Clear Cell Renal Cell Carcinoma

Common Name(s)

Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma is a cancer of the kidney.  The name "clear cell" refers to the appearance of the cancer cells when viewed with a microscope.   Clear cell renal cell carcinoma occurs when cells in the kidney quickly increase in number, creating a lump (mass).  Though the exact cause of clear cell renal cell carcinoma is unknown, smoking, the excessive use of certain medications, and several genetic predisposition conditions (such as von Hippel Lindau syndrome) may contribute to the development of this type of cancer.  Treatment often begins with surgery to remove as much of the cancer as possible, and may be followed by radiation therapy, chemotherapy, biological therapy, or targeted therapy.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clear Cell Renal Cell Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clear Cell Renal Cell Carcinoma" returned 244 free, full-text research articles on human participants. First 3 results:

Organ-specific and tumor-size-dependent responses to sunitinib in clear cell renal cell carcinoma.
 

Author(s): Norihiko Tsuchiya, Takeshi Yuasa, Shinya Maita, Shintaro Narita, Takamitsu Inoue, Kazuyuki Numakura, Mitsuru Saito, Shigeru Satoh, Junji Yonese, Tomonori Habuchi

Journal:

 

Tyrosine kinase inhibitors (TKIs) have been used as standard therapy for patients with advanced renal cell carcinoma (RCC). However, information on factors predicting response to treatment with TKIs is lacking. This study aimed to assess the association between initial tumor size, ...

Last Updated: 18 Mar 2014

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Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal carcinoma.
 

Author(s): Francesco Gatto, Intawat Nookaew, Jens Nielsen

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Mar;111(9):E866-75.

 

Several common oncogenic pathways have been implicated in the emergence of renowned metabolic features in cancer, which in turn are deemed essential for cancer proliferation and survival. However, the extent to which different cancers coordinate their metabolism to meet these requirements ...

Last Updated: 5 Mar 2014

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ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma.
 

Author(s): Jeanette E Eckel-Passow, Daniel J Serie, Brian M Bot, Richard W Joseph, John C Cheville, Alexander S Parker

Journal:

 

An association between cigarette smoking and increased risk of clear cell renal cell carcinoma (ccRCC) has been established; however, there are limited data regarding the molecular mechanisms that underlie this association. We used a multi-stage design to identify and validate genes ...

Last Updated: 7 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clear Cell Renal Cell Carcinoma" returned 15 free, full-text review articles on human participants. First 3 results:

Tumor necrosis factor receptor 2: its contribution to acute cellular rejection and clear cell renal carcinoma.
 

Author(s): Jun Wang, Rafia S Al-Lamki

Journal: Biomed Res Int. 2013 ;2013():821310.

 

Tumor necrosis factor receptor 2 (TNFR2) is a type I transmembrane glycoprotein and one of the two receptors that orchestrate the complex biological functions of tumor necrosis factor (TNF, also designed TNF- α ). Accumulating experimental evidence suggests that TNFR2 plays an important ...

Last Updated: 18 Dec 2013

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Concurrent primary carcinoid tumor arising within mature teratoma and clear cell renal cell carcinoma in the horseshoe kidney: report of a rare case and review of the literature.
 

Author(s): Ke Sun, Qihan You, Ming Zhao, Hongtian Yao, Hua Xiang, Lijun Wang

Journal:

 

Primary carcinoid tumor arising in a mature teratoma of the horseshoe kidney is exceptionally rare and only 4 such cases have been reported in the world literature to date. The simultaneous occurrence of different subtypes of renal cell carcinoma (RCC) or RCC coexistence with non-RCC ...

Last Updated: 14 Nov 2013

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Targeted therapies and the treatment of non-clear cell renal cell carcinoma.
 

Author(s): J Bellmunt, J Dutcher

Journal: Ann. Oncol.. 2013 Jul;24(7):1730-40.

 

Targeted therapies have shown profound effects on the outcome of patients with advanced renal cell carcinoma (RCC). However, the optimal treatment for RCC of non-clear cell histology (nccRCC)-typically excluded from trials of targeted agents-remains uncertain.

Last Updated: 26 Jun 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Neoadjuvant Sunitinib Treatment for Metastatic Clear Cell Renal Cell Carcinoma (RCC)
 

Status: Recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma; Metastasis

 

Last Updated: 21 Jun 2011

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AMG 172 First in Human Study in Patients With Kidney Cancer
 

Status: Recruiting

Condition Summary: Renal Cell Adenocarcinoma; Clear Cell Renal Carcinoma; Clear Cell Renal Cell Carcinoma; Renal Cell Carcinoma

 

Last Updated: 17 Jul 2014

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Pazopanib Hydrochloride and Bevacizumab in Treating Patients With Previously Untreated Metastatic Kidney Cancer
 

Status: Recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma; Stage IV Renal Cell Cancer

 

Last Updated: 4 Aug 2014

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