Acromegaly

Common Name(s)

Acromegaly

Acromegaly is a hormonal disorder that results from the pituitary gland producing too much growth hormone (GH). It is most often diagnosed in middle-aged adults, although symptoms can appear at any age. Signs and symptoms include abnormal growth and swelling of the hands and feet; bone changes that alter various facial features; arthritis; carpal tunnel syndrome; enlargement of body organs; and various other symptoms. The condition is usually caused by benign tumors on the pituitary called adenomas. Rarely, it is caused by tumors of the pancreas, lungs, and other parts of the brain. Acromegaly is usually treatable but when left untreated, it can result in serious illness and premature death. When GH-producing tumors occur in childhood, the disease that results is called gigantism rather than acromegaly.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acromegaly" for support, advocacy or research.

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Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

Last Updated: 20 Feb 2013

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Acromegaly" for support, advocacy or research.

Logo
Pituitary Network Association

To support, pursue, encourage, promote, and, where possible, fund research on pituitary disorders in a sustained and full-time effort to find a cure for these illnesses. The PNA will disseminate information helpful to the medical community, the public, and to pituitary patients and their families on matters regarding early detection, symptoms, treatments and resources available to patients with pituitary disease.

http://www.pituitary.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Acromegaly" returned 462 free, full-text research articles on human participants. First 3 results:

Pasireotide versus octreotide in acromegaly: a head-to-head superiority study.
 

Author(s): A Colao, M D Bronstein, P Freda, F Gu, C-C Shen, M Gadelha, M Fleseriu, A J van der Lely, A J Farrall, K Hermosillo Reséndiz, M Ruffin, Y Chen, M Sheppard,

Journal: J. Clin. Endocrinol. Metab.. 2014 Mar;99(3):791-9.

 

Biochemical control reduces morbidity and increases life expectancy in patients with acromegaly. With current medical therapies, including the gold standard octreotide long-acting-release (LAR), many patients do not achieve biochemical control.

Last Updated: 14 May 2014

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Tumor shrinkage with lanreotide Autogel 120 mg as primary therapy in acromegaly: results of a prospective multicenter clinical trial.
 

Author(s): Philippe J Caron, John S Bevan, Stephan Petersenn, Daniel Flanagan, Antoine Tabarin, Gaëtan Prévost, Pascal Maisonobe, Antoine Clermont,

Journal: J. Clin. Endocrinol. Metab.. 2014 Apr;99(4):1282-90.

 

Methodological shortcomings often compromise investigations into the effects of primary somatostatin-analog treatment on tumor size in acromegaly. There are also limited data for the long-acting lanreotide formulation.

Last Updated: 7 Apr 2014

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Prevalence of thyroid diseases in patients with acromegaly: experience of a Brazilian center.
 

Author(s): Helena Bandeira de Melo Paiva Uchoa, Giovanna Aparecida Balarini Lima, Lívia Lugarinho Corrêa, Ana Paula Sieiro Vidal, Suzana Aquino Cavallieri, Mário Vaisman, Alexandru Buescu, Mônica Roberto Gadelha

Journal: Arq Bras Endocrinol Metabol. 2013 Dec;57(9):685-90.

 

Acromegaly is frequently associated with thyroid diseases. In this study, we evaluated the frequency of thyroid disorders in a series of acromegalic patients.

Last Updated: 9 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Acromegaly" returned 54 free, full-text review articles on human participants. First 3 results:

Place of preoperative treatment of acromegaly with somatostatin analog on surgical outcome: a systematic review and meta-analysis.
 

Author(s): Francisco Pita-Gutierrez, Sonia Pertega-Diaz, Salvador Pita-Fernandez, Lara Pena, Gloria Lugo, Susana Sangiao-Alvarellos, Fernando Cordido

Journal:

 

Transsphenoidal neurosurgery is the accepted first-line treatment of acromegaly in the majority of patients. Previous studies addressing preoperative somatostatin analog (SSA) treatment and subsequent surgical cure rates are conflicting, reporting either benefits or no significant differences.

Last Updated: 1 May 2013

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Double, synchronous pituitary adenomas causing acromegaly and Cushing's disease. A case report and review of literature.
 

Author(s): Grzegorz Zieliński, Maria Maksymowicz, Jan Podgórski, Włodzimierz T Olszewski

Journal: Endocr. Pathol.. 2013 Jun;24(2):92-9.

 

Double pituitary adenomas are very rare and present up to 1 % of pituitary adenomas in unselected autopsy series and up to 2 % in large surgical series. We report a case of a 47-year-old man presented slight clinical features of acromegaly with 2 years duration. Endocrine evaluation ...

Last Updated: 17 May 2013

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Ectopic acromegaly due to growth hormone releasing hormone.
 

Author(s): Ali A Ghazi, Alireza Amirbaigloo, Azizollah Abbasi Dezfooli, Navid Saadat, Siavash Ghazi, Marina Pourafkari, Farrokh Tirgari, Dheepti Dhall, Serguei Bannykh, Shlomo Melmed, Odelia Cooper

Journal: Endocrine. 2013 Apr;43(2):293-302.

 

Acromegaly secondary to extra-pituitary tumors secreting growth hormone releasing hormone (GHRH) is rarely encountered. We review the literature on ectopic acromegaly and present the index report of ectopic acromegaly secondary to GHRH secretion from a mediastinal paraganglioma. Clinical ...

Last Updated: 11 Mar 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lanreotide Levels in Acromegaly
 

Status: Recruiting

Condition Summary: Acromegaly

 

Last Updated: 9 Jun 2009

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The Treatment and Natural History of Acromegaly
 

Status: Recruiting

Condition Summary: Acromegaly; Pituitary Neoplasm

 

Last Updated: 14 Mar 2014

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A Prospective Study of Outcome After Therapy for Acromegaly
 

Status: Recruiting

Condition Summary: Acromegaly

 

Last Updated: 11 Mar 2013

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