Chronic Lymphocytic Leukemia

Common Name(s)

Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is a common neoplasia of B lymphocytes in which these cells progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival (summary by {37:Quesada et al., 2012}). Genetic Heterogeneity of Susceptibility to Chronic Lymphocytic Leukemia Susceptibility loci have been mapped to chromosomes 11p11 (CLLS1; {609630}) and 13q14 (CLLS2; {109543}) by genomewide linkage analysis and translocation studies, respectively. Susceptibility mapping to chromosome 9q34 (CLLS3; {612557}) is associated with downregulation of the DAPK1 gene ({600831}). Genomewide association studies have identified susceptibility loci on chromosomes 6p25.3 (CLLS4; {612558}) and 11q24.1 (CLLS5; {612559}).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Lymphocytic Leukemia" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic Lymphocytic Leukemia" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chronic Lymphocytic Leukemia" returned 1976 free, full-text research articles on human participants. First 3 results:

Chemoimmunotherapy for chronic lymphocytic leukemia. Author reply.
 

Author(s): Valentin Goede, Kirsten Fischer, Michael Hallek

Journal: N. Engl. J. Med.. 2014 Jun;370(24):2348-9.

 

Last Updated: 12 Jun 2014

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MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia.
 

Author(s): Bing Cui, Liguang Chen, Suping Zhang, Marek Mraz, Jessie-F Fecteau, Jian Yu, Emanuela M Ghia, Ling Zhang, Lei Bao, Laura Z Rassenti, Karen Messer, George A Calin, Carlo M Croce, Thomas J Kipps

Journal: Blood. 2014 Jul;124(4):546-54.

 

High-level leukemia cell expression of micro-RNA 155 (miR-155) is associated with more aggressive disease in patients with chronic lymphocytic leukemia (CLL), including those cases with a low-level expression of ζ-chain-associated protein of 70 kD. CLL with high-level miR-155 expressed ...

Last Updated: 25 Jul 2014

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Ibrutinib resistance in chronic lymphocytic leukemia.
 

Author(s): Richard R Furman, Shuhua Cheng, Pin Lu, Menu Setty, Alexendar R Perez, Alijandro R Perez, Ailin Guo, Joelle Racchumi, Guozhou Xu, Hao Wu, Jiao Ma, Susanne M Steggerda, Morton Coleman, Christina Leslie, Y Lynn Wang

Journal: N. Engl. J. Med.. 2014 Jun;370(24):2352-4.

 

Last Updated: 12 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chronic Lymphocytic Leukemia" returned 157 free, full-text review articles on human participants. First 3 results:

Advances in chimeric antigen receptor immunotherapy for chronic lymphocytic leukemia.
 

Author(s): John C Riches, John G Gribben

Journal: Discov Med. 2013 Dec;16(90):295-302.

 

Despite the recent advances with targeted therapies in chronic lymphocytic leukemia (CLL), allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative option. However, this procedure is associated with significant morbidity and mortality due to high rates of ...

Last Updated: 16 Dec 2013

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The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia.
 

Author(s): Gabriele Brachtl, Josefina Piñón Hofbauer, Richard Greil, Tanja Nicole Hartmann

Journal: Ann. Hematol.. 2014 Mar;93(3):361-74.

 

The interactions of chronic lymphocytic leukemia cells with the microenvironment in secondary lymphoid tissues and the bone marrow are known to promote CLL cell survival and proliferation. CD38 and CD49d are both independent prognostic risk parameters in CLL with important roles in ...

Last Updated: 10 Feb 2014

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Genetic susceptibility to chronic lymphocytic leukemia.
 

Author(s): Susan L Slager, Neil E Caporaso, Silvia de Sanjose, Lynn R Goldin

Journal: Semin. Hematol.. 2013 Oct;50(4):296-302.

 

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the West and is an incurable malignancy. No firmly established evidence exists for environmental risk factors in the etiology of CLL. However, CLL is estimated to have one of the highest familial risks for a hematologic ...

Last Updated: 19 Nov 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lenalidomide and Vaccine Therapy in Treating Patients With Early-Stage Asymptomatic Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
 

Status: Recruiting

Condition Summary: Chronic Lymphocytic Leukemia; Stage 0 Chronic Lymphocytic Leukemia; Stage I Chronic Lymphocytic Leukemia; Stage I Small Lymphocytic Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage II Small Lymphocytic Lymphoma

 

Last Updated: 25 Nov 2014

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Fludarabine Phosphate, Radiation Therapy, and Rituximab in Treating Patients Who Are Undergoing Donor Stem Cell Transplant Followed by Rituximab for High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
 

Status: Recruiting

Condition Summary: B-cell Chronic Lymphocytic Leukemia; Prolymphocytic Leukemia; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Stage III Chronic Lymphocytic Leukemia; Stage III Small Lymphocytic Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Small Lymphocytic Lymphoma; T-cell Large Granular Lymphocyte Leukemia

 

Last Updated: 24 Jun 2014

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Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
 

Status: Recruiting

Condition Summary: Anemia; Fever, Sweat, and Hot Flashes; Stage I Chronic Lymphocytic Leukemia; Stage I Small Lymphocytic Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage II Small Lymphocytic Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Small Lymphocytic Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Small Lymphocytic Lymphoma; Weight Change

 

Last Updated: 25 Nov 2014

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