Classic Kaposi Sarcoma

Common Name(s)

Classic Kaposi Sarcoma

Kaposi sarcoma (KS) is an invasive angioproliferative inflammatory condition that occurs commonly in men infected with human immunodeficiency virus (HIV; see {609423}). In the early stages of KS, lesions appear reactive and are stimulated to grow by the actions of inflammatory cytokines and growth factors. In the late stages of KS, a malignant phenotype that appears to be monoclonal can develop. Infection with human herpesvirus-8 (HHV-8), also known as KS-associated herpesvirus (KSHV), is necessary but not sufficient for KS development. Coinfection with HIV markedly increases the likelihood of KS development, and additional environmental, hormonal, and genetic cofactors likely contribute to its pathogenesis (summary by {8:Foster et al., 2000}). {19:Suthaus et al. (2012)} noted that HHV-8 is the etiologic agent not only of KS, but also of primary effusion lymphoma and plasma cell-type multicentric Castleman disease (MCD).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Classic Kaposi Sarcoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Classic Kaposi Sarcoma" returned 24 free, full-text research articles on human participants. First 3 results:

Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood.
 

Author(s): Minji Byun, Cindy S Ma, Arzu Akçay, Vincent Pedergnana, Umaimainthan Palendira, Jinjong Myoung, Danielle T Avery, Yifang Liu, Avinash Abhyankar, Lazaro Lorenzo, Monika Schmidt, Hye Kyung Lim, Olivier Cassar, Melanie Migaud, Flore Rozenberg, Nur Canpolat, Gönül Aydogan, Bernhard Fleckenstein, Jacinta Bustamante, Capucine Picard, Antoine Gessain, Emmanuelle Jouanguy, Ethel Cesarman, Martin Olivier, Philippe Gros, Laurent Abel, Michael Croft, Stuart G Tangye, Jean-Laurent Casanova

Journal: J. Exp. Med.. 2013 Aug;210(9):1743-59.

 

Kaposi sarcoma (KS), a human herpes virus 8 (HHV-8; also called KSHV)-induced endothelial tumor, develops only in a small fraction of individuals infected with HHV-8. We hypothesized that inborn errors of immunity to HHV-8 might underlie the exceedingly rare development of classic ...

Last Updated: 27 Aug 2013

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CD4+ and CD8+ T-cell skewness in classic Kaposi sarcoma.
 

Author(s): Antonio Galleu, Claudio Fozza, Maria Pina Simula, Salvatore Contini, Patrizia Virdis, Giovanna Corda, Simonetta Pardini, Francesca Cottoni, Sara Pruneddu, Antonio Angeloni, Simona Ceccarelli, Maurizio Longinotti

Journal: Neoplasia. 2012 Jun;14(6):487-94.

 

It is widely accepted that a deranged immune system plays a key role in the onset and evolution of classic Kaposi sarcoma (CKS). Nevertheless, the usage of the T-cell receptor (TCR) β-variable (BV) chain repertoire expressed by peripheral blood lymphocytes in patients with CKS is ...

Last Updated: 12 Jul 2012

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A case of classic Kaposi sarcoma in a 11-year-old male.
 

Author(s): Goknur Kalkan, Gulfer Akbay, Emel Gungor, Alev Eken, Ozay Ozkaya, Heinz Kutzner, Meral Eksioglu

Journal: Indian J Dermatol Venereol Leprol. ;77(6):730.

 

Last Updated: 21 Oct 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Classic Kaposi Sarcoma" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gamma Secretase Inhibitor PF-03084014 in Treating Patients With AIDS-Associated Kaposi Sarcoma
 

Status: Not yet recruiting

Condition Summary: AIDS-related Kaposi Sarcoma; HIV Infection; Recurrent Kaposi Sarcoma

 

Last Updated: 12 May 2014

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Bortezomib in Treating Patients With Relapsed or Refractory AIDS-Related Kaposi Sarcoma
 

Status: Recruiting

Condition Summary: AIDS-related Kaposi Sarcoma; HIV Infection; Recurrent Kaposi Sarcoma

 

Last Updated: 28 Jul 2014

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A Study to Investigate ALDOXORUBICIN in HIV-infected Subjects With Kaposi's Sarcoma
 

Status: Recruiting

Condition Summary: Kaposi's Sarcoma; HIV+; HIV Positive; AIDS

 

Last Updated: 5 Mar 2014

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