Clear Cell Renal Cell Carcinoma

Common Name(s)

Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma is a cancer of the kidney.  The name "clear cell" refers to the appearance of the cancer cells when viewed with a microscope.   Clear cell renal cell carcinoma occurs when cells in the kidney quickly increase in number, creating a lump (mass).  Though the exact cause of clear cell renal cell carcinoma is unknown, smoking, the excessive use of certain medications, and several genetic predisposition conditions (such as von Hippel Lindau syndrome) may contribute to the development of this type of cancer.  Treatment often begins with surgery to remove as much of the cancer as possible, and may be followed by radiation therapy, chemotherapy, biological therapy, or targeted therapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clear Cell Renal Cell Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clear Cell Renal Cell Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clear Cell Renal Cell Carcinoma" returned 417 free, full-text research articles on human participants. First 3 results:

P2X7 receptor predicts postoperative cancer-specific survival of patients with clear-cell renal cell carcinoma.
 

Author(s): Zheng Liu, Yidong Liu, Le Xu, Huimin An, Yuan Chang, Yuanfeng Yang, Weijuan Zhang, Jiejie Xu

Journal: Cancer Sci.. 2015 Sep;106(9):1224-31.

 

The P2X7 receptor, an ATP-gated plasma membrane ion channel, is involved in inflammation, apoptosis and cell proliferation, and thereby plays a crucial role during oncogenic transformation in various malignancies. This study aims to evaluate the impact of P2X7 receptor expression ...

Last Updated: 23 Sep 2015

Go To URL
Assessment of survival of patients with metastatic clear cell renal cell carcinoma after radical cytoreductive nephrectomy versus no surgery: a seer analysis.
 

Author(s): Wen-Jun Xiao, Yao Zhu, Bo Dai, Hai-Liang Zhang, Ding-Wei Ye

Journal: Int Braz J Urol. ;41(2):288-95.

 

To examine the factors related to the choice of cytoreductive nephrectomy (CN) for patients with metastatic clear cell renal cell carcinoma (mCCRCC), and compare the population-based survival rates of patients treated with or without surgery in the modern targeted therapy era.

Last Updated: 26 May 2015

Go To URL
Frequent epigenetic suppression of tumor suppressor gene glutathione peroxidase 3 by promoter hypermethylation and its clinical implication in clear cell renal cell carcinoma.
 

Author(s): Qianling Liu, Jie Jin, Jianming Ying, Mengkui Sun, Yun Cui, Lian Zhang, Ben Xu, Yu Fan, Qian Zhang

Journal:

 

The goal of this study is to identify novel tumor suppressor genes silenced by promoter methylation in clear cell renal cell carcinoma (ccRCC) and discover new epigenetic biomarkers for early cancer detection. Reactive oxygen species (ROS) is a major cause of DNA damage that correlates ...

Last Updated: 14 May 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clear Cell Renal Cell Carcinoma" returned 21 free, full-text review articles on human participants. First 3 results:

Association of primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with clear cell renal carcinoma.
 

Author(s): Letícia da Silva Gomes, Carolina A M Kulak, Tatiana Munhoz da Rocha Lemos Costa, Evandro Cezar Guerreiro Vasconcelos, Maurício de Carvalho, Victoria Zeghbi Cochenski Borba

Journal: Arch Endocrinol Metab. 2015 Feb;59(1):84-8.

 

Hypercalcemia is found frequently in patients with cancer. Besides the etiology related to the malignancy, other causes should be considered in the differential diagnostic, as primary hyperparathyroidism, granulomatous diseases and the use of thiazide diuretics. We present a case ...

Last Updated: 30 Apr 2015

Go To URL
Frontiers in clinical and molecular diagnostics and staging of metastatic clear cell renal cell carcinoma.
 

Author(s): Anna M Czarnecka, Anna Kornakiewicz, Wojciech Kukwa, Cezary Szczylik

Journal: Future Oncol. 2014 May;10(6):1095-111.

 

The last few years have brought advances in the understanding of the molecular biology of metastatic clear cell renal cell carcinoma (RCC). Both preclinical research and clinical trials brought together results from the latest advancements in RCC diagnostic and staging. Understanding ...

Last Updated: 19 Jun 2014

Go To URL
Improving outcomes in metastatic clear cell renal cell carcinoma by sequencing therapy.
 

Author(s): Manuela Schmidinger

Journal: Am Soc Clin Oncol Educ Book. 2014 ;():e228-38.

 

Targeted agents have substantially improved outcomes in metastatic clear cell renal cell carcinoma. However, due to multiple mechanisms of evasive resistance, almost all patients progress at some point and may require subsequent therapies. Various agents have been explored after failure ...

Last Updated: 26 May 2014

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma
 

Status: Recruiting

Condition Summary: ccRCC; RCC; Kidney Cancer; Clear Cell Renal Cell Carcinoma; Renal Cell Carcinoma

 

Last Updated: 6 Aug 2015

Go to URL
Study of Neoadjuvant Nivolumab in Patients With Non-metastatic Stage II-IV Clear Cell Renal Cell Carcinoma
 

Status: Not yet recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma

 

Last Updated: 13 Oct 2015

Go to URL
Safety and Activity of G-202 in Patients With Clear Cell Renal Cell Carcinoma That Expresses PSMA
 

Status: Not yet recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma

 

Last Updated: 16 Nov 2015

Go to URL