Acromegaly

Common Name(s)

Acromegaly

Acromegaly is a hormonal disorder that results from the pituitary gland producing too much growth hormone (GH). It is most often diagnosed in middle-aged adults, although symptoms can appear at any age. Signs and symptoms include abnormal growth and swelling of the hands and feet; bone changes that alter various facial features; arthritis; carpal tunnel syndrome; enlargement of body organs; and various other symptoms. The condition is usually caused by benign tumors on the pituitary called adenomas. Rarely, it is caused by tumors of the pancreas, lungs, and other parts of the brain. Acromegaly is usually treatable but when left untreated, it can result in serious illness and premature death. When GH-producing tumors occur in childhood, the disease that results is called gigantism rather than acromegaly.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acromegaly" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acromegaly" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acromegaly" returned 590 free, full-text research articles on human participants. First 3 results:

Adiponectin and Cardiac Hypertrophy in Acromegaly.
 

Author(s): Sabriye Gurbulak, Fulya Akin, Emrah Yerlikaya, Guzin F Yaylali, Senay Topsakal, Halil Tanriverdi, Beyza Akdag, Bunyamin Kaptanoglu

Journal: Adv Clin Exp Med. ;25(3):449-55.

 

Adiponectin is an adipocytes-derived hormone which has been shown to possess insulin-sensitizing, antiatherogenic, and anti-inflammatory properties. In acromegaly, the data on adiponectin is contradictory. The relationship between adiponectin levels and cardiac parameters has not been studied.

Last Updated: 16 Sep 2016

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Switching patients with acromegaly from octreotide to pasireotide improves biochemical control: crossover extension to a randomized, double-blind, Phase III study.
 

Author(s): Marcello D Bronstein, Maria Fleseriu, Sebastian Neggers, Annamaria Colao, Michael Sheppard, Feng Gu, Chiung-Chyi Shen, Mônica Gadelha, Andrew J Farrall, Karina Hermosillo Reséndiz, Matthieu Ruffin, YinMiao Chen, Pamela Freda,

Journal:

 

Many patients with acromegaly do not achieve biochemical control with first-generation somatostatin analogues. A large, multicenter, randomized, Phase III core study demonstrated that pasireotide LAR had significantly superior efficacy over octreotide LAR. This analysis explores the ...

Last Updated: 4 Apr 2016

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Structural tendon changes in patients with acromegaly: assessment of Achilles tendon with sonoelastography.
 

Author(s): Eda Demil Onal, Ali Ipek, Berna Evranos, Ilkay Sedakat Idilman, Bekir Cakir, Reyhan Ersoy

Journal: Med Ultrason. 2016 Mar;18(1):30-5.

 

To describe the sonoelastographic appearance of the Achilles tendon in acromegalic patients and to determine whether the blood concentrations of growth hormone (GH) and insulin-like growth factor (IGF-1) are associated with the various sonographic elasticity types of Achilles tendons.

Last Updated: 10 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acromegaly" returned 67 free, full-text review articles on human participants. First 3 results:

Pasireotide: a novel treatment for patients with acromegaly.
 

Author(s): Daniel Cuevas-Ramos, Maria Fleseriu

Journal:

 

Morbidity and mortality rates in patients with active acromegaly are higher than the general population. Adequate biochemical control restores mortality to normal rates. Now, medical therapy has an increasingly important role in the treatment of patients with acromegaly. Somatostatin ...

Last Updated: 26 Jan 2016

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Current therapies and mortality in acromegaly.
 

Author(s): S Găloiu, C Poiană

Journal: J Med Life. ;8(4):411-5.

 

Acromegaly is a rare disease most frequently due to a GH secreting pituitary adenoma. Without an appropriate therapy, life of patients with acromegaly can be shortened with ten years. Pituitary surgery is usually the first line therapy for GH secreting pituitary adenomas. A meta-analysis ...

Last Updated: 15 Dec 2015

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Review of current and emerging treatment options in acromegaly.
 

Author(s): A Muhammad, A J van der Lely, S J C M M Neggers

Journal: Neth J Med. 2015 Oct;73(8):362-7.

 

In almost every patient, acromegaly is caused by a growth hormone secreting pituitary adenoma. Clinical features are the result of excessive growth hormone secretion and the consecutive excess in insulin-like growth factor I levels. This results in somatic overgrowth and metabolic ...

Last Updated: 19 Oct 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Prospective Study of Outcome After Therapy for Acromegaly
 

Status: Recruiting

Condition Summary: Acromegaly

 

Last Updated: 4 Aug 2016

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Last Updated: 14 Jan 2017

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Acromegaly & Sleep Apnoea
 

Status: Recruiting

Condition Summary: Acromegaly

 

Last Updated: 19 Feb 2015

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