Clear Cell Renal Cell Carcinoma

Common Name(s)

Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma is a cancer of the kidney.  The name "clear cell" refers to the appearance of the cancer cells when viewed with a microscope.   Clear cell renal cell carcinoma occurs when cells in the kidney quickly increase in number, creating a lump (mass).  Though the exact cause of clear cell renal cell carcinoma is unknown, smoking, the excessive use of certain medications, and several genetic predisposition conditions (such as von Hippel Lindau syndrome) may contribute to the development of this type of cancer.  Treatment often begins with surgery to remove as much of the cancer as possible, and may be followed by radiation therapy, chemotherapy, biological therapy, or targeted therapy.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clear Cell Renal Cell Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clear Cell Renal Cell Carcinoma" returned 493 free, full-text research articles on human participants. First 3 results:

Renal clear cell carcinoma metastasis to salivary glands - a series of 9 cases: clinico-pathological study.
 

Author(s): H Majewska, A Skálová, K Radecka, D Stodulski, M Hyrcza, C Stankiewicz, W Biernat

Journal: Pol J Pathol. 2016 Mar;67(1):39-45.

 

Metastatic tumors involving salivary glands arising from the non-head and neck area are very rare. Renal cell carcinoma (RCC) is known for its high propensity for metastasis to unusual localizations. RCC metastasis to the maxillofacial area is an uncommon event (16%), but metastasis ...

Last Updated: 15 May 2016

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Transcriptome Sequencing (RNAseq) Enables Utilization of Formalin-Fixed, Paraffin-Embedded Biopsies with Clear Cell Renal Cell Carcinoma for Exploration of Disease Biology and Biomarker Development.
 

Author(s): Oystein Eikrem, Christian Beisland, Karin Hjelle, Arnar Flatberg, Andreas Scherer, Lea Landolt, Trude Skogstrand, Sabine Leh, Vidar Beisvag, Hans-Peter Marti

Journal:

 

Formalin-fixed, paraffin-embedded (FFPE) tissues are an underused resource for molecular analyses. This proof of concept study aimed to compare RNAseq results from FFPE biopsies with the corresponding RNAlater® (Qiagen, Germany) stored samples from clear cell renal cell carcinoma ...

Last Updated: 23 Feb 2016

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Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma.
 

Author(s): Mark Bi, Siming Zhao, Jonathan W Said, Maria J Merino, Adebowale J Adeniran, Zuoquan Xie, Cayce B Nawaf, Jaehyuk Choi, Arie S Belldegrun, Allan J Pantuck, Harriet M Kluger, Kaya Bilgüvar, Richard P Lifton, Brian Shuch

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2016 Feb;113(8):2170-5.

 

The presence of sarcomatoid features in clear cell renal cell carcinoma (ccRCC) confers a poor prognosis and is of unknown pathogenesis. We performed exome sequencing of matched normal-carcinomatous-sarcomatoid specimens from 21 subjects. Two tumors had hypermutation consistent with ...

Last Updated: 24 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clear Cell Renal Cell Carcinoma" returned 22 free, full-text review articles on human participants. First 3 results:

Coexistence of multiple myeloma and clear cell renal cell carcinoma: a case report and review of literature.
 

Author(s): Gaixiang Xu, Min Yang, Jian Huang, Jie Jin

Journal:

 

Coexistence of multiple myeloma (MM) and renal cell carcinoma (RCC) is an extremely rare condition. Nevertheless, there is a higher than expected incidence of co-occurrence of these two malignancies. Several case series, in the recent past, have postulated an association between MM ...

Last Updated: 11 Aug 2015

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Association of primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with clear cell renal carcinoma.
 

Author(s): Letícia da Silva Gomes, Carolina A M Kulak, Tatiana Munhoz da Rocha Lemos Costa, Evandro Cezar Guerreiro Vasconcelos, Maurício de Carvalho, Victoria Zeghbi Cochenski Borba

Journal: Arch Endocrinol Metab. 2015 Feb;59(1):84-8.

 

Hypercalcemia is found frequently in patients with cancer. Besides the etiology related to the malignancy, other causes should be considered in the differential diagnostic, as primary hyperparathyroidism, granulomatous diseases and the use of thiazide diuretics. We present a case ...

Last Updated: 30 Apr 2015

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Frontiers in clinical and molecular diagnostics and staging of metastatic clear cell renal cell carcinoma.
 

Author(s): Anna M Czarnecka, Anna Kornakiewicz, Wojciech Kukwa, Cezary Szczylik

Journal: Future Oncol. 2014 May;10(6):1095-111.

 

The last few years have brought advances in the understanding of the molecular biology of metastatic clear cell renal cell carcinoma (RCC). Both preclinical research and clinical trials brought together results from the latest advancements in RCC diagnostic and staging. Understanding ...

Last Updated: 19 Jun 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma
 

Status: Recruiting

Condition Summary: ccRCC; RCC; Kidney Cancer; Clear Cell Renal Cell Carcinoma; Renal Cell Carcinoma

 

Last Updated: 29 Apr 2016

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Study of Neoadjuvant Nivolumab in Patients With Non-metastatic Stage II-IV Clear Cell Renal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma

 

Last Updated: 22 Aug 2016

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Safety and Activity of G-202 in Patients With Clear Cell Renal Cell Carcinoma That Expresses PSMA
 

Status: Recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma

 

Last Updated: 2 Jul 2016

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