Classic Kaposi Sarcoma

Common Name(s)

Classic Kaposi Sarcoma

Kaposi sarcoma (KS) is an invasive angioproliferative inflammatory condition that occurs commonly in men infected with human immunodeficiency virus (HIV; see {609423}). In the early stages of KS, lesions appear reactive and are stimulated to grow by the actions of inflammatory cytokines and growth factors. In the late stages of KS, a malignant phenotype that appears to be monoclonal can develop. Infection with human herpesvirus-8 (HHV-8), also known as KS-associated herpesvirus (KSHV), is necessary but not sufficient for KS development. Coinfection with HIV markedly increases the likelihood of KS development, and additional environmental, hormonal, and genetic cofactors likely contribute to its pathogenesis (summary by {8:Foster et al., 2000}). {19:Suthaus et al. (2012)} noted that HHV-8 is the etiologic agent not only of KS, but also of primary effusion lymphoma and plasma cell-type multicentric Castleman disease (MCD).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Classic Kaposi Sarcoma" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Classic Kaposi Sarcoma" returned 23 free, full-text research articles on human participants. First 3 results:

[Classic and aggressive Kaposi sarcoma with bone involvement].
 

Author(s): Mouhcine Sbiyaa, Adil El Alaoui, Mohammed El Bardai, Amine Mezzani, Kamal Lahrach, Amine Marzouki, Fawzi Boutayeb

Journal:

 

Classic Kaposi sarcoma is a multifocal rare tumor originating from vascular endothelial cells with progressive evolution and little malignant predisposition. Although Kaposi sarcoma with extensive visceral involvement is sometimes observed among HIV-positive patients, tumor dissemination ...

Last Updated: 27 Jun 2016

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Risk of Classic Kaposi Sarcoma With Combinations of Killer Immunoglobulin-Like Receptor and Human Leukocyte Antigen Loci: A Population-Based Case-control Study.
 

Author(s): James J Goedert, Maureen P Martin, Francesco Vitale, Carmela Lauria, Denise Whitby, Ying Qi, Xiaojiang Gao, Mary Carrington

Journal: J. Infect. Dis.. 2016 Feb;213(3):432-8.

 

Kaposi sarcoma (KS) is a complication of KS-associated herpesvirus (KSHV) infection. Other oncogenic viral infections and malignancies are associated with certain HLA alleles and their natural killer (NK) cell immunoglobulin-like receptor (KIR) ligands. We tested whether HLA-KIR influences ...

Last Updated: 8 Jan 2016

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Classic Kaposi Sarcoma: to treat or not to treat?
 

Author(s): Bruno Vincenzi, Loretta D'Onofrio, Anna Maria Frezza, Rosario Francesco Grasso, Valentina Fausti, Daniele Santini, Angelo Paolo Dei Tos, Giuseppe Tonini

Journal:

 

Classic Kaposi Sarcoma (KS) is vascular sarcoma, known to be more common in Mediterranean elderly men and characterized by an indolent clinical behavior. To our knowledge, this is the first evidence in literature, describing a spontaneous partial regression in a non-HIV, non-iatrogenic KS.

Last Updated: 19 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Classic Kaposi Sarcoma" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Nivolumab and Ipilimumab in Classical Kaposi Sarcoma (CKS)
 

Status: Not yet recruiting

Condition Summary: Classic Kaposi Sarcoma

 

Last Updated: 28 Sep 2017

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Phase II Multicentric Study of Digoxin Per os in Classic or Endemic Kaposi' s Sarcoma
 

Status: Recruiting

Condition Summary: Kaposi' s Sarcoma; Classic Kaposi' s Sarcoma; Endemic Kaposi' s Sarcoma; Lymph Angio Proliferations

 

Last Updated: 15 Apr 2016

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