Chronic Lymphocytic Leukemia

Common Name(s)

Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is a common neoplasia of B lymphocytes in which these cells progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival (summary by {37:Quesada et al., 2012}). Genetic Heterogeneity of Susceptibility to Chronic Lymphocytic Leukemia Susceptibility loci have been mapped to chromosomes 11p11 (CLLS1; {609630}) and 13q14 (CLLS2; {109543}) by genomewide linkage analysis and translocation studies, respectively. Susceptibility mapping to chromosome 9q34 (CLLS3; {612557}) is associated with downregulation of the DAPK1 gene ({600831}). Genomewide association studies have identified susceptibility loci on chromosomes 6p25.3 (CLLS4; {612558}) and 11q24.1 (CLLS5; {612559}).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Lymphocytic Leukemia" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

View Details
National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Lymphocytic Leukemia" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

View Details
National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chronic Lymphocytic Leukemia" returned 1839 free, full-text research articles on human participants. First 3 results:

Chemoimmunotherapy for chronic lymphocytic leukemia. Author reply.
 

Author(s): Valentin Goede, Kirsten Fischer, Michael Hallek

Journal: N. Engl. J. Med.. 2014 Jun;370(24):2348-9.

 

Last Updated: 12 Jun 2014

Go To URL
Ibrutinib resistance in chronic lymphocytic leukemia.
 

Author(s): Richard R Furman, Shuhua Cheng, Pin Lu, Menu Setty, Alexendar R Perez, Alijandro R Perez, Ailin Guo, Joelle Racchumi, Guozhou Xu, Hao Wu, Jiao Ma, Susanne M Steggerda, Morton Coleman, Christina Leslie, Y Lynn Wang

Journal: N. Engl. J. Med.. 2014 Jun;370(24):2352-4.

 

Last Updated: 12 Jun 2014

Go To URL
Thalidomide regulation of NF-κB proteins limits Tregs activity in chronic lymphocytic leukemia.
 

Author(s): Katarzyna Skórka, Nupur Bhattacharya, Paulina Własiuk, Małgorzata Kowal, Daniel Mertens, Anna Dmoszyńska, Krzysztof Giannopoulos

Journal: Adv Clin Exp Med. ;23(1):25-32.

 

Thalidomide may represent a novel therapeutic strategy in the treatment of chronic lymphocytic leukemia (CLL). Since the activation of nuclear factor kappa B (NF-κB) causes not only malignant transformation and tumor progression, but also allows tumor cells to evade immune surveillance, ...

Last Updated: 5 Mar 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chronic Lymphocytic Leukemia" returned 138 free, full-text review articles on human participants. First 3 results:

The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia.
 

Author(s): Gabriele Brachtl, Josefina Piñón Hofbauer, Richard Greil, Tanja Nicole Hartmann

Journal: Ann. Hematol.. 2014 Mar;93(3):361-74.

 

The interactions of chronic lymphocytic leukemia cells with the microenvironment in secondary lymphoid tissues and the bone marrow are known to promote CLL cell survival and proliferation. CD38 and CD49d are both independent prognostic risk parameters in CLL with important roles in ...

Last Updated: 10 Feb 2014

Go To URL
Role of signaling pathways and miRNAs in chronic lymphocytic leukemia.
 

Author(s): Pei-Pei Li, Xin Wang

Journal: Chin. Med. J.. 2013 Nov;126(21):4175-82.

 

To summarize the recent findings of dysregulation of signaling pathways and miRNAs in chronic lymphocytic leukemia (CLL).

Last Updated: 15 Nov 2013

Go To URL
Lenalidomide and chronic lymphocytic leukemia.
 

Author(s): Ana Pilar González-Rodríguez, Angel R Payer, Andrea Acebes-Huerta, Leticia Huergo-Zapico, Monica Villa-Alvarez, Esther Gonzalez-García, Segundo Gonzalez

Journal: Biomed Res Int. 2013 ;2013():932010.

 

Lenalidomide is an oral immunomodulatory drug used in multiple myeloma and myelodysplastic syndrome and most recently it has shown to be effective in the treatment of various lymphoproliferative disorders such as chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma. The mechanism ...

Last Updated: 28 Oct 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Lenalidomide and Vaccine Therapy in Treating Patients With Early-Stage Asymptomatic Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
 

Status: Recruiting

Condition Summary: B-cell Chronic Lymphocytic Leukemia; Contiguous Stage II Small Lymphocytic Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Stage 0 Chronic Lymphocytic Leukemia; Stage I Chronic Lymphocytic Leukemia; Stage I Small Lymphocytic Lymphoma; Stage II Chronic Lymphocytic Leukemia

 

Last Updated: 28 Jul 2014

Go to URL
Curcumin and Cholecalciferol in Treating Patients With Previously Untreated Stage 0-II Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
 

Status: Not yet recruiting

Condition Summary: Contiguous Stage II Small Lymphocytic Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Stage 0 Chronic Lymphocytic Leukemia; Stage I Chronic Lymphocytic Leukemia; Stage I Small Lymphocytic Lymphoma; Stage II Chronic Lymphocytic Leukemia

 

Last Updated: 27 Mar 2014

Go to URL
Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
 

Status: Recruiting

Condition Summary: Anemia; Fever, Sweats, and Hot Flashes; Stage I Chronic Lymphocytic Leukemia; Stage I Small Lymphocytic Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage II Small Lymphocytic Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Small Lymphocytic Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Small Lymphocytic Lymphoma; Weight Changes

 

Last Updated: 28 Jul 2014

Go to URL