Cleft lip/palate

Common Name(s)

Cleft lip/palate, Cleft lip and palate

Cleft lip and palate are common birth defects that affect the development of the lip or roof of the mouth (palate). Cleft lip occurs when the lip does not completely form and leaves a cleft or split in the upper lip on either side of the nose (unilateral cleft lip) or both sides (bilateral cleft lip). Cleft palate is when the palate does not completely close leaving a gap in the roof of the mouth inside. It is possible to have either cleft palate or cleft lip alone, or both cleft lip and palate. Cleft lip and palate are noted at birth and can sometimes be seen on ultrasound during pregnancy. Clefts occur very early in pregnancy, typically before most women even know they are pregnant (between 4-6 weeks).

The cause of both types of clefting is considered multifactorial meaning that risk factors include both genetic and environmental influences. These risk factors may include but are not limited to family history, race (most common in Indian and Asian backgrounds), gender (cleft lip more common in boys, cleft palate more common in girls), certain medications during pregnancy, chemical or drug exposures during pregnancy, viruses and genetic factors as well. Risks to have a child with a cleft lip and/or palate increase when other family members have been born with clefts. In families with no family history who have had a child born with a cleft lip or palate have a 2-6% risk for a second child to be born with a cleft. Even within families, the type and severity of clefts can vary greatly.

Babies born with clefts may have difficulty feeding, more frequent ear infections, sometimes hearing loss and dental problems. Surgery to correct a cleft lip is usually done by 12 months and 18 months for a cleft palate closure. Although many children born with clefts require dental and orthodontic care or other surgeries later, they typically lead a normal life after treatment.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cleft lip/palate" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cleft lip/palate" returned 31 free, full-text research articles on human participants. First 3 results:

Computer-Assisted Orthognathic Surgery for Patients with Cleft Lip/Palate: From Traditional Planning to Three-Dimensional Surgical Simulation.
 

Author(s): Daniel Lonic, Betty Chien-Jung Pai, Kazuaki Yamaguchi, Peerasak Chortrakarnkij, Hsiu-Hsia Lin, Lun-Jou Lo

Journal:

 

Although conventional two-dimensional (2D) methods for orthognathic surgery planning are still popular, the use of three-dimensional (3D) simulation is steadily increasing. In facial asymmetry cases such as in cleft lip/palate patients, the additional information can dramatically ...

Last Updated: 23 Mar 2016

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Novel FGFR1 and KISS1R Mutations in Chinese Kallmann Syndrome Males with Cleft Lip/Palate.
 

Author(s): Hao Xu, Yonghua Niu, Tao Wang, Simin Liu, Hua Xu, Shaogang Wang, Jihong Liu, Zhangqun Ye

Journal: Biomed Res Int. 2015 ;2015():649698.

 

Kallmann syndrome (KS) is characterized by isolated hypogonadotropic hypogonadism (IHH) with anosmia and is sometimes associated with cleft lip/palate (CLP). In order to describe the clinical features, genetic etiology, and treatment outcome of KS males with CLP, we performed genetic ...

Last Updated: 22 Jul 2015

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Accelerated wound closure in vitro by fibroblasts from a subgroup of cleft lip/palate patients: role of transforming growth factor-α.
 

Author(s): Joël Beyeler, Isabelle Schnyder, Christos Katsaros, Matthias Chiquet

Journal:

 

In a fraction of patients surgically treated for cleft lip/palate, excessive scarring disturbs maxillary growth and dento-alveolar development. Since certain genes are involved in craniofacial morphogenesis as well as tissue repair, a primary defect causing cleft lip/palate could ...

Last Updated: 1 Nov 2014

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Reviews from the PubMed Database

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The terms "Cleft lip/palate" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate
 

Status: Recruiting

Condition Summary: Cleft Lip and Palate

 

Last Updated: 27 May 2016

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Efficiency of Novel Nasoalveolar Molding Method on Parents' Satisfaction in Unilateral Cleft Infants
 

Status: Not yet recruiting

Condition Summary: Cleft Lip and Palate

 

Last Updated: 22 Jul 2016

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