Clear Cell Renal Cell Carcinoma

Common Name(s)

Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma is a cancer of the kidney.  The name "clear cell" refers to the appearance of the cancer cells when viewed with a microscope.   Clear cell renal cell carcinoma occurs when cells in the kidney quickly increase in number, creating a lump (mass).  Though the exact cause of clear cell renal cell carcinoma is unknown, smoking, the excessive use of certain medications, and several genetic predisposition conditions (such as von Hippel Lindau syndrome) may contribute to the development of this type of cancer.  Treatment often begins with surgery to remove as much of the cancer as possible, and may be followed by radiation therapy, chemotherapy, biological therapy, or targeted therapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clear Cell Renal Cell Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Clear Cell Renal Cell Carcinoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Clear Cell Renal Cell Carcinoma" returned 229 free, full-text research articles on human participants. First 3 results:

Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal carcinoma.
 

Author(s): Francesco Gatto, Intawat Nookaew, Jens Nielsen

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Mar;111(9):E866-75.

 

Several common oncogenic pathways have been implicated in the emergence of renowned metabolic features in cancer, which in turn are deemed essential for cancer proliferation and survival. However, the extent to which different cancers coordinate their metabolism to meet these requirements ...

Last Updated: 5 Mar 2014

Go To URL
FUT11 as a potential biomarker of clear cell renal cell carcinoma progression based on meta-analysis of gene expression data.
 

Author(s): Elżbieta Zodro, Marcin Jaroszewski, Agnieszka Ida, Tomasz Wrzesiński, Zbigniew Kwias, Hans Bluyssen, Joanna Wesoly

Journal: Tumour Biol.. 2014 Mar;35(3):2607-17.

 

In this paper, we provide a comprehensive summary of available clear cell renal cell carcinoma (ccRCC) microarray data in the form of meta-analysis of genes differentially regulated in tumors as compared to healthy tissue, using effect size to measure the strength of a relationship ...

Last Updated: 27 Mar 2014

Go To URL
Lower mRNA and protein expression levels of LC3 and Beclin1, markers of autophagy, were correlated with progression of renal clear cell carcinoma.
 

Author(s): Qian Deng, Zhenlong Wang, Lei Wang, Liandong Zhang, Xiaolong Xiang, Ziming Wang, Tie Chong

Journal: Jpn. J. Clin. Oncol.. 2013 Dec;43(12):1261-8.

 

The aim of this study was to examine the level of autophagy in renal clear cell carcinoma, stratify by clinicopathologic grades and stages and compare it with healthy renal tissue in order to hypothesize on the role of autophagy in the proliferation of renal clear cell carcinoma.

Last Updated: 28 Nov 2013

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Clear Cell Renal Cell Carcinoma" returned 14 free, full-text review articles on human participants. First 3 results:

Concurrent primary carcinoid tumor arising within mature teratoma and clear cell renal cell carcinoma in the horseshoe kidney: report of a rare case and review of the literature.
 

Author(s): Ke Sun, Qihan You, Ming Zhao, Hongtian Yao, Hua Xiang, Lijun Wang

Journal:

 

Primary carcinoid tumor arising in a mature teratoma of the horseshoe kidney is exceptionally rare and only 4 such cases have been reported in the world literature to date. The simultaneous occurrence of different subtypes of renal cell carcinoma (RCC) or RCC coexistence with non-RCC ...

Last Updated: 14 Nov 2013

Go To URL
Targeted therapies and the treatment of non-clear cell renal cell carcinoma.
 

Author(s): J Bellmunt, J Dutcher

Journal: Ann. Oncol.. 2013 Jul;24(7):1730-40.

 

Targeted therapies have shown profound effects on the outcome of patients with advanced renal cell carcinoma (RCC). However, the optimal treatment for RCC of non-clear cell histology (nccRCC)-typically excluded from trials of targeted agents-remains uncertain.

Last Updated: 26 Jun 2013

Go To URL
A gallbladder tumor revealing metastatic clear cell renal carcinoma: report of case and review of literature.
 

Author(s): Merieme Ghaouti, Kaoutar Znati, Ahmed Jahid, Fouad Zouaidia, Zakiya Bernoussi, Youssef El Fakir, Najat Mahassini

Journal:

 

Metastatic renal cell carcinoma in the gallbladder is extremely rare, with reported frequencies of less than 0.6% in large autopsy reviews. Only 40 cases were reported in the literature. We report a first case of gallbladder polypoid tumor revealing metastatic clear cell renal cell ...

Last Updated: 17 Jan 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Neoadjuvant Sunitinib Treatment for Metastatic Clear Cell Renal Cell Carcinoma (RCC)
 

Status: Recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma; Metastasis

 

Last Updated: 21 Jun 2011

Go to URL
AMG 172 First in Human Study in Patients With Kidney Cancer
 

Status: Recruiting

Condition Summary: Renal Cell Adenocarcinoma; Clear Cell Renal Carcinoma; Clear Cell Renal Cell Carcinoma; Renal Cell Carcinoma

 

Last Updated: 17 Jul 2014

Go to URL
Pazopanib Hydrochloride and Bevacizumab in Treating Patients With Previously Untreated Metastatic Kidney Cancer
 

Status: Recruiting

Condition Summary: Clear Cell Renal Cell Carcinoma; Stage IV Renal Cell Cancer

 

Last Updated: 7 Mar 2014

Go to URL