Clear Cell Renal Cell Carcinoma

Common Name(s)

Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma is a cancer of the kidney.  The name "clear cell" refers to the appearance of the cancer cells when viewed with a microscope.   Clear cell renal cell carcinoma occurs when cells in the kidney quickly increase in number, creating a lump (mass).  Though the exact cause of clear cell renal cell carcinoma is unknown, smoking, the excessive use of certain medications, and several genetic predisposition conditions (such as von Hippel Lindau syndrome) may contribute to the development of this type of cancer.  Treatment often begins with surgery to remove as much of the cancer as possible, and may be followed by radiation therapy, chemotherapy, biological therapy, or targeted therapy.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clear Cell Renal Cell Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clear Cell Renal Cell Carcinoma" returned 534 free, full-text research articles on human participants. First 3 results:

Sinonasal renal cell-like adenocarcinoma, a unique variant of primary clear cell carcinoma of the head and neck: The first reported case in Korea.
 

Author(s): Nah-Ihm Kim, Jung-In Yang, Sung-Sun Kim, Ji-Shin Lee, Sang-Chul Lim, Shin Jung, Jae-Hyuk Lee, Kyung-Sub Moon, Kyung-Hwa Lee

Journal: Medicine (Baltimore). 2017 Aug;96(31):e7711.

 

Primary sinonasal renal cell-like adenocarcinoma (SNRCLA) is a rare and unique neoplasm.

Last Updated: 2 Aug 2017

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An Immune Atlas of Clear Cell Renal Cell Carcinoma.
 

Author(s): Stéphane Chevrier, Jacob Harrison Levine, Vito Riccardo Tomaso Zanotelli, Karina Silina, Daniel Schulz, Marina Bacac, Carola Hermine Ries, Laurie Ailles, Michael Alexander Spencer Jewett, Holger Moch, Maries van den Broek, Christian Beisel, Michael Beda Stadler, Craig Gedye, Bernhard Reis, Dana Pe'er, Bernd Bodenmiller

Journal: Cell. 2017 May;169(4):736-749.e18.

 

Immune cells in the tumor microenvironment modulate cancer progression and are attractive therapeutic targets. Macrophages and T cells are key components of the microenvironment, yet their phenotypes and relationships in this ecosystem and to clinical outcomes are ill defined. We ...

Last Updated: 5 May 2017

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BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: tumor heterogeneity and concordance with paired primary tumor.
 

Author(s): Jeanette E Eckel-Passow, Daniel J Serie, John C Cheville, Thai H Ho, Payal Kapur, James Brugarolas, R Houston Thompson, Bradley C Leibovich, Eugene D Kwon, Richard W Joseph, Alexander S Parker

Journal:

 

BAP1 and PBRM1 are frequently mutated in primary clear cell renal cell carcinoma (ccRCC) tumors; however, the frequency and clinical relevance of these mutations in metastatic ccRCC tumors is unknown. Additionally, while intra-tumor heterogeneity has been shown to be common in primary ...

Last Updated: 22 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clear Cell Renal Cell Carcinoma" returned 25 free, full-text review articles on human participants. First 3 results:

Clear cell papillary renal cell carcinoma, renal angiomyoadenomatous tumor, and renal cell carcinoma with leiomyomatous stroma relationship of 3 types of renal tumors: a review.
 

Author(s): Ondrej Hes, Eva Maria Compérat, Nathalie Rioux-Leclercq

Journal: Ann Diagn Pathol. 2016 Apr;21():59-64.

 

Renal angiomyoadenomatous tumor has been described in 2000, followed by description of clear cell papillary renal cell carcinoma in 2006. Discussions about possible relationship of both tumors were published since their description. The main differential diagnostic feature was considered ...

Last Updated: 4 Apr 2016

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[Diagnosis of a clear cell renal carcinoma by biopsy of an iris metastasis associated with ocular hypertension in a black man from Martinique: Case report and literature review].
 

Author(s): J Marie-Louise, H Merle, A Donnio, L Ayeboua, A Jean-Charles, J Guyomarc'h, R Richer

Journal: J Fr Ophtalmol. 2015 Dec;38(10):e247-8.

 

Last Updated: 17 Dec 2015

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Coexistence of multiple myeloma and clear cell renal cell carcinoma: a case report and review of literature.
 

Author(s): Gaixiang Xu, Min Yang, Jian Huang, Jie Jin

Journal:

 

Coexistence of multiple myeloma (MM) and renal cell carcinoma (RCC) is an extremely rare condition. Nevertheless, there is a higher than expected incidence of co-occurrence of these two malignancies. Several case series, in the recent past, have postulated an association between MM ...

Last Updated: 11 Aug 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Diagnostic Imaging for Clear Cell Renal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma

 

Last Updated: 11 Aug 2017

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Study of Neoadjuvant Nivolumab in Patients With Non-metastatic Stage II-IV Clear Cell Renal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma

 

Last Updated: 6 Jul 2017

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Nivolumab and Stereotactic Ablative Radiation Therapy (SAbR) for Metastatic Clear Cell Renal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Metastatic Clear Cell Renal Cell Carcinoma

 

Last Updated: 21 Jun 2017

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