Acromegaly

Common Name(s)

Acromegaly

Acromegaly is a hormonal disorder that results from the pituitary gland producing too much growth hormone (GH). It is most often diagnosed in middle-aged adults, although symptoms can appear at any age. Signs and symptoms include abnormal growth and swelling of the hands and feet; bone changes that alter various facial features; arthritis; carpal tunnel syndrome; enlargement of body organs; and various other symptoms. The condition is usually caused by benign tumors on the pituitary called adenomas. Rarely, it is caused by tumors of the pancreas, lungs, and other parts of the brain. Acromegaly is usually treatable but when left untreated, it can result in serious illness and premature death. When GH-producing tumors occur in childhood, the disease that results is called gigantism rather than acromegaly.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acromegaly" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acromegaly" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acromegaly" returned 575 free, full-text research articles on human participants. First 3 results:

Patient-reported outcomes of parenteral somatostatin analogue injections in 195 patients with acromegaly.
 

Author(s): Christian J Strasburger, Niki Karavitaki, Sylvère Störmann, Peter J Trainer, Ilonka Kreitschmann-Andermahr, Michael Droste, Márta Korbonits, Berit Feldmann, Kathrin Zopf, Violet Fazal Sanderson, David Schwicker, Dana Gelbaum, Asi Haviv, Martin Bidlingmaier, Nienke R Biermasz

Journal: Eur. J. Endocrinol.. 2016 Mar;174(3):355-62.

 

Long-acting somatostatin analogues delivered parenterally are the most widely used medical treatment in acromegaly. This patient-reported outcomes survey was designed to assess the impact of chronic injections on subjects with acromegaly.

Last Updated: 23 Jan 2016

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Prevalence of lung structure abnormalities in patients with acromegaly and their relationship with gas exchange: cross-sectional analytical study with a control group.
 

Author(s): Marcelo Palmeira Rodrigues, Luciana Ansaneli Naves, Carlos Alberto Viegas, Cesar Augusto Melo-Silva, Wagner Diniz de Paula, Márcia Teixeira Cabral, Renata Rodrigues Araújo, Luiz Augusto Casulari

Journal: Sao Paulo Med J. ;133(5):394-400.

 

Different functional respiratory alterations have been described in acromegaly, but their relationship with pulmonary tissue abnormalities is unknown. The objective of this study was to observe possible changes in lung structure and explain their relationship with gas exchange abnormalities.

Last Updated: 9 Dec 2015

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Acromegaly presenting with low insulin-like growth factor-1 levels and diabetes: a case report.
 

Author(s): Dilushi Rowena Wijayaratne, M H Arambewela, Chamara Dalugama, Dishni Wijesundera, Noel Somasundaram, Prasad Katulanda

Journal:

 

Acromegaly is an endocrine disorder arising from excessive serum growth hormone levels in adulthood and is characterized by progressive somatic enlargement. Biochemical confirmation is achieved by demonstration of elevated baseline serum growth hormone levels which are not suppressed ...

Last Updated: 30 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acromegaly" returned 63 free, full-text review articles on human participants. First 3 results:

Current therapies and mortality in acromegaly.
 

Author(s): S Găloiu, C Poiană

Journal: J Med Life. ;8(4):411-5.

 

Acromegaly is a rare disease most frequently due to a GH secreting pituitary adenoma. Without an appropriate therapy, life of patients with acromegaly can be shortened with ten years. Pituitary surgery is usually the first line therapy for GH secreting pituitary adenomas. A meta-analysis ...

Last Updated: 15 Dec 2015

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Review of current and emerging treatment options in acromegaly.
 

Author(s): A Muhammad, A J van der Lely, S J C M M Neggers

Journal: Neth J Med. 2015 Oct;73(8):362-7.

 

In almost every patient, acromegaly is caused by a growth hormone secreting pituitary adenoma. Clinical features are the result of excessive growth hormone secretion and the consecutive excess in insulin-like growth factor I levels. This results in somatic overgrowth and metabolic ...

Last Updated: 19 Oct 2015

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60 YEARS OF NEUROENDOCRINOLOGY: Acromegaly.
 

Author(s): Cristina Capatina, John A H Wass

Journal: J. Endocrinol.. 2015 Aug;226(2):T141-60.

 

Acromegaly (ACM) is a chronic, progressive disorder caused by the persistent hypersecretion of GH, in the vast majority of cases secreted by a pituitary adenoma. The consequent increase in IGF1 (a GH-induced liver protein) is responsible for most clinical features and for the systemic ...

Last Updated: 25 Jul 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lanreotide Levels in Acromegaly
 

Status: Recruiting

Condition Summary: Acromegaly

 

Last Updated: 9 Jun 2009

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The Treatment and Natural History of Acromegaly
 

Status: Recruiting

Condition Summary: Acromegaly; Pituitary Neoplasm

 

Last Updated: 24 Jun 2016

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