Acromegaly

Common Name(s)

Acromegaly

Acromegaly is a hormonal disorder that results from the pituitary gland producing too much growth hormone (GH). It is most often diagnosed in middle-aged adults, although symptoms can appear at any age. Signs and symptoms include abnormal growth and swelling of the hands and feet; bone changes that alter various facial features; arthritis; carpal tunnel syndrome; enlargement of body organs; and various other symptoms. The condition is usually caused by benign tumors on the pituitary called adenomas. Rarely, it is caused by tumors of the pancreas, lungs, and other parts of the brain. Acromegaly is usually treatable but when left untreated, it can result in serious illness and premature death. When GH-producing tumors occur in childhood, the disease that results is called gigantism rather than acromegaly.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acromegaly" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acromegaly" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acromegaly" returned 549 free, full-text research articles on human participants. First 3 results:

Long-term effects of pegvisomant on comorbidities in patients with acromegaly: a retrospective single-center study.
 

Author(s): Emmanuelle Kuhn, Luigi Maione, Amir Bouchachi, Myriam Rozière, Sylvie Salenave, Sylvie Brailly-Tabard, Jacques Young, Peter Kamenicky, Patrick Assayag, Philippe Chanson

Journal: Eur. J. Endocrinol.. 2015 Nov;173(5):693-702.

 

The effect of pegvisomant on IGF1 levels in patients with acromegaly is well documented, but little is known of its long-term impact on comorbidity.

Last Updated: 2 Oct 2015

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Lanreotide Autogel 120 mg at extended dosing intervals in patients with acromegaly biochemically controlled with octreotide LAR: the LEAD study.
 

Author(s): Sebastian J C M M Neggers, Vyacheslav Pronin, Inga Balcere, Moon-Kyu Lee, Liudmila Rozhinskaya, Marcello D Bronstein, Mônica R Gadelha, Pascal Maisonobe, Caroline Sert, Aart Jan van der Lely,

Journal: Eur. J. Endocrinol.. 2015 Sep;173(3):313-23.

 

To evaluate extended dosing intervals (EDIs) with lanreotide Autogel 120 mg in patients with acromegaly previously biochemically controlled with octreotide LAR 10 or 20 mg.

Last Updated: 5 Aug 2015

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A male patient with acromegaly and breast cancer: treating acromegaly to control tumor progression.
 

Author(s): Paola Leporati, Rodolfo Fonte, Luca de Martinis, Alberto Zambelli, Flavia Magri, Lorenzo Pavesi, Mario Rotondi, Luca Chiovato

Journal:

 

Acromegaly is a rare disease associated with an increased risk of developing cancer.

Last Updated: 19 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acromegaly" returned 60 free, full-text review articles on human participants. First 3 results:

60 YEARS OF NEUROENDOCRINOLOGY: Acromegaly.
 

Author(s): Cristina Capatina, John A H Wass

Journal: J. Endocrinol.. 2015 Aug;226(2):T141-60.

 

Acromegaly (ACM) is a chronic, progressive disorder caused by the persistent hypersecretion of GH, in the vast majority of cases secreted by a pituitary adenoma. The consequent increase in IGF1 (a GH-induced liver protein) is responsible for most clinical features and for the systemic ...

Last Updated: 25 Jul 2015

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The quality of life and psychological, social and cognitive functioning of patients with acromegaly.
 

Author(s): Dorota Szcześniak, Aleksandra Jawiarczyk-Przybyłowska, Joanna Rymaszewska

Journal: Adv Clin Exp Med. ;24(1):167-72.

 

Acromegaly is a rare and chronic disease, most often caused by a pituitary adenoma. Excessive secretion of the growth hormone (GH) leads to hepatic secretion of insulin-like growth factor-1 (IGF-1), which in turn causes characteristic changes in the patient's appearance, many skeletal ...

Last Updated: 30 Apr 2015

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Advances in the pharmacotherapy of patients with acromegaly.
 

Author(s): Maria Fleseriu

Journal: Discov Med. 2014 Jun;17(96):329-38.

 

Acromegaly is a disease characterized by growth hormone (GH) excess originating, in approximately 95% of cases, from a somatotroph pituitary adenoma. Symptomatology and clinical features are due to GH and insulin-like growth factor 1 excess; unfortunately, for most patients diagnosis ...

Last Updated: 1 Jul 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lanreotide Levels in Acromegaly
 

Status: Recruiting

Condition Summary: Acromegaly

 

Last Updated: 9 Jun 2009

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The Treatment and Natural History of Acromegaly
 

Status: Recruiting

Condition Summary: Acromegaly; Pituitary Neoplasm

 

Last Updated: 28 Aug 2015

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