleft lip and palate

Cleft lip and palate are common birth defects that affect the development of the lip or roof of the mouth (palate). Cleft lip occurs when the lip does not completely form and leaves a cleft or split in the upper lip on either side of the nose (unilateral cleft lip) or both (bilateral cleft lip). Cleft palate is when the palate does not completely close leaving a gap in the roof of the mouth inside. It is possible to have either cleft palate or cleft lip alone, or both cleft lip and palate. These types of defects are noted at birth and can sometimes be seen on ultrasound during pregnancy. Clefts occur very early in pregnancy, typically before most women even know they are pregnant (between 4-6 weeks). The cause of both types of clefting is considered multifactorial meaning that risk factors include both genetic and environmental influences. These risk factors may include but are not limited to family history, race (most common in Indian and Asian backgrounds), gender (cleft lip more common in boys, cleft palate more common in girls), certain medications during pregnancy, chemical or drug exposures during pregnancy, viruses and genetic factors as well. Risks to have a chlid with a cleft lip and/or palate increase when other family members have been born with clefts. In families with no family history who have had a child born with a cleft lip or palate have a 2-6% risk for a second child to be born with a cleft. Even within families, the type and severity of clefts can vary greatly. Babies born with clefts may have difficulty feeding, more frequent ear infections, sometimes hearing loss and dental problems. Surgery to correct a cleft lip is usually done by 12 months and 18 moths for a cleft palate closure. Although many children born with clefts require dental and orthodontic care or other surgeries later, they typically lead a normal life after treatment.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cleft Lip/Palate" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cleft Lip/Palate" returned 22 free, full-text research articles on human participants. First 3 results:

A genome-wide study of de novo deletions identifies a candidate locus for non-syndromic isolated cleft lip/palate risk.
 

Author(s): Samuel G Younkin, Robert B Scharpf, Holger Schwender, Margaret M Parker, Alan F Scott, Mary L Marazita, Terri H Beaty, Ingo Ruczinski

Journal:

 

Copy number variants (CNVs) may play an important part in the development of common birth defects such as oral clefts, and individual patients with multiple birth defects (including clefts) have been shown to carry small and large chromosomal deletions. In this paper we investigate ...

Last Updated: 20 Feb 2014

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Registries of cleft lip/palate cases between 2004 and 2010 in Denizli, Turkey.
 

Author(s): A G Tomatir, I Acikbas, B Akdag, A Köksal

Journal:

 

Oral clefts are one of the most common birth defects in humans. However, few population-based studies of these defects have been carried out in Turkey. Our objective was to determine the registries of cases of cleft lip and palate. All cases of cleft lip and palate referred to central ...

Last Updated: 13 Nov 2013

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[Ectrodactyly, ectodermal dysplasia and cleft lip/palate syndrome, report of a case with variable expressivity].
 

Author(s): Luis Enrique Meza Escobar, Carolina Isaza, Harry Pachajoa

Journal: Arch Argent Pediatr. 2012 Oct;110(5):e95-8.

 

The ectrodactyly-ectodermal dysplasia-cleft lip/palate syndrome is a rare entity associated with mutations in the genes that express the protein p63. We present a case of a patient with right foot ectrodactyly associated with cleft lip and palate, without other evident anomalies. ...

Last Updated: 16 Oct 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cleft Lip/Palate" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients
 

Status: Recruiting

Condition Summary: Cleft Lip and Palate

 

Last Updated: 30 Aug 2013

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One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy
 

Status: Recruiting

Condition Summary: Cleft Lip and Palate; Le Fort

 

Last Updated: 3 Jun 2013

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