Chronic Myelomonocytic Leukemia

Common Name(s)

Chronic Myelomonocytic Leukemia

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Myelomonocytic Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chronic Myelomonocytic Leukemia" returned 95 free, full-text research articles on human participants. First 3 results:

DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells.
 

Author(s): Jie Xu, Yue-Ying Wang, Yu-Jun Dai, Wu Zhang, Wei-Na Zhang, Shu-Min Xiong, Zhao-Hui Gu, Kan-Kan Wang, Rong Zeng, Zhu Chen, Sai-Juan Chen

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Feb;111(7):2620-5.

 

The gene encoding DNA methyltransferase 3A (DNMT3A) is mutated in ∼20% of acute myeloid leukemia cases, with Arg882 (R882) as the hotspot. Here, we addressed the transformation ability of the DNMT3A-Arg882His (R882H) mutant by using a retroviral transduction and bone marrow transplantation ...

Last Updated: 19 Feb 2014

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Importance of genetics in the clinical management of chronic myelomonocytic leukemia.
 

Author(s): Eric Padron, Omar Abdel-Wahab

Journal: J. Clin. Oncol.. 2013 Jul;31(19):2374-6.

 

Last Updated: 1 Jul 2013

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Prognostic score including gene mutations in chronic myelomonocytic leukemia.
 

Author(s): Raphaël Itzykson, Olivier Kosmider, Aline Renneville, Véronique Gelsi-Boyer, Manja Meggendorfer, Margot Morabito, Céline Berthon, Lionel Adès, Pierre Fenaux, Odile Beyne-Rauzy, Norbert Vey, Thorsten Braun, Torsten Haferlach, François Dreyfus, Nicholas C P Cross, Claude Preudhomme, Olivier A Bernard, Michaela Fontenay, William Vainchenker, Susanne Schnittger, Daniel Birnbaum, Nathalie Droin, Eric Solary

Journal: J. Clin. Oncol.. 2013 Jul;31(19):2428-36.

 

Several prognostic scoring systems have been proposed for chronic myelomonocytic leukemia (CMML), a disease in which some gene mutations-including ASXL1-have been associated with poor prognosis in univariable analyses. We developed and validated a prognostic score for overall survival ...

Last Updated: 1 Jul 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chronic Myelomonocytic Leukemia" returned 4 free, full-text review articles on human participants. First 3 results:

Management recommendations for chronic myelomonocytic leukemia: consensus statements from the SIE, SIES, GITMO groups.
 

Author(s): Francesco Onida, Giovanni Barosi, Giuseppe Leone, Luca Malcovati, Enrica Morra, Valeria Santini, Giorgina Specchia, Sante Tura

Journal: Haematologica. 2013 Sep;98(9):1344-52.

 

With the aim of reviewing critical concepts and producing recommendations for the management of chronic myelomonocytic leukemia, key questions were selected according to the criterion of clinical relevance. Recommendations were produced using a Delphi process and four consensus conferences ...

Last Updated: 5 Sep 2013

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Spliceosome mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia.
 

Author(s): Virginie Chesnais, Olivier Kosmider, Frederik Damm, Raphael Itzykson, Olivier A Bernard, Eric Solary, Michaela Fontenay

Journal: Oncotarget. 2012 Nov;3(11):1284-93.

 

The recently discovered spliceosome mutations represent a group of acquired genetic alterations that affect both myeloid and lymphoid malignancies. A substantial proportion of patients with myelodysplastic syndromes (MDS), chronic myelomonocytoic leukemia (CMML) or chronic lymphocytic ...

Last Updated: 18 Jan 2013

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Chronic myelomonocytic leukemia and atypical chronic myeloid leukemia: novel pathogenetic lesions.
 

Author(s): Hideki Muramatsu, Hideki Makishima, Jaroslaw P Maciejewski

Journal: Semin. Oncol.. 2012 Feb;39(1):67-73.

 

Chronic myelomonocytic leukemia (CMML) and atypical chronic myeloid leukemia (aCML) are distinct, yet related, entities of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) characterized by morphologic dysplasia with accumulation of monocytes or neutrophils, respectively. Our ...

Last Updated: 31 Jan 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study of Sotatercept for the Treatment of Anemia in low-or Intermediate-1 Risk Myelodysplastic Syndromes (MDS) or Non-proliferative Chronic Myelomonocytic Leukemia (CMML)
 

Status: Recruiting

Condition Summary: Anemia; Myelodysplastic Syndromes (MDS); Chronic Myelomonocytic Leukemia (CMML); Low to Intermediate-1 MDS

 

Last Updated: 4 Aug 2014

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The Expression of PTEN Protein and mRNA in Malignant Cells of Chronic Myelomonocytic Leukemia
 

Status: Recruiting

Condition Summary: Chronic Myelomonocytic Leukemia

 

Last Updated: 14 Aug 2014

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Volasertib in Combination With Azacitidine in Japanese Patients With Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia
 

Status: Recruiting

Condition Summary: Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic

 

Last Updated: 19 Sep 2014

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