Acromegaly

Common Name(s)

Acromegaly

Acromegaly is a hormonal disorder that results from the pituitary gland producing too much growth hormone (GH). It is most often diagnosed in middle-aged adults, although symptoms can appear at any age. Signs and symptoms include abnormal growth and swelling of the hands and feet; bone changes that alter various facial features; arthritis; carpal tunnel syndrome; enlargement of body organs; and various other symptoms. The condition is usually caused by benign tumors on the pituitary called adenomas. Rarely, it is caused by tumors of the pancreas, lungs, and other parts of the brain. Acromegaly is usually treatable but when left untreated, it can result in serious illness and premature death. When GH-producing tumors occur in childhood, the disease that results is called gigantism rather than acromegaly.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acromegaly" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acromegaly" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acromegaly" returned 625 free, full-text research articles on human participants. First 3 results:

Suffocation due to Thoracic Deformity Caused by Acromegaly.
 

Author(s): Toshihiko Yoshizawa, Masayuki Iwazaki, Kei Jitsuiki, Kouhei Ishikawa, Hiromichi Ohsaka, Youichi Yanagawa

Journal: Intern. Med.. 2017 ;56(8):949-951.

 

A 61-year-old man with gigantism and acromegaly choked and fell into a coma. Immediate tracheal intubation resulted in a return of his consciousness. Enhanced computed tomography indicated that the trachea and left main bronchus were compressed by the thoracic spine and sternum. He ...

Last Updated: 19 Apr 2017

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The association between biochemical control and cardiovascular risk factors in acromegaly.
 

Author(s): John D Carmichael, Michael S Broder, Dasha Cherepanov, Eunice Chang, Adam Mamelak, Qayyim Said, Maureen P Neary, Vivien Bonert

Journal:

 

The study aim was to estimate the proportion of acromegaly patients with various comorbidities and to determine if biochemical control was associated with reduced proportion of cardiovascular risk factors.

Last Updated: 10 Mar 2017

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Thyroid lesions in patients with acromegaly - case-control study and update to the meta-analysis.
 

Author(s): Kosma Woliński, Adam Stangierski, Edyta Gurgul, Barbara Bromińska, Agata Czarnywojtek, Martha Lodyga, Marek Ruchała

Journal: Endokrynol Pol. 2017 ;68(1):2-6.

 

Acromegaly results from oversecretion of growth hormone and subsequently insulin growth factor-1. According to some authors, the disease can cause increased prevalence of nodular goitre and thyroid cancer (TC). However, the number of studies comparing acromegalic patients with control ...

Last Updated: 3 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acromegaly" returned 79 free, full-text review articles on human participants. First 3 results:

The genetic background of acromegaly.
 

Author(s): Mônica R Gadelha, Leandro Kasuki, Márta Korbonits

Journal: Pituitary. 2017 Feb;20(1):10-21.

 

Acromegaly is caused by a somatotropinoma in the vast majority of the cases. These are monoclonal tumors that can occur sporadically or rarely in a familial setting. In the last few years, novel familial syndromes have been described and recent studies explored the landscape of somatic ...

Last Updated: 5 Feb 2017

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Epidemiology of acromegaly: review of population studies.
 

Author(s): Aikaterini Lavrentaki, Alessandro Paluzzi, John A H Wass, Niki Karavitaki

Journal: Pituitary. 2017 Feb;20(1):4-9.

 

Acromegaly is a rare condition necessitating large population studies for the generation of reliable epidemiological data. In this review, we systematically analysed the epidemiological profile of this condition based on recently published population studies from various geographical ...

Last Updated: 15 Oct 2016

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Pregnancy and acromegaly.
 

Author(s): Ammar Muhammad, Sebastian J Neggers, Aart J van der Lely

Journal: Pituitary. 2017 Feb;20(1):179-184.

 

Acromegaly is a rare disorder in which, due to the high incidence of secondary hypogonadism, pregnancies are relatively rare. However, some women with acromegaly do get pregnant, which brings along questions about medication, complications and follow-up. This review tries to address ...

Last Updated: 28 Aug 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment Patterns and Treatment Outcomes for Acromegaly
 

Status: Recruiting

Condition Summary: Acromegaly

 

Last Updated: 2 Feb 2017

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Last Updated: 22 May 2017

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A Prospective Study of Outcome After Therapy for Acromegaly
 

Status: Recruiting

Condition Summary: Acromegaly

 

Last Updated: 2 Feb 2017

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