Chronic Lymphocytic Leukemia

Common Name(s)

Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is a cancer of the lymphocytes (a type of white blood cell) that begins in the stem cells of the bone marrow and then invades the blood. Overtime, CLL may also spread to the lymph nodes and other organs including the liver, spleen and lungs.  It occurs when the stem cells that make lymphocytes become out of control and produce increasing amounts of abnormal lymphocytes (also called leukemic cells). Eventually, these abnormal cells replace normal lymphocytes and can crowd out other types of normal blood cells, leading to the features of the condition. Early signs and symptoms of CLL may include fatigue, weight loss, loss of appetite, fever, night sweats and/or frequent infections.  The exact underlying cause of CLL is unknown; however, approximately 5% of affected people have other family members with the condition, which suggests there may be a genetic component in rare cases. The best treatment depends on many factors including the stage of the condition, the age of the affected person, the blood cell counts, whether the CLL has recurred, and the signs and symptoms present in each person.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Lymphocytic Leukemia" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Lymphocytic Leukemia" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chronic Lymphocytic Leukemia" returned 2626 free, full-text research articles on human participants. First 3 results:

Dysregulation of H/ACA ribonucleoprotein components in chronic lymphocytic leukemia.
 

Author(s): Patricia Carolina Dos Santos, Julieta Panero, Carmen Stanganelli, Virginia Palau Nagore, Flavia Stella, Raimundo Bezares, Irma Slavutsky

Journal:

 

Telomeres are protective repeats of TTAGGG sequences located at the end of human chromosomes. They are essential to maintain chromosomal integrity and genome stability. Telomerase is a ribonucleoprotein complex containing an internal RNA template (hTR) and a catalytic subunit (hTERT). ...

Last Updated: 30 Jun 2017

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Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody.
 

Author(s): Mark T Winkler, Ryan T Bushey, Elizabeth B Gottlin, Michael J Campa, Eross S Guadalupe, Alicia D Volkheimer, J Brice Weinberg, Edward F Patz

Journal:

 

Rituximab therapy for B cell chronic lymphocytic leukemia (B-CLL) has met with mixed success. Among several factors to which resistance can be attributed is failure to activate complement dependent cytotoxicity (CDC) due to protective complement regulatory proteins, including the ...

Last Updated: 28 Jun 2017

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Telomere length analysis in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia Binet A.
 

Author(s): F M Furtado, P S Scheucher, B A Santana, N F Scatena, R T Calado, E M Rego, D M Matos, R P Falcão

Journal:

 

Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic clinical entity characterized by the proliferation of monoclonal B cells not meeting the diagnosis criteria for chronic lymphocytic leukemia (CLL). MBL may precede the development of CLL, but the molecular mechanisms responsible ...

Last Updated: 19 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chronic Lymphocytic Leukemia" returned 197 free, full-text review articles on human participants. First 3 results:

Advances in the treatment of relapsed/refractory chronic lymphocytic leukemia.
 

Author(s): C Shustik, I Bence-Bruckler, R Delage, C J Owen, C L Toze, S Coutre

Journal: Ann. Hematol.. 2017 Jul;96(7):1185-1196.

 

Treatment of chronic lymphocytic leukemia (CLL) has advanced with the introduction of chemoimmunotherapy (CIT) agents that have improved the outcomes of frontline therapy. However, most treated patients will relapse and require subsequent therapy. This review focuses on recent advances ...

Last Updated: 8 Apr 2017

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Biclonal chronic lymphocytic leukemia: A study of two cases and review of literature.
 

Author(s): Kiran Ashok Ghodke, Nikhil V Patkar, P G Subramanian, Sumeet Gujral, Pratibha Aamre Kadam, Prashant R Tembhare

Journal: Indian J Pathol Microbiol. ;60(1):84-86.

 

Chronic lymphocytic leukemia (CLL) is a common, immunophenotypically well-defined mature B-cell neoplasm. Demonstration of more than 5000/μL CD5+ B-cell population with co-expression of CD23, weak expression of CD20, and one type of immunoglobin light chain (either kappa or lambda) ...

Last Updated: 14 Feb 2017

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Obinutuzumab in chronic lymphocytic leukemia: design, development and place in therapy.
 

Author(s): Othman Al-Sawaf, Kirsten Fischer, Anja Engelke, Natali Pflug, Michael Hallek, Valentin Goede

Journal:

 

For decades, treatment of chronic lymphocytic leukemia (CLL) has been based on chemotherapy. This changed when the first CD20 antibody rituximab was introduced. Since 2008, the combination of chemotherapy and CD20 antibodies has become the standard of care for most patients, and a ...

Last Updated: 9 Feb 2017

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Clinical Trial Information This information is provided by ClinicalTrials.gov

B Cell Repertoires in Chronic Lymphocytic Leukemia and Aging
 

Status: Recruiting

Condition Summary: Chronic Lymphocytic Leukemia

 

Last Updated: 2 Nov 2016

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A Study of Ibrutinib + Obinutuzumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
 

Status: Recruiting

Condition Summary: Chronic Lymphocytic Leukemia

 

Last Updated: 5 Jul 2017

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Last Updated: 22 Jun 2017

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