Classic Kaposi Sarcoma

Common Name(s)

Classic Kaposi Sarcoma

Kaposi sarcoma (KS) is an invasive angioproliferative inflammatory condition that occurs commonly in men infected with human immunodeficiency virus (HIV; see {609423}). In the early stages of KS, lesions appear reactive and are stimulated to grow by the actions of inflammatory cytokines and growth factors. In the late stages of KS, a malignant phenotype that appears to be monoclonal can develop. Infection with human herpesvirus-8 (HHV-8), also known as KS-associated herpesvirus (KSHV), is necessary but not sufficient for KS development. Coinfection with HIV markedly increases the likelihood of KS development, and additional environmental, hormonal, and genetic cofactors likely contribute to its pathogenesis (summary by {8:Foster et al., 2000}). {19:Suthaus et al. (2012)} noted that HHV-8 is the etiologic agent not only of KS, but also of primary effusion lymphoma and plasma cell-type multicentric Castleman disease (MCD).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Classic Kaposi Sarcoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Classic Kaposi Sarcoma" returned 26 free, full-text research articles on human participants. First 3 results:

Classic Kaposi Sarcoma: to treat or not to treat?
 

Author(s): Bruno Vincenzi, Loretta D'Onofrio, Anna Maria Frezza, Rosario Francesco Grasso, Valentina Fausti, Daniele Santini, Angelo Paolo Dei Tos, Giuseppe Tonini

Journal:

 

Classic Kaposi Sarcoma (KS) is vascular sarcoma, known to be more common in Mediterranean elderly men and characterized by an indolent clinical behavior. To our knowledge, this is the first evidence in literature, describing a spontaneous partial regression in a non-HIV, non-iatrogenic KS.

Last Updated: 19 Apr 2015

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Whole-Genome Sequencing Identifies STAT4 as a Putative Susceptibility Gene in Classic Kaposi Sarcoma.
 

Author(s): Mervi Aavikko, Eevi Kaasinen, Janne K Nieminen, Minji Byun, Iikki Donner, Roberta Mancuso, Pasquale Ferrante, Mario Clerici, Lucia Brambilla, Athanasia Tourlaki, Ronit Sarid, Emma Guttman-Yassky, Minna Taipale, Ekaterina Morgunova, Pirita Pekkonen, Päivi M Ojala, Eero Pukkala, Jean-Laurent Casanova, Outi Vaarala, Pia Vahteristo, Lauri A Aaltonen

Journal: J. Infect. Dis.. 2015 Jun;211(11):1842-51.

 

Classic Kaposi sarcoma (cKS) is an inflammatory tumor caused by human herpesvirus 8 (HHV-8) commonly observed in elderly men of Mediterranean origin. We studied a Finnish family of 5 affected individuals in 2 generations. Except for atypical mycobacterial infection of the index case, ...

Last Updated: 11 May 2015

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Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood.
 

Author(s): Minji Byun, Cindy S Ma, Arzu Akçay, Vincent Pedergnana, Umaimainthan Palendira, Jinjong Myoung, Danielle T Avery, Yifang Liu, Avinash Abhyankar, Lazaro Lorenzo, Monika Schmidt, Hye Kyung Lim, Olivier Cassar, Melanie Migaud, Flore Rozenberg, Nur Canpolat, Gönül Aydogan, Bernhard Fleckenstein, Jacinta Bustamante, Capucine Picard, Antoine Gessain, Emmanuelle Jouanguy, Ethel Cesarman, Martin Olivier, Philippe Gros, Laurent Abel, Michael Croft, Stuart G Tangye, Jean-Laurent Casanova

Journal: J. Exp. Med.. 2013 Aug;210(9):1743-59.

 

Kaposi sarcoma (KS), a human herpes virus 8 (HHV-8; also called KSHV)-induced endothelial tumor, develops only in a small fraction of individuals infected with HHV-8. We hypothesized that inborn errors of immunity to HHV-8 might underlie the exceedingly rare development of classic ...

Last Updated: 27 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Classic Kaposi Sarcoma" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 24 Feb 2011

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Phase II Multicentric Study of Digoxin Per os in Classic or Endemic Kaposi' s Sarcoma
 

Status: Recruiting

Condition Summary: Kaposi' s Sarcoma; Classic Kaposi' s Sarcoma; Endemic Kaposi' s Sarcoma; Lymph Angio Proliferations

 

Last Updated: 15 Apr 2016

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Pembrolizumab in Treating Patients With HIV and Relapsed, Refractory, or Disseminated Malignant Neoplasms
 

Status: Recruiting

Condition Summary: AIDS-Related Non-Hodgkin Lymphoma; Classical Hodgkin Lymphoma; HIV Infection; Kaposi Sarcoma; Locally Advanced Malignant Neoplasm; Metastatic Malignant Neoplasm; Recurrent Hepatocellular Carcinoma; Recurrent Hodgkin Lymphoma; Recurrent Kaposi Sarcoma; Recurrent Malignant Neoplasm; Recurrent Melanoma; Recurrent Melanoma of the Skin; Recurrent Non-Hodgkin Lymphoma; Recurrent Non-Small Cell Lung Carcinoma; Refractory Hodgkin Lymphoma; Refractory Malignant Neoplasm; Solid Neoplasm; Stage IIIA Hepatocellular Carcinoma; Stage IIIA Non-Small Cell Lung Cancer; Stage IIIA Skin Melanoma; Stage IIIB Hepatocellular Carcinoma; Stage IIIB Non-Small Cell Lung Cancer; Stage IIIB Skin Melanoma; Stage IIIC Hepatocellular Carcinoma; Stage IIIC Skin Melanoma; Stage IV Non-Small Cell Lung Cancer; Stage IV Skin Melanoma; Stage IVA Hepatocellular Carcinoma; Stage IVB Hepatocellular Carcinoma

 

Last Updated: 27 Apr 2016

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