Clear Cell Renal Cell Carcinoma

Common Name(s)

Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma is a cancer of the kidney.  The name "clear cell" refers to the appearance of the cancer cells when viewed with a microscope.   Clear cell renal cell carcinoma occurs when cells in the kidney quickly increase in number, creating a lump (mass).  Though the exact cause of clear cell renal cell carcinoma is unknown, smoking, the excessive use of certain medications, and several genetic predisposition conditions (such as von Hippel Lindau syndrome) may contribute to the development of this type of cancer.  Treatment often begins with surgery to remove as much of the cancer as possible, and may be followed by radiation therapy, chemotherapy, biological therapy, or targeted therapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clear Cell Renal Cell Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clear Cell Renal Cell Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clear Cell Renal Cell Carcinoma" returned 287 free, full-text research articles on human participants. First 3 results:

Identification of a suitable qPCR reference gene in metastatic clear cell renal cell carcinoma.
 

Author(s): Piotr M Wierzbicki, Jakub Klacz, Agnieszka Rybarczyk, Tomasz Slebioda, Marcin Stanislawowski, Agata Wronska, Anna Kowalczyk, Marcin Matuszewski, Zbigniew Kmiec

Journal: Tumour Biol.. 2014 Dec;35(12):12473-87.

 

There is no data on reference gene (RG) selection in metastatic clear-cell renal cell carcinoma (mccRCC) for quantitative PCR (qPCR) data normalization. We aimed at selecting the most stable RG for further determination of new prognostic markers. Thirty-five nonmetastatic and 35 mccRCC ...

Last Updated: 24 Dec 2014

Go To URL
Comparative effectiveness of approved first-line anti-angiogenic and molecularly targeted therapeutic agents in the treatment of good and intermediate risk metastatic clear cell renal cell carcinoma.
 

Author(s): Benjamin Haaland, Akhil Chopra, Sanchalika Acharyya, André P Fay, Gilberto de Lima Lopes

Journal:

 

Based on improved clinical outcomes in randomized controlled clinical trials (RCTs) the FDA and EMA have approved bevacizumab with interferon, sunitinib, and pazopanib in the first-line treatment of low to intermediate risk metastatic clear cell renal cell carcinoma (mRCC). However, ...

Last Updated: 27 Aug 2014

Go To URL
Lack of ephrin receptor A1 is a favorable independent prognostic factor in clear cell renal cell carcinoma.
 

Author(s): Marieta I Toma, Kati Erdmann, Michael Diezel, Matthias Meinhardt, Stefan Zastrow, Susanne Fuessel, Manfred P Wirth, Gustavo B Baretton

Journal:

 

The EPH receptor tyrosine kinases and their cell-bound ligands, the ephrins, have been shown to be associated with cancer development and progression. In this study, mRNA and protein expression of the receptors EPHA1 and EPHA2 as well as of their ligand EFNA1 and their prognostic ...

Last Updated: 16 Jul 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clear Cell Renal Cell Carcinoma" returned 17 free, full-text review articles on human participants. First 3 results:

Frontiers in clinical and molecular diagnostics and staging of metastatic clear cell renal cell carcinoma.
 

Author(s): Anna M Czarnecka, Anna Kornakiewicz, Wojciech Kukwa, Cezary Szczylik

Journal: Future Oncol. 2014 May;10(6):1095-111.

 

The last few years have brought advances in the understanding of the molecular biology of metastatic clear cell renal cell carcinoma (RCC). Both preclinical research and clinical trials brought together results from the latest advancements in RCC diagnostic and staging. Understanding ...

Last Updated: 19 Jun 2014

Go To URL
Tumor necrosis factor receptor 2: its contribution to acute cellular rejection and clear cell renal carcinoma.
 

Author(s): Jun Wang, Rafia S Al-Lamki

Journal: Biomed Res Int. 2013 ;2013():821310.

 

Tumor necrosis factor receptor 2 (TNFR2) is a type I transmembrane glycoprotein and one of the two receptors that orchestrate the complex biological functions of tumor necrosis factor (TNF, also designed TNF- α ). Accumulating experimental evidence suggests that TNFR2 plays an important ...

Last Updated: 18 Dec 2013

Go To URL
Concurrent primary carcinoid tumor arising within mature teratoma and clear cell renal cell carcinoma in the horseshoe kidney: report of a rare case and review of the literature.
 

Author(s): Ke Sun, Qihan You, Ming Zhao, Hongtian Yao, Hua Xiang, Lijun Wang

Journal:

 

Primary carcinoid tumor arising in a mature teratoma of the horseshoe kidney is exceptionally rare and only 4 such cases have been reported in the world literature to date. The simultaneous occurrence of different subtypes of renal cell carcinoma (RCC) or RCC coexistence with non-RCC ...

Last Updated: 14 Nov 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma
 

Status: Recruiting

Condition Summary: ccRCC; RCC; Kidney Cancer; Clear Cell Renal Cell Carcinoma; Renal Cell Carcinoma

 

Last Updated: 20 Apr 2015

Go to URL
Neoadjuvant Sunitinib Treatment for Metastatic Clear Cell Renal Cell Carcinoma (RCC)
 

Status: Recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma; Metastasis

 

Last Updated: 21 Jun 2011

Go to URL
Pazopanib Hydrochloride and Bevacizumab in Treating Patients With Previously Untreated Metastatic Kidney Cancer
 

Status: Recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma; Stage IV Renal Cell Cancer

 

Last Updated: 9 Feb 2015

Go to URL