Clear Cell Renal Cell Carcinoma

Common Name(s)

Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma is a cancer of the kidney.  The name "clear cell" refers to the appearance of the cancer cells when viewed with a microscope.   Clear cell renal cell carcinoma occurs when cells in the kidney quickly increase in number, creating a lump (mass).  Though the exact cause of clear cell renal cell carcinoma is unknown, smoking, the excessive use of certain medications, and several genetic predisposition conditions (such as von Hippel Lindau syndrome) may contribute to the development of this type of cancer.  Treatment often begins with surgery to remove as much of the cancer as possible, and may be followed by radiation therapy, chemotherapy, biological therapy, or targeted therapy.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clear Cell Renal Cell Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clear Cell Renal Cell Carcinoma" returned 295 free, full-text research articles on human participants. First 3 results:

Identification of genes and pathways involved in kidney renal clear cell carcinoma.
 

Author(s): William Yang, Kenji Yoshigoe, Xiang Qin, Jun S Liu, Jack Y Yang, Andrzej Niemierko, Youping Deng, Yunlong Liu, A Dunker, Zhongxue Chen, Liangjiang Wang, Dong Xu, Hamid R Arabnia, Weida Tong, Mary Yang

Journal: BMC Bioinformatics. 2014 ;15 Suppl 17():S2.

 

Kidney Renal Clear Cell Carcinoma (KIRC) is one of fatal genitourinary diseases and accounts for most malignant kidney tumours. KIRC has been shown resistance to radiotherapy and chemotherapy. Like many types of cancers, there is no curative treatment for metastatic KIRC. Using advanced ...

Last Updated: 6 Jan 2015

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Birt-Hogg-Dubé syndrome with clear cell renal cell carcinoma in a Chinese family.
 

Author(s): Zhichun Lin, Kenan Gong, Bo Pang, Changqing Zeng, Dake Zhang

Journal: Intern. Med.. 2014 ;53(24):2825-8.

 

Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant genodermatosis that presents as a clinical triad including follicular hamartomas, renal neoplasms and lung cysts associated with an increased risk of pneumothorax. FLCN gene defects have been identified as being responsible ...

Last Updated: 16 Dec 2014

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Identification of a suitable qPCR reference gene in metastatic clear cell renal cell carcinoma.
 

Author(s): Piotr M Wierzbicki, Jakub Klacz, Agnieszka Rybarczyk, Tomasz Slebioda, Marcin Stanislawowski, Agata Wronska, Anna Kowalczyk, Marcin Matuszewski, Zbigniew Kmiec

Journal: Tumour Biol.. 2014 Dec;35(12):12473-87.

 

There is no data on reference gene (RG) selection in metastatic clear-cell renal cell carcinoma (mccRCC) for quantitative PCR (qPCR) data normalization. We aimed at selecting the most stable RG for further determination of new prognostic markers. Thirty-five nonmetastatic and 35 mccRCC ...

Last Updated: 24 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clear Cell Renal Cell Carcinoma" returned 17 free, full-text review articles on human participants. First 3 results:

Frontiers in clinical and molecular diagnostics and staging of metastatic clear cell renal cell carcinoma.
 

Author(s): Anna M Czarnecka, Anna Kornakiewicz, Wojciech Kukwa, Cezary Szczylik

Journal: Future Oncol. 2014 May;10(6):1095-111.

 

The last few years have brought advances in the understanding of the molecular biology of metastatic clear cell renal cell carcinoma (RCC). Both preclinical research and clinical trials brought together results from the latest advancements in RCC diagnostic and staging. Understanding ...

Last Updated: 19 Jun 2014

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Tumor necrosis factor receptor 2: its contribution to acute cellular rejection and clear cell renal carcinoma.
 

Author(s): Jun Wang, Rafia S Al-Lamki

Journal: Biomed Res Int. 2013 ;2013():821310.

 

Tumor necrosis factor receptor 2 (TNFR2) is a type I transmembrane glycoprotein and one of the two receptors that orchestrate the complex biological functions of tumor necrosis factor (TNF, also designed TNF- α ). Accumulating experimental evidence suggests that TNFR2 plays an important ...

Last Updated: 18 Dec 2013

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Concurrent primary carcinoid tumor arising within mature teratoma and clear cell renal cell carcinoma in the horseshoe kidney: report of a rare case and review of the literature.
 

Author(s): Ke Sun, Qihan You, Ming Zhao, Hongtian Yao, Hua Xiang, Lijun Wang

Journal:

 

Primary carcinoid tumor arising in a mature teratoma of the horseshoe kidney is exceptionally rare and only 4 such cases have been reported in the world literature to date. The simultaneous occurrence of different subtypes of renal cell carcinoma (RCC) or RCC coexistence with non-RCC ...

Last Updated: 14 Nov 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma
 

Status: Recruiting

Condition Summary: ccRCC; RCC; Kidney Cancer; Clear Cell Renal Cell Carcinoma; Renal Cell Carcinoma

 

Last Updated: 20 Apr 2015

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Neoadjuvant Sunitinib Treatment for Metastatic Clear Cell Renal Cell Carcinoma (RCC)
 

Status: Recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma; Metastasis

 

Last Updated: 21 Jun 2011

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Pazopanib Hydrochloride and Bevacizumab in Treating Patients With Previously Untreated Metastatic Kidney Cancer
 

Status: Recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma; Stage IV Renal Cell Cancer

 

Last Updated: 9 Feb 2015

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