Clear Cell Renal Cell Carcinoma

Common Name(s)

Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma is a cancer of the kidney.  The name "clear cell" refers to the appearance of the cancer cells when viewed with a microscope.   Clear cell renal cell carcinoma occurs when cells in the kidney quickly increase in number, creating a lump (mass).  Though the exact cause of clear cell renal cell carcinoma is unknown, smoking, the excessive use of certain medications, and several genetic predisposition conditions (such as von Hippel Lindau syndrome) may contribute to the development of this type of cancer.  Treatment often begins with surgery to remove as much of the cancer as possible, and may be followed by radiation therapy, chemotherapy, biological therapy, or targeted therapy.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clear Cell Renal Cell Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clear Cell Renal Cell Carcinoma" returned 455 free, full-text research articles on human participants. First 3 results:

Increased Expression of the Autocrine Motility Factor is Associated With Poor Prognosis in Patients With Clear Cell-Renal Cell Carcinoma.
 

Author(s): Giuseppe Lucarelli, Monica Rutigliano, Francesca Sanguedolce, Vanessa Galleggiante, Andrea Giglio, Simona Cagiano, Pantaleo Bufo, Eugenio Maiorano, Domenico Ribatti, Elena Ranieri, Margherita Gigante, Loreto Gesualdo, Matteo Ferro, Ottavio de Cobelli, Carlo Buonerba, Giuseppe Di Lorenzo, Sabino De Placido, Silvano Palazzo, Carlo Bettocchi, Pasquale Ditonno, Michele Battaglia

Journal: Medicine (Baltimore). 2015 Nov;94(46):e2117.

 

Glucose-6-phosphate isomerase (GPI), also known as phosphoglucose isomerase, was initially identified as the second glycolytic enzyme that catalyzes the interconversion of glucose-6-phosphate to fructose-6-phosphate. Later studies demonstrated that GPI was the same as the autocrine ...

Last Updated: 20 Nov 2015

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Decreased Expression of SETD2 Predicts Unfavorable Prognosis in Patients With Nonmetastatic Clear-Cell Renal Cell Carcinoma.
 

Author(s): Weisi Liu, Qiang Fu, Huimin An, Yuan Chang, Weijuan Zhang, Yu Zhu, Le Xu, Jiejie Xu

Journal: Medicine (Baltimore). 2015 Nov;94(45):e2004.

 

DNA sequencing revealed that mutations in SETD2 occur in 3% to 12% of clear-cell renal cell carcinoma (ccRCC) cases and are associated with poor clinical outcome. In this study, we used an immunohistochemistry (IHC) assay to evaluate the impact of SETD2 loss, with expression of H3K36me3, ...

Last Updated: 12 Nov 2015

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Soluble Serum αKlotho Is a Potential Predictive Marker of Disease Progression in Clear Cell Renal Cell Carcinoma.
 

Author(s): Margherita Gigante, Giuseppe Lucarelli, Chiara Divella, Giuseppe Stefano Netti, Paola Pontrelli, Cesira Cafiero, Giuseppe Grandaliano, Giuseppe Castellano, Monica Rutigliano, Giovanni Stallone, Carlo Bettocchi, Pasquale Ditonno, Loreto Gesualdo, Michele Battaglia, Elena Ranieri

Journal: Medicine (Baltimore). 2015 Nov;94(45):e1917.

 

Renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies, and clear cell RCC (ccRCC), that has a high metastatic index and high relapse rate, is the most common histological subtype. The identification of new biomarkers in ccRCC is fundamental for stratifying ...

Last Updated: 12 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clear Cell Renal Cell Carcinoma" returned 21 free, full-text review articles on human participants. First 3 results:

Association of primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with clear cell renal carcinoma.
 

Author(s): Letícia da Silva Gomes, Carolina A M Kulak, Tatiana Munhoz da Rocha Lemos Costa, Evandro Cezar Guerreiro Vasconcelos, Maurício de Carvalho, Victoria Zeghbi Cochenski Borba

Journal: Arch Endocrinol Metab. 2015 Feb;59(1):84-8.

 

Hypercalcemia is found frequently in patients with cancer. Besides the etiology related to the malignancy, other causes should be considered in the differential diagnostic, as primary hyperparathyroidism, granulomatous diseases and the use of thiazide diuretics. We present a case ...

Last Updated: 30 Apr 2015

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Frontiers in clinical and molecular diagnostics and staging of metastatic clear cell renal cell carcinoma.
 

Author(s): Anna M Czarnecka, Anna Kornakiewicz, Wojciech Kukwa, Cezary Szczylik

Journal: Future Oncol. 2014 May;10(6):1095-111.

 

The last few years have brought advances in the understanding of the molecular biology of metastatic clear cell renal cell carcinoma (RCC). Both preclinical research and clinical trials brought together results from the latest advancements in RCC diagnostic and staging. Understanding ...

Last Updated: 19 Jun 2014

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Improving outcomes in metastatic clear cell renal cell carcinoma by sequencing therapy.
 

Author(s): Manuela Schmidinger

Journal: Am Soc Clin Oncol Educ Book. 2014 ;():e228-38.

 

Targeted agents have substantially improved outcomes in metastatic clear cell renal cell carcinoma. However, due to multiple mechanisms of evasive resistance, almost all patients progress at some point and may require subsequent therapies. Various agents have been explored after failure ...

Last Updated: 26 May 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Neoadjuvant Nivolumab in Patients With Non-metastatic Stage II-IV Clear Cell Renal Cell Carcinoma
 

Status: Recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma

 

Last Updated: 29 Feb 2016

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Safety and Activity of G-202 in Patients With Clear Cell Renal Cell Carcinoma That Expresses PSMA
 

Status: Not yet recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma

 

Last Updated: 16 Nov 2015

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Neoadjuvant Sunitinib Treatment for Metastatic Clear Cell Renal Cell Carcinoma (RCC)
 

Status: Recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma; Metastasis

 

Last Updated: 21 Jun 2011

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